-
公开(公告)号:US5718912A
公开(公告)日:1998-02-17
申请号:US736705
申请日:1996-10-28
申请人: Wayne J. Thomspon , Pierre Mallorga , Richard W. Ransom , Ian M. Bell , Michael F. Sugrue , Peter M. Munson
发明人: Wayne J. Thomspon , Pierre Mallorga , Richard W. Ransom , Ian M. Bell , Michael F. Sugrue , Peter M. Munson
IPC分类号: C07D401/04 , A61F2/00 , A01N43/40 , A61K31/445
CPC分类号: C07D401/04
摘要: This invention is concerned with novel 1-�cycloalkylpioeridin-4-yl!-2H benzimidazolones, their compositions and method of use. The novel compounds are selective muscarinic agonists of the m2 subtype with low activity at the m3 subtype. The compounds are effective for the treatment of glaucoma with fewer side effects than the pilocarpine therapy.
摘要翻译: 本发明涉及新的1- [环烷基吡啶-4-基] -2H-苯并咪唑酮,其组合物和使用方法。 新型化合物是m2亚型的选择性毒蕈碱激动剂,在m3亚型下具有低活性。 该化合物对于治疗与毛果芸香碱治疗相比副作用较小的青光眼有效。