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公开(公告)号：US20110006007A1
公开(公告)日：2011-01-13
申请号：US12746961
申请日：2008-12-19
申请人： Gokhan Kuruc , Marjorie Bucholz , Todd E. Arnold , Robert T. Fitzsimons, JR. , Kannan Seshadri , Steven M. Heilmann , Andrew W. Rabins , Catherine A. Bothof
发明人： Gokhan Kuruc , Marjorie Bucholz , Todd E. Arnold , Robert T. Fitzsimons, JR. , Kannan Seshadri , Steven M. Heilmann , Andrew W. Rabins , Catherine A. Bothof
CPC分类号： B01J20/26 , B01D39/1653 , B01D2239/086 , B01J20/2803 , B01J20/285 , B01J2220/58 , B01J2220/66 , C02F1/285 , C02F2103/343
摘要： Provided are filtration media, matrixes, and systems for liquid purification that utilize functional polymer particles. The functional polymer particles can comprise a cationic charge. Exemplary functional polymer particles comprise comprise [3-(methacryloylamino)propyl]-trimethylammonium chloride (MAPTAC) polymerized with trimethylolpropane trimethacrylate (TMPTMA).
摘要翻译： 提供了使用功能性聚合物颗粒的过滤介质，基质和用于液体纯化的系统。 功能性聚合物颗粒可以包含阳离子电荷。 示例性功能性聚合物颗粒包含由三羟甲基丙烷三甲基丙烯酸酯（TMPTMA）聚合的[3-（甲基丙烯酰氨基）丙基] - 三甲基氯化铵（MAPTAC）。
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公开(公告)号：US06635201B1
公开(公告)日：2003-10-21
申请号：US09291355
申请日：1999-04-14
IPC分类号： B29C6500
CPC分类号： B01J20/28033 , B01D61/00 , B01D61/007 , B01D61/18 , B01D63/16 , B01D69/10 , B01D69/141 , B01J20/28004 , B01J20/28019 , B01J20/28026 , B01J20/28028 , B01J20/2803 , B01J2220/64 , B01L3/0275 , G01N30/466 , G01N30/6004 , G01N30/6052 , G01N30/6065 , G01N2030/528 , G01N2035/1053 , G01N2035/1055
摘要： A method for casting-in-place composite and/or non-filled structures which are useful as sorptive or reactive media or for size-based separations. Any particular housing size or configuration can be used, and the inclusion of a large amount of adsorptive particles in polymer is achieved while still maintaining the membrane three dimensional structure. In a first preferred embodiment, the composite structures comprise particles entrapped within a porous polymeric substrate, and are cast in-place into a housing such as a pipette tip, thereby providing an effective platform for micromass handling. With the appropriate selection of particle chemistry, virtually any separation or purification operation can be conducted, including selective bind/elute chromatography operations, on sample mass loads less than 1 microgram in volumes of a few microliters, as well as larger mass loads and volumes. The present invention also encompasses the composite structures as well as sample preparation devices containing the same. In a second structures are cast in situ in a suitable housing and can be used for size-based separations wherein the cast structure acts as a semi-permeable barrier. The present invention also encompasses these structures as well as housings containing these structures.
摘要翻译： 用于现浇复合和/或非填充结构的方法，其可用作吸附或反应介质或基于尺寸的分离。 可以使用任何特定的壳体尺寸或构型，并且在保持膜三维结构的同时实现在聚合物中包含大量吸附颗粒。 在第一优选实施方案中，复合结构包括捕获在多孔聚合物基底内的颗粒，并且被放置在诸如移液管尖端的壳体中，从而为微粒处理提供有效的平台。 通过适当的颗粒化学选择，可以进行任何分离或纯化操作，包括选择性结合/洗脱色谱操作，样品质量负载小于1微克体积的几微升，以及较大的质量负载和体积。 本发明还包括复合结构以及含有该结构的样品制备装置。 在第二结构中，在合适的壳体中原位铸造，并且可以用于基于尺寸的间隔，其中铸造结构用作半渗透屏障。 本发明还包括这些结构以及包含这些结构的壳体。
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公开(公告)号：US06830717B2
公开(公告)日：2004-12-14
申请号：US10209390
申请日：2002-07-31
IPC分类号： B29C6500
CPC分类号： B01J20/28033 , B01D61/00 , B01D61/007 , B01D61/18 , B01D63/16 , B01D69/10 , B01D69/141 , B01J20/28004 , B01J20/28019 , B01J20/28026 , B01J20/28028 , B01J20/2803 , B01J2220/64 , B01L3/0275 , G01N30/466 , G01N30/6004 , G01N30/6052 , G01N30/6065 , G01N2030/528 , G01N2035/1053 , G01N2035/1055
摘要： A method for casting-in-place composite and/or non-filled structures which are useful as sorptive or reactive media or for size-based separations. Any particular housing size or configuration can be used, and the inclusion of a large amount of adsorptive particles in polymer is achieved while still maintaining the membrane three dimensional structure. In a first preferred embodiment, the composite structures comprise particles entrapped within a porous polymeric substrate, and are cast in-place into a housing such as a pipette tip, thereby providing an effective platform for micromass handling. With the appropriate selection of particle chemistry, virtually any separation or purification operation can be conducted, including selective bind/elute chromatography operations, on sample mass loads less than 1 microgram in volumes of a few microliters, as well as larger mass loads' and volumes. The present invention also encompasses the composite structures as well as sample preparation devices containing the same. In a second preferred embodiment, self-retaining, self-supporting structures are cast in situ in a suitable housing and can be used for size-based separations wherein the cast structure acts as a semi-permeable barrier. The present invention also encompasses these structures as well as housings containing these structures.
摘要翻译： 用于现浇复合和/或非填充结构的方法，其可用作吸附或反应介质或基于尺寸的分离。 可以使用任何特定的壳体尺寸或构型，并且在保持膜三维结构的同时实现在聚合物中包含大量吸附颗粒。 在第一优选实施方案中，复合结构包括捕获在多孔聚合物基底内的颗粒，并且被放置在诸如移液管尖端的壳体中，从而为微粒处理提供有效的平台。 通过适当的颗粒化学选择，可以进行任何分离或纯化操作，包括选择性结合/洗脱色谱操作，样品质量负载小于1微克体积的几微升，以及较大的质量负载和体积 。 本发明还包括复合结构以及含有该结构的样品制备装置。 在第二优选实施例中，自固位自支撑结构在合适的壳体中原位铸造，并且可用于基于尺寸的间隔，其中铸造结构用作半渗透屏障。 本发明还包括这些结构以及包含这些结构的壳体。
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公开(公告)号：US06998047B1
公开(公告)日：2006-02-14
申请号：US09698378
申请日：2000-10-27
IPC分类号： B01D63/00
CPC分类号： B01L3/0275 , B01J20/28026 , B01J20/28033 , B01J2220/64 , B01L3/50255 , B01L2300/0681 , B01L2300/0829
摘要： A method for casting-in-place composite and/or non-filled structures which are useful as sorptive or reactive media or for size-based separations. Any particular housing size or configuration can be used, and the inclusion of a large amount of adsorptive particles in polymer is achieved while still maintaining the membrane three dimensional structure. In a first preferred embodiment, the composite structures comprise particles entrapped within a porous polymeric substrate, and are cast in-place into a housing such as a pipette tip, thereby providing an effective platform for micromass handling. With the appropriate selection of particle chemistry, virtually any separation or purification operation can be conducted, including selective bind/elute chromatography operations, on sample mass loads less than 1 microgram in volumes of a few microliters, as well as larger mass loads and volumes. The present invention also encompasses the composite structures as well as sample preparation devices containing the same. In a second preferred embodiment, self-retaining, self-supporting structures are cast in situ in a suitable housing and can be used for size-based separations wherein the cast structure acts as a semi-permeable barrier. The present invention also encompasses these structures as well as housings containing these structures.
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公开(公告)号：US6048457A
公开(公告)日：2000-04-11
申请号：US7320
申请日：1998-01-15
IPC分类号： G01N1/10 , B01D61/00 , B01D61/18 , B01D63/00 , B01D63/16 , B01D67/00 , B01D69/10 , B01D69/14 , B01J20/28 , B01L3/02 , C12M1/00 , C12M1/12 , C12M1/26 , G01N1/36 , G01N30/46 , G01N30/52 , G01N30/60 , G01N35/10
CPC分类号： B01J20/28033 , B01D61/00 , B01D61/007 , B01D61/18 , B01D63/16 , B01D69/10 , B01D69/141 , B01J20/28004 , B01J20/28019 , B01J20/28026 , B01J20/28028 , B01J20/2803 , B01L3/0275 , G01N30/6065 , B01J2220/64 , G01N2030/528 , G01N2035/1053 , G01N2035/1055 , G01N30/466 , G01N30/6004 , G01N30/6052
摘要： A method for casting-in-place composite and/or non-filled structures which are useful as sorptive or reactive media or for size-based separations. Any particular housing size or configuration can be used, and the inclusion of a large amount of adsorptive particles in polymer is achieved while still maintaining the membrane three dimensional structure. In a first preferred embodiment, the composite structures comprise particles entrapped within a porous polymeric substrate, and are cast in-place into a housing such as a pipette tip, thereby providing an effective platform for micromass handling. With the appropriate selection of particle chemistry, virtually any separation or purification operation can be conducted, including selective bind/elute chromatography operations, on sample mass loads less than 1 microgram in volumes of a few microliters, as well as larger mass loads and volumes. The present invention also encompasses the composite structures as well as sample preparation devices containing the same. In a second preferred embodiment, self-retaining, self-supporting structures are cast in situ in a suitable housing and can be used for size-based separations wherein the cast structure acts as a semi-permeable barrier. The present invention also encompasses these structures as well as housings containing these structures.
摘要翻译： 用于现浇复合和/或非填充结构的方法，其可用作吸附或反应介质或基于尺寸的分离。 可以使用任何特定的壳体尺寸或构型，并且在保持膜三维结构的同时实现在聚合物中包含大量的吸附颗粒。 在第一优选实施方案中，复合结构包括捕获在多孔聚合物基底内的颗粒，并且被放置在诸如移液管尖端的壳体中，从而为微粒处理提供有效的平台。 通过适当的颗粒化学选择，可以进行任何分离或纯化操作，包括选择性结合/洗脱色谱操作，样品质量负载小于1微克体积的几微升，以及较大的质量负载和体积。 本发明还包括复合结构以及含有该结构的样品制备装置。 在第二优选实施例中，自固位自支撑结构在合适的壳体中原位铸造，并且可用于基于尺寸的间隔，其中铸造结构用作半渗透屏障。 本发明还包括这些结构以及包含这些结构的壳体。
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公开(公告)号：US06200474B1
公开(公告)日：2001-03-13
申请号：US09366134
申请日：1999-08-02
IPC分类号： B01D6300
CPC分类号： B01J20/28033 , B01D61/00 , B01D61/007 , B01D61/18 , B01D63/16 , B01D69/10 , B01D69/141 , B01J20/28004 , B01J20/28019 , B01J20/28026 , B01J20/28028 , B01J20/2803 , B01J2220/64 , B01L3/0275 , G01N30/466 , G01N30/6004 , G01N30/6052 , G01N30/6065 , G01N2030/528 , G01N2035/1053 , G01N2035/1055
摘要： A method for casting-in-place composite and/or non-filled structures which are useful as sorptive or reactive media or for size-based separations. Any particular housing size or configuration can be used, and the inclusion of a large amount of adsorptive particles in polymer is achieved while still maintaining the membrane three dimensional structure. In a first preferred embodiment, the composite structures comprise particles entrapped within a porous polymeric substrate, and are cast in-place into a housing such as a pipette tip, thereby providing an effective platform for micromass handling. With the appropriate selection of particle chemistry, virtually any separation or purification operation can be conducted, including selective bind/elute chromatography operations, on sample mass loads less than 1 microgram in volumes of a few microliters, as well as larger mass loads and volumes. The present invention also encompasses the composite structures as well as sample preparation devices containing the same. In a second preferred embodiment, self-retaining, self-supporting structures are cast in situ in a suitable housing and can be used for size-based separations wherein the cast structure acts as a semi-permeable barrier. The present invention also encompasses these structures as well as housings containing these structures.
摘要翻译： 用于现浇复合和/或非填充结构的方法，其可用作吸附或反应介质或基于尺寸的分离。 可以使用任何特定的壳体尺寸或构型，并且在保持膜三维结构的同时实现在聚合物中包含大量吸附颗粒。 在第一优选实施方案中，复合结构包括捕获在多孔聚合物基底内的颗粒，并且被放置在诸如移液管尖端的壳体中，从而为微粒处理提供有效的平台。 通过适当的颗粒化学选择，可以进行任何分离或纯化操作，包括选择性结合/洗脱色谱操作，样品质量负载小于1微克体积的几微升，以及较大的质量负载和体积。 本发明还包括复合结构以及含有该结构的样品制备装置。 在第二优选实施例中，自固位自支撑结构在合适的壳体中原位铸造，并且可用于基于尺寸的间隔，其中铸造结构用作半渗透屏障。 本发明还包括这些结构以及包含这些结构的壳体。
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