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1.发明申请BETA 1,3-N-ACETYL-D-GALACTOSAMINE TRANSFERASE PROTEIN, NUCLEIC ACID ENCODING THE SAME AND METHOD OF EXAMINING CANCERATION USING THE SAME 失效BETA 1,3-N-乙酰-D-糖苷酶转移蛋白，编码其的核酸和使用其的检查癌症的方法公开(公告)号：US20100279355A1
公开(公告)日：2010-11-04
申请号：US12772117
申请日：2010-04-30
申请人： Hisashi NARIMATSU , Akira Togayachi , Niro Inaba , Toru Hiruma , Yasuko Ishizuka
发明人： Hisashi NARIMATSU , Akira Togayachi , Niro Inaba , Toru Hiruma , Yasuko Ishizuka
CPC分类号： C12N9/1051
摘要： The N-acetyl-D-galactosamine transferase protein of the present invention is characterized by transferring N-acetyl-D-galactosamine to N-acetyl-D-glucosamine with β1,3 linkage, and it preferably has the amino acid sequence shown in SEQ ID NO: 2 or 4. The canceration assay according to the present invention uses a nucleic acid for measurement which hybridizes under stringent conditions to the nucleotide sequence shown in SEQ ID NO: 1 or 3 or a nucleotide sequence complementary to at least one of them.
摘要翻译： 本发明的N-乙酰基-D-半乳糖胺转移酶蛋白的特征在于将N-乙酰基-D-半乳糖胺转移至具有1,3-连接的N-乙酰基-D-葡糖胺，并且其优选具有所示的氨基酸序列 根据本发明的癌化测定使用在严格条件下与SEQ ID NO：1或3所示的核苷酸序列杂交的核酸或与至少一个氨基酸互补的核苷酸序列的核酸 的他们。
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2.发明申请Glycosyltransferase, nucleic acid encoding the glycosyltransferase and method of testing canceration using the nucleic acid 审中-公开糖基转移酶，编码糖基转移酶的核酸和使用核酸测试癌变的方法公开(公告)号：US20090081668A1
公开(公告)日：2009-03-26
申请号：US12155320
申请日：2008-06-02
申请人： Hisashi Narimatsu , Takashi Kudo , Akira Togayachi , Toru Hiruma
发明人： Hisashi Narimatsu , Takashi Kudo , Akira Togayachi , Toru Hiruma
CPC分类号： C12N9/1051
摘要： A tumor marker nucleic acid of the present invention is concerned with a nucleic acid hybridizing under stringent conditions to a nucleotide sequence described in SEQ ID NO: 1 or a complementary nucleotide sequence thereof. A method of testing canceration of the present invention is a method comprising diagnosing a biological sample as being cancerous when the transcription level of the nucleic acid in the biological sample significantly exceeds that in a normal biological sample as a control. The present invention also relates to a β1,3-N-acetyl-D-glucosaminyltransferase protein having an activity of transferring N-acetyl-D-glucosamine from a donor substrate to an acceptor substrate through β1,3-linkage.
摘要翻译： 本发明的肿瘤标志物核酸涉及在严格条件下与SEQ ID NO：1所述核苷酸序列或其互补核苷酸序列杂交的核酸。 测定本发明的癌症的方法是当生物样品中的核酸的转录水平显着超过作为对照的正常生物样品中的生物样品时，将生物样品诊断为癌变的方法。 本发明还涉及具有通过β1,3键将N-乙酰基-D-葡糖胺从供体底物转移到受体底物的活性的β1,3-N-乙酰基-D-葡糖胺基转移酶蛋白。
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3.发明授权公开(公告)号：US06339089B2
公开(公告)日：2002-01-15
申请号：US09132706
申请日：1998-08-12
IPC分类号： C07D23995
CPC分类号： C07D401/12 , C07D239/95 , C07D405/12 , C07D409/12 , C07D495/04
摘要： A pyrimidine nucleus-containing compound represented by the formula (I): wherein ring A represents the ring of the formula (a): in which R1 is a nitro group, an amino group, a substituted amino group or a halogen atom, or the ring of the formula (b): in which R1′ is the group such as an alkyl group or an alkenyl group; R2 to R5 independently represent the group such as an alkyl group or an alkenyl group; with the proviso that at least one of R2 to R5 is an alkenyl group, or acid addition salts thereof.
摘要翻译： 由式（I）表示的含嘧啶核的化合物：其中环A表示式（a）的环：其中R 1为硝基，氨基，取代的氨基或卤素原子，或 式（b）的环：其中R1'为烷基或烯基等基团; R2至R5独立地表示烷基或烯基等基团; 条件是R2至R5中的至少一个为烯基，或其酸加成盐。
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4.发明申请Beta1,3-N-acetyl-D-galactosamine transferase protein, nucleic acid encoding the same and method of examining canceration using the same 审中-公开β1,3-N-乙酰基-D-半乳糖胺转移酶蛋白，编码相同的核酸和使用其的癌症检查方法公开(公告)号：US20080299615A1
公开(公告)日：2008-12-04
申请号：US12216077
申请日：2008-06-30
申请人： Hisashi Narimatsu , Akira Togayachi , Niro Inaba , Toru Hiruma , Yasuko Ishizuka
发明人： Hisashi Narimatsu , Akira Togayachi , Niro Inaba , Toru Hiruma , Yasuko Ishizuka
CPC分类号： C12N9/1051
摘要： The N-acetyl-D-galactosamine transferase protein of the present invention is characterized by transferring N-acetyl-D-galactosamine to N-acetyl-D-glucosamine with β1,3 linkage, and it preferably has the amino acid sequence shown in SEQ ID NO: 2 or 4. The canceration assay according to the present invention uses a nucleic acid for measurement which hybridizes under stringent conditions to the nucleotide sequence shown in SEQ ID NO: 1 or 3 or a nucleotide sequence complementary to at least one of them.
摘要翻译： 本发明的N-乙酰基-D-半乳糖胺转移酶蛋白的特征在于将N-乙酰基-D-半乳糖胺转移至具有β1,3键的N-乙酰基-D-葡糖胺，并且其优选具有SEQ所示的氨基酸序列 根据本发明的癌化测定使用在严格条件下与SEQ ID NO：1或3所示的核苷酸序列杂交的核酸或与至少一种互补的核苷酸序列的核酸 。
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5.发明授权Glycosyltransferase, nucleic acid encoding the glycosyltransferase and method of testing canceration using the nucleic acid 失效糖基转移酶，编码糖基转移酶的核酸和使用核酸测试癌变的方法公开(公告)号：US07396666B2
公开(公告)日：2008-07-08
申请号：US10539834
申请日：2003-12-26
申请人： Hisashi Narimatsu , Takashi Kudo , Akira Togayachi , Toru Hiruma
发明人： Hisashi Narimatsu , Takashi Kudo , Akira Togayachi , Toru Hiruma
CPC分类号： C12N9/1051
摘要： A tumor marker nucleic acid of the present invention is concerned with a nucleic acid hybridizing under stringent conditions to a nucleotide sequence described in SEQ ID NO: 1 or a complementary nucleotide sequence thereof. A method of testing canceration of the present invention is a method comprising diagnosing a biological sample as being cancerous when the transcription level of the nucleic acid in the biological sample significantly exceeds that in a normal biological sample as a control. The present invention also relates to a β1,3-N-acetyl-D-glucosaminyltransferase protein having an activity of transferring N-acetyl-D-glucosamine from a donor substrate to an acceptor substrate through β1,3-linkage.
摘要翻译： 本发明的肿瘤标志物核酸涉及在严格条件下与SEQ ID NO：1所述核苷酸序列或其互补核苷酸序列杂交的核酸。 测定本发明的癌症的方法是当生物样品中的核酸的转录水平显着超过作为对照的正常生物样品中的生物样品时，将生物样品诊断为癌变的方法。 本发明还涉及具有通过β1,3键将N-乙酰基-D-葡糖胺从供体底物转移到受体底物的活性的β1,3-N-乙酰基-D-葡糖胺基转移酶蛋白。
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6.发明申请Ss 1,3-n-acetyl-d-galactosamine transferase protein, nucleic acid encoding the same and method of examining canceration using the same 审中-公开Ss 1,3-n-乙酰基-D-半乳糖胺转移酶蛋白，编码相同的核酸以及使用其进行癌变检查的方法公开(公告)号：US20060166211A1
公开(公告)日：2006-07-27
申请号：US10539450
申请日：2004-01-23
申请人： Hisashi Narimatsu , Akira Togayachi , Niro Inaba , Toru Hiruma , Yasuko Ishizuka
发明人： Hisashi Narimatsu , Akira Togayachi , Niro Inaba , Toru Hiruma , Yasuko Ishizuka
CPC分类号： C12N9/1051
摘要： The N-acetyl-D-galactosamine transferase protein of the present invention is characterized by transferring N-acetyl-D-galactosamine to N-acetyl-D-glucosamine with β1,3 linkage, and it preferably has the amino acid sequence shown in SEQ ID NO: 2 or 4. The canceration assay according to the present invention uses a nucleic acid for measurement which hybridizes under stringent conditions to the nucleotide sequence shown in SEQ ID NO: 1 or 3 or a nucleotide sequence complementary to at least one of them.
摘要翻译： 本发明的N-乙酰基-D-半乳糖胺转移酶蛋白的特征在于将N-乙酰基-D-半乳糖胺转移至具有β1,3键的N-乙酰基-D-葡糖胺，并且其优选具有SEQ所示的氨基酸序列 根据本发明的癌化测定使用在严格条件下与SEQ ID NO：1或3所示的核苷酸序列杂交的核酸或与至少一种互补的核苷酸序列的核酸 。
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7.发明申请BETA 1,3-N-ACETYL-D-GALACTOSAMINE TRANSFERASE PROTEIN, NUCLEIC ACID ENCODING THE SAME AND METHOD OF EXAMINING CANCERATION USING THE SAME 失效BETA 1,3-N-乙酰-D-糖苷酶转移蛋白，编码其的核酸和使用其的检查癌症的方法公开(公告)号：US20130004995A1
公开(公告)日：2013-01-03
申请号：US13539290
申请日：2012-06-29
申请人： Hisashi NARIMATSU , Akira Togayachi , Niro Inaba , Toru Hiruma , Yasuko Ishizuka
发明人： Hisashi NARIMATSU , Akira Togayachi , Niro Inaba , Toru Hiruma , Yasuko Ishizuka
IPC分类号： C12P19/26
CPC分类号： C12N9/1051
摘要： The N-acetyl-D-galactosamine transferase protein of the present invention is characterized by transferring N-acetyl-D-galactosamine to N-acetyl-D-glucosamine with β1,3 linkage, and it preferably has the amino acid sequence shown in SEQ ID NO: 2 or 4. The canceration assay according to the present invention uses a nucleic acid for measurement which hybridizes under stringent conditions to the nucleotide sequence shown in SEQ ID NO: 1 or 3 or a nucleotide sequence complementary to at least one of them.
摘要翻译： 本发明的N-乙酰基-D-半乳糖胺转移酶蛋白的特征在于将N-乙酰基-D-半乳糖胺转移至具有1,3-连接的N-乙酰基-D-葡糖胺，并且其优选具有所示的氨基酸序列 根据本发明的癌化测定使用在严格条件下与SEQ ID NO：1或3所示的核苷酸序列杂交的核酸或与至少一个氨基酸互补的核苷酸序列的核酸 的他们。
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公开(公告)号：US20060177822A1
公开(公告)日：2006-08-10
申请号：US10539834
申请日：2003-12-26
申请人： Hisashi Narimatsu , Takashi Kudo , Akira Togayachi , Toru Hiruma
发明人： Hisashi Narimatsu , Takashi Kudo , Akira Togayachi , Toru Hiruma
CPC分类号： C12N9/1051
摘要： A tumor marker nucleic acid of the present invention is concerned with a nucleic acid hybridizing under stringent conditions to a nucleotide sequence described in SEQ ID NO: 1 or a complementary nucleotide sequence thereof. A method of testing canceration of the present invention is a method comprising diagnosing a biological sample as being cancerous when the transcription level of the nucleic acid in the biological sample significantly exceeds that in a normal biological sample as a control. The present invention also relates to a β1,3-N-acetyl-D-glucosaminyltransferase protein having an activity of transferring N-acetyl-D-glucosamine from a donor substrate to an acceptor substrate through β1,3-linkage.
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9.发明授权β1,3-N-acetyl-D-galactosamine transferase protein, nucleic acid encoding the same and method of examining canceration using the same 失效β1,3-N-乙酰基-D-半乳糖胺转移酶蛋白，编码相同的核酸和使用其的癌症检查方法公开(公告)号：US08431365B2
公开(公告)日：2013-04-30
申请号：US13539290
申请日：2012-06-29
申请人： Hisashi Narimatsu , Akira Togayachi , Niro Inaba , Toru Hiruma , Yasuko Ishizuka
发明人： Hisashi Narimatsu , Akira Togayachi , Niro Inaba , Toru Hiruma , Yasuko Ishizuka
CPC分类号： C12N9/1051
摘要： The N-acetyl-D-galactosamine transferase protein of the present invention is characterized by transferring N-acetyl-D-galactosamine to N-acetyl-D-glucosamine with β1,3 linkage, and it preferably has the amino acid sequence shown in SEQ ID NO: 2 or 4. The canceration assay according to the present invention uses a nucleic acid for measurement which hybridizes under stringent conditions to the nucleotide sequence shown in SEQ ID NO: 1 or 3 or a nucleotide sequence complementary to at least one of them.
摘要翻译： 本发明的N-乙酰基-D-半乳糖胺转移酶蛋白的特征在于将N-乙酰基-D-半乳糖胺转移至具有β1,3键的N-乙酰基-D-葡糖胺，并且其优选具有SEQ所示的氨基酸序列 根据本发明的癌化测定使用在严格条件下与SEQ ID NO：1或3所示的核苷酸序列杂交的核酸或与至少一种互补的核苷酸序列的核酸 。
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10.发明授权β1,3-N-acetyl-D-galactosamine transferase protein, nucleic acid encoding the same and method of examining canceration using the same 失效1,3-N-乙酰基-D-半乳糖胺转移酶蛋白，编码该核酸的核酸和使用其的癌症检查方法公开(公告)号：US08227213B2
公开(公告)日：2012-07-24
申请号：US12772117
申请日：2010-04-30
申请人： Hisashi Narimatsu , Akira Togayachi , Niro Inaba , Toru Hiruma , Yasuko Ishizuka
发明人： Hisashi Narimatsu , Akira Togayachi , Niro Inaba , Toru Hiruma , Yasuko Ishizuka
IPC分类号： C12P19/18 , C12P19/46 , C12P19/26 , C12P19/30 , C12P33/20 , C12P21/06 , C12P19/34 , C12N9/10 , C07K1/00 , C07H21/04
CPC分类号： C12N9/1051
摘要： The N-acetyl-D-galactosamine transferase protein of the present invention is characterized by transferring N-acetyl-D-galactosamine to N-acetyl-D-glucosamine with β1,3 linkage, and it preferably has the amino acid sequence shown in SEQ ID NO: 2 or 4. The canceration assay according to the present invention uses a nucleic acid for measurement which hybridizes under stringent conditions to the nucleotide sequence shown in SEQ ID NO: 1 or 3 or a nucleotide sequence complementary to at least one of them.
摘要翻译： 本发明的N-乙酰基-D-半乳糖胺转移酶蛋白的特征在于将N-乙酰基-D-半乳糖胺转移至具有1,3-连接的N-乙酰基-D-葡糖胺，并且其优选具有所示的氨基酸序列 根据本发明的癌化测定使用在严格条件下与SEQ ID NO：1或3所示的核苷酸序列杂交的核酸或与至少一个氨基酸互补的核苷酸序列的核酸 的他们。
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