公开(公告)号：US5066817A

公开(公告)日：1991-11-19

申请号：US516304

申请日：1990-04-30

申请人： Hirofumi Nakano ,  Mitsunobu Hara ,  Tsuyoshi Mokudai ,  Isao Kawamoto ,  Mayumi Yoshida ,  Eiji Kobayashi

发明人： Hirofumi Nakano ,  Mitsunobu Hara ,  Tsuyoshi Mokudai ,  Isao Kawamoto ,  Mayumi Yoshida ,  Eiji Kobayashi

IPC分类号： C07D407/04 ,  C12P17/06

CPC分类号： C07D407/04 ,  C12P17/06 ,  Y10S435/886

摘要： Disclosed are DC115A compounds represented by the following general formula: ##STR1## wherein R represents ethyl, propyl or 1-propenyl, and which have antibacterial and anti-tumor activity. DC115A compounds are produced by culturing a microorganism belonging to the genus Streptomyces.

公开(公告)号：US08303820B2

公开(公告)日：2012-11-06

申请号：US12063318

申请日：2006-08-10

申请人： Hideki Murata ,  Tsuyoshi Mokudai ,  Michio Shiomi

发明人： Hideki Murata ,  Tsuyoshi Mokudai ,  Michio Shiomi

IPC分类号： B01D19/30 ,  B01D15/36 ,  B01J39/12 ,  C12P19/30 ,  C07H19/10

CPC分类号： C12P19/32 ,  C07H19/10

摘要： A method of purifying cytidine diphosphate choline, which comprises contacting a cytidine diphosphate choline solution containing a nucleic acid analogue and having a pH of not less than 0.5 and not more than 5.0 with an H-type strongly acidic cation exchange resin, and eluting cytidine diphosphate choline adsorbed onto the resin with water or an aqueous solution having an ion concentration of not more than 0.1 mol/L to separate and purify the cytidine diphosphate choline.

摘要翻译： 一种纯化胞苷二磷酸胆碱的方法，其包括使用H型强酸性阳离子交换树脂使含有核酸类似物的胞苷二磷酸胆碱溶液与pH值不小于0.5且不大于5.0的条件接触，并将胞苷二磷酸 用水或离子浓度不超过0.1mol / L的水溶液吸附到树脂上的胆碱分离和纯化胞苷二磷酸胆碱。

公开(公告)号：US20090286284A1

公开(公告)日：2009-11-19

申请号：US12063318

申请日：2006-08-10

申请人： Hideki Murata ,  Tsuyoshi Mokudai ,  Michio Shiomi

发明人： Hideki Murata ,  Tsuyoshi Mokudai ,  Michio Shiomi

IPC分类号： C12P19/40 ,  C07H19/048

CPC分类号： C12P19/32 ,  C07H19/10

摘要： A method of purifying cytidine diphosphate choline, which comprises contacting a cytidine diphosphate choline solution containing a nucleic acid analogue and having a pH of not less than 0.5 and not more than 5.0 with an H-type strongly acidic cation exchange resin, and eluting cytidine diphosphate choline adsorbed onto the resin with water or an aqueous solution having an ion concentration of not more than 0.1 mol/L to separate and purify the cytidine diphosphate choline.

摘要翻译： 一种纯化胞苷二磷酸胆碱的方法，其包括使用H型强酸性阳离子交换树脂使含有核酸类似物的胞苷二磷酸胆碱溶液与pH值不小于0.5且不大于5.0的条件接触，并将胞苷二磷酸 用水或离子浓度不超过0.1mol / L的水溶液吸附到树脂上的胆碱分离和纯化胞苷二磷酸胆碱。