-
公开(公告)号：US07514448B2
公开(公告)日：2009-04-07
申请号：US11098751
申请日：2005-04-04
申请人： Jeremy Green , Andrew Miller , Juan-Miguel Jimenez , Craig Marhefka , Jingrong Cao , John Court , Upul Bandarage , Huai Gao , Suganthini Nanthakumar
发明人： Jeremy Green , Andrew Miller , Juan-Miguel Jimenez , Craig Marhefka , Jingrong Cao , John Court , Upul Bandarage , Huai Gao , Suganthini Nanthakumar
IPC分类号： A01N43/42 , A61K31/44 , C07D471/02 , C07D491/02 , C07D498/02 , C07D513/02 , C07D515/02
CPC分类号： C07D471/04
摘要： The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。
-
公开(公告)号：US20120065213A1
公开(公告)日：2012-03-15
申请号：US13253322
申请日：2011-10-05
申请人： Jeremy Green , Jingrong Cao , Upul Bandarage , Jon Come , Craig Marhefka
发明人： Jeremy Green , Jingrong Cao , Upul Bandarage , Jon Come , Craig Marhefka
IPC分类号： A61K31/496 , C07D417/04 , A61K31/4439 , A61P35/00 , A61P9/00 , A61P29/00 , A61P25/00 , C12N9/99 , C07D417/14
CPC分类号： C07D409/04 , C07D409/14 , C07D417/04 , C07D417/14
摘要： Described herein are compounds that are useful as ROCK inhibitors. These compounds, and pharmaceutically acceptable compositions thereof, are useful for treating or lessening the severity of a variety of disorders, including cardiovascular, inflammatory, neurological, or proliferative diseases or disorders.
摘要翻译： 本文描述的是可用作ROCK抑制剂的化合物。 这些化合物及其药学上可接受的组合物可用于治疗或减轻各种病症（包括心血管，炎症，神经系统或增殖性疾病或病症）的严重性。
-
公开(公告)号：US08058271B2
公开(公告)日：2011-11-15
申请号：US11801686
申请日：2007-05-10
申请人： Jeremy Green , Jingrong Cao , Upul Bandarage , Jon Come , Craig Marhefka
发明人： Jeremy Green , Jingrong Cao , Upul Bandarage , Jon Come , Craig Marhefka
IPC分类号： A61K31/5377 , A61K31/496 , A61K31/4545 , A61K31/4436 , C07D409/04 , C07D409/14 , C07D413/14
CPC分类号： C07D409/04 , C07D409/14 , C07D417/04 , C07D417/14
摘要： Described herein are compounds that are useful as ROCK inhibitors. These compounds, and pharmaceutically acceptable compositions thereof, are useful for treating or lessening the severity of a variety of disorders, including cardiovascular, inflammatory, neurological, or proliferative diseases or disorders.
摘要翻译： 本文描述的是可用作ROCK抑制剂的化合物。 这些化合物及其药学上可接受的组合物可用于治疗或减轻各种病症（包括心血管，炎症，神经系统或增殖性疾病或病症）的严重性。
-
公开(公告)号：US07485664B2
公开(公告)日：2009-02-03
申请号：US10741164
申请日：2003-12-19
申请人： Upul Bandarage , Jon H. Come , Emanuele Perola , Govinda Rao Bhisetti , Jeffrey O. Saunders , Tiansheng Wang , Shi-Kai Tian
发明人： Upul Bandarage , Jon H. Come , Emanuele Perola , Govinda Rao Bhisetti , Jeffrey O. Saunders , Tiansheng Wang , Shi-Kai Tian
IPC分类号： A61K31/40 , C07D207/00
CPC分类号： C07D401/12 , C07C323/65 , C07C2601/08 , C07D205/04 , C07D207/12 , C07D261/04 , C07D403/12 , C07D413/12
摘要： The present invention relates to compounds that inhibit TACE, compositions thereof, and methods of using those compounds and compositions for treating diseases.
摘要翻译： 本发明涉及抑制TACE的化合物，其组合物，以及使用这些化合物和组合物治疗疾病的方法。
-
公开(公告)号：US20080033002A1
公开(公告)日：2008-02-07
申请号：US11823762
申请日：2007-06-28
申请人： Upul Bandarage , Jinwang Xu , Robert Davies , Paul Charifson , Rieko Arimoto
发明人： Upul Bandarage , Jinwang Xu , Robert Davies , Paul Charifson , Rieko Arimoto
IPC分类号： A61K31/44 , A61P25/00 , C07D401/00 , C12N5/06
CPC分类号： A61K31/4545 , A61K31/438 , A61K31/46 , A61K31/5355 , C07D221/20 , C07D401/04 , C07D405/06 , C07D409/06 , C07D451/04
摘要： The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.
-
公开(公告)号：US20070270386A1
公开(公告)日：2007-11-22
申请号：US11801686
申请日：2007-05-10
申请人： Jeremy Green , Jingrong Cao , Upul Bandarage , Jon Come , Craig Marhefka
发明人： Jeremy Green , Jingrong Cao , Upul Bandarage , Jon Come , Craig Marhefka
IPC分类号： A61K31/675 , A61K31/4439 , C07D417/02
CPC分类号： C07D409/04 , C07D409/14 , C07D417/04 , C07D417/14
摘要： Described herein are compounds that are useful as ROCK inhibitors. These compounds, and pharmaceutically acceptable compositions thereof, are useful for treating or lessening the severity of a variety of disorders, including cardiovascular, inflammatory, neurological, or proliferative diseases or disorders.
摘要翻译： 本文描述的是可用作ROCK抑制剂的化合物。 这些化合物及其药学上可接受的组合物可用于治疗或减轻各种病症（包括心血管，炎症，神经系统或增殖性疾病或病症）的严重性。
-
公开(公告)号：US20060003968A1
公开(公告)日：2006-01-05
申请号：US11098751
申请日：2005-04-04
申请人： Jeremy Green , Andrew Miller , Juan-Miguel Jimenez , Craig Marhefka , Jingrong Cao , John Court , Upul Bandarage , Huai Gao , Suganthini Nanthakumar
发明人： Jeremy Green , Andrew Miller , Juan-Miguel Jimenez , Craig Marhefka , Jingrong Cao , John Court , Upul Bandarage , Huai Gao , Suganthini Nanthakumar
IPC分类号： A61K31/675 , C07D471/02
CPC分类号： C07D471/04
摘要： The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
-
公开(公告)号：US08492365B2
公开(公告)日：2013-07-23
申请号：US12481368
申请日：2009-06-09
申请人： Mark L. Nelson , Roger Frechette , Peter Viski , Mohamed Ismail , Todd Bowser , Beena Bhatia , David Messersmith , Laura McIntyre , Darrell Koza , Glen Rennie , Paul Sheahan , Paul Hawkins , Atul Verma , Tadeusz Warchol , Upul Bandarage
发明人： Mark L. Nelson , Roger Frechette , Peter Viski , Mohamed Ismail , Todd Bowser , Beena Bhatia , David Messersmith , Laura McIntyre , Darrell Koza , Glen Rennie , Paul Sheahan , Paul Hawkins , Atul Verma , Tadeusz Warchol , Upul Bandarage
IPC分类号： A61K31/65 , A61K31/42 , A61K31/426 , A61K31/4402 , A61K31/505 , A61K31/5375 , C07C237/26 , C07D239/26 , C07D295/104 , C07D261/08 , C07D277/42
CPC分类号： C07D213/64 , C07C237/26 , C07C251/24 , C07C251/48 , C07C271/22 , C07C271/28 , C07C271/58 , C07C275/24 , C07C311/06 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07C2603/46 , C07D207/22 , C07D213/50 , C07D213/56 , C07D239/36 , C07D261/18 , C07D277/30 , C07D277/42 , C07D295/096 , C07D295/135 , C07D295/155 , C07D307/54 , C07D307/68 , C07D307/79 , C07D317/60 , C07D333/24 , C07D333/28 , C07D333/60 , C07F9/2475
摘要： The present invention pertains, at least in part, to novel 7-substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
-
公开(公告)号：US08481513B2
公开(公告)日：2013-07-09
申请号：US12727114
申请日：2010-03-18
CPC分类号： C07C237/26 , A61K31/65 , C07D265/12 , C07D317/54 , Y02A50/411
摘要： The present invention pertains to novel 3, 10, and/or 12a-substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
摘要翻译： 本发明涉及新的3,10和/或12a取代的四环素化合物。 这些四环素化合物可用于治疗多种四环素化合物反应状态，例如细菌感染和肿瘤，以及其他已知的米诺环素和四环素化合物的一般应用，例如阻断四环素外排和调节基因表达。
-
公开(公告)号：US20100190756A1
公开(公告)日：2010-07-29
申请号：US12727114
申请日：2010-03-18
IPC分类号： A61K31/65 , C07C237/26
CPC分类号： C07C237/26 , A61K31/65 , C07D265/12 , C07D317/54 , Y02A50/411
摘要： The present invention pertains to novel 3, 10, and/or 12a-substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
摘要翻译： 本发明涉及新的3,10和/或12a取代的四环素化合物。 这些四环素化合物可用于治疗多种四环素化合物反应状态，例如细菌感染和肿瘤，以及其他已知的米诺环素和四环素化合物的一般应用，例如阻断四环素外排和调节基因表达。
-
-
-
-
-
-
-
-
-
搜索结果
26 条记录 (耗时 0.028 秒)
