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公开(公告)号：US06919329B2
公开(公告)日：2005-07-19
申请号：US10373286
申请日：2003-02-24
申请人： Richard Charles Thomas , Toni-Jo Poel , Michael Robert Barbachyn , Mikhail F. Gordeev , Gary W. Luehr , Adam Renslo , Upinder Singh
发明人： Richard Charles Thomas , Toni-Jo Poel , Michael Robert Barbachyn , Mikhail F. Gordeev , Gary W. Luehr , Adam Renslo , Upinder Singh
IPC分类号： C07D263/24 , A61K31/421 , A61K31/422 , A61K31/423 , A61K31/428 , A61K31/437 , A61K31/4439 , A61K31/454 , A61K31/4709 , A61K31/496 , A61K31/5377 , A61K31/538 , A61K31/541 , A61K31/5415 , A61P31/04 , C07D261/12 , C07D263/20 , C07D263/58 , C07D307/33 , C07D307/58 , C07D413/04 , C07D413/10 , C07D417/04 , C07D417/10 , C07D471/04 , C07F9/6558 , A61K31/55 , A61P31/00 , C07D223/02
CPC分类号： C07D263/20 , C07D263/58 , C07D413/04 , C07D413/10 , C07D417/04 , C07D417/10 , C07D471/04 , C07F9/65583
摘要： The present invention provides antibacterial agents having the formulae I, II, and III described herein.
摘要翻译： 本发明提供具有本文所述的式I，II和III的抗菌剂。
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公开(公告)号：US20130323770A1
公开(公告)日：2013-12-05
申请号：US13985559
申请日：2012-02-14
申请人： Uma Lakshmipathy , Upinder Singh , Scott Grecian , Rene Quintanilla , Kyle Gee , Mahendra Rao
发明人： Uma Lakshmipathy , Upinder Singh , Scott Grecian , Rene Quintanilla , Kyle Gee , Mahendra Rao
IPC分类号： C12Q1/42
CPC分类号： G01N33/5005 , C09B11/24 , C09B19/00 , C09B21/00 , C09B57/00 , C09B57/02 , C12Q1/42 , C12Y301/03001 , G01N1/30 , G01N33/5073 , G01N33/581 , G01N33/582 , G01N33/586 , G01N2001/302 , G01N2333/916
摘要： The invention relates to novel substrates and methods for staining live stem cells. The stain may be used to identify induced pluripotent stem cell colonies during the process of somatic cell reprogramming.
摘要翻译： 本发明涉及用于染色活的干细胞的新的底物和方法。 染色可用于在体细胞重编程过程中鉴定诱导的多能干细胞集落。
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公开(公告)号：US07105547B2
公开(公告)日：2006-09-12
申请号：US10497626
申请日：2003-10-03
IPC分类号： A61K31/4439 , C07D413/10
CPC分类号： C07D413/14 , C07D413/10
摘要： The present invention provides antibacterial agents of formula I, or a pharmaceutically acceptable salt thereof.
摘要翻译： 本发明提供式I的抗菌剂或其药学上可接受的盐。
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公开(公告)号：US20130209550A1
公开(公告)日：2013-08-15
申请号：US13812807
申请日：2011-07-28
申请人： Brian Agnew , David Graham , Upinder Singh , Scott Grecian
发明人： Brian Agnew , David Graham , Upinder Singh , Scott Grecian
IPC分类号： A61K31/655 , A61K45/06 , A61K31/7024
CPC分类号： A61K31/655 , A61K31/7024 , A61K31/7088 , A61K38/212 , A61K38/215 , A61K45/06 , A61K2300/00
摘要： Methods of using azide-modified biomolecules, such as fatty acids, carbohydrates and lipids, to treat a plant, an insect or an animal infected with a virus or to inhibit infectivity of a virus, such as the human immunodeficiency virus, are provided. Also provided are methods of labeling a virus, such as human immunodeficiency virus, with an azide-modified biomolecule, such as a fatty acid, a carbohydrate, or an isoprenoid lipid. Also, provided are methods of tracking a virus in vivo, with an azide-modified biomolecule, such as a fatty acid, a carbohydrate, or an isoprenoid lipid. The azide-modified biomolecules may be combined with a pharmaceutically acceptable excipient to produce a pharmaceutical composition, optionally containing another anti-viral agent and/or a delivery agent, such as a liposome.
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公开(公告)号：US20120027846A1
公开(公告)日：2012-02-02
申请号：US13192959
申请日：2011-07-28
申请人： Brian AGNEW , David GRAHAM , Upinder SINGH , Scott GRECIAN
发明人： Brian AGNEW , David GRAHAM , Upinder SINGH , Scott GRECIAN
IPC分类号： A61K9/127 , A61K38/21 , A61K31/7088 , A61K31/7072 , A61K31/708 , A61K31/7068 , A61K31/7076 , A61K31/7056 , A61K38/16 , C12N7/04 , A61P31/12 , A61P31/14 , A61P31/20 , A61P31/18 , A61K31/655
CPC分类号： A61K31/655 , A61K31/7024 , A61K31/7088 , A61K38/212 , A61K38/215 , A61K45/06 , A61K2300/00
摘要： Methods of using azide-modified biomolecules, such as fatty acids, carbohydrates and lipids, to treat a plant, an insect or an animal infected with a virus or to inhibit infectivity of a virus, such as the human immunodeficiency virus, are provided. Also provided are methods of labeling a virus, such as human immunodeficiency virus, with an azide-modified biomolecule, such as a fatty acid, a carbohydrate, or an isoprenoid lipid. Also, provided are methods of tracking a virus in vivo, with an azide-modified biomolecule, such as a fatty acid, a carbohydrate, or an isoprenoid lipid. The azide-modified biomolecules may be combined with a pharmaceutically acceptable excipient to produce a pharmaceutical composition, optionally containing another anti-viral agent and/or a delivery agent, such as a liposome.
摘要翻译： 提供了使用叠氮化物修饰的生物分子如脂肪酸，碳水化合物和脂质来治疗植物，昆虫或感染病毒的动物或抑制病毒如人类免疫缺陷病毒的感染性的方法。 还提供了用叠氮化物修饰的生物分子如脂肪酸，碳水化合物或类异戊二烯脂质来标记病毒（例如人类免疫缺陷病毒）的方法。 此外，提供了利用叠氮化物修饰的生物分子如脂肪酸，碳水化合物或类异戊二烯脂质体内追踪病毒的方法。 叠氮化物修饰的生物分子可以与药学上可接受的赋形剂组合以产生药物组合物，任选地含有另一种抗病毒剂和/或递送剂，例如脂质体。
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公开(公告)号：US20070015801A1
公开(公告)日：2007-01-18
申请号：US11524754
申请日：2006-09-21
申请人： Richard Thomas , Toni-Jo Poel , Michael Barbachyn , Mikhail Gordeev , Gary Luehr , Adam Renslo , Upinder Singh , Vara Nagendra Josyula
发明人： Richard Thomas , Toni-Jo Poel , Michael Barbachyn , Mikhail Gordeev , Gary Luehr , Adam Renslo , Upinder Singh , Vara Nagendra Josyula
IPC分类号： A61K31/4245 , A61K31/421 , A61K31/42 , A61K31/4035
CPC分类号： C07D263/20 , A61K31/4035 , A61K31/42 , A61K31/421 , A61K31/4245 , C07D263/58 , C07D413/04 , C07D413/10 , C07D417/04 , C07D417/10 , C07D471/04 , C07F9/65583
摘要： The present invention provides antibacterial agents having the formulae I, II, and III described herein.
摘要翻译： 本发明提供具有本文所述的式I，II和III的抗菌剂。
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公开(公告)号：US20060211603A1
公开(公告)日：2006-09-21
申请号：US11198763
申请日：2005-08-04
申请人： Bore Raju , Romeo Ciabatti , Sonia Maffioli , Upinder Singh , Gabriella Romano , Elena Michelucci , Paolo Tiseni , Gianpaolo Candiani , Bum Kim , Hardwin O'Dowd
发明人： Bore Raju , Romeo Ciabatti , Sonia Maffioli , Upinder Singh , Gabriella Romano , Elena Michelucci , Paolo Tiseni , Gianpaolo Candiani , Bum Kim , Hardwin O'Dowd
摘要： Novel ramoplanin derivatives are disclosed. These ramoplanin derivatives exhibit antibacterial activity. As the compounds of the subject invention exhibit potent activities against gram positive bacteria, they are useful antimicrobial agents. Methods of synthesis and of use of the compounds are also disclosed.
摘要翻译： 公开了新的拉莫拉宁衍生物。 这些拉莫拉宁衍生物具有抗菌活性。 由于本发明化合物表现出对革兰氏阳性细菌的有效活性，因此它们是有用的抗微生物剂。 还公开了化合物的合成和使用方法。
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公开(公告)号：US09334523B2
公开(公告)日：2016-05-10
申请号：US13985559
申请日：2012-02-14
申请人： Uma Lakshmipathy , Upinder Singh , Scott Grecian , Rene Quintanilla , Kyle Gee , Mahendra Rao
发明人： Uma Lakshmipathy , Upinder Singh , Scott Grecian , Rene Quintanilla , Kyle Gee , Mahendra Rao
CPC分类号： G01N33/5005 , C09B11/24 , C09B19/00 , C09B21/00 , C09B57/00 , C09B57/02 , C12Q1/42 , C12Y301/03001 , G01N1/30 , G01N33/5073 , G01N33/581 , G01N33/582 , G01N33/586 , G01N2001/302 , G01N2333/916
摘要： The invention relates to novel substrates and methods for staining live stem cells. The stain may be used to identify induced pluripotent stem cell colonies during the process of somatic cell reprogramming.
摘要翻译： 本发明涉及用于染色活的干细胞的新的底物和方法。 染色可用于在体细胞重编程过程中鉴定诱导的多能干细胞集落。
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公开(公告)号：US20150072396A1
公开(公告)日：2015-03-12
申请号：US14000819
申请日：2012-03-01
申请人： Kyle Gee , Upinder Singh , Scott Grecian , Scott Clarke
发明人： Kyle Gee , Upinder Singh , Scott Grecian , Scott Clarke
IPC分类号： G01N33/58 , C07K14/575 , C07D401/14
CPC分类号： G01N33/582 , C07D213/53 , C07D213/68 , C07D213/74 , C07D213/78 , C07D213/79 , C07D213/81 , C07D215/12 , C07D235/14 , C07D401/04 , C07D401/14 , C07K14/575 , C09B11/24 , C09B23/06 , C09B23/083 , G01N33/533
摘要： Low-copper click chemistry, 1.3-dipolar cycloadditions, and Staudinger ligations for modifying biomolecules is provided. Compositions, methods, and kits relating to low-copper click chemistry, 1.3-dipolar cycloadditions, and Staudinger ligations are also provided.
摘要翻译： 提供了低铜点击化学，1.3偶极环加成和用于修饰生物分子的Staudinger连接。 还提供了与低铜点击化学，1.3偶极环加成和Staudinger连接有关的组合物，方法和试剂盒。
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公开(公告)号：US20130209364A1
公开(公告)日：2013-08-15
申请号：US13812533
申请日：2011-07-28
申请人： Brian Agnew , Upinder Singh , Scott Grecian
发明人： Brian Agnew , Upinder Singh , Scott Grecian
IPC分类号： A61K31/655
CPC分类号： A61K31/655 , A61K31/7008 , C12N7/00 , C12N2710/14151 , C12N2710/14163 , C12N2740/16051 , C12N2740/16063
摘要： Methods of using azide-modified biomolecules, such as fatty acids, carbohydrates and lipids, to treat a plant, an insect or an animal infected with a virus or to inhibit infectivity of a virus, such as the human immunodeficiency virus, are provided. Also provided are methods of labeling a virus, such as human immunodeficiency virus, with an azide-modified biomolecule, such as a fatty acid, a carbohydrate, or an isoprenoid lipid. Also, provided are methods of tracking a virus in vivo, with an azide-modified biomolecule, such as a fatty acid, a carbohydrate, or an isoprenoid lipid. The azide-modified biomolecules may be combined with a pharmaceutically acceptable excipient to produce a pharmaceutical composition, optionally containing another anti-viral agent and/or a delivery agent, such as a liposome.
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