公开(公告)号：US20080058521A1

公开(公告)日：2008-03-06

申请号：US11698258

申请日：2007-01-25

申请人： Lalitha Krishnan ,  David Blum ,  Anja Dilley ,  Sherry Pan ,  John Potoski ,  Uresh Shah ,  Archana Sharma ,  Henry Strong ,  Yanzhong Wu ,  Mei-Yi Zhang ,  Cynthia Blum

发明人： Lalitha Krishnan ,  David Blum ,  Anja Dilley ,  Sherry Pan ,  John Potoski ,  Uresh Shah ,  Archana Sharma ,  Henry Strong ,  Yanzhong Wu ,  Mei-Yi Zhang ,  Cynthia Blum

IPC分类号： C07D239/02 ,  C07D213/02 ,  C07D241/02 ,  C07D333/52

CPC分类号： C07D409/12 ,  C07D213/61 ,  C07D333/70

摘要： The present invention provides improved synthetic methods for the preparation of compounds that modulate proliferation or differentiation in a cell or tissue.

摘要翻译： 本发明提供了改进的调节细胞或组织中增殖或分化的化合物的合成方法。

公开(公告)号：US20060160881A1

公开(公告)日：2006-07-20

申请号：US11372716

申请日：2006-03-10

申请人： Deborah Evrard ,  Uresh Shah ,  Gary Stack

发明人： Deborah Evrard ,  Uresh Shah ,  Gary Stack

IPC分类号： A61K31/405 ,  A61K31/381 ,  A61K31/335

CPC分类号： C07D405/12

摘要： Compounds of the Formula I: are useful for the treatment of depression (including but not limited to major depressive disorder, childhood depression and dysthymia), anxiety, panic disorder, post-traumatic stress disorder, premenstrual dysphoric disorder (also known as pre-menstrual syndrome), attention deficit disorder (with and without hyperactivity), obsessive compulsive disorder, social anxiety disorder, generalized anxiety disorder, obesity, eating disorders such as anorexia nervosa and bulimia nervosa, vasomotor flushing, cocaine and alcohol addiction, sexual dysfunction and related illnesses.

公开(公告)号：US20050032873A1

公开(公告)日：2005-02-10

申请号：US10898866

申请日：2004-07-26

申请人： Nicole Hatzenbuhler ,  Deborah Evrard ,  Richard Mewshaw ,  Dahui Zhou ,  Uresh Shah ,  Jennifer Inghrim ,  Steven Lenicek ,  Reinhardt Baudy ,  John Butera ,  Annmarie Sabb ,  Amedeo Failli ,  Pudukkaraipudur Ramamoorthy

发明人： Nicole Hatzenbuhler ,  Deborah Evrard ,  Richard Mewshaw ,  Dahui Zhou ,  Uresh Shah ,  Jennifer Inghrim ,  Steven Lenicek ,  Reinhardt Baudy ,  John Butera ,  Annmarie Sabb ,  Amedeo Failli ,  Pudukkaraipudur Ramamoorthy

IPC分类号： C07C237/48 ,  C07D209/10 ,  C07D209/12 ,  C07D209/14 ,  C07D405/12 ,  C07D407/12 ,  C07D409/12 ,  A61K31/405 ,  A61K31/353 ,  A61K31/381 ,  C07D45/02 ,  C07D49/02

CPC分类号： C07D405/12 ,  C07C237/48 ,  C07D209/10 ,  C07D209/12 ,  C07D209/14 ,  C07D407/12 ,  C07D409/12

摘要： 3-Amino chroman and 2-amino tetralin derivatives and compositions containing such compounds are disclosed. Methods of using the 3-amino chroman and 2-amino tetralin compounds and compositions containing such compounds in the treatment of serotonin disorders, such as depression and anxiety, are also disclosed.

摘要翻译： 公开了3-氨基苯并二氢吡喃和2-氨基四氢化萘衍生物和含有这些化合物的组合物。 还公开了使用3-氨基苯并二氢吡喃和2-氨基四氢化萘化合物的方法和含有这些化合物的组合物在治疗5-羟色胺疾病如抑郁和焦虑中的方法。

公开(公告)号：US20060148881A1

公开(公告)日：2006-07-06

申请号：US11373666

申请日：2006-03-10

申请人： Deborah Evrard ,  Uresh Shah ,  Gary Stack

发明人： Deborah Evrard ,  Uresh Shah ,  Gary Stack

IPC分类号： A61K31/404 ,  A61K31/381 ,  C07D409/02 ,  C07D405/02

CPC分类号： C07D405/12

摘要： Compounds of the Formula I: are useful for the treatment of depression (including but not limited to major depressive disorder, childhood depression and dysthymia), anxiety, panic disorder, post-traumatic stress disorder, premenstrual dysphoric disorder (also known as pre-menstrual syndrome), attention deficit disorder (with and without hyperactivity), obsessive compulsive disorder, social anxiety disorder, generalized anxiety disorder, obesity, eating disorders such as anorexia nervosa and bulimia nervosa, vasomotor flushing, cocaine and alcohol addiction, sexual dysfunction and related illnesses.

摘要翻译： 式I化合物可用于治疗抑郁症（包括但不限于重度抑郁障碍，儿童抑郁症和心境恶化），焦虑症，惊恐障碍，创伤后应激障碍，经前期焦虑障碍（也称月经前） 综合征），注意缺陷障碍（伴有和不伴有多动症），强迫症，社会焦虑症，广泛性焦虑症，肥胖症，进食障碍如神经性厌食症和神经性贪食症，血管舒缩性潮红，可卡因和酒精成瘾，性功能障碍及相关疾病 。