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公开(公告)号:US20110177002A1
公开(公告)日:2011-07-21
申请号:US13054606
申请日:2009-07-14
IPC分类号: A61K49/06 , A61K49/00 , C12N9/96 , A61K31/395 , C07K14/00 , C07K16/00 , C07D255/02 , C07D257/02 , C07D259/00
CPC分类号: C07D405/12 , A61K49/0043 , A61K49/0052 , A61K51/0482 , C07D257/02
摘要: The invention pertains to a compound for detecting cell death. According to the invention, the compound comprises a cyclic polyamine unit for the complexation of a bi- or trivalent metal ion. The compound of the invention may contain a reporting tag like fluorescein or a radioisotope including substituent.
摘要翻译: 本发明涉及用于检测细胞死亡的化合物。 根据本发明,化合物包含用于使二价或三价金属离子络合的环状多胺单元。 本发明的化合物可以含有报告标签如荧光素或包含取代基的放射性同位素。
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公开(公告)号:US20150110715A1
公开(公告)日:2015-04-23
申请号:US14335055
申请日:2014-07-18
IPC分类号: A61K49/00 , A61K51/04 , C07D311/90 , G01N33/574 , C07D209/18 , C07D401/14 , G01N33/58 , C07D497/10 , C07D209/60
CPC分类号: A61K49/0002 , A61K49/0021 , A61K49/0032 , A61K49/0041 , A61K49/0052 , A61K51/0402 , A61K51/0497 , C07D209/18 , C07D209/60 , C07D311/90 , C07D401/14 , C07D497/10 , G01N33/57492 , G01N33/582
摘要: The present invention relates to a compound or a pharmaceutically acceptable salt thereof having a chemical structure comprising: (A) at least one motif specifically binding to cell membranes of neoplastic cells; (B) at least one chelator moiety of radiometals; and (C) at least one dye moiety; wherein said compound has a molecular weight of not more than 5 kDa. Further, the invention refers to a method for producing such compound and to the in vivo and in vitro uses thereof.
摘要翻译: 本发明涉及具有以下化学结构的化合物或其药学上可接受的盐:(A)至少一个与肿瘤细胞的细胞膜特异性结合的基序; (B)至少一种放射性金属螯合剂部分; 和(C)至少一个染料部分; 其中所述化合物的分子量不超过5kDa。 此外,本发明涉及生产这种化合物的方法及其体内和体外用途。
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