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    Prismatic beam expander for light beam shaping in a flow cytometry apparatus
    1.
    发明授权
    Prismatic beam expander for light beam shaping in a flow cytometry apparatus 失效
    棱镜光束扩束器，用于流式细胞术仪器中的光束成形

    公开(公告)号：US4545677A

    公开(公告)日：1985-10-08

    申请号：US586162

    申请日：1984-03-05

    申请人： Vernon L. Chupp

    发明人： Vernon L. Chupp

    IPC分类号： G01N33/49 ,  G01N15/14 ,  G01N33/48 ,  G02B19/00

    CPC分类号： G01N15/1434 ,  G01N15/147 ,  G01N2015/149 ,  G01N2015/1497

    摘要： A flow cytometry apparatus for determining characteristics of cells or the like flowing in a liquid stream includes a nozzle for generating a liquid flow path for moving cells therethrough substantially one at a time. A light source, such as a laser, provides a beam of illumination. At least one prism is interposed in the path of the incident beam of illumination for expanding the beam in at least one direction and for directing the expanded beam toward the cells in the flow path. A lens is provided to focus the expanded beam on the moving cells. An appropriate sensor detects light with respect to each moving cell for associating that detected light with a characteristic of such cell.

    摘要翻译： 用于确定在液体流中流动的细胞等的特性的流式细胞仪装置包括用于产生用于每次一个地移动细胞的液体流路的喷嘴。 诸如激光器的光源提供照明光束。 至少一个棱镜插入到入射光束的路径中，用于在至少一个方向上扩展光束，并且用于将扩展的光束引向流动路径中的细胞。 提供透镜以将扩展的光束聚焦在移动的单元上。 合适的传感器相对于每个移动单元检测光，以将该检测到的光与这样的单元的特性相关联。

    Asymmetric double pass grating monochromator
    2.
    发明授权
    Asymmetric double pass grating monochromator 失效
    非对称双光栅单色仪

    公开(公告)号：US4025196A

    公开(公告)日：1977-05-24

    申请号：US555049

    申请日：1975-03-03

    申请人： Vernon L. Chupp ,  Jack J. Duffield

    发明人： Vernon L. Chupp ,  Jack J. Duffield

    IPC分类号： G01J3/00 ,  G01J3/04 ,  G01J3/18 ,  G01J3/28

    CPC分类号： G01J3/04 ,  G01J3/1804 ,  G01J2003/2866 ,  G01J3/0229

    摘要： Apparatus to perform correlation spectroscopy utilizes a zero dispersion monochromator having entrance, intermediate and exit slits. A ruled grating is located in the beam path between entrance and exit slits and is operable to disperse a beam of radiation incident thereon both prior and subsequent to radiation passage through the intermediate slit. A first axis is parallel to the grating rulings, the entrance and exit slits symmetrically disposed at opposite sides of a plane bisecting and normal to a line extending between the entrance and exit slits, the plane also passing through the intermediate slit. That axis is located to have intersection with and to extend at an angle .PSI. relative to a normal to the plane that passes through said intersection thereby to substantially eliminate spectral overlap. Further, an array of sets of slits is provided adjacent the intermediate slit position of the monochromator, the sets of slits in the array being successively movable into the focal plane at the intermediate slit position.

    摘要翻译： 执行相关光谱的装置利用具有入口，中间和出口狭缝的零色散单色仪。 格栅光栅位于入口和出口狭缝之间的光束路径中，并且可操作以在辐射通过中间狭缝之前和之后分散入射在其上的辐射束。 第一轴平行于光栅刻痕，入口和出口狭缝对称地设置在与入射和出射狭缝之间延伸的线平分和垂直的平面的相对侧，该平面也穿过中间狭缝。 该轴被定位成与穿过所述交叉点的平面的法线相交并且以一角度PSI延伸，从而基本上消除了光谱重叠。 此外，在单色器的中间狭缝位置附近设置有一组狭缝，阵列中的狭缝组在中间狭缝位置可连续移动到焦平面。

    Optical arrangement for double-passing Ebert monochromator and for coupling double monochromator systems
    5.
    发明授权
    Optical arrangement for double-passing Ebert monochromator and for coupling double monochromator systems 失效
    用于双通道Ebert单色仪的光学布置和耦合双色单色系统

    公开(公告)号：US3936191A

    公开(公告)日：1976-02-03

    申请号：US453826

    申请日：1974-03-22

    申请人： Vernon L. Chupp

    发明人： Vernon L. Chupp

    IPC分类号： G01J3/12 ,  G01J3/18

    CPC分类号： G01J3/1804

    摘要： Coupling optics is located in the beam path between intermediate slits S.sub.2 and S.sub.3 of an additive dispersion, double-pass monochromator, for imaging S.sub.2 onto S.sub.3 and for re-imaging an aperture stop back on itself, the stop defined by dispersing means. The slits S.sub.2 and S.sub.3 along with entrance and exit slits S.sub.1 and S.sub.4 may have curvature defining a circle.

    摘要翻译： 耦合光学器件位于添加剂分散体双通单色仪的中间狭缝S2和S3之间的光束路径中，用于将S2成像到S3上，并且用于对其自身重新成像孔径光阑，由分散装置限定的停止点。 狭缝S2和S3以及入口和出口狭缝S1和S4可以具有限定圆的曲率。

    Method for performing automated analysis
    7.
    发明授权
    Method for performing automated analysis 失效
    执行自动分析的方法

    公开(公告)号：US5891734A

    公开(公告)日：1999-04-06

    申请号：US682334

    申请日：1996-07-17

    申请人： James E. Gill ,  Vernon L. Chupp ,  Luc Van Hove

    发明人： James E. Gill ,  Vernon L. Chupp ,  Luc Van Hove

    IPC分类号： G01N33/536 ,  B01F5/04 ,  G01N1/00 ,  G01N15/00 ,  G01N15/14 ,  G01N35/00 ,  G01N35/10 ,  G01N33/533

    CPC分类号： G01N35/1095 ,  B01F5/0453 ,  B01F5/046 ,  G01N15/14 ,  G01N15/1404 ,  G01N35/0092 ,  G01N35/1004 ,  G01N35/109 ,  G01N1/14 ,  G01N15/1459 ,  G01N2015/0069 ,  G01N2015/0076 ,  G01N2015/0084 ,  G01N2015/1413 ,  G01N2035/00356 ,  G01N2035/00524 ,  G01N2035/1032 ,  G01N35/10 ,  Y10S435/973 ,  Y10S436/805 ,  Y10T436/11 ,  Y10T436/25 ,  Y10T436/25125 ,  Y10T436/2575

    摘要： Provided are automated methods for distinguishing and differentiating cells in a whole blood sample. In one of the methods, a whole blood sample is provided. One or more tests to be performed on the whole blood sample is selected. The tests to be performed on the whole blood sample are correlated. A volume of the whole blood sample is aspirated into an automated instrument system which automatically performs conventional hematology analysis and fluorescent cytometry analysis on the whole blood sample. A first aliquot of the whole blood sample is dispensed into at least one sample receiving vessel. The first aliquot of the whole blood sample is mixed with a fluorescent reagent. The first aliquot of the whole blood sample mixed with fluorescent reagent is diluted and transported through a flow transducer system. The flow transducer system detects multi-angle light scatter and fluorescence from the first aliquot of the whole blood sample mixed with fluorescent reagent and counts and differentiates platelets or platelet clumps or both in the sample. Detecting and differentiation data for the one or more tests performed on the whole blood sample are stored. Results of the one or more tests performed on the whole blood sample are reported in a quantitative manner if so requested. The instrument system automatically performs all method steps without physically separating cells from the whole blood sample or an aliquot of the sample and results of a conventional hematology analysis may be utilized in at least reporting of results of the fluorescent cytometry testing.

    摘要翻译： 提供了用于区分和分化全血样品中的细胞的自动化方法。 在其中一种方法中，提供了全血样品。 选择对全血样进行一次或多次测试。 对全血样进行的检测是相关的。 将全血样品的体积吸入自动化仪器系统中，自动进行全血样品的常规血液学分析和荧光细胞分析。 将全血样品的第一等分试样分配到至少一个样品接收容器中。 将全血样品的第一等份与荧光试剂混合。 与荧光试剂混合的全血样品的第一等份被稀释并通过流量传感器系统传输。 流量传感器系统检测来自与荧光试剂混合的全血样品的第一等分试样的多角度光散射和荧光，并对样品中的血小板或血小板结块或两者进行计数和微分。 存储对全血样品进行的一次或多次测试的检测和分化数据。 如果要求，则以定量方式报告对全血样品进行的一项或多项测试的结果。 仪器系统自动执行所有方法步骤，而不用从全血样品或样品的等分试样物质分离细胞，并且常规血液学分析的结果可以用于至少报告荧光细胞测定结果。

    Fully automated analysis method with optical system for blood cell analyzer
    8.
    发明授权
    Fully automated analysis method with optical system for blood cell analyzer 失效
    用于血细胞分析仪的光学系统的全自动分析方法

    公开(公告)号：US5812419A

    公开(公告)日：1998-09-22

    申请号：US509650

    申请日：1995-07-31

    申请人： Vernon L. Chupp ,  Suresh N. Mehta

    发明人： Vernon L. Chupp ,  Suresh N. Mehta

    IPC分类号： G01N15/00 ,  G01N15/14 ,  G01N35/10 ,  G06F19/00

    CPC分类号： G06T7/0012 ,  G01N35/1004 ,  G01N35/109 ,  G01N2015/0076 ,  G01N2015/0084 ,  G01N2015/1413 ,  G06T2207/10056 ,  G06T2207/30024

    摘要： A method of performing a first analysis and a second analysis on a single blood sample obtained with a single blood draw from a patient with an automated analyzer includes the steps of supplying the single blood sample obtained with the single blood draw from the patient to the automated analyzer. A memory on the automated analyzer containing a software routine is automatically accessed. The software routine is useful to adapt an optical system on the automated analyzer to correspond to the first analysis and the second analysis. The optical system on the automated analyzer is automatically adapted with the software routine in real time to correspond to the first analysis. The first analysis is automatically performed with the automated analyzer. The optical system on the automated analyzer is automatically adapted with the software routine in real time to correspond to the second analysis. The second analysis is automatically performed with the automated analyzer.

    摘要翻译： 用自动化分析仪从患者单次抽血获得的单一血液样品上进行第一次分析和第二次分析的方法包括以下步骤：将从患者获得的单次血液抽取所获得的单一血液样本提供给自动化 分析仪 包含软件程序的自动分析仪上的内存被自动访问。 软件程序对于自动化分析仪的光学系统的适应性是对应于第一次分析和第二次分析的。 自动分析仪上的光学系统自动适应软件程序实时对应于第一次分析。 自动分析仪自动进行第一次分析。 自动分析仪上的光学系统自动适应软件程序实时对应于第二次分析。 自动分析仪自动进行第二次分析。

    Pseudo telecentric optical design for flow cytometric blood cell analyzer
    9.
    发明授权
    Pseudo telecentric optical design for flow cytometric blood cell analyzer 失效
    用于流式细胞分析仪的伪远心光学设计

    公开(公告)号：US5631730A

    公开(公告)日：1997-05-20

    申请号：US508502

    申请日：1995-07-28

    申请人： Vernon L. Chupp ,  Suresh N. Mehta

    发明人： Vernon L. Chupp ,  Suresh N. Mehta

    IPC分类号： G01N33/48 ,  B01F5/04 ,  G01N1/00 ,  G01N1/36 ,  G01N15/00 ,  G01N15/14 ,  G01N21/05 ,  G01N21/47 ,  G01N27/02 ,  G01N27/06 ,  G01N33/483 ,  G01N33/49 ,  G01N35/00 ,  G01N35/02 ,  G01N35/10 ,  G01N21/53

    CPC分类号： G01N35/109 ,  B01F5/0453 ,  B01F5/046 ,  G01N15/14 ,  G01N15/1404 ,  G01N35/0092 ,  G01N35/1004 ,  G01N1/14 ,  G01N2015/0076 ,  G01N2015/0084 ,  G01N2015/1413 ,  G01N2035/00356 ,  G01N2035/00524 ,  G01N2035/1032 ,  G01N35/10

    摘要： A pseudo telecentric flow cytometric optical system for the simultaneous detection of several characteristics of particles suspended in a flowing medium. The system is made up of a flowcell through which the particles pass substantially one particle at a time, an optical system for directing light from a light source onto the flowing particles in the flowcell, a side angle optical collection system for receiving light from the flowing particles and for directing the light to one or more of a first set of detectors, and a forward angle collection system for receiving light from the flowing particles and for directing the light to one or more of a second set of detectors. The side angle optical collection system can include a condenser lens for directing light toward the first set of detectors with an exit pupil of the condenser lens located at the back focal plane of the condenser lens; a photosensitive surface of one or more of the first set of detectors is located at conjugate points of the back focal plane of the condenser lens such that an image of the exit pupil is positioned at the photosensitive surface of one or more of the first set of detectors. The forward angle optical collection system can include a collecting lens for directing light toward the second set of detectors where the collecting lens exit pupil is located in the back focal plane of the collecting lens and a photosensitive surface of one or more of the second set of detectors is located at the back focal plane of the collecting lens.

    摘要翻译： 一种用于同时检测悬浮在流动介质中的颗粒的几种特征的伪远心流式细胞计数光学系统。 该系统由流通池组成，颗粒一次通过基本上一个颗粒，用于将来自光源的光引导到流动池中的流动颗粒上的光学系统，用于接收来自流动的流体的光的侧视角光学收集系统 颗粒并用于将光引导到第一组检测器中的一个或多个，以及用于接收来自流动颗粒的光并用于将光引导到第二组检测器中的一个或多个的前角收集系统。 侧角光学收集系统可以包括聚光透镜，用于将光朝向第一组检测器引导，聚光透镜的出射光瞳位于聚光透镜的后焦平面; 第一组检测器中的一个或多个的感光表面位于聚光透镜的后焦平面的共轭点处，使得出射光瞳的图像位于第一组中的一个或多个的感光表面 探测器 前向角度光学收集系统可以包括收集透镜，用于将光引导到第二组检测器，其中收集透镜出射光瞳位于收集透镜的后焦平面中，以及第二组光束的一个或多个的感光表面 检测器位于收集透镜的后焦平面上。

    Dual laser excitation from single laser source
    10.
    发明授权
    Dual laser excitation from single laser source 失效
    单激光源双激光激发

    公开(公告)号：US4710635A

    公开(公告)日：1987-12-01

    申请号：US852007

    申请日：1986-04-14

    申请人： Vernon L. Chupp

    发明人： Vernon L. Chupp

    IPC分类号： G01N33/483 ,  G01N15/14 ,  G01N21/53 ,  G01N33/48 ,  G01N33/49 ,  H01S3/08 ,  H01S3/13 ,  H01S3/23 ,  G01N21/64

    CPC分类号： H01S3/2383 ,  G01N15/1427 ,  H01S3/13 ,  G01N2015/1438 ,  G01N2015/1477 ,  G01N2015/149 ,  G01N2015/1497 ,  G01N2021/6421 ,  G01N21/53 ,  G01N21/6428 ,  H01S2301/08 ,  H01S3/0809

    摘要： A dual laser excitation apparatus comprises a first laser for providing a first beam of light with a plurality of energy lines. A filter or wavelength disperser is included for dividing the first beam of light into two portions. One of these portions of the light beam is spectrally separated and at least one separated line is directed to a first area of illumination. A second laser is positioned to receive the other portion of the divided light beam and is adapted to be energized thereby. The second laser produces a second beam of light directed to a second area of illumination. Such a dual laser excitation apparatus is well suited for flow cytometry purposes.

    摘要翻译： 双激光激发装置包括用于提供具有多条能量线的第一光束的第一激光器。 包括滤波器或波长分散器，用于将第一光束分成两部分。 光束的这些部分中的一个被光谱分离，并且至少一个分开的线指向第一照明区域。 第二激光器被定位成接收分割的光束的另一部分并且适于由此激励。 第二激光器产生指向第二照明区域的第二光束。 这种双激光激发装置非常适用于流式细胞术。