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公开(公告)号：US08779111B2
公开(公告)日：2014-07-15
申请号：US13620170
申请日：2012-09-14
申请人： Arthur B. Raitano , Karen Jane Meyrick Morrison , Wangmao Ge , Pia M. Challita-Eid , Aya Jakobovits
发明人： Arthur B. Raitano , Karen Jane Meyrick Morrison , Wangmao Ge , Pia M. Challita-Eid , Aya Jakobovits
CPC分类号： C07K16/18 , A01K2217/05 , A01K2267/03 , A61K38/1709 , A61K48/00 , C07K14/705 , C12N2799/026 , C12N2799/027 , G01N33/57492
摘要： A novel gene 024P4C12 (also designated 24P4C12) and its encoded protein, and variants thereof, are described wherein 24P4C12 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 24P4C12 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 24P4C12 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 24P4C12 can be used in active or passive immunization.
摘要翻译： 描述了一种新型基因024P4C12（也称为24P4C12）及其编码蛋白及其变体，其中24P4C12在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，24P4C12提供诊断， 癌症的预后，预防和/或治疗靶标。 24P4C12基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与24P4C12反应的抗体或T细胞可用于主动或被动免疫。
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2.发明授权Nucleic acid and corresponding protein entitled 125P5C8 useful in treatment and detection of cancer 失效核酸和相应的蛋白质125P5C8可用于治疗和检测癌症公开(公告)号：US08647826B2
公开(公告)日：2014-02-11
申请号：US13052002
申请日：2011-03-18
申请人： Mary Faris , Pia M. Challita-Eid , Rene S. Hubert , Daniel E. H. Afar , Arthur B. Raitano , Wangmao Ge , Robert Kendall Morrison , Karen Jane Meyrick Morrison , Aya Jakobovits
发明人： Mary Faris , Pia M. Challita-Eid , Rene S. Hubert , Daniel E. H. Afar , Arthur B. Raitano , Wangmao Ge , Robert Kendall Morrison , Karen Jane Meyrick Morrison , Aya Jakobovits
IPC分类号： G01N33/53
CPC分类号： C07K14/4748 , A61K31/7088 , A61K38/1764 , C12Q1/6886 , C12Q2600/158 , G01N33/574 , G01N33/57434
摘要： A novel gene (designated 125P5C8) and its encoded protein, and variants thereof, are described wherein 125P5C8 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 125P5C8 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 125P5C8 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 125P5C8 can be used in active or passive immunization.
摘要翻译： 描述了一种新型基因（称为125P5C8）及其编码的蛋白及其变体，其中125P5C8在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，125P5C8提供诊断，预后， 癌症的预防和/或治疗靶标。 125P5C8基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与125P5C8反应的抗体或T细胞可用于主动或被动免疫。
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3.发明申请公开(公告)号：US20130267024A1
公开(公告)日：2013-10-10
申请号：US13913360
申请日：2013-06-07
IPC分类号： C12N5/09
CPC分类号： C12N5/0693 , A01K2217/05 , A01K2217/075 , A61K38/00 , A61K47/6851 , A61K2039/505 , C07K14/435 , C07K14/47 , C07K2319/00 , G01N33/57484 , Y02A50/466
摘要： A novel gene 282P1G3 and its encoded protein, and variants thereof, are described wherein 282P1G3 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 282P1G3 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 282P1G3 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 282P1G3 can be used in active or passive immunization.
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4.发明授权Nucleic acids and corresponding proteins entitled 158P3D2 useful in treatment and detection of cancer 失效题为158P3D2的核酸和相应的蛋白质可用于治疗和检测癌症公开(公告)号：US08524872B2
公开(公告)日：2013-09-03
申请号：US13481637
申请日：2012-05-25
申请人： Arthur B. Raitano , Aya Jakobovits , Pia M. Challita-Eid , Steven B. Kanner , Wangmao Ge , Juan J. Perez-Villar , Robert Kendall Morrison
发明人： Arthur B. Raitano , Aya Jakobovits , Pia M. Challita-Eid , Steven B. Kanner , Wangmao Ge , Juan J. Perez-Villar , Robert Kendall Morrison
IPC分类号： C07K14/00
CPC分类号： C07K14/4748 , A61K39/00 , C07K16/30
摘要： A novel gene 158P3D2 and its encoded protein, and variants thereof, are described wherein 158P3D2 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 158P3D2 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 158P3D2 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 158P3D2 can be used in active or passive immunization.
摘要翻译： 描述了一种新型基因158P3D2及其编码的蛋白及其变体，其中158P3D2在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，158P3D2提供诊断，预后，预防和/ 或癌症的治疗靶标。 158P3D2基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与158P3D2反应的抗体或T细胞可用于主动或被动免疫。
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公开(公告)号：US20130090376A1
公开(公告)日：2013-04-11
申请号：US13620170
申请日：2012-09-14
申请人： Arthur B. Raitano , Karen Jane Meyrick Morrison , Wangmao Ge , Pia M. Challita-Eid , Aya Jakobovits
发明人： Arthur B. Raitano , Karen Jane Meyrick Morrison , Wangmao Ge , Pia M. Challita-Eid , Aya Jakobovits
IPC分类号： C07K16/18
CPC分类号： C07K16/18 , A01K2217/05 , A01K2267/03 , A61K38/1709 , A61K48/00 , C07K14/705 , C12N2799/026 , C12N2799/027 , G01N33/57492
摘要： A novel gene 024P4C12 (also designated 24P4C12) and its encoded protein, and variants thereof, are described wherein 24P4C12 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 24P4C12 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 24P4C12 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 24P4C12 can be used in active or passive immunization.
摘要翻译： 描述了一种新型基因024P4C12（也称为24P4C12）及其编码蛋白及其变体，其中24P4C12在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，24P4C12提供诊断， 癌症的预后，预防和/或治疗靶标。 24P4C12基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与24P4C12反应的抗体或T细胞可用于主动或被动免疫。
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6.发明授权Nucleic acid and corresponding protein entitled 213P1F11 useful in treatment and detection of cancer 失效核酸和相应的蛋白质213P1F11可用于治疗和检测癌症公开(公告)号：US08173132B2
公开(公告)日：2012-05-08
申请号：US12357253
申请日：2009-01-21
申请人： Pia M. Challita-Eid , Arthur B. Raitano , Mary Faris , Rene S. Hubert , Robert Kendall Morrison , Wangmao Ge , Aya Jakobovits
发明人： Pia M. Challita-Eid , Arthur B. Raitano , Mary Faris , Rene S. Hubert , Robert Kendall Morrison , Wangmao Ge , Aya Jakobovits
IPC分类号： A61K39/00
CPC分类号： C07K14/82 , A01K2217/05 , A01K2267/0331
摘要： A novel gene (designated 213P1F11) and its encoded protein, and variants thereof, are described wherein 213P1F11 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 213P1F11 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 213P1F11 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 213P1F11 can be used in active or passive immunization.
摘要翻译： 描述了一种新型基因（称为213P1F11）及其编码的蛋白及其变体，其中213P1F11在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，213P1F11提供诊断，预后， 癌症的预防和/或治疗靶标。 213P1F11基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与213P1F11反应的抗体或T细胞可用于主动或被动免疫。
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7.发明授权Nucleic acids and corresponding proteins entitled 191P4D12(b) useful in treatment and detection of cancer 有权题为191P4D12（b）的核酸和相应的蛋白质可用于治疗和检测癌症公开(公告)号：US07968090B2
公开(公告)日：2011-06-28
申请号：US12820279
申请日：2010-06-22
IPC分类号： A61K39/395
CPC分类号： C07K14/47 , A61K38/00 , A61K39/00 , Y02A50/466
摘要： A novel gene 191P4D12(b) and its encoded protein, and variants thereof, are described wherein 191P4D12(b) exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 191P4D12(b) provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 191P4D12(b) gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 191P4D12(b) can be used in active or passive immunization.
摘要翻译： 描述了一种新颖的基因191P4D12（b）及其编码的蛋白及其变体，其中191P4D12（b）在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，191P4D12（b） 提供癌症的诊断，预后，预防和/或治疗靶标。 191P4D12（b）基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与191P4D12（b）反应的抗体或T细胞可用于主动或被动免疫。
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8.发明申请NUCLEIC ACIDS AND CORRESPONDING PROTEINS ENTITLED 58P1D12 USEFUL IN TREATMENT AND DETECTION OF CANCER 审中-公开核酸和对照蛋白58P1D12有效治疗和检测癌症公开(公告)号：US20110008393A1
公开(公告)日：2011-01-13
申请号：US12836449
申请日：2010-07-14
IPC分类号： A61K39/00 , C12N5/10 , C12N5/071 , C12N1/21 , C12N1/19 , C12N15/63 , C07K14/00 , C07K16/44 , C07H21/04 , A61P35/00
CPC分类号： C07K14/7056 , A01K2217/05 , A61K38/00 , A61K39/00 , A61K2039/505 , C07K16/30 , C07K2317/73 , C12N2799/026 , C12N2799/027 , C12Q1/6881 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , G01N33/574 , G01N33/57434 , G01N2500/04
摘要： A novel gene 58P1D12 and its encoded protein, and variants thereof, are described wherein 58P1D12 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 58P1D12 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 58P1D12 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 58P1D12 can be used in active or passive immunization.
摘要翻译： 描述了一种新型基因58P1D12及其编码的蛋白及其变体，其中58P1D12在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，58P1D12提供诊断，预后，预防和/ 或癌症的治疗靶标。 58P1D12基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与58P1D12反应的抗体或T细胞可用于主动或被动免疫。
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9.发明授权Nucleic acids and corresponding proteins entitled 58P1D12 useful in treatment and detection of cancer 失效题为58P1D12的核酸和相应的蛋白质可用于治疗和检测癌症公开(公告)号：US07842458B2
公开(公告)日：2010-11-30
申请号：US10919654
申请日：2004-08-16
IPC分类号： C12Q1/68 , G01N33/53 , G01N33/574 , C07H21/04 , C07K14/435
CPC分类号： C07K14/7056 , A01K2217/05 , A61K38/00 , A61K39/00 , A61K2039/505 , C07K16/30 , C07K2317/73 , C12N2799/026 , C12N2799/027 , C12Q1/6881 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , G01N33/574 , G01N33/57434 , G01N2500/04
摘要： A novel gene 58P1D12 and its encoded protein, and variants thereof, are described wherein 58P1D12 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 58P1D12 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 58P1D12 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 58P1D12 can be used in active or passive immunization.
摘要翻译： 描述了一种新型基因58P1D12及其编码的蛋白及其变体，其中58P1D12在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，58P1D12提供诊断，预后，预防和/ 或癌症的治疗靶标。 58P1D12基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与58P1D12反应的抗体或T细胞可用于主动或被动免疫。
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公开(公告)号：US20100291126A1
公开(公告)日：2010-11-18
申请号：US12842971
申请日：2010-07-23
申请人： AYA JAKOBOVITS , MARY FARIS , ARTHUR B. RAITANO , ROBERT KENDALL MORRISON , DOUGLAS SAFFRAN , WANGMAO GE , PIA M. CHALLITA-EID
发明人： AYA JAKOBOVITS , MARY FARIS , ARTHUR B. RAITANO , ROBERT KENDALL MORRISON , DOUGLAS SAFFRAN , WANGMAO GE , PIA M. CHALLITA-EID
IPC分类号： A61K39/00 , G01N33/566
CPC分类号： G01N33/68 , A01K2217/05 , A61K38/00 , A61K39/00 , A61K2039/505 , A61K2039/53 , C07K14/47 , C07K14/705 , C07K16/28 , C07K2317/34 , G01N33/5017 , G01N33/57434
摘要： A novel gene (designated 101P3A11 or PHOR-1) and its encoded protein, and variants thereof, are described wherein 101P3A11 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 101P3A11 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 101P3A11 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 101P3A11 can be used in active or passive immunization.
摘要翻译： 描述了一种新型基因（称为101P3A11或PHOR-1）及其编码蛋白及其变体，其中101P3A11在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，101P3A11提供 诊断，预后，预防和/或治疗靶标。 101P3A11基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与101P3A11反应的抗体或T细胞可用于主动或被动免疫。
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