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公开(公告)号：US20090075996A1
公开(公告)日：2009-03-19
申请号：US11995683
申请日：2006-07-14
申请人： Phillip B. Alper , Thomas Marsilje , Arnab Chatterjee , Wenshuo Lu , Daniel Mutnick , Michael Roberts , Yun He
发明人： Phillip B. Alper , Thomas Marsilje , Arnab Chatterjee , Wenshuo Lu , Daniel Mutnick , Michael Roberts , Yun He
IPC分类号： A61K31/5377 , C07D209/82 , C07D413/08 , A61K31/403
CPC分类号： C08J7/04 , C07D209/80 , C07D209/94 , C07D401/04 , C07D403/04 , C07D413/04 , C07D417/04 , C07D491/04 , C07D495/04 , C08J7/045 , C08J2369/00
摘要： The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated TPO activity, particularly diseases or disorders that involve thrombocytopenia.
摘要翻译： 本发明提供了一类新颖的化合物，包含这些化合物的药物组合物和使用这些化合物治疗或预防与异常或失调的TPO活性相关的疾病或病症的方法，特别是涉及血小板减少症的疾病或病症。
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公开(公告)号：US20060089401A1
公开(公告)日：2006-04-27
申请号：US11261858
申请日：2005-10-27
IPC分类号： A61K31/405 , A61K31/165 , C07C235/66
CPC分类号： C12Q1/485 , G01N2500/04
摘要： The present invention provides a method for identifying inhibitors of protein kinases. Methods are also provided for inhibiting protein kinase activity. Specific non-peptide protein tyrosine kinase inhibitors are provided. The protein kinases produced using the method of the present invention may be used to treat a number of conditions in patients, including cancer, psoriasis, atherosclerosis, or immune system activity.
摘要翻译： 本发明提供了鉴定蛋白激酶抑制剂的方法。 还提供了用于抑制蛋白激酶活性的方法。 提供了特异性的非肽蛋白酪氨酸激酶抑制剂。 使用本发明的方法产生的蛋白激酶可用于治疗患者的许多病症，包括癌症，牛皮癣，动脉粥样硬化或免疫系统活性。
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公开(公告)号：US20050014724A1
公开(公告)日：2005-01-20
申请号：US10849079
申请日：2004-05-19
申请人： Thomas Marsilje , Nathanel Gray , Tao Jiang , Wenshuo Lu , Shifeng Pan
发明人： Thomas Marsilje , Nathanel Gray , Tao Jiang , Wenshuo Lu , Shifeng Pan
IPC分类号： A61K20060101 , A61K31/195 , A61K31/216 , A61K31/397 , A61K31/40 , A61K31/445 , A61K31/495 , A61K31/675 , C07C323/63 , C07D205/04 , C07D207/12 , C07D211/32 , C07D241/04 , C07F9/22 , C07F9/28
CPC分类号： C07C323/32 , C07C317/32 , C07C2601/14 , C07D205/04
摘要： The present invention relates to immunosuppressant, process for their production, their uses and pharmaceutical compositions containing them. The invention provides a novel class of compounds useful in the treatment or prevention of diseases or disorders mediated by lymphocyte interactions, particularly diseases associated with EDG receptor mediated signal transduction.
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公开(公告)号：US08153671B2
公开(公告)日：2012-04-10
申请号：US11995683
申请日：2006-07-14
申请人： Phillip B. Alper , Thomas Marsilje , Arnab Chatterjee , Wenshuo Lu , Daniel Mutnick , Michael Roberts , Yun He
发明人： Phillip B. Alper , Thomas Marsilje , Arnab Chatterjee , Wenshuo Lu , Daniel Mutnick , Michael Roberts , Yun He
IPC分类号： A61K31/404 , C07D487/02
CPC分类号： C08J7/04 , C07D209/80 , C07D209/94 , C07D401/04 , C07D403/04 , C07D413/04 , C07D417/04 , C07D491/04 , C07D495/04 , C08J7/045 , C08J2369/00
摘要： The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated TPO activity, particularly diseases or disorders that involve thrombocytopenia.
摘要翻译： 本发明提供了一类新颖的化合物，包含这些化合物的药物组合物和使用这些化合物治疗或预防与异常或失调的TPO活性相关的疾病或病症的方法，特别是涉及血小板减少症的疾病或病症。
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公开(公告)号：US07572811B2
公开(公告)日：2009-08-11
申请号：US10590618
申请日：2005-02-24
申请人： Shifeng Pan , Thomas Marsilje , Wenshuo Lu , Wenqi Gao , Nathanael Schiander Gray , Yun He , Yahua Liu , Yuan Mi , Yongping Xie
发明人： Shifeng Pan , Thomas Marsilje , Wenshuo Lu , Wenqi Gao , Nathanael Schiander Gray , Yun He , Yahua Liu , Yuan Mi , Yongping Xie
IPC分类号： A61K31/445 , C07D211/30
CPC分类号： C07D401/04 , C07D205/04 , C07D207/08 , C07D207/12 , C07D211/22 , C07D213/74 , C07D237/22 , C07D239/46 , C07D295/108 , C07D295/15 , C07D401/06 , C07D403/04 , C07D403/06 , C07D409/04 , C07D409/12 , C07D413/10 , C07D417/10
摘要： The present invention relates to immunosuppressant, process for their production, their uses and pharmaceutical compositions containing them. The invention provides a novel class of compounds useful in the treatment or prevention of diseases or disorders mediated by lymphocyte interactions, particularly diseases associated with EDG receptor mediated signal transduction.
摘要翻译： 本发明涉及免疫抑制剂，其生产方法及其用途和含有它们的药物组合物。 本发明提供了一类新颖的化合物，其可用于治疗或预防由淋巴细胞相互作用介导的疾病或病症，特别是与EDG受体介导的信号转导相关的疾病。
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公开(公告)号：US20070203100A1
公开(公告)日：2007-08-30
申请号：US10590618
申请日：2005-02-24
申请人： Shifeng Pan , Thomas Marsilje , Wenshuo Lu , Gao Wenqi , Nathanael Gray , Yun He , Yahua Liu , Yuan Mi , Yongping Xie
发明人： Shifeng Pan , Thomas Marsilje , Wenshuo Lu , Gao Wenqi , Nathanael Gray , Yun He , Yahua Liu , Yuan Mi , Yongping Xie
IPC分类号： A61K31/675 , A61K31/495 , A61K31/454 , A61K31/453 , A61K31/40
CPC分类号： C07D401/04 , C07D205/04 , C07D207/08 , C07D207/12 , C07D211/22 , C07D213/74 , C07D237/22 , C07D239/46 , C07D295/108 , C07D295/15 , C07D401/06 , C07D403/04 , C07D403/06 , C07D409/04 , C07D409/12 , C07D413/10 , C07D417/10
摘要： The present invention relates to immunosuppressant, process for their production, their uses and pharmaceutical compositions containing them. The invention provides a novel class of compounds useful in the treatment or prevention of diseases or disorders mediated by lymphocyte interactions, particularly diseases associated with EDG receptor mediated signal transduction.
摘要翻译： 本发明涉及免疫抑制剂，其生产方法及其用途和含有它们的药物组合物。 本发明提供了一类新颖的化合物，其可用于治疗或预防由淋巴细胞相互作用介导的疾病或病症，特别是与EDG受体介导的信号转导相关的疾病。
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公开(公告)号：US07816542B2
公开(公告)日：2010-10-19
申请号：US12063350
申请日：2006-08-15
申请人： Thomas Marsilje , Wenshuo Lu , Phillip B. Alper , Daniel Mutnick , Yun He
发明人： Thomas Marsilje , Wenshuo Lu , Phillip B. Alper , Daniel Mutnick , Yun He
IPC分类号： A61K31/404 , C07D209/10
CPC分类号： C07D209/14 , C07D209/18 , C07D235/18
摘要： The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated TPO activity, particularly diseases or disorders that involve thrombocytopenia.
摘要翻译： 本发明提供了一类新颖的化合物，包含这些化合物的药物组合物和使用这些化合物治疗或预防与异常或失调的TPO活性相关的疾病或病症的方法，特别是涉及血小板减少症的疾病或病症。
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公开(公告)号：US20080194668A1
公开(公告)日：2008-08-14
申请号：US12063350
申请日：2006-08-15
申请人： Thomas Marsilje , Wenshuo Lu , Phil Alper , Daniel Mutnick , Yun He
发明人： Thomas Marsilje , Wenshuo Lu , Phil Alper , Daniel Mutnick , Yun He
IPC分类号： A61K31/404 , C07D209/04 , A61P7/00
CPC分类号： C07D209/14 , C07D209/18 , C07D235/18
摘要： The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated TPO activity, particularly diseases or disorders that involve thrombocytopenia.
摘要翻译： 本发明提供了一类新颖的化合物，包含这些化合物的药物组合物和使用这些化合物治疗或预防与异常或失调的TPO活性相关的疾病或病症的方法，特别是涉及血小板减少症的疾病或病症。
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