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公开(公告)号:US08580930B2
公开(公告)日:2013-11-12
申请号:US13589664
申请日:2012-08-20
申请人: William M. Winston, Jr. , S. Kirk Wright , May Han , Lyne Breault , Jie Lin , Bijan Etemad-Gilbertson , Christine Knuehl , Jeno Gyuris , Arnold Horwitz
发明人: William M. Winston, Jr. , S. Kirk Wright , May Han , Lyne Breault , Jie Lin , Bijan Etemad-Gilbertson , Christine Knuehl , Jeno Gyuris , Arnold Horwitz
CPC分类号: C07K16/22 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要: The present invention provides a family of binding proteins that bind and neutralize the activity of hepatocyte growth factor (HGF), in particular human HGF. The binding proteins can be used as diagnostic and/or therapeutic agents. With regard to their therapeutic activity, the binding proteins can be used to treat certain HGF responsive disorders, for example, certain HGF responsive tumors.
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2.
公开(公告)号:US08187601B2
公开(公告)日:2012-05-29
申请号:US12494965
申请日:2009-06-30
申请人: Zhigang Weng , William M. Winston, Jr. , Lyne Breault , Kristan Meetze , Solly Weiler , Jeno Gyuris
发明人: Zhigang Weng , William M. Winston, Jr. , Lyne Breault , Kristan Meetze , Solly Weiler , Jeno Gyuris
IPC分类号: C07K16/28
CPC分类号: C07K16/2863 , A61K2039/505 , C07K2317/24 , C07K2317/73
摘要: Monoclonal antibodies that bind and inhibit activation of fibroblast growth factor receptor 3 (FGFR3) are disclosed. The antibodies can be used to treat cell proliferative diseases and disorders, including certain forms of cancer, associated with activation of FGFR3.
摘要翻译: 公开了结合并抑制成纤维细胞生长因子受体3(FGFR3)活化的单克隆抗体。 抗体可用于治疗与FGFR3的激活相关的细胞增殖性疾病和病症,包括某些形式的癌症。
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公开(公告)号:US07943344B2
公开(公告)日:2011-05-17
申请号:US12632765
申请日:2009-12-07
申请人: William M. Winston, Jr. , S. Kirk Wright , May Han , Lyne Breault , Jie Lin , Bijan Etemad-Gilbertson , Christine Knuehl , Jeno Gyuris , Arnold Horwitz
发明人: William M. Winston, Jr. , S. Kirk Wright , May Han , Lyne Breault , Jie Lin , Bijan Etemad-Gilbertson , Christine Knuehl , Jeno Gyuris , Arnold Horwitz
CPC分类号: C07K16/22 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要: The present invention provides a family of binding proteins that bind and neutralize the activity of hepatocyte growth factor (HGF), in particular human HGF. The binding proteins can be used as diagnostic and/or therapeutic agents. With regard to their therapeutic activity, the binding proteins can be used to treat certain HGF responsive disorders, for example, certain HGF responsive tumors.
摘要翻译: 本发明提供结合并中和肝细胞生长因子(HGF),特别是人HGF的活性的结合蛋白家族。 结合蛋白可用作诊断和/或治疗剂。 关于它们的治疗活性,结合蛋白可用于治疗某些HGF应答性病症,例如某些HGF反应性肿瘤。
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公开(公告)号:US07935502B2
公开(公告)日:2011-05-03
申请号:US12632758
申请日:2009-12-07
申请人: May Han , S. Kirk Wright , William M. Winston, Jr. , Lyne Breault , Jie Lin , Bijan Etemad-Gilbertson , Christine Knuehl , Jeno Gyuris
发明人: May Han , S. Kirk Wright , William M. Winston, Jr. , Lyne Breault , Jie Lin , Bijan Etemad-Gilbertson , Christine Knuehl , Jeno Gyuris
CPC分类号: C07K16/22 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要: The present invention provides a family of binding proteins that bind and neutralize the activity of hepatocyte growth factor (HGF), in particular human HGF. The binding proteins can be used as diagnostic and/or therapeutic agents. With regard to their therapeutic activity, the binding proteins can be used to treat certain HGF responsive disorders, for example, certain HGF responsive tumors.
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公开(公告)号:US07649083B2
公开(公告)日:2010-01-19
申请号:US11757059
申请日:2007-06-01
申请人: William M. Winston, Jr. , S. Kirk Wright , May Han , Lyne Breault , Jie Lin , Bijan Etemad-Gilbertson , Christine Knuehl , Jeno Gyuris , Arnold Horwitz
发明人: William M. Winston, Jr. , S. Kirk Wright , May Han , Lyne Breault , Jie Lin , Bijan Etemad-Gilbertson , Christine Knuehl , Jeno Gyuris , Arnold Horwitz
CPC分类号: C07K16/22 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要: The present invention provides a family of binding proteins that bind and neutralize the activity of hepatocyte growth factor (HGF), in particular human HGF. The binding proteins can be used as diagnostic and/or therapeutic agents. With regard to their therapeutic activity, the binding proteins can be used to treat certain HGF responsive disorders, for example, certain HGF responsive tumors.
摘要翻译: 本发明提供结合并中和肝细胞生长因子(HGF),特别是人HGF的活性的结合蛋白家族。 结合蛋白可用作诊断和/或治疗剂。 关于它们的治疗活性,结合蛋白可用于治疗某些HGF应答性病症,例如某些HGF反应性肿瘤。
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公开(公告)号:US08481687B2
公开(公告)日:2013-07-09
申请号:US13082852
申请日:2011-04-08
申请人: Sylvie Vincent , William M. Winston, Jr. , Fang Wang , Solly Weiler , Kristan Meetze , Lyne Breault , Steve Bottega , Ting Chen , Michael DePrima , Christina Fleet , Steven Tyler , Jin-Kyeung Woo , Jeno Gyuris
发明人: Sylvie Vincent , William M. Winston, Jr. , Fang Wang , Solly Weiler , Kristan Meetze , Lyne Breault , Steve Bottega , Ting Chen , Michael DePrima , Christina Fleet , Steven Tyler , Jin-Kyeung Woo , Jeno Gyuris
IPC分类号: C07K16/28
CPC分类号: C07K16/32 , A61K39/39558 , A61K2039/505 , C07K16/30 , C07K2317/24 , C07K2317/51 , C07K2317/515 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要: Monoclonal antibodies that bind and inhibit activation of epidermal growth factor receptor related member ErbB3/HER3 are disclosed. The antibodies can be used to treat cell proliferative diseases and disorders, including certain forms of cancer, associated with activation of ErbB3/HER3.
摘要翻译: 公开了结合并抑制表皮生长因子受体相关成分ErbB3 / HER3活化的单克隆抗体。 抗体可用于治疗与ErbB3 / HER3的激活相关的细胞增殖性疾病和病症,包括某些形式的癌症。
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公开(公告)号:US08273355B2
公开(公告)日:2012-09-25
申请号:US13051481
申请日:2011-03-18
申请人: William M. Winston, Jr. , S. Kirk Wright , May Han , Lyne Breault , Jie Lin , Bijan Etemad-Gilbertson , Christine Knuehl , Jeno Gyuris , Arnold Horwitz
发明人: William M. Winston, Jr. , S. Kirk Wright , May Han , Lyne Breault , Jie Lin , Bijan Etemad-Gilbertson , Christine Knuehl , Jeno Gyuris , Arnold Horwitz
IPC分类号: A61K39/395
CPC分类号: C07K16/22 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要: The present invention provides a family of binding proteins that bind and neutralize the activity of hepatocyte growth factor (HGF), in particular human HGF. The binding proteins can be used as diagnostic and/or therapeutic agents. With regard to their therapeutic activity, the binding proteins can be used to treat certain HGF responsive disorders, for example, certain HGF responsive tumors.
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公开(公告)号:US08268315B2
公开(公告)日:2012-09-18
申请号:US13051474
申请日:2011-03-18
申请人: May Han , S. Kirk Wright , William M. Winston, Jr. , Lyne Breault , Jie Lin , Bijan Etemad-Gilbertson , Christine Knuehl , Jeno Gyuris
发明人: May Han , S. Kirk Wright , William M. Winston, Jr. , Lyne Breault , Jie Lin , Bijan Etemad-Gilbertson , Christine Knuehl , Jeno Gyuris
IPC分类号: A61K39/395
CPC分类号: C07K16/22 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要: The present invention provides a family of binding proteins that bind and neutralize the activity of hepatocyte growth factor (HGF), in particular human HGF. The binding proteins can be used as diagnostic and/or therapeutic agents. With regard to their therapeutic activity, the binding proteins can be used to treat certain HGF responsive disorders, for example, certain HGF responsive tumors.
摘要翻译: 本发明提供结合并中和肝细胞生长因子(HGF),特别是人HGF的活性的结合蛋白家族。 结合蛋白可用作诊断和/或治疗剂。 关于它们的治疗活性,结合蛋白可用于治疗某些HGF应答性病症,例如某些HGF反应性肿瘤。
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公开(公告)号:US07659378B2
公开(公告)日:2010-02-09
申请号:US11757094
申请日:2007-06-01
申请人: May Han , S. Kirk Wright , William M. Winston, Jr. , Lyne Breault , Jie Lin , Bijan Etemad-Gilbertson , Christine Knuehl , Jeno Gyuris
发明人: May Han , S. Kirk Wright , William M. Winston, Jr. , Lyne Breault , Jie Lin , Bijan Etemad-Gilbertson , Christine Knuehl , Jeno Gyuris
CPC分类号: C07K16/22 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要: The present invention provides a family of binding proteins that bind and neutralize the activity of hepatocyte growth factor (HGF), in particular human HGF. The binding proteins can be used as diagnostic and/or therapeutic agents. With regard to their therapeutic activity, the binding proteins can be used to treat certain HGF responsive disorders, for example, certain HGF responsive tumors.
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10.
公开(公告)号:US20100003258A1
公开(公告)日:2010-01-07
申请号:US12494965
申请日:2009-06-30
申请人: Zhigang Weng , William M. Winston, JR. , Lyne Breault , Kristan Meetze , Solly Weiler , Jeno Gyuris
发明人: Zhigang Weng , William M. Winston, JR. , Lyne Breault , Kristan Meetze , Solly Weiler , Jeno Gyuris
IPC分类号: A61K39/395 , C07K16/28 , C12N15/13 , C12N15/85 , C12N5/16 , C12P21/02 , A61P35/00 , C12N5/00
CPC分类号: C07K16/2863 , A61K2039/505 , C07K2317/24 , C07K2317/73
摘要: Monoclonal antibodies that bind and inhibit activation of fibroblast growth factor receptor 3 (FGFR3) are disclosed. The antibodies can be used to treat cell proliferative diseases and disorders, including certain forms of cancer, associated with activation of FGFR3.
摘要翻译: 公开了结合并抑制成纤维细胞生长因子受体3(FGFR3)活化的单克隆抗体。 抗体可用于治疗与FGFR3的激活相关的细胞增殖性疾病和病症,包括某些形式的癌症。
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