公开(公告)号：US20220409567A1

公开(公告)日：2022-12-29

申请号：US17356319

申请日：2021-06-23

申请人： Thomas Winston

发明人： Thomas Winston

IPC分类号： A61K31/232 ,  A61K31/155 ,  A61K31/352 ,  A61K31/436 ,  A61K31/198

摘要： Disclosed herein are pharmaceutical compositions for adjuvant and complementary therapies to treat, prevent, reduce the incidence of, or reduce the severity of cancer or one or more secondary or side effects of primary cancer treatments comprising an effective amount of one or more mTOR inhibitors and optionally an effective amount of one or more thyroid hormones. Further disclosed herein are methods of treating, preventing, reducing the incidence of, or reducing the severity of cancer and one or more secondary or side effects of primary cancer treatments comprising administering an effective amount of a pharmaceutical composition of one or more mTOR inhibitors and optionally an effective amount of one or more thyroid hormones.

公开(公告)号：US20220304986A1

公开(公告)日：2022-09-29

申请号：US17656855

申请日：2022-03-28

申请人： Thomas Winston

发明人： Thomas Winston

IPC分类号： A61K31/436 ,  A61K31/23 ,  A61K31/155 ,  A61K31/352 ,  A61K31/593 ,  A61K31/07 ,  A61K31/519 ,  A61K31/375 ,  A61K31/355 ,  A61K31/122 ,  A61K31/51 ,  A61K31/525 ,  A61K31/455 ,  A61K31/4188 ,  A61K31/197 ,  A61K33/06 ,  A61K33/42 ,  A61K33/18 ,  A61K33/30 ,  A61K33/34 ,  A61K33/04 ,  A61K33/32 ,  A61K33/24

摘要： Disclosed herein are pharmaceutical compositions for the treatment of acquired brain injury (ABI), including traumatic brain injury (TBI) and acute non-traumatic brain injury (ANBI), post-traumatic stress disorder (PTSD), and other degenerative neurological disorders that may or may not be associated with ABI comprising an effective amount of one or more mTOR inhibitors and optionally an effective amount of one or more thyroid hormones. Further disclosed herein are methods of treating, preventing, reducing the intensity of or reducing the severity of ABI and/or PTSD, the method comprising administering an effective amount of one or more mTOR inhibitors and optionally an effective amount of one or more thyroid hormones.

公开(公告)号：US07007275B1

公开(公告)日：2006-02-28

申请号：US09422775

申请日：1999-10-21

申请人： Charles Albin Hanson ,  Thomas Winston Johnson ,  Carol Jean O'Hara ,  Koon-yui Poon ,  Roger Anthony Redding

发明人： Charles Albin Hanson ,  Thomas Winston Johnson ,  Carol Jean O'Hara ,  Koon-yui Poon ,  Roger Anthony Redding

IPC分类号： G06F9/46

CPC分类号： G06F9/5055 ,  G06F2209/5017

摘要： Heterogeneous data at a plurality of remote nodes is accessed automatically in parallel at high speed from a user site using a simple script request containing a data source object name wherein the heterogeneous data is treated as a single data source object, the script further containing at least one method to be performed on the data source object and at least a second method to be automatically performed on the results of executing the first method. A user site agent breaks the user-generated script into new scripts appropriate for execution at the remote nodes and determines whether the second method should be executed at the remote nodes or at the user site. A messenger process transmits the new scripts to the appropriate remote nodes where respective agent processes respond to automatically access the appropriate data and to automatically execute the specified methods.

摘要翻译： 使用包含数据源对象名称的简单脚本请求，从用户站以高速并行地自动并行地访问多个远程节点处的异构数据，其中异构数据被视为单个数据源对象，该脚本还至少包含 要对数据源对象执行一种方法，以及至少第二种方法来执行第一种方法的结果。 用户站点代理将用户生成的脚本分解为适合在远程节点执行的新脚本，并确定是否应在远程节点或用户站点执行第二种方法。 信使过程将新脚本发送到相应的代理进程响应的相应远程节点，以自动访问适当的数据并自动执行指定的方法。

公开(公告)号：US20210401812A1

公开(公告)日：2021-12-30

申请号：US17344078

申请日：2021-06-10

申请人： Thomas Winston

发明人： Thomas Winston

IPC分类号： A61K31/436 ,  A61K31/232 ,  A61K31/155 ,  A61K38/22 ,  A61K45/06 ,  A61P3/04 ,  A61K31/352

摘要： Disclosed herein are pharmaceutical compositions to treat or prevent obesity, excess or overweight conditions, and metabolic syndrome comprising an effective amount of one or more mTOR inhibitors and optionally an effective amount of one or more thyroid hormones and/or an effective amount of one or more cholesterol-lowering agents. Further disclosed herein are methods of treating or preventing obesity, excess or overweight conditions, and metabolic syndrome comprising administering an effective amount of a pharmaceutical composition comprising one or more mTOR inhibitors and optionally an effective amount of one or more thyroid hormones and/or an effective amount of one or more cholesterol-lowering agents.

公开(公告)号：US06912530B1

公开(公告)日：2005-06-28

申请号：US09495492

申请日：2000-02-01

申请人： Charles Albin Hanson ,  Thomas Winston Johnson ,  Carol Jean O'Hara ,  Koon-yui Poon ,  Roger Anthony Redding

发明人： Charles Albin Hanson ,  Thomas Winston Johnson ,  Carol Jean O'Hara ,  Koon-yui Poon ,  Roger Anthony Redding

IPC分类号： G06F17/30

CPC分类号： G06F17/30566 ,  G06F17/30572

摘要： Methods are executed upon data objects distributed across a plurality of nodes of a system from a user-held “special” device (such as a cell phone, palm top, set top, car GPS system, . . . ). Heterogeneous data at a plurality of remote nodes is accessed automatically in parallel at high speed using a simple script request containing a data source object name wherein the heterogeneous data is treated as a single data source object, the script further containing code representing a user-defined program to be executed on the data source object. An agent breaks the user-generated script into new scripts appropriate for execution at the remote nodes. A messenger process transmits the new scripts to the appropriate remote nodes where respective agent processes respond to automatically access the appropriate data and to automatically execute the specified program. If the program is a user-defined script or executable, the respective agent processes access a metadata repository to obtain the specified program. A set of complex transactions may be built up and executed by simply touching or updating the special device screen, according to a visual methodology in which the results of each sub-transaction are displayed and become the basis for the next point and touch operation in the sequence of transactions.

摘要翻译： 在从用户持有的“特殊”设备（诸如手机，掌上，机顶，汽车GPS系统等）的系统的多个节点上分布的数据对象上执行方法。 使用包含数据源对象名称的简单脚本请求，以多个远程节点自动并行地访问多个远程节点上的异构数据，其中异构数据被视为单个数据源对象，该脚本还包含代表用户定义的代码 要在数据源对象上执行的程序。 代理将用户生成的脚本分解为适合在远程节点执行的新脚本。 信使进程将新脚本发送到相应的代理进程响应的相应远程节点，以自动访问适当的数据并自动执行指定的程序。 如果程序是用户定义的脚本或可执行文件，则相应的代理进程访问元数据存储库以获取指定的程序。 可以通过简单地触摸或更新专用设备屏幕来构建和执行一组复杂事务，根据其中显示每个子事务的结果的视觉方法，并且成为下一个点的基础和触摸操作 交易顺序。

公开(公告)号：US20050010208A1

公开(公告)日：2005-01-13

申请号：US10911911

申请日：2004-08-05

申请人： Thomas Winston ,  John Neet

发明人： Thomas Winston ,  John Neet

IPC分类号： A61B18/20 ,  A61B1/00 ,  A61B17/00 ,  A61B18/12 ,  A61B18/14 ,  A61B18/22 ,  A61L31/00 ,  A61M25/01

CPC分类号： A61B18/1492 ,  A61B18/22 ,  A61B2017/00061 ,  A61B2017/00247 ,  A61B2018/00392 ,  A61B2018/144

摘要： A guide wire assembly includes a guide wire, an optical fiber, and an insulating coating. The guide wire has a distal end, a proximal end, and a bore extending through the wire between the distal and proximal ends. The an optical fiber also includes a distal end and a proximal end and is located within the bore of the guide wire. The optical fiber extends at least between the distal and proximal ends of the guide wire. The insulating coating is around an outside diameter of the guide wire, and is applied such that the distal ends of the guide wire and optical fiber are exposed.

摘要翻译： 导丝线组件包括导线，光纤和绝缘涂层。 引导线具有远端，近端和在远端和近端之间延伸穿过线的孔。 光纤还包括远端和近端并且位于引导线的孔内。 光纤至少在导丝的远端和近端之间延伸。 绝缘涂层围绕导丝的外径，并且被施加使得引导线和光纤的远端露出。

公开(公告)号：US06490585B1

公开(公告)日：2002-12-03

申请号：US09439580

申请日：1999-11-12

申请人： Charles Albin Hanson ,  Thomas Winston Johnson ,  Carol Jean O'Hara ,  Koon-yui Poon ,  Roger Anthony Redding

发明人： Charles Albin Hanson ,  Thomas Winston Johnson ,  Carol Jean O'Hara ,  Koon-yui Poon ,  Roger Anthony Redding

IPC分类号： G06F1730

CPC分类号： G06F17/30545

摘要： A number of partitions of a cellular multiprocessor (CMP) are connected to respective databases and form respective nodes of a data warehouse. Heterogeneous data stored across the nodes is accessed automatically in parallel at high speed from a user site using a simple script request containing a data source object name wherein the heterogeneous data is treated as a single data source object, the script further containing at least one method to be performed on the data source object. Respective agent processes are stored in memory dedicated to each partition and automatically generate descriptor files containing metadata corresponding to the data source object from a repository available to each partition. A messenger process transmits the new scripts to the appropriate nodes via memory-based messaging using a shared portion of the CMP memory. Respective agent processes at each node respond to automatically access the appropriate data and execute specified methods upon it.

摘要翻译： 蜂窝多处理器（CMP）的多个分区连接到相应的数据库并形成数据仓库的相应节点。 通过使用包含数据源对象名称的简单脚本请求，用户站点以高速并行地自动并行地访问跨节点存储的异构数据，其中异构数据被视为单个数据源对象，该脚本还包含至少一个方法 要对数据源对象执行。 相应的代理进程存储在专用于每个分区的内存中，并且从每个分区可用的存储库中自动生成包含与数据源对象相对应的元数据的描述符文件。 信使过程使用CMP存储器的共享部分，通过基于存储器的消息传送将新脚本发送到适当的节点。 每个节点上的各个代理进程响应自动访问适当的数据并执行指定的方法。

公开(公告)号：US20210379025A1

公开(公告)日：2021-12-09

申请号：US16946105

申请日：2020-06-05

申请人： Thomas Winston

发明人： Thomas Winston

IPC分类号： A61K31/436 ,  A61K31/155 ,  A61K31/232 ,  A61K31/05 ,  A61K45/06

摘要： Disclosed herein are pharmaceutical compositions for the treatment of cytokine storm syndrome, and methods of administering such compositions for the treatment of acute respiratory distress syndrome, and the prevention of multiple organ failure in patients with cytokine storm syndrome and/or acute respiratory distress syndrome, comprising an effective amount of one or more mTor inhibitors.

公开(公告)号：US20220133700A1

公开(公告)日：2022-05-05

申请号：US17397216

申请日：2021-08-09

申请人： Thomas Winston

发明人： Thomas Winston

IPC分类号： A61K31/436 ,  A61K31/232 ,  A61K31/155 ,  A61K31/352 ,  A61K31/05 ,  A61K36/68 ,  A61K31/12 ,  A61K33/06 ,  A61K36/9066 ,  A61K31/522 ,  A61K38/07 ,  A61K31/7072 ,  A61P25/28

摘要： Disclosed herein are pharmaceutical compositions for the treatment of neurologic disorders comprising an effective amount of one or more mTOR inhibitors and/or one or more BDNF inducers and optionally an effective amount of one or more thyroid hormones. Further disclosed herein are methods of treating or preventing neurologic disorders comprising administering an effective amount of a pharmaceutical composition comprising one or more mTOR inhibitors and/or one or more BDNF inducers and optionally an effective amount of one or more thyroid hormones.

公开(公告)号：US20070270787A1

公开(公告)日：2007-11-22

申请号：US11888027

申请日：2007-07-30

申请人： Thomas Winston ,  John Neet

发明人： Thomas Winston ,  John Neet

IPC分类号： A61B18/18

CPC分类号： A61B18/245 ,  A61B18/24 ,  A61B2017/22051 ,  A61B2018/00214 ,  A61B2018/00577 ,  A61B2018/2211 ,  A61B2018/2238 ,  A61B2018/2266 ,  A61B2018/2288 ,  A61M25/0021 ,  A61M25/0023 ,  A61M25/1002 ,  A61M29/02 ,  A61M2025/0024 ,  A61M2025/1004

摘要： Expandable laser catheters for utilizing laser energy to remove obstructions from body passages are described. In one embodiment, the laser catheter includes a shaftway having a distal end including a flexible portion configured in a series of radial folds. Multiple optical fibers, configured to transmit laser energy, extend along the shaftway and are attached to the flexible portion. An inflatable, ring-shaped balloon is attached to the catheter within the flexible portion. In use, the catheter is inserted into a body passage such as an artery, and advanced until the distal end is adjacent to an obstruction. The balloon is inflated to expand the flexible portion and to bring the optical fibers nearer the inner wall of the body passage. Laser energy is directed by the optical fibers toward targeted regions of the obstruction. As the catheter is advanced and the process repeated, a core is formed from the obstruction and contained within the flexible portion. The flexible portion is then contracted to hold the core, and the core is removed from the body passage by withdrawing the catheter.

摘要翻译： 描述了用于利用激光能量去除身体通道的障碍物的可扩展激光导管。 在一个实施例中，激光导管包括具有远端的轴通道，该远端包括构造成一系列径向折叠的柔性部分。 被配置为传递激光能量的多个光纤沿着轴线延伸并附接到柔性部分。 可膨胀的环形气囊在柔性部分内连接到导管。 在使用中，将导管插入诸如动脉的身体通道中，并且前进直到远端与障碍物相邻。 气球膨胀以使柔性部分膨胀并使光纤更接近身体通道的内壁。 激光能量由光纤引导到障碍物的目标区域。 当导管前进并且重复该过程时，从障碍物形成芯并且包含在柔性部分内。 然后将柔性部分收缩以保持芯部，并且通过抽出导管将芯部从身体通道移除。