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公开(公告)号:US4742154A
公开(公告)日:1988-05-03
申请号:US790666
申请日:1985-10-23
IPC分类号: C07K14/575 , A61K38/00 , A61K38/11 , A61P5/00 , A61P9/12 , C07K1/113 , C07K7/06 , C07K7/16 , A61K37/00 , C07C103/52
CPC分类号: C07K7/16 , A61K38/00 , Y10S514/807 , Y10S930/15
摘要: Peptides whose structures resemble those of vasopressin antagonists but have both a carboxamido amino acid unit and a basic amino acid unit in the side chain have good antagonist activity. A species of the invention is [1-(.beta.-mercapto-.beta.,.beta.-cyclopentamethylenepropionic acid)-2-(O-ethyl)-D-tyrosine-4-valine-8-glutamine-9-desglycine]-vasopressin.
摘要翻译: 其结构类似于加压素拮抗剂但具有侧链中的甲酰胺基氨基酸单元和碱性氨基酸单元的肽具有良好的拮抗剂活性。 本发明的一种是[1-(β-巯基-β,β-环戊二烯丙酸)-2-(O-乙基)-D-酪氨酸-4-缬氨酸-8-谷氨酰胺-9-去糖基甘氨酸]维生素。
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公开(公告)号:US4478984A
公开(公告)日:1984-10-23
申请号:US535184
申请日:1983-09-23
申请人: William M. Bryan
发明人: William M. Bryan
摘要: N-(.alpha.-Chlorobenzyl)-phthalimide is condensed with a styrene resin in the presence of stannic chloride to give, after splitting the protective imide, benzhydrylamine resin for use in solid phase peptide synthesis.
摘要翻译: N-(α-氯苄基) - 邻苯二甲酰亚胺在氯化锡存在下与苯乙烯树脂缩合,在分离保护酰亚胺后,得到用于固相肽合成的二苯甲基胺树脂。
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公开(公告)号:US07109238B2
公开(公告)日:2006-09-19
申请号:US10761986
申请日:2004-01-21
申请人: Maria Amparo Lago , James Francis Callahan , Pradip Kumar Bhatnagar , Eric G. Del Mar , William M. Bryan , Joelle L. Burgess
发明人: Maria Amparo Lago , James Francis Callahan , Pradip Kumar Bhatnagar , Eric G. Del Mar , William M. Bryan , Joelle L. Burgess
IPC分类号: A61K31/335 , A61K31/195 , C07C303/08 , C07C63/04 , C07D255/03
CPC分类号: C07D303/22 , C07C33/34 , C07C69/616 , C07C69/738 , C07C211/26 , C07C211/30 , C07C229/36 , C07C233/05 , C07C251/48 , C07C255/57 , C07C255/58 , C07C2602/08
摘要: Novel calcilytic compounds and methods of using them are provided.
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公开(公告)号:US06294531B1
公开(公告)日:2001-09-25
申请号:US09402310
申请日:1999-10-01
申请人: Robert M. Barmore , Pradip Kumar Bhatnagar , William M. Bryan , Joelle Lorraine Burgess , James Francis Callahan , Raul Rolando Calvo , Eric G. Del Mar , Maria Amparo Lago , Thomas The Nguyen , Derek Sheehan , Robert Lawrence Smith , Linda Sue Southall , Bradford C. Van Wagenen
发明人: Robert M. Barmore , Pradip Kumar Bhatnagar , William M. Bryan , Joelle Lorraine Burgess , James Francis Callahan , Raul Rolando Calvo , Eric G. Del Mar , Maria Amparo Lago , Thomas The Nguyen , Derek Sheehan , Robert Lawrence Smith , Linda Sue Southall , Bradford C. Van Wagenen
IPC分类号: C07C25550
CPC分类号: C07D295/192 , C07C255/57 , C07C311/08 , C07C311/21 , C07C311/29 , C07C323/17 , C07C2601/02 , C07C2603/32 , C07D267/20 , C07D295/215
摘要: Novel arylalkylamino compounds exhibiting calcilytic properties are provided.
摘要翻译: 提供了具有钙离子性质的新型芳基烷基氨基化合物
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