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1.
公开(公告)号:US20240230634A9
公开(公告)日:2024-07-11
申请号:US18382849
申请日:2023-10-23
发明人: Leidong Mao , Yang Liu
IPC分类号: G01N33/543 , B01L3/00 , G01N15/14 , G01N15/1404
CPC分类号: G01N33/54366 , B01L3/50273 , B01L3/502753 , B01L3/502761 , G01N15/1404 , G01N15/1484 , B01L2200/0647 , B01L2400/043 , G01N2015/1006
摘要: The present disclosure provides devices, kits, and methods for focusing/enriching and/or separating/sorting submicron size particles, including biological entities such as exosomes and other submicron size extracellular vesicles. Devices, kits, and methods of the present disclosure utilize ferrohydrodynamic manipulation to focus populations of submicron particles into a stream for enrichment and/or further sort various sub-populations of submicron particles based on size differences.
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公开(公告)号:USPP35985P2
公开(公告)日:2024-07-09
申请号:US18225815
申请日:2023-07-25
发明人: John M. Ruter
IPC分类号: A01H6/00
摘要: A new and distinct cultivar of Ilex plant named ‘RutHol8’ is characterized by a combination of its upright, v-shaped growth habit, its attractive reddish new growth, its intermediate height:width ratio, and its resistance to spider mites.
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3.
公开(公告)号:US12016974B2
公开(公告)日:2024-06-25
申请号:US17397488
申请日:2021-08-09
发明人: Hitesh Handa , Marcus Goudie
IPC分类号: A61L29/06 , A61L29/08 , A61L29/16 , C08J7/046 , C09D183/04
CPC分类号: A61L29/06 , A61L29/085 , A61L29/16 , C08J7/046 , C09D183/04 , A61L2300/114 , A61L2420/06
摘要: Embodiments of the present disclosure provide for treated articles of tubing having anti-fouling characteristics, methods of making treated articles of tubing, and the like. Disclosed herein are treated articles of tubing impregnated with a silicone oil and a nitric oxide release agent. Also described are methods for preparing a treated article of tubing and methods for delivering a pharmaceutically acceptable fluid to a subject in need thereof, wherein the fluid is transferred from a fluid source through treated articles of tubing to the subject.
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公开(公告)号:US20240199662A1
公开(公告)日:2024-06-20
申请号:US18435109
申请日:2024-02-07
发明人: Uma Sharan Singh , Chung Chu
IPC分类号: C07F9/6558 , A61K31/675 , A61K45/06 , A61P31/22
CPC分类号: C07F9/65586 , A61K31/675 , A61K45/06 , A61P31/22
摘要: In an embodiment, the invention is directed to prodrug compounds of L-BHDU according to the chemical structure I:
Where R1 is a —(CH2)n—O—R1a group or a —(CH2)j—O—C(O)Ok—R2a group;
R2 is H, a —(CH2)n—O—R1a group or a —(CH2)j—O—C(O)Ok— R2a group;
R1a is independently a C6-C30alkyl group, often a C12-C22 alkyl group, often a C14-C20 alkyl group or a C16-C18 alkyl group, often a C16 or C18 alkyl group;
R2a is independently a C1-C12 alkyl group, often a C2-C6 alkyl group, a C3-C4 alkyl group, an isopropyl, t-butyl or sec-butyl group, or an isopropyl or t-butyl group;
Each j is independently 1-6, 1-3, often 1 or 2;
Each k is 0 or 1;
Each n is independently 1-6, 1-4, 2-4 or 2 or 3; or
A pharmaceutically acceptable salt, solute or polymorph thereof. Additional embodiments are directed to pharmaceutical compositions based upon the disclosed chemical compounds and methods of treating or reducing the likelihood of VZV, HSV-1 or HSV-2 infections. Methods of synthesizing compounds according to the present invention represent further embodiments of the invention.-
公开(公告)号:US20240165235A1
公开(公告)日:2024-05-23
申请号:US18282705
申请日:2022-03-18
发明人: Jin XIE
IPC分类号: A61K41/00 , A61K9/51 , A61K33/244 , A61K33/44 , A61P35/00
CPC分类号: A61K41/0038 , A61K9/5115 , A61K33/244 , A61K33/44 , A61P35/00
摘要: Gd-encapsulated carbonaceous dots (Gd@C-dots) hold great potential in clinical translation as T1 contrast agent for magnetic resonance imaging. Disclosed are methods of using said particles as radiosensitizing agents.
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公开(公告)号:US20240080101A1
公开(公告)日:2024-03-07
申请号:US18271762
申请日:2022-01-11
发明人: Mable P. Fok , Qidi Liu
IPC分类号: H04B10/27
CPC分类号: H04B10/27 , H04B2210/003 , H04B2210/006 , H04B2210/256
摘要: Various examples are provided related to single channel and multi-channel radio frequency (RF) steganography. In one example, a method includes generating an amplified spontaneous emission (ASE) broadband signal; spectrally slicing the ASE broad-band light to achieve taps for generating a dynamic photonic finite impulse response in an RF domain; generating a stealth-modulated broadband optical carrier by combining a stealth signal with the spectrally sliced ASE broadband light; passing the stealth-modulated broadband optical carrier to a dispersive medium to achieve the dynamic photonic FIR in the RF domain; and transmitting the stealth-modulated optical comb carrier via a transmission fiber. The ASE broadband light can have wavelength and intensity corresponding to background noise of a photonic system. In another example, a system for RF steganography includes a stealth transmitter. The stealth transmitter can generate and transmit the stealth-modulated optical comb carrier to a stealth receiver via a transmission fiber.
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公开(公告)号:US20240079091A1
公开(公告)日:2024-03-07
申请号:US18242921
申请日:2023-09-06
发明人: Natarajan Kannan , Zhongliang Zhou , Sheng Li , Wayland Yeung
摘要: Various examples are provided related to phosphosite prediction. In one example, a system includes a computing device and an application for phosphosite prediction stored in memory. When executed, the application can cause the computing device to transform a protein sequence to a context-aware protein sequence by a Phosformer based transformer. The transformation can include predicting phosphorylation associations from the protein sequence based upon a trained Phosformer model and generating the context-aware protein sequence based upon the predicted phosphorylation associations, the context-aware protein sequence including a predicted phosphosite. The predicted phosphosite can be rendered for presentation to a user.
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公开(公告)号:US11911615B2
公开(公告)日:2024-02-27
申请号:US17220625
申请日:2021-04-01
发明人: Kevin K. McCully
CPC分类号: A61N1/3601 , A61N1/0456
摘要: In one embodiment, an assessment system includes an electrical stimulation device configured to generate current, stimulation electrodes configured to apply the current generated by the electrical stimulation device to a neck of a subject at a location that results in stimulation of a phrenic nerve of the subject, a movement sensor configured to sense movement of an upper abdomen of the subject caused by twitching of a diaphragm of the subject responsive to the stimulation of the phrenic nerve, and a controller configured to receive data sensed by the movement sensor, analyze the received data to evaluate the activity of the diaphragm, and generate an assessment of the subject's respiratory function or phrenic nerve.
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公开(公告)号:US20240024435A1
公开(公告)日:2024-01-25
申请号:US18199685
申请日:2023-05-19
CPC分类号: A61K38/47 , A61P31/04 , C12N1/20 , C12N9/2402 , C12Y302/01031 , C12N2510/00
摘要: Provided herein is a protein, referred to as a Pn3Pase protein, that degrades the capsular polysaccharide of serotype 3 Streptococcus pneumoniae. The disclosure includes a genetically modified cell that includes a Pn3Pase protein, and compositions that include the protein, the polynucleotide encoding the protein, the genetically modified cell, or a combination thereof. Also provided are methods for using a Pn3Pase protein, including methods for contacting a S. pneumoniae having a type III capsular polysaccharide with a Pn3Pase protein, increasing deposition of at least one complement component on the surface of a S. pneumoniae, treating an infection in a subject, treating a symptom in a subject, decreasing colonization of a subject by S. pneumoniae, or a combination thereof.
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10.
公开(公告)号:US11841365B2
公开(公告)日:2023-12-12
申请号:US16930664
申请日:2020-07-16
发明人: Leidong Mao , Yang Liu
IPC分类号: G01N33/543 , B01L3/00 , G01N15/14 , G01N15/10
CPC分类号: G01N33/54366 , B01L3/50273 , B01L3/502753 , B01L3/502761 , G01N15/1404 , G01N15/1484 , B01L2200/0647 , B01L2400/043 , G01N2015/1006 , G01N2015/149 , G01N2015/1415 , G01N2015/1486
摘要: The present disclosure provides devices, kits, and methods for focusing/enriching and/or separating/sorting submicron size particles, including biological entities such as exosomes and other submicron size extracellular vesicles. Devices, kits, and methods of the present disclosure utilize ferrohydrodynamic manipulation to focus populations of submicron particles into a stream for enrichment and/or further sort various sub-populations of submicron particles based on size differences.
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