公开(公告)号：US12221609B2

公开(公告)日：2025-02-11

申请号：US17271982

申请日：2019-09-20

Applicant: University of Connecticut

Inventor： Stormy Chamberlain ,  Noelle Germain

IPC: C12N15/113 ,  C12N15/86

Abstract: The present invention relates to compositions and methods for activating expression from the paternally-inherited allele of UBE3A in human Angelman's Syndrome neurons using viral vector delivery of short hairpin RNAs, ribozymes, and/or microRNAs.

公开(公告)号：US20250037904A1

公开(公告)日：2025-01-30

申请号：US18915078

申请日：2024-10-14

Applicant: The Board of Regents of the University of Oklahoma ,  The Board of Trustees of The Leland Stanford Junior University ,  The University of Connecticut

Inventor： Hamidreza Shabgard ,  Amir Faghri ,  Kenneth Goodson ,  Mehdi Asheghi

IPC: H01B7/42 ,  B60L53/18 ,  B60L53/302 ,  F28D15/04 ,  F28D21/00

Abstract: A connector apparatus for an electric charging cable, such as for use with a charging station and an electric vehicle, the connector apparatus comprising: a connector block having a first end and a second end, the first end having one or more connectors configured to pass electrical energy through an electric cable; the electric cable having an end portion that is fixed within the connector block, the electric cable extending out of the connector block from the second end of the connector block and configured to transfer electric current; and a plurality of heat pipes having fixed ends fixed within the connector block and having exposed ends extending out of the second end of the connector block, the plurality of heat pipes configured to dissipate heat from the connector block through the exposed ends of the plurality of heat pipes.

公开(公告)号：US20250034631A1

公开(公告)日：2025-01-30

申请号：US18710724

申请日：2022-11-16

Applicant: UNIVERSITY OF CONNECTICUT

Inventor： Changchun LIU ,  Xiong DING

IPC: C12Q1/6844 ,  C12Q1/6806 ,  C12Q1/70 ,  G01N21/77 ,  G01N21/80

Abstract: Disclosed are methods, devices and kits for extracting, amplifying, detecting and visualizing nucleic acids of interest for use in onsite rapid diagnostics.

公开(公告)号：US20250022481A1

公开(公告)日：2025-01-16

申请号：US18770039

申请日：2024-07-11

Applicant: University of Connecticut

Inventor： Anthony John Brammer ,  Insoo Kim

IPC: G10L21/0364 ,  G10L21/0208

Abstract: A method for improving intelligibility of speech and/or warning sounds generated in a noisy environment including receiving an audio signal from the noisy environment, segmenting the audio signal into a plurality of frequency bandwidths to provide a plurality of temporal bandwidth limited signals, and providing each temporal bandwidth limited signal to an associated signal path and an associated control path in parallel with the associated signal path. The method also includes filtering the temporal envelope bandwidth signal in each associated control path using a delayless filter to provide an associated control signal, modulating an amplitude of the temporal bandpass signal in each associated signal path using the associated control signal to provide an associated output signal, and combining the associated output signals to provide a combined output signal that improves the intelligibility of the speech and/or warning sounds generated in the noisy environment.

公开(公告)号：US20240342496A1

公开(公告)日：2024-10-17

申请号：US18659762

申请日：2024-05-09

Applicant: University of Connecticut

Inventor： Ki Chon ,  Mahdi Pirayesh Shirazi Nejad

IPC: A61N1/39

CPC classification number: A61N1/395 ,  A61N1/3987 ,  G06N3/045 ,  G06N3/0464

Abstract: An apparatus for treating a person having cardiac arrest includes a processor and a lead in communication with the processor, the lead being configured to receive a segment of electrocardiogram (ECG) data from the person while undergoing cardiopulmonary resuscitation (CPR). The apparatus also includes a non-transitory computer-readable medium having: a first Convolutional Neural Network-based Encoder-Decoder (CNNED) structure to reduce artifacts due to the CPR; a second CNNED structure cascaded with the first CNNED structure to further reduce artifacts; and instructions to determine a first arrhythmia classification using the first CNNED structure, determine a second arrhythmia classification using the second CNNED structure in response to the first arrhythmia classification indicating a shockable arrhythmia event; and transmit a signal to apply a defibrillation shock to the person in response to the first arrhythmia classification and the second arrhythmia classification indicating a shockable arrhythmia of the person.

公开(公告)号：US20240336833A1

公开(公告)日：2024-10-10

申请号：US18627866

申请日：2024-04-05

Applicant: UNIVERSITY OF CONNECTICUT

Inventor： Gregory Allen Sotzing

IPC: C09K9/02 ,  C08J5/18 ,  C09D5/08 ,  C09D123/02 ,  C09D167/02 ,  C09D175/04 ,  G02F1/1516 ,  H01G4/14 ,  H01G4/33

CPC classification number: C09K9/02 ,  C08J5/18 ,  C09D5/08 ,  C09D123/02 ,  C09D167/02 ,  C09D175/04 ,  G02F1/15165 ,  H01G4/14 ,  H01G4/33 ,  C08J2367/02

Abstract: Disclosed herein are polycannabinoids and polycannabinoid compositions which find use as a commodity polymer and for commodity electronics. Suitable uses include coatings and paints. Polycannabinoids can be used as polymer dielectrics for capacitors and capacitive energy storage. Also disclosed are new electrochromic materials comprising polycannabinoids and a salt. Further disclosed are electrochromic devices prepared from the electrochromic materials and electrochromic material compositions.

公开(公告)号：US12103950B2

公开(公告)日：2024-10-01

申请号：US18159906

申请日：2023-01-26

Applicant: UNIVERSITY OF CONNECTICUT

Inventor： Gerald Berkowitz ,  Samuel Haiden ,  Yi Ma

IPC: C07K14/415 ,  C12N15/82

CPC classification number: C07K14/415 ,  C12N15/8223 ,  C12N15/8243

Abstract: The present disclosure provides compositions and methods related to genetically engineered plants. In particular, the present disclosure provides novel compositions for transgenic cannabis plants that overexpress a R2R3-MYB transcription factor gene and methods related to the genetic regulation of the development of a glandular trichome in plants.

公开(公告)号：US12064759B2

公开(公告)日：2024-08-20

申请号：US17245381

申请日：2021-04-30

Applicant: NUtech Ventures ,  UNIVERSITY OF CONNECTICUT

Inventor： Ruiguo Yang ,  Arian Jaberi ,  Amir Monemian Esfahani ,  Ali Tamayol

IPC: B01L3/00 ,  C12M1/34 ,  C12N1/34

CPC classification number: B01L3/5025 ,  C12M41/46 ,  C12N1/34 ,  B01L2300/087 ,  B01L2300/0877 ,  B01L2300/0883 ,  C12N2513/00

Abstract: Microfluidic gradient generators that can create robust platforms that can not only be used for creating co-cultures of cells with various ratios, but also can simultaneously generate gradients of mechanical and chemical stresses. A chip utilizes microchambers embedded within channels to provide space for 3D cell culture and exposes these cells to gradients of mechanical shear stress and a chemical treatment.

公开(公告)号：US12060555B2

公开(公告)日：2024-08-13

申请号：US17663378

申请日：2022-05-13

Applicant: Yale University ,  University of Connecticut

Inventor： Farida Ahangari ,  Naftali Kaminski ,  Carlos Fernandez-Hernando ,  Raman Bahal

IPC: C12N15/113 ,  A61K31/713 ,  A61P9/10 ,  C12N15/11

CPC classification number: C12N15/111 ,  A61K31/713 ,  A61P9/10 ,  C12N15/113

Abstract: In one aspect, the present disclosure provides a microRNA-33 (miR-33) inhibitor comprising a peptide nucleic acid covalently bound to a pH low insertion peptide. In another aspect, the present disclosure provides a method of treating pulmonary fibrosis in a subject, the method comprising administering to the subject a therapeutically effective amount of the miR-33 inhibitor. In some embodiments, the pulmonary fibrosis is idiopathic pulmonary fibrosis.

公开(公告)号：US20240207358A1

公开(公告)日：2024-06-27

申请号：US18288244

申请日：2022-05-10

Applicant: University of Connecticut

Inventor： LIPING XIAO ,  Marja HURLEY ,  Tannin SCHMIDT

IPC: A61K38/17 ,  A61P7/06

CPC classification number: A61K38/1709 ,  A61P7/06

Abstract: The present disclosure is directed to administration of native or recombinant human PRG4 (rhPRG4) as a means to treat sickle cell disease or other disorders in subjects in need of treatment thereof.