公开(公告)号：US07003440B2

公开(公告)日：2006-02-21

申请号：US10088550

申请日：2001-07-13

申请人： Takashi Gojobori ,  Yuzuru Tanaka ,  Toshitsugu Okayama

发明人： Takashi Gojobori ,  Yuzuru Tanaka ,  Toshitsugu Okayama

IPC分类号： G06G7/48

CPC分类号： G06G7/48 ,  G06F19/12 ,  G06F19/20 ,  G06F19/26 ,  G06F19/28 ,  G06T11/206

摘要： A method for use in displaying an expression phenomenon in a living matter that are capable of displaying (printing), in a format directly appealing to the eyes or sense, information indicative of gene expression phenomena occurring with time to assist a researcher with easy elucidation of a gene network mechanism. It comprises memorizing means that memorizes an expression data in a cell unit or a site unit along a time axis; and processing means adapted to visualize and display a gene expression phenomenon on a display screen, and comprises the steps of displaying, as a three-dimensional image on a display screen, a shape of a living matter of a cell or site of which expression phenomenon is observed; setting a viewpoint on a three-dimensional space where the gene expression phenomenon in the shape of the living matter displayed is to be observed; and creating a three-dimensional image representing the expression phenomenon at the set viewpoint or at a fixed viewpoint, to display it in one color or multiple colors in various scales depending on a frequency of expression of a gene in the subject cell or site.

摘要翻译： 用于在生物体中显示表现现象的方法，其能够以直接吸引眼睛或感觉的形式显示（印刷）指示随时间发生的基因表达现象的信息，以帮助研究者容易地阐明 一个基因网络机制。 它包括沿着时间轴存储单元单元或站点单元中的表达数据的记忆装置; 以及适于在显示屏幕上显示和显示基因表达现象的处理装置，并且包括以下步骤：在显示屏幕上显示表现现象的单元格或场所的生物的形状 被观察到 在要观察生物体形状的基因表达现象的三维空间中设定观点; 并且在设定的视点或固定的视点上创建表示表现现象的三维图像，以根据被检体细胞或位点中的基因的表达的频率将其以各种尺度显示为一种颜色或多种颜色。

公开(公告)号：US5706498A

公开(公告)日：1998-01-06

申请号：US312689

申请日：1994-09-26

申请人： Hitoshi Fujimiya ,  Shinichiro Yamamoto ,  Norio Maru ,  Toshitsugu Okayama ,  Hisanori Nasu

发明人： Hitoshi Fujimiya ,  Shinichiro Yamamoto ,  Norio Maru ,  Toshitsugu Okayama ,  Hisanori Nasu

IPC分类号： C12N15/09 ,  G06F17/30 ,  G06F19/22 ,  G06F19/28 ,  G06F13/12

CPC分类号： G06F19/28 ,  Y10S707/99936

摘要： The gene database retrieval system, for making a retrieval for a gene sequence having a sequence similar to a sequence data from a gene database, contains a gene database for storing the sequence data of genes whose structures or sequences have already been analyzed and identified, a dynamic programming operation unit for determining the degree of similarity between target data and key data by utilizing the sequence data of the bases of the gene from the gene database as the target data and the sequence data of the bases as the key for retrieval, and a central processing device unit for executing the access process to make access to the gene database, in parallel to the operation process for determining the degree of similarity by transmitting the sequence data of the bases from the gene database continually one after another into the dynamic programming operation unit as the target data, by controlling the gene database and the dynamic programming operation unit.

摘要翻译： 用于对具有与基因数据库的序列数据类似的序列的基因序列的检索的基因数据库检索系统包含用于存储其结构或序列已被分析和鉴定的基因的序列数据的基因数据库， 用于通过利用来自基因数据库的基因的碱基的序列数据作为目标数据和碱基的序列数据作为检索关键来确定目标数据和关键数据之间的相似程度的动态规划操作单元，以及 中央处理装置单元，用于执行访问过程以访问基因数据库，与用于通过将基因的序列数据从基因数据库连续地依次发送到动态规划操作中来确定相似度的操作过程并行地进行 单元作为目标数据，通过控制基因数据库和动态编程操作单元。

公开(公告)号：US20100205204A1

公开(公告)日：2010-08-12

申请号：US12529506

申请日：2008-02-29

申请人： Takashi Gojobori ,  Kazuho Ikeo ,  Toshitsugu Okayama

发明人： Takashi Gojobori ,  Kazuho Ikeo ,  Toshitsugu Okayama

IPC分类号： G06F17/30

CPC分类号： G06F16/90344 ,  G16B30/00

摘要： A homology retrieval can be performed with higher accuracy than conventional technologies when comparing a query sequence with a target sequence, and retrieving a similar location in the target sequence. The sequence information of a query sequence and a genomic-scale target sequence is acquired, the acquired information is compressingly converted into a compressed query sequence and a compressed target sequence in each of which a homopolymer region including two or more consecutive identical bases is replaced with a single base of the bases, the two sequences are compared, and a refining search is performed for a compressed target partial sequence that matches the compressed query sequence in the compressed target sequence. For the refined compressed candidate sequence and the query sequence, based on the information on the number of consecutive identical bases in the each of the sequences before compression, the number of consecutive bases is compared between the two compressed sequences for each corresponding base, and the degree of similarity indicating homology of the candidate sequence with the query sequence is computed from a degree of match or a degree of mismatch in the number of consecutive bases. By ranking and selecting an arbitrary number of candidate sequences having relatively high homology with the query sequence from this degree of similarity, it is possible to avoid the influence of the number of consecutive identical bases in a homopolymer region, thereby performing a homology retrieval accurately.

摘要翻译： 当将查询序列与目标序列进行比较时，可以以比传统技术更高的精度执行同源性检索，并且在目标序列中检索类似的位置。 获取查询序列和基因组大小目标序列的序列信息，将所获取的信息压缩转换为压缩查询序列，并将压缩的目标序列分别包含两个或多个连续相同的碱基的均聚物区域替换为 碱基的单个碱基，比较两个序列，并且对与压缩的目标序列中的压缩查询序列匹配的压缩目标部分序列进行精制搜索。 对于经精制的压缩候选序列和查询序列，基于压缩前每个序列中连续相同碱基数的信息，对于每个对应的碱基，在两个压缩序列之间比较连续碱基数， 从候选序列与查询序列的同源性的相似度的程度根据匹配度或连续基数的失配程度计算。 通过从该相似度排序和选择与查询序列具有相对高同源性的任意数量的候选序列，可以避免在均聚物区域中连续相同碱基的数量的影响，从而准确地进行同源性检索。

公开(公告)号：US5246866A

公开(公告)日：1993-09-21

申请号：US849631

申请日：1992-03-02

申请人： Hisanori Nasu ,  Toshitsugu Okayama ,  Hitoshi Fujimiya

发明人： Hisanori Nasu ,  Toshitsugu Okayama ,  Hitoshi Fujimiya

IPC分类号： G01N27/447

CPC分类号： G01N27/44721 ,  Y10T436/143333

摘要： A DNA sequence transcribing method involves labeling a DNA fragment with a fluorescent substance, subjecting the labeled fragments to electrophoresis, exposing a gel containing the DNA fragment to light during electrophoresis, and detecting fluorescence generated upon exposure. An image corresponding to a fluorescent image on the gel is transcribed on a recording medium by entering a detecting signal in synchronization with operation of detecting fluorescence on the gel containing the DNA fragment after electrophoresis. This arrangement enables a crude fluorescent image on the gel containing the DNA fragment to be recorded as an intact image of the DNA sequencing on the basis of the fluorescent method, and the image can be retained.

摘要翻译： DNA序列转录方法包括用荧光物质标记DNA片段，对标记的片段进行电泳，在电泳期间将含有DNA片段的凝胶暴露于光，并检测在暴露时产生的荧光。 通过在电泳后含有DNA片段的凝胶上检测荧光的操作同步地输入检测信号，将与凝胶上的荧光图像对应的图像记录在记录介质上。 这种布置使得能够基于荧光方法将含有DNA片段的凝胶上的粗荧光图像记录为DNA测序的完整图像，并且可以保留图像。

公开(公告)号：US5121320A

公开(公告)日：1992-06-09

申请号：US422578

申请日：1989-10-17

申请人： Yoshiaki Aoki ,  Toshitsugu Okayama

发明人： Yoshiaki Aoki ,  Toshitsugu Okayama

IPC分类号： G01N27/447 ,  G01N33/50 ,  G06F19/20 ,  G06Q50/00 ,  G06Q50/10 ,  G06Q50/22 ,  G06T1/00 ,  G06T7/00

CPC分类号： G06T7/0012 ,  G01N27/44717 ,  G06T2207/30004

摘要： The edit processing includes band deletion processing and band addition processing for correcting the DNA pattern image. Additionally, a concentration graph display indicative of a distribution of concentration of the DNA pattern is provided.

摘要翻译： 编辑处理包括用于校正DNA图案图像的频带删除处理和频带添加处理。 此外，提供了指示DNA图案的浓度分布的浓度图显示。