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公开(公告)号：US09110075B2
公开(公告)日：2015-08-18
申请号：US13252778
申请日：2011-10-04
申请人： Sharat Singh , Hossein Salimi-Moosavi , Syed Hasan Tahir , Gerald J. Wallweber , Hrair Kirakossian , Tracy J. Matray , Vincent S. Hernandez
发明人： Sharat Singh , Hossein Salimi-Moosavi , Syed Hasan Tahir , Gerald J. Wallweber , Hrair Kirakossian , Tracy J. Matray , Vincent S. Hernandez
IPC分类号： G01N33/533 , C07K1/13 , G01N33/68
CPC分类号： G01N33/6842 , C07K16/00 , C07K2317/40 , G01N33/582 , G01N33/6803
摘要： Methods, compositions and kits are disclosed for determining one or more target polypeptides in a sample where the target polypeptides have undergone a post-translational modification.
摘要翻译： 公开了用于确定样品中一种或多种靶多肽已经经历了翻译后修饰的方法，组合物和试剂盒。
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公开(公告)号：US08895534B2
公开(公告)日：2014-11-25
申请号：US12848051
申请日：2010-07-30
申请人： Stephen J. Baker , Vincent S. Hernandez , Rashmi Sharma , James A. Nieman , Tsutomu Akama , Yong-Kang Zhang , Jacob J. Plattner , Michael Richard Kevin Alley , Rajeshwar Singh , Fernando Rock
发明人： Stephen J. Baker , Vincent S. Hernandez , Rashmi Sharma , James A. Nieman , Tsutomu Akama , Yong-Kang Zhang , Jacob J. Plattner , Michael Richard Kevin Alley , Rajeshwar Singh , Fernando Rock
IPC分类号： C07F5/02
CPC分类号： C07F5/025 , A61K31/69 , Y02A50/387
摘要： Novel monosubstituted and disubstutituted oxaboroles and pharmaceutical compositions containing such oxaboroles are provided, which are useful for treating bacterial infections, as well as combinations of these oxaboroles with at least one additional therapeutically effective agent.
摘要翻译： 提供了新的单取代和二取代的奥沙伏醇和含有这种恶唑烷的药物组合物，其可用于治疗细菌感染，以及这些恶唑烷与至少一种另外的治疗有效药剂的组合。
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公开(公告)号：US20110172187A1
公开(公告)日：2011-07-14
申请号：US12944690
申请日：2010-11-11
申请人： Vincent S. HERNANDEZ , Xiangeng Li , Suoming ZHANG , Tsutomu AKAMA , Yanchen ZHANG , Yang LIU , Jacob J. PLATTNER , Michael Richard Kevin ALLEY , Yasheen ZHOU , James A. NIEMAN
发明人： Vincent S. HERNANDEZ , Xiangeng Li , Suoming ZHANG , Tsutomu AKAMA , Yanchen ZHANG , Yang LIU , Jacob J. PLATTNER , Michael Richard Kevin ALLEY , Yasheen ZHOU , James A. NIEMAN
CPC分类号： C07F5/025
摘要： This invention relates to, among other items, 6-substituted benzoxaborole compounds and their use for treating bacterial infections.
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公开(公告)号：US20100267981A1
公开(公告)日：2010-10-21
申请号：US12629753
申请日：2009-12-02
申请人： Stephen J. Baker , Tsutomu Akama , Michael Richard Kevin Alley , Steven J. Benkovic , Michael DiPierro , Vincent S. Hernandez , Karin M. Hold , Isaac Kennedy , Igor Likhotvorik , Weimin Mao , Kirk R. Maples , Jacob J. Plattner , Fernando Rock , Virginia Sanders , Aaron M. Stemphoski , George Petros Yiannikouros , Siead Zegar , Yong-Kang Zhang , Huchen Zhou
发明人： Stephen J. Baker , Tsutomu Akama , Michael Richard Kevin Alley , Steven J. Benkovic , Michael DiPierro , Vincent S. Hernandez , Karin M. Hold , Isaac Kennedy , Igor Likhotvorik , Weimin Mao , Kirk R. Maples , Jacob J. Plattner , Fernando Rock , Virginia Sanders , Aaron M. Stemphoski , George Petros Yiannikouros , Siead Zegar , Yong-Kang Zhang , Huchen Zhou
IPC分类号： C07F5/02
CPC分类号： C07F5/025 , A61K9/0012 , A61K9/08 , A61K31/69 , A61K31/70 , A61K31/7076 , A61K47/10 , C07F5/04 , C07H19/06 , C07H19/16 , C07H21/00 , C07H23/00 , Y02A50/473
摘要： This invention relates to compounds useful for treating fungal infections, more specifically topical treatment of onychomycosis and/or cutaneous fungal infections. This invention is directed to compounds that are active against fungi and have properties that allow the compound, when placed in contact with a patient, to reach the particular part of the skin, nail, hair, claw or hoof infected by the fungus. In particular the present compounds have physiochemical properties that facilitate penetration of the nail plate.
摘要翻译： 本发明涉及可用于治疗真菌感染的化合物，更具体地涉及甲真菌病和/或皮肤真菌感染的局部治疗。 本发明涉及对真菌具有活性的化合物，并具有允许化合物与患者接触时达到感染真菌的皮肤，指甲，毛发，爪或蹄特定部位的性质。 特别地，本发明化合物具有促进钉板穿透的物理化学性质。
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公开(公告)号：US20100256092A1
公开(公告)日：2010-10-07
申请号：US12464829
申请日：2009-05-12
申请人： Yi Xia , Michael Richard Kevin Alley , Yasheen Zhou , Vincent S. Hernandez , Jacob J. Plattner , Charles Z. Ding , Kathy Cao , Yong-Kang Zhang , Andrew Benowitz , Tsutomu Akama , Jessica Sligar , Guofeng Jia , Ligong Ou , Neerja Saraswat , Sreekanth Ramachandran , Chris Diaper , Yanchen Zhang , Goverdhan Reddy Banda , James A. Nieman , Mehdi Keramane , Rahim Mohammed , Rajendra Subedi , Hong Liang , Rajeshwar Singh
发明人： Yi Xia , Michael Richard Kevin Alley , Yasheen Zhou , Vincent S. Hernandez , Jacob J. Plattner , Charles Z. Ding , Kathy Cao , Yong-Kang Zhang , Andrew Benowitz , Tsutomu Akama , Jessica Sligar , Guofeng Jia , Ligong Ou , Neerja Saraswat , Sreekanth Ramachandran , Chris Diaper , Yanchen Zhang , Goverdhan Reddy Banda , James A. Nieman , Mehdi Keramane , Rahim Mohammed , Rajendra Subedi , Hong Liang , Rajeshwar Singh
CPC分类号： A61K31/33 , A61K31/43 , A61K45/06 , C07F5/025 , Y02A50/401 , Y02A50/411 , A61K2300/00
摘要： This invention relates to, among other items, 6-substituted benzoxaborole compounds and their use for treating bacterial infections.
摘要翻译： 本发明涉及6-取代的苯并恶唑化合物及其用于治疗细菌感染的用途。
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公开(公告)号：US07582621B2
公开(公告)日：2009-09-01
申请号：US11357687
申请日：2006-02-16
申请人： Stephen J. Baker , Tsutomu Akama , Carolyn Bellinger-Kawahara , Vincent S. Hernandez , Karin M. Hold , James J. Leyden , Kirk R. Maples , Jacob J. Plattner , Virginia Sanders , Yong-Kang Zhang
发明人： Stephen J. Baker , Tsutomu Akama , Carolyn Bellinger-Kawahara , Vincent S. Hernandez , Karin M. Hold , James J. Leyden , Kirk R. Maples , Jacob J. Plattner , Virginia Sanders , Yong-Kang Zhang
CPC分类号： C07F5/025 , A61K9/0012 , A61K31/69 , C07F5/02 , C07F5/027
摘要： This invention relates to compounds useful for treating fungal infections, more specifically topical treatment of onychomycosis and/or cutaneous fungal infections. This invention is directed to compounds that are active against fungi and have properties that allow the compound, when placed in contact with a patient, to reach the particular part of the skin, nail, hair, claw or hoof infected by the fungus. In particular the present compounds have physiochemical properties that facilitate penetration of the nail plate.
摘要翻译： 本发明涉及可用于治疗真菌感染的化合物，更具体地涉及甲真菌病和/或皮肤真菌感染的局部治疗。 本发明涉及对真菌具有活性的化合物，并具有允许化合物与患者接触时达到感染真菌的皮肤，指甲，毛发，爪或蹄特定部位的性质。 特别地，本发明化合物具有促进钉板穿透的物理化学性质。
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公开(公告)号：US08461134B2
公开(公告)日：2013-06-11
申请号：US12944690
申请日：2010-11-11
申请人： Vincent S. Hernandez , Xianfeng Li , Suoming Zhang , Tsutomu Akama , Yanchen Zhang , Yang Liu , Jacob J. Plattner , Michael Richard Kevin Alley , Yasheen Zhou , James A. Nieman
发明人： Vincent S. Hernandez , Xianfeng Li , Suoming Zhang , Tsutomu Akama , Yanchen Zhang , Yang Liu , Jacob J. Plattner , Michael Richard Kevin Alley , Yasheen Zhou , James A. Nieman
CPC分类号： C07F5/025
摘要： This invention relates to, among other items, 6-substituted benzoxaborole compounds and their use for treating bacterial infections.
摘要翻译： 本发明涉及6-取代的苯并恶唑化合物及其用于治疗细菌感染的用途。
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公开(公告)号：US20130059803A1
公开(公告)日：2013-03-07
申请号：US13607321
申请日：2012-09-07
申请人： Stephen J. Baker , Tsutomu Akama , Michael Richard Kevin Alley , Stephen J. Benkovic , Michael DiPierro , Vincent S. Hernandez , Karin M. Hold , Isaac Kennedy , Igor Likhotvorik , Weimin Mao , Kirk R. Maples , Jacob J. Plattner , Fernando Rock , Virginia Sanders , Aaron M. Stemphoski , George Petros Yiannikouros , Siead Zagar , Yong-Kang Zhang , Huchen Zhou
发明人： Stephen J. Baker , Tsutomu Akama , Michael Richard Kevin Alley , Stephen J. Benkovic , Michael DiPierro , Vincent S. Hernandez , Karin M. Hold , Isaac Kennedy , Igor Likhotvorik , Weimin Mao , Kirk R. Maples , Jacob J. Plattner , Fernando Rock , Virginia Sanders , Aaron M. Stemphoski , George Petros Yiannikouros , Siead Zagar , Yong-Kang Zhang , Huchen Zhou
IPC分类号： A61K31/69 , A61P31/10 , A61K31/7028
CPC分类号： C07F5/025 , A61K9/0012 , A61K9/08 , A61K31/69 , A61K31/70 , A61K31/7076 , A61K47/10 , C07F5/04 , C07H19/06 , C07H19/16 , C07H21/00 , C07H23/00 , Y02A50/473
摘要： This invention relates to compounds useful for treating fungal infections, more specifically topical treatment of onychomycosis and/or cutaneous fungal infections. This invention is directed to compounds that are active against fungi and have properties that allow the compound, when placed in contact with a patient, to reach the particular part of the skin, nail, hair, claw or hoof infected by the fungus. In particular the present compounds have physiochemical properties that facilitate penetration of the nail plate.
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公开(公告)号：US20120115813A1
公开(公告)日：2012-05-10
申请号：US13227444
申请日：2011-09-07
申请人： Vincent S. Hernandez , Charles Ding , Jacob J. Plattner , Michael Richard Kevin Alley , Fernando Rock , Suoming Zhang , Eric Easom , Xianfeng Li , Ding Zhou
发明人： Vincent S. Hernandez , Charles Ding , Jacob J. Plattner , Michael Richard Kevin Alley , Fernando Rock , Suoming Zhang , Eric Easom , Xianfeng Li , Ding Zhou
CPC分类号： C07F5/025
摘要： This invention relates to, among other items, benzoxaborole compounds and their use for treating bacterial infections.
摘要翻译： 本发明涉及苯并恶唑化合物及其用于治疗细菌感染的用途。
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公开(公告)号：US20120088307A1
公开(公告)日：2012-04-12
申请号：US13252778
申请日：2011-10-04
申请人： Sharat Singh , Hossein Salimi-Moosavi , Syed Hasan Tahir , Gerald J. Wallweber , Hrair Kirakossian , Tracy J. Matray , Vincent S. Hernandez
发明人： Sharat Singh , Hossein Salimi-Moosavi , Syed Hasan Tahir , Gerald J. Wallweber , Hrair Kirakossian , Tracy J. Matray , Vincent S. Hernandez
IPC分类号： G01N27/00
CPC分类号： G01N33/6842 , C07K16/00 , C07K2317/40 , G01N33/582 , G01N33/6803
摘要： Methods, compositions and kits are disclosed for determining one or more target polypeptides in a sample where the target polypeptides have undergone a post-translational modification.
摘要翻译： 公开了用于确定样品中一种或多种靶多肽已经经历了翻译后修饰的方法，组合物和试剂盒。
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