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    APOC1 genetic markers associated with age of onset of Alzheimer's Disease
    6.
    发明申请
    APOC1 genetic markers associated with age of onset of Alzheimer's Disease 审中-公开
    与阿尔茨海默病发病年龄相关的APOC1遗传标记

    公开(公告)号：US20050255498A1

    公开(公告)日：2005-11-17

    申请号：US11035105

    申请日：2005-01-14

    申请人： Jeroen Aerssens ,  Maria Athanasiou ,  Carlos Brain ,  Nadine Cohen ,  Bradley Dain ,  R. Denton ,  Richard Judson ,  Vural Ozdemir ,  Carol Reed

    发明人： Jeroen Aerssens ,  Maria Athanasiou ,  Carlos Brain ,  Nadine Cohen ,  Bradley Dain ,  R. Denton ,  Richard Judson ,  Vural Ozdemir ,  Carol Reed

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/172

    摘要： Haplotypes in the APOC1 gene associated with age of onset of Alzheimer's Disease are disclosed. Compositions and methods for detecting and using these APOC1 haplotypes in a variety of clinical applications are disclosed. Such applications include articles of manufacture comprising compounds effective in delaying the age of onset of AD in individuals at risk for developing AD and having one of these APOC1 haplotypes, methods and kits for predicting the age of onset of AD in an individual at risk for developing AD based upon his/her haplotype profile, and methods for delaying the age of onset of AD in individuals at risk for developing AD based upon their haplotype profile.

    摘要翻译： 公开了与阿尔茨海默病发病年龄相关的APOC1基因中的单倍型。 公开了用于在各种临床应用中检测和使用这些APOC1单元型的组合物和方法。 这样的应用包括具有有效延迟发展AD风险的个体的AD发病年龄并具有这些APOC1单倍型之一的化合物的制品，用于预测发展中的个体的AD发病年龄的方法和试剂盒 基于他/她的单倍型分布的AD，以及基于其单倍型分布来延缓发展AD风险的个体中AD发病年龄的方法。