公开(公告)号：US4554281A

公开(公告)日：1985-11-19

申请号：US545930

申请日：1983-10-27

申请人： Walter vonBebenburg, deceased ,  Joachim Heese ,  Jurgen Engel ,  Kurt Thiele

发明人： Walter vonBebenburg, deceased ,  Joachim Heese ,  Jurgen Engel ,  Kurt Thiele

IPC分类号： C07D213/74 ,  A61K31/44 ,  A61P25/08 ,  C07D213/75

CPC分类号： C07D213/75

摘要： Compounds of the formula ##STR1## where R is a C.sub.1 -C.sub.4 alkyl group, a C.sub.1 -C.sub.4 alkoxy group, a phenoxy group or a phenyl-C.sub.1 -C.sub.2 -alkoxy group, R.sub.1 is hydrogen or a C.sub.1 -C.sub.4 -alkyl group and R.sub.5 is hydrogen or a C.sub.1 -C.sub.4 -alkyl group and the groups R.sub.2, R.sub.3, and R.sub.4 are the same or different and are hydrogen, halogen atoms, C.sub.1 -C.sub.4 alkyl groups, C.sub.1 -C.sub.4 -alkylcarbonyl group, the aminosulfonyl group, the trifluoromethyl group and their acid addition salts are effective as antiepileptics.

摘要翻译： 其中R是C 1 -C 4烷基，C 1 -C 4烷氧基，苯氧基或苯基-C 1 -C 2 - 烷氧基的式Ⅺ化合物，R 1是氢或C 1 -C 4 - 烷基 并且R 5为氢或C 1 -C 4烷基，基团R 2，R 3和R 4相同或不同，为氢，卤素原子，C 1 -C 4烷基，C 1 -C 4烷基羰基，氨基磺酰基， 三氟甲基及其酸加成盐作为抗癫痫药有效。

公开(公告)号：US3966752A

公开(公告)日：1976-06-29

申请号：US520899

申请日：1974-11-04

申请人： Friedrich Asinger ,  Heribert Offermanns ,  Karl-Heinz Gluzek ,  Walter VONBebenburg

发明人： Friedrich Asinger ,  Heribert Offermanns ,  Karl-Heinz Gluzek ,  Walter VONBebenburg

IPC分类号： C07D277/06 ,  C07D277/60

CPC分类号： C07D277/60 ,  C07D277/06

摘要： The D-form of an optically active protected penicillamine is prepared by treating a solution of D,L protected penicillamine of the formula: ##EQU1## wherein Ac is formyl, and R.sub.1 and R.sub.2 are both methyl or are joined together to form the pentamethylene group.

摘要翻译： 光学活性受保护的青霉胺的D型是通过将下式所示的D，L保护的青霉胺溶液，其中Ac是甲酰基，其中Ac是甲酰基来处理，其结果为：COOH | HC-N-Ac || CH 3 R1 ANGLE CC ANGLE CH3 ANGLE R2 R1和R2都是甲基或连接在一起形成五亚甲基。

公开(公告)号：US4073792A

公开(公告)日：1978-02-14

申请号：US459371

申请日：1974-04-09

申请人： Walter vonBebenburg ,  Heribert Offermanns

发明人： Walter vonBebenburg ,  Heribert Offermanns

IPC分类号： C07D471/14 ,  A61K31/55 ,  A61K31/625 ,  A61P25/08 ,  A61P25/20 ,  A61P29/00 ,  C07D20060101 ,  C07D213/00 ,  C07D243/00 ,  C07D249/00 ,  C07D487/04

CPC分类号： C07D487/04

摘要： Compounds are prepared having the formula: ##STR1## where R.sub.1 is alkyl of 1 to 6 carbon atoms or phenyl and R.sub.2 is hydrogen or halogen and tautomeric form and pharmacologically acceptable salts thereof. The compounds have sedative, psychosedative, anxiolytic and spasmolytic properties and in some cases antiphlogistic properties.

摘要翻译： 制备具有下式的化合物：其中R 1是1至6个碳原子的烷基或苯基，R 2是氢或卤素和互变异构形式及其药理学上可接受的盐。 这些化合物具有镇静，精神病，抗焦虑和解痉性质，在某些情况下具有消炎特性。

公开(公告)号：US4009271A

公开(公告)日：1977-02-22

申请号：US590285

申请日：1975-06-25

申请人： Walter VONBebenburg ,  Heribert Offermanns

发明人： Walter VONBebenburg ,  Heribert Offermanns

IPC分类号： C07D213/57 ,  C07D213/73 ,  C07D213/74 ,  C07D213/75 ,  C07D471/04 ,  A61K31/44

CPC分类号： C07D213/73 ,  C07D213/57 ,  C07D213/74 ,  C07D213/75 ,  C07D471/04

摘要： There are produced 6-aza-3H-1,4-benzodiazepines and 6-aza-1,2-dihydro-3H-1,4-benzodiazepines of the formula: ##STR1## wherein R.sub.1 is the group --NR.sub.a R.sub.b or --NR.sub.a R.sub.b R.sub.c halide and R.sub.a and R.sub.b are the same or different and are hydrogen, alkyl groups of 1 to 6 carbon atoms, or alkyl groups of 1 to 6 carbon atoms substituted by hydroxy, phenyl or a carboxy group, and R.sub.c can be as defined for R.sub.a and R.sub.b except it cannot be hydrogen and wherein the group --NR.sub.a R.sub.b also can be a saturated closed 5, 6 or 7 membered ring which in a given case has a further oxygen atom or nitrogen atom or contains a nitrogen atom substituted with an alkyl group having 1 to 4 carbon atoms;R.sub.2 and R.sub.3 are the same or different and are hydrogen, halogen, trifluoromethyl, nitro, nitrile, hydroxy, lower alkyl or lower alkoxy;R.sub.4 is hydrogen;Z is a nitrogen atom or the NO group;R.sub.5 is hydrogen, lower alkyl, lower alkenyl, aminoalkyl of 2 to 4 carbon atoms, mono or di lower alkyl substituted aminoalkyl of 2 to 4 carbon atoms; andA is oxygen, and the --N(R.sub.5)--C--(=A)--can also be in the tautomeric form --N=C(AR.sub.5)--, pharmacologically acceptable salts and quaternary ammonium and alkyl ammonium compounds thereof. The compounds have pharmacodynamic properties including psychosedative and anxiolytic properties as well as antiphlogistic properties.