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14 条记录 (耗时 0.028 秒)

    DENDRIMER CONJUGATES
    2.
    发明申请
    DENDRIMER CONJUGATES 有权
    DENDRIMER联合

    公开(公告)号：US20120277376A1

    公开(公告)日：2012-11-01

    申请号：US13547929

    申请日：2012-07-12

    申请人： James R. Baker, JR. ,  Xue-min Cheng ,  Thommey P. Thomas ,  Baohua Mark Huang

    发明人： James R. Baker, JR. ,  Xue-min Cheng ,  Thommey P. Thomas ,  Baohua Mark Huang

    IPC分类号： C08G69/48

    CPC分类号： C07D305/08

    摘要： The present invention relates to novel therapeutic and diagnostic dendrimers. In particular, the present invention is directed to dendrimer-linker conjugates, methods of synthesizing the same, compositions comprising the conjugates, as well as systems and methods utilizing the conjugates (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutics, imaging, and/or targeting agents (e.g., in disease (e.g., cancer) diagnosis and/or therapy, pain therapy, etc.)). Accordingly, dendrimer-linker conjugates of the present invention may further comprise one or more components for targeting, imaging, sensing, and/or providing a therapeutic or diagnostic material and/or monitoring response to therapy.

    摘要翻译： 本发明涉及新的治疗和诊断树枝状大分子。 特别地，本发明涉及树枝状大分子 - 连接体缀合物，其合成方法，包含缀合物的组合物，以及利用缀合物的系统和方法（例如，在诊断和/或治疗设置（例如，用于递送 治疗，成像和/或靶向剂（例如，在疾病（例如癌症）诊断和/或治疗，疼痛治疗等中））。因此，本发明的树枝状大分子 - 接头缀合物还可包含一种或多种 用于靶向，成像，感测和/或提供治疗或诊断材料和/或监测治疗反应的组分。

    Dendrimer conjugates
    7.
    发明授权
    Dendrimer conjugates 有权

    公开(公告)号：US08445528B2

    公开(公告)日：2013-05-21

    申请号：US13547929

    申请日：2012-07-12

    申请人： James R. Baker, Jr. ,  Xue-min Cheng ,  Thommey P. Thomas ,  Baohua Mark Huang

    发明人： James R. Baker, Jr. ,  Xue-min Cheng ,  Thommey P. Thomas ,  Baohua Mark Huang

    IPC分类号： A61K31/403 ,  A61K31/485 ,  C07D209/12 ,  C07D471/04

    CPC分类号： C07D305/08

    摘要： The present invention relates to novel therapeutic and diagnostic dendrimers. In particular, the present invention is directed to dendrimer-linker conjugates, methods of synthesizing the same, compositions comprising the conjugates, as well as systems and methods utilizing the conjugates (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutics, imaging, and/or targeting agents (e.g., in disease (e.g., cancer) diagnosis and/or therapy, pain therapy, etc.)). Accordingly, dendrimer-linker conjugates of the present invention may further comprise one or more components for targeting, imaging, sensing, and/or providing a therapeutic or diagnostic material and/or monitoring response to therapy.

    Dendrimer conjugates
    8.
    发明授权
    Dendrimer conjugates 有权
    树枝状结合物

    公开(公告)号：US08252834B2

    公开(公告)日：2012-08-28

    申请号：US12403179

    申请日：2009-03-12

    申请人： James R. Baker, Jr. ,  Xue-min Cheng ,  Thommey P. Thomas ,  Baohua Mark Huang

    发明人： James R. Baker, Jr. ,  Xue-min Cheng ,  Thommey P. Thomas ,  Baohua Mark Huang

    IPC分类号： A61K31/403 ,  A61K31/485 ,  C07D209/12 ,  C07D471/04

    CPC分类号： C07D305/08

    摘要： The present invention relates to novel therapeutic and diagnostic dendrimers. In particular, the present invention is directed to dendrimer-linker conjugates, methods of synthesizing the same, compositions comprising the conjugates, as well as systems and methods utilizing the conjugates (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutics, imaging, and/or targeting agents (e.g., in disease (e.g., cancer) diagnosis and/or therapy, pain therapy, etc.)). Accordingly, dendrimer-linker conjugates of the present invention may further comprise one or more components for targeting, imaging, sensing, and/or providing a therapeutic or diagnostic material and/or monitoring response to therapy.

    摘要翻译： 本发明涉及新的治疗和诊断树枝状大分子。 特别地，本发明涉及树枝状大分子 - 连接体缀合物，其合成方法，包含缀合物的组合物，以及利用缀合物的系统和方法（例如，在诊断和/或治疗设置（例如，用于递送 治疗，成像和/或靶向剂（例如，在疾病（例如癌症）诊断和/或治疗，疼痛治疗等中））。因此，本发明的树枝状大分子 - 接头缀合物还可包含一种或多种 用于靶向，成像，感测和/或提供治疗或诊断材料和/或监测治疗反应的组分。

    PRO-DRUG COMPLEXES AND RELATED METHODS OF USE
    9.
    发明申请
    PRO-DRUG COMPLEXES AND RELATED METHODS OF USE 有权
    PRO-DRUG复合物及相关使用方法

    公开(公告)号：US20120171227A1

    公开(公告)日：2012-07-05

    申请号：US13378178

    申请日：2010-06-30

    申请人： James R. Baker, JR. ,  Baohua M. Huang ,  Thommey P. Thomas

    发明人： James R. Baker, JR. ,  Baohua M. Huang ,  Thommey P. Thomas

    IPC分类号： A61K31/4745 ,  C07K14/71 ,  C07K17/02 ,  C12N5/09 ,  A61K38/18 ,  A61K39/44 ,  A61K38/12 ,  A61P35/00 ,  C07D491/22 ,  C07K7/64

    CPC分类号： A61K31/437 ,  A61K47/64

    摘要： The present invention provides methods, compositions and applications for efficient, site-specific drug delivery using pro-drug complexes comprising therapeutic agents and one or more functional groups (e.g., imaging agents, targeting agents, and trigger agents). In particular, the present invention relates to pro-drug complexes comprising one or more functional groups conjugated with a therapeutic agent (e.g., a chemotherapeutic agent), methods of synthesizing the same, as well as systems and methods utilizing the therapeutic and diagnostic compositions (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutics, imaging, and/or targeting agents (e.g., in disease (e.g., cancer) diagnosis and/or therapy, etc.)).

    摘要翻译： 本发明提供了使用包含治疗剂和一种或多种官能团（例如成像剂，靶向剂和触发剂）的前药复合物进行有效的位点特异性药物递送的方法，组合物和应用。 特别地，本发明涉及包含与治疗剂缀合的一种或多种官能团（例如化学治疗剂）的前药复合物，其合成方法以及利用治疗和诊断组合物的系统和方法（ 例如，在诊断和/或治疗设置中（例如，用于递送治疗剂，成像和/或靶向剂（例如，在疾病（例如，癌症）诊断和/或治疗中）））。

    DENDRIMER CONJUGATES
    10.
    发明申请
    DENDRIMER CONJUGATES 有权
    DENDRIMER联合

    公开(公告)号：US20090287005A1

    公开(公告)日：2009-11-19

    申请号：US12403179

    申请日：2009-03-12

    申请人： James R. Baker, JR. ,  Xue-min Cheng ,  Thommey P. Thomas ,  Baohua Mark Huang

    发明人： James R. Baker, JR. ,  Xue-min Cheng ,  Thommey P. Thomas ,  Baohua Mark Huang

    IPC分类号： C07D305/08

    CPC分类号： C07D305/08

    摘要： The present invention relates to novel therapeutic and diagnostic dendrimers. In particular, the present invention is directed to dendrimer-linker conjugates, methods of synthesizing the same, compositions comprising the conjugates, as well as systems and methods utilizing the conjugates (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutics, imaging, and/or targeting agents (e.g., in disease (e.g., cancer) diagnosis and/or therapy, pain therapy, etc.)). Accordingly, dendrimer-linker conjugates of the present invention may further comprise one or more components for targeting, imaging, sensing, and/or providing a therapeutic or diagnostic material and/or monitoring response to therapy.

    摘要翻译： 本发明涉及新的治疗和诊断树枝状大分子。 特别地，本发明涉及树枝状大分子 - 连接体缀合物，其合成方法，包含缀合物的组合物，以及利用缀合物的系统和方法（例如，在诊断和/或治疗设置（例如，用于递送 治疗，成像和/或靶向剂（例如，在疾病（例如癌症）诊断和/或治疗，疼痛治疗等中））。因此，本发明的树枝状大分子 - 接头缀合物还可包含一种或多种 用于靶向，成像，感测和/或提供治疗或诊断材料和/或监测治疗反应的组分。