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1.NOVEL COMPOUNDS AS ANTAGONISTS OR INVERSE AGONISTS FOR OPIOID RECEPTORS 审中-公开
标题翻译: 新的化合物作为阿片受体的拮抗剂或逆转药物公开(公告)号:US20100222345A1
公开(公告)日:2010-09-02
申请号:US12376577
申请日:2007-08-08
申请人: Caroline Jean Diaz , Curt Dale Haffner , Jason Daniel Speake , Cunyu Zhang , Wendy Yoon Mills , Paul Kenneth Spearing , David John Cowan , Gary Martin Green
发明人: Caroline Jean Diaz , Curt Dale Haffner , Jason Daniel Speake , Cunyu Zhang , Wendy Yoon Mills , Paul Kenneth Spearing , David John Cowan , Gary Martin Green
IPC分类号: A61K31/4184 , C07D235/04 , C07D413/12 , C07D405/12 , C07D471/04 , C07D401/10 , A61K31/5377 , A61K31/4439 , A61K31/4725
CPC分类号: C07D235/08 , C07D209/08 , C07D231/56 , C07D263/56 , C07D401/04 , C07D417/04 , C07D471/04 , C07D487/04
摘要: This invention relates to novel compounds which are antagonists or inverse agonists at one or more of the opioid receptors, to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy.
摘要翻译: 本发明涉及作为一种或多种阿片受体的拮抗剂或反向激动剂的新化合物,含有它们的药物组合物,其制备方法及其在治疗中的用途。
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2.AMINOPHENYLCYCLOPROPYL CARBOXYLIC ACIDS AND DERIVATIVES AS AGONISTS TO GPR40 失效
标题翻译: 氨基苯甲酰基羧酸和衍生物作为GPR40的激素公开(公告)号:US20090105257A1
公开(公告)日:2009-04-23
申请号:US10595892
申请日:2004-11-15
申请人: David Francis Corbett , Kate Anna Dwornik , Dulce Maria Garrido , Stephen Carl McKeown , Wendy Yoon Mills , Andrew James Peat , Terrence Lee Smalley, JR.
发明人: David Francis Corbett , Kate Anna Dwornik , Dulce Maria Garrido , Stephen Carl McKeown , Wendy Yoon Mills , Andrew James Peat , Terrence Lee Smalley, JR.
IPC分类号: A61K31/196 , C07C229/46 , C07D213/55 , C07D277/34 , A61K31/4418 , A61K31/34 , A61K31/4439 , A61P3/00 , A61P9/00 , A61P25/00 , A61K31/5375 , A61K31/381 , A61K31/426 , C07D333/24 , C07D417/12 , C07D295/14
CPC分类号: C07C229/46 , C07C237/24 , C07C323/37 , C07C2601/02 , C07D213/38 , C07D277/28 , C07D277/34 , C07D295/13 , C07D307/52 , C07D333/20 , C07D407/12
摘要: The present invention relates generally to novel therapeutic compounds and more particularly to novel compounds, their use as GPR40 agonists, processes for their manufacture, and intermediates useful in their preparation.
摘要翻译: 本发明一般涉及新的治疗化合物,更具体地涉及新化合物,它们作为GPR40激动剂的用途,其制备方法和用于其制备的中间体。
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3.Aminophenylcyclopropyl carboxylic acids and derivatives as agonists to GPR40 失效
标题翻译: 氨基苯基环丙基羧酸及其衍生物作为GPR40的激动剂公开(公告)号:US07834013B2
公开(公告)日:2010-11-16
申请号:US10595892
申请日:2004-11-15
申请人: David Francis Corbett , Kate Anna Dwornik , Dulce Maria Garrido , Stephen Carl McKeown , Wendy Yoon Mills , Andrew James Peat , Terrence Lee Smalley, Jr.
发明人: David Francis Corbett , Kate Anna Dwornik , Dulce Maria Garrido , Stephen Carl McKeown , Wendy Yoon Mills , Andrew James Peat , Terrence Lee Smalley, Jr.
IPC分类号: A61K31/5375 , A61K31/4439 , A61K31/426 , A61K31/381 , A61K31/196 , C07D295/14 , C07D417/12 , C07D277/20 , C07D333/24 , C07C229/46
CPC分类号: C07C229/46 , C07C237/24 , C07C323/37 , C07C2601/02 , C07D213/38 , C07D277/28 , C07D277/34 , C07D295/13 , C07D307/52 , C07D333/20 , C07D407/12
摘要: The present invention relates generally to novel therapeutic compounds and more particularly to novel compounds, their use as GPR40 agonists, processes for their manufacture, and intermediates useful in their preparation.
摘要翻译: 本发明一般涉及新的治疗化合物,更具体地涉及新化合物,它们作为GPR40激动剂的用途,其制备方法和用于其制备的中间体。
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