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公开(公告)号:US07442808B2
公开(公告)日:2008-10-28
申请号:US11801841
申请日:2007-05-11
申请人: Min Ge , Jiafang He , Fiona Wai Yu Lau , Gui-Bai Liang , Songnian Lin , Weiguo Liu , Shawn P. Walsh , Lihu Yang
发明人: Min Ge , Jiafang He , Fiona Wai Yu Lau , Gui-Bai Liang , Songnian Lin , Weiguo Liu , Shawn P. Walsh , Lihu Yang
IPC分类号: C07D495/00 , C07D307/92 , C07D209/94 , C07D209/00 , C07C229/00 , C07C62/00 , A61K31/38 , A61K31/34 , A61K31/19 , A61K31/195 , A61K31/40
CPC分类号: C07D213/643 , C07C62/34 , C07C62/38 , C07C229/50 , C07C2603/08 , C07D307/93 , C07D311/94 , C07D333/78 , C07D405/04 , C07D407/12 , C07D413/12 , C07D417/12
摘要: Tricyclic compounds containing a cyclopropyl carboxylic acid or carboxylic acid derivative (e.g. amide) fused to a bicyclic ring, including pharmaceutically acceptable salts and prodrugs thereof, are agonists of G-protein coupled receptor 40 (GPR40) and are useful as therapeutic compounds, particularly in the treatment of Type 2 diabetes mellitus, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia.
摘要翻译: 与环双环稠合的环状羧酸或羧酸衍生物(如酰胺)的三环化合物(包括其药学上可接受的盐和前体药物)是G-蛋白偶联受体40(GPR40)的激动剂,可用作治疗性化合物,特别是在 2型糖尿病的治疗,以及经常与该疾病相关的病症,包括肥胖症和脂质疾病,例如混合或糖尿病性血脂异常,高脂血症,高胆固醇血症和高甘油三酯血症。
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公开(公告)号:US20080076810A1
公开(公告)日:2008-03-27
申请号:US11597817
申请日:2005-05-26
IPC分类号: A61K31/422 , A61K31/428 , A61P3/00 , C07D413/14 , C07D417/14
CPC分类号: C07D413/10 , C07D235/26 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14
摘要: Benzourea compounds of Formula I having aryl-(CH2)x-oxazolidinedione or aryl-(CH2)x-thiazolidinedione substituents on one of the N atoms of the benzourea ring, wherein x is 0 or 1, are PPAR gamma agonists or partial agonists and are useful in the treatment and control of type II diabetes, including hyperglycemia and other symptoms such as dyslipidemia, hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, and obesity, that are often associated with type 2 diabetes.
摘要翻译: 式I的苯并脲化合物,其具有芳基 - (CH 2)2 - 恶唑烷二酮或芳基 - (CH 2 CH 2)x SUB 苯并呋喃环的一个N原子上的噻唑烷二酮取代基,其中x为0或1,是PPARγ激动剂或部分激动剂,可用于治疗和控制II型糖尿病,包括高血糖症和其他症状如血脂异常 ,高脂血症,高胆固醇血症,高甘油三酯血症和肥胖症,其通常与2型糖尿病有关。
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公开(公告)号:US06967196B1
公开(公告)日:2005-11-22
申请号:US09890927
申请日:2000-02-22
申请人: David W. Smith , Benito Munoz , Kumar Srinivasan , Carl P. Bergstrom , Prasad V. Chaturvedula , Milind S. Deshpande , Daniel J. Keavy , Wai Yu Lau , Michael F. Parker , Charles P. Sloan , Owen B. Wallace , Henry Hui Wang
发明人: David W. Smith , Benito Munoz , Kumar Srinivasan , Carl P. Bergstrom , Prasad V. Chaturvedula , Milind S. Deshpande , Daniel J. Keavy , Wai Yu Lau , Michael F. Parker , Charles P. Sloan , Owen B. Wallace , Henry Hui Wang
IPC分类号: A61K31/40 , A61K31/407 , A61K31/47 , A61K31/4965 , A61K31/54 , A61P25/00 , C07C311/21 , C07C323/41
CPC分类号: C07D285/06 , C07C311/21 , C07C323/41 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2602/10 , C07C2602/42 , C07C2603/74 , C07D205/04 , C07D207/08 , C07D207/12 , C07D207/20 , C07D207/48 , C07D211/22 , C07D211/24 , C07D211/46 , C07D211/70 , C07D213/30 , C07D213/76 , C07D217/04 , C07D233/61 , C07D277/06 , C07D277/46 , C07D295/088 , C07D295/12 , C07D295/205 , C07D311/20 , C07D333/48 , C07D491/10
摘要: In accordance with the present invention, there is provided a novel class of sulfonamide compounds. Compounds of the invention contain a core sulfonamide group. Variable moieties connected to the sulfur atom and nitrogen atom of the sulfonamide group include substituted or unsubstituted hydrocarbyl moieties, substituted or unsubstituted heterocycle moieties, polycyclic moieties, halogen, alkoxy, ether, ester, amide, sulfonyl, sulfonamidyl, sulfide, carbamate, and the like. Invention compounds are capable of a wide variety of uses. For example sulfonamide compounds can act to modulate production of amyloid β protein and are useful in the prevention or treatment of a variety of diseases. Pharmaceutical compositions containing invention compounds are also provided. Such compositions have wide utility for the prevention or treatment of a variety of diseases.
摘要翻译: 根据本发明,提供了一类新型的磺酰胺化合物。 本发明的化合物含有核心磺酰胺基团。 连接到磺酰胺基团的硫原子和氮原子的可变部分包括取代或未取代的烃基部分,取代或未取代的杂环部分,多环部分,卤素,烷氧基,醚,酯,酰胺,磺酰基,磺酰胺基,硫醚,氨基甲酸酯,和 喜欢。 本发明化合物能够具有多种用途。 例如,磺酰胺化合物可以起到调节淀粉样蛋白β蛋白的产生的作用,并且可用于预防或治疗各种疾病。 还提供含有本发明化合物的药物组合物。 这样的组合物可广泛用于预防或治疗各种疾病。
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公开(公告)号:US20070265332A1
公开(公告)日:2007-11-15
申请号:US11801841
申请日:2007-05-11
申请人: Min Ge , Jiafang He , Fiona Wai Yu Lau , Gui-Bai Liang , Songnian Lin , Weiguo Liu , Shawn P. Walsh , Lihu Yang
发明人: Min Ge , Jiafang He , Fiona Wai Yu Lau , Gui-Bai Liang , Songnian Lin , Weiguo Liu , Shawn P. Walsh , Lihu Yang
IPC分类号: A61K31/381 , A61K31/343 , A61K31/192 , A61K31/195
CPC分类号: C07D213/643 , C07C62/34 , C07C62/38 , C07C229/50 , C07C2603/08 , C07D307/93 , C07D311/94 , C07D333/78 , C07D405/04 , C07D407/12 , C07D413/12 , C07D417/12
摘要: Tricyclic compounds containing a cyclopropyl carboxylic acid or carboxylic acid derivative (e.g. amide) fused to a bicyclic ring, including pharmaceutically acceptable salts and prodrugs thereof, are agonists of G-protein coupled receptor 40 (GPR40) and are useful as therapeutic compounds, particularly in the treatment of Type 2 diabetes mellitus, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia.
摘要翻译: 与环双环稠合的环状羧酸或羧酸衍生物(如酰胺)的三环化合物(包括其药学上可接受的盐和前体药物)是G-蛋白偶联受体40(GPR40)的激动剂,可用作治疗性化合物,特别是在 2型糖尿病的治疗,以及经常与该疾病相关的病症,包括肥胖症和脂质疾病,例如混合或糖尿病性血脂异常,高脂血症,高胆固醇血症和高甘油三酯血症。
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