摘要:
The present invention relates in part to diagnosing the occurrence of heart failure, particularly in subjects who exhibit a normal body fluid level of a natriuretic peptide. The present invention further relates in part to assigning an outcome risk (e.g., worsening cardiac function or a mortality risk, a risk of rehospitalization) to a subject. The methods comprise performing one or more assays that detect one or more biomarkers selected from the group consisting of WAP4C, ESAM, LTBR, Mesothelin, and Syndecan-1 performed on a body fluid sample obtained from a subject, and assigning diagnosis or risk based, at least in part, on the result(s) obtained thereby.
摘要:
The present invention provides novel fused ring heterocycle kinase modulators and methods of using the novel fused ring heterocycle kinase modulators to treat diseases mediated by kinase activity.
摘要:
The present invention provides novel pyrrolo-pyridine kinase modulators and methods of using the novel pyrrolo-pyridine kinase modulators to treat diseases mediated by kinase activity.
摘要:
The present invention provides novel fused ring heterocycle kinase modulators and methods of using the novel fused ring heterocycle kinase modulators to treat diseases mediated by kinase activity.
摘要:
A public notification system includes a first database comprising phone numbers and one or more data fields associated with each phone number. Phone numbers (callees) in the first database are selected based on the data fields associated therewith. A recorded voice message is transmitted to callees through a plurality of outgoing phone lines, and callees are prompted to enter one of several dial codes, which is recorded. The database record for the callee is automatically updated based on the response dial code, so that the updated field may be used to select whether to send a future call to the callee. A second database comprising records identifying convicted criminals is also included in the public notification system. Each record in the second database comprises one or more data fields associated with a convicted criminal. If the callee's dial code response indicates an interest in receiving information about convicted criminals, future calls will be made to the callee concerning the existence of convicted criminals in a particular geographic area of interest to the callee.
摘要:
An office system comprising a desk and a file folder and basket frame. Each comprises a group of tubular components, file folder frames and baskets, some of which can be used for either the desk or the file holder frame and basket. Assembly is easy using household tools. A stop can be snapped in place to limit sliding movement of either or both the file holder frame or the basket.
摘要:
The present invention provides novel pyrimidinyl-thiophene kinase modulators and methods of using the novel pyrimidinyl-thiophene kinase modulators to treat diseases mediated by kinase activity.