摘要:
The present invention aims at providing a peptide fragment capable of improving biostability of a bioactive substance while maintaining the activity of the bioactive substance, and a bioactive substance to which the peptide fragment is added. The present invention relates to a partial peptide of a GA module having 5 to 25 amino acids, including a partial sequence of a GA module (SEQ ID NO: 1) and the amino acid sequence Ile-Asp-Glu-Ile-Leu (SEQ ID NO: 2), and a bioactive complex in which the partial peptide of the GA module is bound to a bioactive substance. The bioactive substance includes GLP-1, GLP-2, GIP, VIP, somatostatin, amylin, ghrelin, derivatives thereof, and the like.
摘要翻译:本发明的目的在于提供能够提高生物活性物质生物活性的肽片段,同时保持生物活性物质的活性,以及加入肽片段的生物活性物质。 本发明涉及具有5至25个氨基酸的GA模块的部分肽,包括GA模块(SEQ ID NO:1)和氨基酸序列Ile-Asp-Glu-Ile-Leu(SEQ ID NO:1)的部分序列 ID NO:2),以及GA模块的部分肽与生物活性物质结合的生物活性复合物。 生物活性物质包括GLP-1,GLP-2,GIP,VIP,生长抑素,胰岛淀粉样多肽,生长素释放肽及其衍生物等。