公开(公告)号：US4052419A

公开(公告)日：1977-10-04

申请号：US580900

申请日：1975-05-27

Applicant: Solomon Aronovich Giller ,  Karl Karlovich Venter ,  Margarita Aldonovna Trushule ,  Guntis Erikovich Berggrin ,  Robert Avgustovich Brinkmanis ,  Uldis Yanovich Mikstais ,  Paul Alexandrovich Stankevich

Inventor： Solomon Aronovich Giller ,  Karl Karlovich Venter ,  Margarita Aldonovna Trushule ,  Guntis Erikovich Berggrin ,  Robert Avgustovich Brinkmanis ,  Uldis Yanovich Mikstais ,  Paul Alexandrovich Stankevich

IPC: C07D307/71

CPC classification number: C07D307/71

Abstract: A method of preparing 5-nitrofurfural diacetate which comprises nitration furfural or furfural diacetate at a temperature within the range of from -10.degree. to +10.degree. C; said nitration being effected by the gradual simultaneous addition of furfural or a furfural diacetate solution in acetic anhydride and a mixture of nitric and sulphuric acids into acetic anhydride at a temperature within the range of from -10.degree. to +10.degree. C under continuous stirring of the reaction mixture. In doing so, molar proportions of furfural or furfural diacetate and nitric acid and sulphuric acid are maintained equal to 1:1.1-2:0.036-0.041 respectively and said compounds are added into acetic anhydride at such rates as to maintain the nitration reaction temperature at a predetermined level. The reaction mixture resulting from the nitration is treated with water at a weight ratio between water and the starting acetic anhydride ranging from 1.1:1 to 1.8:1 respectively and at a temperature within the range of from 0.degree. to 15.degree. C; the reaction mixture is then neutralized with an alkali to a pH = 3.5 - 5 at a temperature within the range of from 0.degree. to 25.degree. C, maintained at a temperature of from 45.degree. to 55.degree. C, and the desired product is thereafter isolated from said reaction mixture.

公开(公告)号：US3947492A

公开(公告)日：1976-03-30

申请号：US349672

申请日：1973-04-09

Applicant: Vsevolod Vasilievich Perekalin ,  Alexandra Semenovna Sopova ,  Maiva Mikhailovna Zobacheva ,  Rasma Yanovna Spunde ,  Uldis Yanovich Mikstais ,  Maiya Petrovna Silaya

Inventor： Vsevolod Vasilievich Perekalin ,  Alexandra Semenovna Sopova ,  Maiva Mikhailovna Zobacheva ,  Rasma Yanovna Spunde ,  Uldis Yanovich Mikstais ,  Maiya Petrovna Silaya

IPC: C07C205/53 ,  C07D207/26 ,  C07D207/277 ,  C07C99/00 ,  C07C99/06

CPC classification number: C07D207/277 ,  C07C205/53

Abstract: The invention relates to a new substance, namely the hydrochloride of .beta.-phenyl- .gamma.-aminobutyric acid of the following formula: ##EQU1## and to the process for its production which comprises condensing malonic ester with .beta.-nitrostyrene resulting in the separation of an ester of .gamma.-carbomethoxy-.beta.-phenyl-.gamma.-nitrobutyric acid at a temperature ranging from 0.degree. to 14.degree.C, reducing the ester thus obtained with hydrogen in the presence of the Raney nickel under a pressure of 6 to 30 atm, treating 3-carbomethoxy-4-phenyl-2-pyrrolidone, as formed by the reduction, with hydrochloric acid, and separating the desired product.

Abstract translation: 本发明涉及一种新物质，即下式的β-苯基-γ-氨基丁酸的盐酸盐：O HCl。 H2NCH2CHCH2C ANGLE |OH C6H5及其生产方法，其包括将丙二酸酯与β-硝基苯乙烯缩合，从而在0℃至14℃的温度范围内分离γ-甲酯基-β-苯基-γ-硝基丁酸酯 DEG，在阮内镍的存在下，在6〜30atm的压力下，用氢还原酯，用盐酸处理由还原形成的3-甲酯基-4-苯基-2-吡咯烷酮，和 分离所需产品。