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公开(公告)号：US08852550B2
公开(公告)日：2014-10-07
申请号：US12571508
申请日：2009-10-01
Applicant: Colin Mill Archer , Harry John Wadsworth , Torgrim Engell
Inventor： Colin Mill Archer , Harry John Wadsworth , Torgrim Engell
CPC classification number: C07K7/06 , A61K38/00 , A61K47/60 , A61K47/6425 , A61K49/0002 , A61K51/088 , C07K14/745
Abstract: The present invention relates to improved chelator conjugates with biological targeting molecules, suitable for forming metal complexes with radiometals. The radiometal complexes, especially with the radiometal 99mTc, are useful as radiopharmaceuticals.
Abstract translation: 本发明涉及具有生物靶向分子的改进的螯合剂缀合物，适用于与放射性金属形成金属络合物。 放射性金属配合物，特别是与放射性金属99mTc，作为放射性药物是有用的。
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公开(公告)号：US07994134B2
公开(公告)日：2011-08-09
申请号：US12423953
申请日：2009-04-15
Applicant: Alan Cuthbertson , Bård Indrevoll , Magne Solbakken , Torgrim Engell , Colin Mill Archer , Harry John Wadsworth
Inventor： Alan Cuthbertson , Bård Indrevoll , Magne Solbakken , Torgrim Engell , Colin Mill Archer , Harry John Wadsworth
IPC: A61K38/00 , A61K38/12 , C07K14/705
CPC classification number: C07K7/06 , A61K38/00 , A61K47/60 , A61K47/6425 , A61K49/0002 , A61K51/082 , A61K51/088 , C07K14/745
Abstract: The invention relates to new peptide-based compounds for use as diagnostic imaging agents or as therapeutic agents wherein the agents comprise targeting vectors which bind to integrin receptors.
Abstract translation: 本发明涉及用作诊断显像剂或作为治疗剂的新的基于肽的化合物，其中所述试剂包含与整联蛋白受体结合的靶向载体。
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公开(公告)号：US20130274436A1
公开(公告)日：2013-10-17
申请号：US13996020
申请日：2011-12-15
Applicant: Torgrim Engell , Nigel Osborn
Inventor： Torgrim Engell , Nigel Osborn
IPC: C07K7/64
CPC classification number: C07K7/64 , A61K47/50 , A61K51/0497
Abstract: A method of radiostabilizing an oxime ligation or imine formation reaction using aniline is described.
Abstract translation: 描述了使用苯胺对肟连接或亚胺形成反应进行放射稳定化的方法。
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公开(公告)号：US20130259804A1
公开(公告)日：2013-10-03
申请号：US13992800
申请日：2011-12-09
Applicant: Torgrim Engell , Julian Grigg , Dimtrios Mantzilas
Inventor： Torgrim Engell , Julian Grigg , Dimtrios Mantzilas
IPC: A61K51/08
CPC classification number: A61K51/088 , A61K51/0497 , A61K51/082 , C07B59/008 , C07K1/13
Abstract: The present invention relates to improved radiotracer imaging agent compositions, which comprises 18F-labelled biological targeting moieties, wherein impurities which affect imaging in vivo are identified and suppressed. Also provided are radiopharmaceuticals comprising said improved compositions, together with radiofluorinated aldehyde compositions useful in preparing said radiotracer compositions. The invention also includes methods of imaging and/or diagnosis using the radiopharmaceutical compositions described.
Abstract translation: 本发明涉及改进的放射性示踪剂成像剂组合物，其包含18F标记的生物靶向部分，其中鉴定和抑制影响体内成像的杂质。 还提供了包含所述改进的组合物的放射性药物，以及可用于制备所述放射性示踪剂组合物的放射性氟化醛组合物。 本发明还包括使用所述放射性药物组合物进行成像和/或诊断的方法。
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公开(公告)号：US20100040542A1
公开(公告)日：2010-02-18
申请号：US12571508
申请日：2009-10-01
Applicant: COLIN MILL ARCHER , HARRY JOHN WADSWORTH , TORGRIM ENGELL
Inventor： COLIN MILL ARCHER , HARRY JOHN WADSWORTH , TORGRIM ENGELL
IPC: A61K51/10 , C07C251/32 , C07K5/08 , C07K5/10 , C07K16/00 , C12N9/00 , C07H21/00 , C07F13/00 , A61P43/00 , A61K51/00 , A61K51/08 , A61K51/06 , C07K7/00 , C07K14/00
CPC classification number: C07K7/06 , A61K38/00 , A61K47/60 , A61K47/6425 , A61K49/0002 , A61K51/088 , C07K14/745
Abstract: The present invention relates to improved chelator conjugates with biological targeting molecules, suitable for forming metal complexes with radiometals. The radiometal complexes, especially with the radiometal 99mTc, are useful as radiopharmaceuticals.
Abstract translation: 本发明涉及具有生物靶向分子的改进的螯合剂缀合物，适用于与放射性金属形成金属络合物。 放射性金属配合物，特别是与放射性金属99mTc，作为放射性药物是有用的。
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公开(公告)号：US20090203584A1
公开(公告)日：2009-08-13
申请号：US12423953
申请日：2009-04-15
Applicant: Alan Cuthbertson , Bard Indrevoll , Magne Solbakken , Torgrim Engell , Colin MIll Archer , Harry John Wadsworth
Inventor： Alan Cuthbertson , Bard Indrevoll , Magne Solbakken , Torgrim Engell , Colin MIll Archer , Harry John Wadsworth
CPC classification number: C07K7/06 , A61K38/00 , A61K47/60 , A61K47/6425 , A61K49/0002 , A61K51/082 , A61K51/088 , C07K14/745
Abstract: The invention relates to new peptide-based compounds for use as diagnostic imaging agents or as therapeutic agents wherein the agents comprise targeting vectors which bind to integrin receptors.
Abstract translation: 本发明涉及用作诊断显像剂或作为治疗剂的新的基于肽的化合物，其中所述试剂包含与整联蛋白受体结合的靶向载体。
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公开(公告)号：US20070020176A1
公开(公告)日：2007-01-25
申请号：US10541949
申请日：2004-01-09
Applicant: Magne Solbakken , Torgrim Engell , Harry Wadsworth , Colin Archer
Inventor： Magne Solbakken , Torgrim Engell , Harry Wadsworth , Colin Archer
CPC classification number: C07K5/0819 , A61K49/0002 , A61K51/0497 , C07D403/10 , C07D493/10 , C07D495/04
Abstract: The present invention relates to a contrast agent of Formula I V-L-Z Formula I where V is a non-peptidic vector having affinity for the Angiotensin II receptor, L is a bond, a spacer or a linker moiety and Z represents a moiety detectable in an in vivo imaging procedure of a human or animal body.
Abstract translation: 本发明涉及式I VLZ式I的造影剂，其中V是对血管紧张素II受体具有亲和力的非肽载体，L是键，间隔基或连接体部分，Z表示可以在 人体或动物体的体内成像过程。
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公开(公告)号：US08536375B2
公开(公告)日：2013-09-17
申请号：US13141337
申请日：2009-12-07
Applicant: Torgrim Engell
Inventor： Torgrim Engell
IPC: C07C229/26 , C07D403/12
CPC classification number: C08G65/329 , A61K47/60 , C08G65/3324 , C08G65/33341 , C08L2203/02
Abstract: The present invention provides novel and more efficient synthesis's for obtaining an intermediate in the synthesis of obtaining a protecting group aminoxy PEG linker.
Abstract translation: 本发明提供了用于获得合成获得保护基团氨基PEG接头的中间体的新型和更有效的合成。
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公开(公告)号：US08415510B2
公开(公告)日：2013-04-09
申请号：US12918391
申请日：2009-02-10
Applicant: Torgrim Engell
Inventor： Torgrim Engell
CPC classification number: C07C269/06 , A61K47/62 , A61K47/65 , C07K7/06 , Y02P20/55 , C07C271/18
Abstract: The present invention provides novel synthesis's for obtaining a protecting group aminoxy PEG-6 linker from cost effective, and readily available starting materials and chemicals or modified polyethylene glycols. More specifically, a novel synthesis of obtaining a modified Boc-protected aminoxy PEG-6 linker was achieved so that said linker may be attached to a vector such as a peptide based fragment.
Abstract translation: 本发明提供了从成本有效的和容易得到的原料和化学品或改性聚乙二醇获得保护基团氨基PEG-6连接体的新型合成方法。 更具体地，获得获得修饰的Boc-保护的氨基羟基PEG-6接头的新合成，使得所述接头可以连接到载体如基于肽的片段上。
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公开(公告)号：US20120020882A1
公开(公告)日：2012-01-26
申请号：US13204935
申请日：2011-08-08
Applicant: Alan Cuthbertson , Bard Indrevoll , Magne Solbakken , Torgrim Engell , Colin Mill Archer , Harry John Wadsworth
Inventor： Alan Cuthbertson , Bard Indrevoll , Magne Solbakken , Torgrim Engell , Colin Mill Archer , Harry John Wadsworth
CPC classification number: C07K7/06 , A61K38/00 , A61K47/60 , A61K47/6425 , A61K49/0002 , A61K51/082 , A61K51/088 , C07K14/745
Abstract: The invention relates to new peptide-based compounds for use as diagnostic imaging agents or as therapeutic agents wherein the agents comprise targeting vectors which bind to integrin receptors.
Abstract translation: 本发明涉及用作诊断显像剂或作为治疗剂的新的基于肽的化合物，其中所述试剂包含与整联蛋白受体结合的靶向载体。
