公开(公告)号：US20250053294A1

公开(公告)日：2025-02-13

申请号：US18798254

申请日：2024-08-08

Applicant: University of Houston System

Inventor： Ryan P. Kennedy

IPC: G06F3/0486 ,  G06F3/0482

Abstract: In an embodiment, a deliberation experience system includes processor-executable instructions to: generate a deliberation platform including a plurality of forums and a manager dashboard to facilitate monitoring deliberation in each forum of the plurality of forums, the manager dashboard presented on a manager user device; receive a first input from the manager user device indicative of assigning a respective set of participant user devices to each forum and communicatively couple the respective set of participant user devices to each forum; receive a second input from the manager user device indicative of a selected issue guide of a plurality of issue guides, the selected issue guide including a plurality of discussion topics; and instruct a computer-automated moderator to initiate a guided discussion on each forum by progressing through each discussion topic of the selected issue guide in each forum and moderating discussion between participants on each forum.

公开(公告)号：US12214298B2

公开(公告)日：2025-02-04

申请号：US17048779

申请日：2019-04-17

Applicant: University of Houston System

Inventor： Richard C. Willson ,  Ujwal Patil ,  Binh V. Vu ,  Ekaterini Kourentzi ,  Mary Crum

IPC: B01D15/38 ,  G01N27/00 ,  G01N30/88

Abstract: The present disclosure relates to the detection of analytes in high volumetric flow applications. Particular embodiments relate to the use of fluorescence polarization/anisotropy based for detection of analytes in a flow cell. In one testing format, an analyte of interest is probed with reagents containing fluorescent labeled recognition elements. When present in a sample or portion of a sample, the labeled analyte produces a shift in fluorescence polarization/anisotropy/intensity/lifetime as the output signal following the binding of the recognition elements to the analytes.

公开(公告)号：US12203935B2

公开(公告)日：2025-01-21

申请号：US16970163

申请日：2019-02-14

Applicant: The University of Houston System

Inventor： Shaun Xiaoliu Zhang ,  Xinping Fu

IPC: G01N33/574 ,  C12N15/86 ,  C12Q1/66 ,  G01N33/50

Abstract: Disclosed are probes based on papilloma virus and modified SV40 that can be used for detecting circulating tumor cells (CTCs) in the blood stream, methods for manufacturing such probes, and methods for using such probes.

公开(公告)号：US20240352422A1

公开(公告)日：2024-10-24

申请号：US18684668

申请日：2022-08-05

Applicant: UNIVERSITY OF HOUSTON SYSTEM

Inventor： Bradley K. McConnell ,  Robert J. Schwartz ,  Nicole Prodan

IPC: C12N5/077

CPC classification number: C12N5/0657 ,  C12N2500/62 ,  C12N2501/11 ,  C12N2501/385 ,  C12N2501/71 ,  C12N2501/73 ,  C12N2501/81 ,  C12N2501/999 ,  C12N2506/45

Abstract: The present disclosure pertains to compositions suitable for use in differentiating cardiac progenitor cells to cells that resemble cardiac Purkinje cells. Additional embodiments pertain to methods of generating such differentiated cardiac cells by exposing cardiac progenitor cells to the compositions. The present disclosure also pertains to methods of treating or preventing a cardiovascular disease in a subject by administering the compositions or differentiated cardiac cells to the subject. Further embodiments pertain to methods of generating a cardiac tissue by exposing cardiac progenitor cells to a composition of the present disclosure and associating the cardiac progenitor cells with a tissue scaffold. The present disclosure also pertains to the use of the differentiated cardiac progenitor cells to assess the efficacy of one or more compounds in the treatment or prevention of a cardiovascular disease. The present disclosure also pertains to the differentiated cardiac cells and cardiac tissues that include them.

公开(公告)号：US20240336477A1

公开(公告)日：2024-10-10

申请号：US18292013

申请日：2022-08-08

Applicant: University of Houston System

Inventor： Hadi Ghasemi

IPC: C01B3/00 ,  H01M10/34

CPC classification number: C01B3/0084 ,  C01B3/0015 ,  H01M10/345

Abstract: A hydrogen storage device comprising (i) hydrogen gas and (ii) a host framework material. A hydrogen discharge device comprising (i) hydrogen gas and (ii) a host framework material. A method of storing hydrogen comprising introducing hydrogen gas to a host framework material comprising a zeolite, carbon, silica, nickel foam, carbon nanosponge (CNS), a graphene aerogel or a combination thereof under conditions suitable for the formation of hydrogen gas hydrates. A battery comprising a host framework material comprising hydrogen gas hydrates wherein the host framework material comprises a zeolite, carbon, silica, nickel foam, carbon nanosponge (CNS), a graphene aerogel or a combination thereof.

公开(公告)号：US12077568B2

公开(公告)日：2024-09-03

申请号：US17281870

申请日：2019-09-11

Applicant: University of Houston System

Inventor： Ke-He Ruan

IPC: C07K14/62 ,  A61K38/00 ,  A61P3/10 ,  C12N15/70 ,  C12N15/81 ,  C12N15/85 ,  C12N15/86

CPC classification number: C07K14/62 ,  A61P3/10 ,  C12N15/70 ,  C12N15/81 ,  C12N15/85 ,  C12N15/86 ,  A61K38/00 ,  C12N2750/14143

Abstract: Described herein are single chain polypeptides comprising both the b- and a-chains of insulin fused to each other by a linker. Also provided are nucleic acids coding for the same, host cells expressing the same, and methods of use therefor.

公开(公告)号：US12049532B2

公开(公告)日：2024-07-30

申请号：US17982767

申请日：2022-11-08

Applicant: UNIVERSITY OF HOUSTON SYSTEM

Inventor： Loi H. Do ,  Thi V. Tran

IPC: C08F4/70 ,  C08F2/06 ,  C08F210/02

CPC classification number: C08F4/7098 ,  C08F2/06 ,  C08F210/02

Abstract: This invention relates to nickel catalysts with alkali ions for homopolymerization and copolymerization.

公开(公告)号：US12042525B2

公开(公告)日：2024-07-23

申请号：US16959944

申请日：2018-12-31

Applicant: University of Houston System

Inventor： Robert J. Schwartz ,  Dinakar Iyer

IPC: A61K38/17 ,  A61K45/06 ,  A61K47/69 ,  C12N15/86

CPC classification number: A61K38/1709 ,  A61K47/6929 ,  C12N15/86 ,  A61K45/06

Abstract: Loss of cardiomyocytes underlies most causes of heart failure, and normal repair processes are inadequate to deal with extensive myocardial damage. The inventors have identified mutations of the N-terminus of serum response factor (SRF)'s MADS box, termed STEMINs, that block cardiac differentiation, but also powerfully activate the stem cell marker genes Nanog and Octomer 4, as well as cyclins, which promotes adult myocyte replication. SRF Stemin mutations are not cardiac-specific, and also propel mammalian fibroblasts into a proliferative state. Thus, STEMINs may be useful for regeneration of all tissue and organ types, by activating partial pluripotency programs and enhancing repair by increased cell replication. Following withdrawal of STEMINs, the cells then return to normal cell identity.

公开(公告)号：US20240173844A1

公开(公告)日：2024-05-30

申请号：US18283738

申请日：2022-03-10

Applicant: UNIVERSITY OF HOUSTON SYSTEM

Inventor： Zheng Chen ,  Wenyu Zuo ,  Gangbing Song ,  John Allen

IPC: B25J5/00 ,  B25J15/10

CPC classification number: B25J5/007 ,  B25J15/10

Abstract: A force application system for placement on and removal from an actuable latch with a robotic arm includes a driving pad configured for attachment to the actuable latch, a force application mechanism configured to increase an input force to an amplified output force that is applied by the force application mechanism to the driving pad, and a frame for engagement by the robotic arm.

公开(公告)号：US11923105B2

公开(公告)日：2024-03-05

申请号：US17887844

申请日：2022-08-15

Applicant: The University of Houston System

Inventor： Goran Majkic ,  Venkat Selvamanickam

IPC: H01B12/06 ,  C23C16/02 ,  C23C16/40 ,  C23C16/448 ,  C23C16/54 ,  H01B13/00 ,  H01B13/008 ,  H10N60/01

CPC classification number: H01B12/06 ,  C23C16/0209 ,  C23C16/408 ,  C23C16/448 ,  C23C16/545 ,  H01B13/00 ,  H01B13/0026 ,  H01B13/008 ,  H10N60/0464

Abstract: An MOCVD system fabricates high quality superconductor tapes with variable thicknesses. The MOCVD system can include a gas flow chamber between two parallel channels in a housing. A substrate tape is heated and then passed through the MOCVD housing such that the gas flow is perpendicular to the tape's surface. Precursors are injected into the gas flow for deposition on the substrate tape. In this way, superconductor tapes can be fabricated with variable thicknesses, uniform precursor deposition, and high critical current densities.