-
公开(公告)号:US06569890B2
公开(公告)日:2003-05-27
申请号:US10054273
申请日:2002-01-22
IPC分类号: A61K31402
CPC分类号: C07D401/04 , C07D207/34
摘要: Pyrrole compounds that are potent and selective inhibitors of PDE4, as well as methods of making the same, are disclosed. Use of the compounds in the treatment of inflammatory diseases and other diseases involving elevated levels of cytokines, as well as central nervous system (CNS) disorders, also is disclosed.
-
公开(公告)号:US06258833B1
公开(公告)日:2001-07-10
申请号:US09471846
申请日:1999-12-23
申请人: Timothy J. Martins , Kerry W. Fowler , Joshua Odingo , Edward Kesicki , Amy Oliver , Laurence E. Burgess , John J. Gaudino , Zachary S. Jones , Bradley J. Newhouse , Stephen T. Schlacter
发明人: Timothy J. Martins , Kerry W. Fowler , Joshua Odingo , Edward Kesicki , Amy Oliver , Laurence E. Burgess , John J. Gaudino , Zachary S. Jones , Bradley J. Newhouse , Stephen T. Schlacter
IPC分类号: A61K31415
CPC分类号: C07D207/08 , A61K31/40 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/06 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/06 , C07D417/12 , Y02A50/411
摘要: Novel pyrrolidine compounds that are potent and selective inhibitors of PDE4, as well as methods of making the same, are disclosed. Use of the compounds in the treatment of inflammatory diseases and other diseases involving elevated levels of cytokines, as well as central nervous system (CNS) disorders, also is disclosed.
摘要翻译: 公开了作为PDE4的有效和选择性抑制剂的新型吡咯烷化合物及其制备方法。 还公开了化合物在治疗炎性疾病和涉及细胞因子水平升高的其它疾病以及中枢神经系统(CNS)病症中的用途。
-
公开(公告)号:US07087634B2
公开(公告)日:2006-08-08
申请号:US10418556
申请日:2003-04-18
IPC分类号: A61K31/415 , C07D231/12
CPC分类号: C07D401/04 , C07D231/14
摘要: Pyrazole compounds that are potent and selective inhibitors of PDE4, as well as methods of making the same, are disclosed. Use of the compounds in the treatment of inflammatory diseases and other diseases involving elevated levels of cytokines, as well as central nervous system (CNS) disorders, also is disclosed.
-
公开(公告)号:US06423710B1
公开(公告)日:2002-07-23
申请号:US09717956
申请日:2000-11-21
申请人: Timothy J. Martins , Kerry W. Fowler , Joshua Odingo , Edward A. Kesicki , Amy Oliver , Laurence E. Burgess , John J. Gaudino , Zachary S. Jones , Bradley J. Newhouse , Stephen T. Schlachter
发明人: Timothy J. Martins , Kerry W. Fowler , Joshua Odingo , Edward A. Kesicki , Amy Oliver , Laurence E. Burgess , John J. Gaudino , Zachary S. Jones , Bradley J. Newhouse , Stephen T. Schlachter
IPC分类号: A61K31535
CPC分类号: C07D207/08 , A61K31/40 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/06 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/06 , C07D417/12 , Y02A50/411
摘要: Novel pyrrolidine compounds that are potent and selective inhibitors of PDE4, as well as methods of making the same, are disclosed. Use of the compounds in the treatment of inflammatory diseases and other diseases involving elevated levels of cytokines, as well as central nervous system (CNS) disorders, also is disclosed.
摘要翻译: 公开了作为PDE4的有效和选择性抑制剂的新型吡咯烷化合物及其制备方法。 还公开了化合物在治疗炎性疾病和涉及细胞因子水平升高的其它疾病以及中枢神经系统(CNS)病症中的用途。
-
公开(公告)号:US06376489B1
公开(公告)日:2002-04-23
申请号:US09731591
申请日:2000-12-07
申请人: Timothy J. Martins , Kerry W. Fowler , Joshua Odingo , Laurence E. Burgess , Stephen T. Schlachter
发明人: Timothy J. Martins , Kerry W. Fowler , Joshua Odingo , Laurence E. Burgess , Stephen T. Schlachter
IPC分类号: A61K3154
CPC分类号: A61K31/40 , A61K31/4025 , A61K31/454 , A61K45/06 , C07D207/09 , Y02A50/411 , A61K2300/00
摘要: Novel compounds that are potent and selective inhibitors of PDE4, as well as methods of making the same, are disclosed. Use of the compounds in the treatment of inflammatory disease and other diseases involving elevated levels of cytokines, as well as central nervous system (CNS) disorders, also is disclosed.
摘要翻译: 公开了作为PDE4的有效和选择性抑制剂的新型化合物及其制备方法。 还公开了这些化合物在治疗炎性疾病和涉及升高的细胞因子水平的其它疾病以及中枢神经系统(CNS)病症中的用途。
-
公开(公告)号:US07176229B2
公开(公告)日:2007-02-13
申请号:US11268374
申请日:2005-11-07
申请人: Timothy J. Martins , Kerry W. Fowler , Joshua Odingo , Edward A. Kesicki , Amy Oliver , Laurence Edward Burgess , John Joseph Gaudino , Zachary S. Jones , Bradley J. Newhouse , Stephen T. Schlachter
发明人: Timothy J. Martins , Kerry W. Fowler , Joshua Odingo , Edward A. Kesicki , Amy Oliver , Laurence Edward Burgess , John Joseph Gaudino , Zachary S. Jones , Bradley J. Newhouse , Stephen T. Schlachter
IPC分类号: A61K31/40 , A61K31/403 , C07D207/04
CPC分类号: C07D207/08 , A61K31/40 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/06 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/06 , C07D417/12 , Y02A50/411
摘要: Novel pyrrolidine compounds that are potent and selective inhibitors of PDE4, as well as methods of making the same, are disclosed. Use of the compounds in the treatment of inflammatory diseases and other diseases involving elevated levels of cytokines, as well as central nervous system (CNS) disorders, also is disclosed.
摘要翻译: 公开了作为PDE4的有效和选择性抑制剂的新型吡咯烷化合物及其制备方法。 还公开了化合物在治疗炎性疾病和涉及细胞因子水平升高的其它疾病以及中枢神经系统(CNS)病症中的用途。
-
公开(公告)号:US06998416B2
公开(公告)日:2006-02-14
申请号:US10758675
申请日:2004-01-15
申请人: Timothy J. Martins , Kerry W. Fowler , Joshua Odingo , Edward A. Kesicki , Amy Oliver , Laurence E. Burgess , John J. Gaudino , Zachary S. Jones , Bradley J. Newhouse , Stephen T. Schlachter
发明人: Timothy J. Martins , Kerry W. Fowler , Joshua Odingo , Edward A. Kesicki , Amy Oliver , Laurence E. Burgess , John J. Gaudino , Zachary S. Jones , Bradley J. Newhouse , Stephen T. Schlachter
IPC分类号: A61K31/40
CPC分类号: C07D207/08 , A61K31/40 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/06 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/06 , C07D417/12 , Y02A50/411
摘要: Novel pyrrolidine compounds that are potent and selective inhibitors of PDE4, as well as methods of making the same, are disclosed. Use of the compounds in the treatment of inflammatory diseases and other diseases involving elevated levels of cytokines, as well as central nervous system (CNS) disorders, also is disclosed.
-
公开(公告)号:US06716871B2
公开(公告)日:2004-04-06
申请号:US10151202
申请日:2002-05-17
申请人: Timothy J. Martins , Kerry W. Fowler , Joshua Odingo , Edward A. Kesicki , Amy Oliver , Laurence E Burgess , John J. Gaudino , Zachary S Jones , Bradley J Newhouse , Stephen T. Schlachter
发明人: Timothy J. Martins , Kerry W. Fowler , Joshua Odingo , Edward A. Kesicki , Amy Oliver , Laurence E Burgess , John J. Gaudino , Zachary S Jones , Bradley J Newhouse , Stephen T. Schlachter
IPC分类号: A61K3140
CPC分类号: C07D207/08 , A61K31/40 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/06 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/06 , C07D417/12 , Y02A50/411
摘要: Novel pyrrolidine compounds that are potent and selective inhibitors of PDE4, as well as methods of making the same, are disclosed. Use of the compounds in the treatment of inflammatory diseases and other diseases involving elevated levels of cytokines, as well as central nervous system (CNS) disorders, also is disclosed.
摘要翻译: 公开了作为PDE4的有效和选择性抑制剂的新型吡咯烷化合物及其制备方法。 还公开了化合物在治疗炎性疾病和涉及细胞因子水平升高的其它疾病以及中枢神经系统(CNS)病症中的用途。
-
公开(公告)号:US06680336B2
公开(公告)日:2004-01-20
申请号:US10077154
申请日:2002-02-15
申请人: Timothy J. Martins , Kerry W. Fowler , Joshua Odingo , Laurence E. Burgess , Stephen T. Schlachter
发明人: Timothy J. Martins , Kerry W. Fowler , Joshua Odingo , Laurence E. Burgess , Stephen T. Schlachter
IPC分类号: A61K3140
CPC分类号: C07D207/09 , A61K31/40 , A61K31/402 , A61K31/4025 , A61K31/454 , A61K45/06 , Y02A50/411 , A61K2300/00
摘要: Novel compounds that are potent and selective inhibitors of PDE4, as well as methods of making the same, are disclosed. Use of the compounds in the treatment of inflammatory diseases and other diseases involving elevated levels of cytokines, as well as central nervous system (CNS) disorders, also is disclosed.
摘要翻译: 公开了作为PDE4的有效和选择性抑制剂的新型化合物及其制备方法。 还公开了化合物在治疗炎性疾病和涉及细胞因子水平升高的其它疾病以及中枢神经系统(CNS)病症中的用途。
-
公开(公告)号:US06569885B1
公开(公告)日:2003-05-27
申请号:US09692364
申请日:2000-10-19
IPC分类号: A61K31415
CPC分类号: C07D401/04 , C07D231/14
摘要: Pyrazole compounds that are potent and selective inhibitors of PDE4, as well as methods of making the same, are disclosed. Use of the compounds in the treatment of inflammatory diseases and other diseases involving elevated levels of cytokines, as well as central nervous system (CNS) disorders, also is disclosed.
-
-
-
-
-
-
-
-
-