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公开(公告)号：US08219417B2
公开(公告)日：2012-07-10
申请号：US13022464
申请日：2011-02-07
申请人： William S. Dalton
发明人： William S. Dalton
摘要： Systems and methods are provided including a system for managing patient data. The system includes a computing system including a processing unit and a storage. The processing unit executes one or more programs for managing patient data. Managing patient data includes enrolling patients in a centralized care network including presenting each patient with an electronic enrollment interface, assigning each patient a patient identifier, and receiving an electronic consent to collect data. Managing patient data further includes providing patient data to the centralized care network including patient data relating to disease progression, clinical trials and treatments rendered.
摘要翻译： 提供了系统和方法，包括用于管理患者数据的系统。 该系统包括包括处理单元和存储器的计算系统。 处理单元执行用于管理患者数据的一个或多个程序。 管理患者数据包括将患者登记在集中护理网络中，包括向每个患者呈现电子登记界面，为每个患者分配患者标识符，并且接收电子同意以收集数据。 管理患者数据还包括将患者数据提供给集中式护理网络，包括与疾病进展相关的患者数据，临床试验和所呈现的治疗。
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2.发明申请公开(公告)号：US20110288890A1
公开(公告)日：2011-11-24
申请号：US13205536
申请日：2011-08-08
申请人： William S. Dalton , Timothy Yeatman
发明人： William S. Dalton , Timothy Yeatman
IPC分类号： G06Q50/00
摘要： Computers, computer program products, and methods for identifying a plurality of subjects for a clinical trial are provided. A candidate set of molecular profiles in a stored plurality of molecular profiles are identified. Each such profile has measurements for a discriminating set of cellular constituents that match the measurements of corresponding cellular constituents in a responder set of biological samples, thereby identifying the plurality of subjects for the trial from those subjects from which the candidate set of molecular profiles were derived. Each respective molecular profile in the stored plurality of profiles has measurements of a plurality of cellular constituents from a respective biological sample in a plurality of samples obtained from a first plurality of subjects. The discriminating set of cellular constituents is identified from those cellular constituents in the plurality of cellular constituents whose measurement values discriminates between the responder and nonresponder sets of biological samples.
摘要翻译： 提供了计算机，计算机程序产品和用于识别用于临床试验的多个对象的方法。 鉴定存储的多个分子谱中的候选分子谱集。 每个这样的简档具有与生物样本的响应者组中的相应细胞成分的测量相匹配的细胞成分鉴别组的测量结果，从而从衍生出候选分子谱的集合的那些受试者中鉴定出试验的多个受试者 。 存储的多个轮廓中的每个相应分子轮廓具有来自从第一组多个受试者获得的多个样本中的相应生物样品的多个细胞成分的测量。 从多个细胞组分中的细胞成分鉴别细胞组分的鉴别集，其测量值区分应答者和生物样品的无应答组。
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公开(公告)号：US20110276339A1
公开(公告)日：2011-11-10
申请号：US13022464
申请日：2011-02-07
申请人： William S. Dalton
发明人： William S. Dalton
摘要： Systems and methods are provided including a system for managing patient data. The system includes a computing system including a processing unit and a storage. The processing unit executes one or more programs for managing patient data. Managing patient data includes enrolling patients in a centralized care network including presenting each patient with an electronic enrollment interface, assigning each patient a patient identifier, and receiving an electronic consent to collect data. Managing patient data further includes providing patient data to the centralized care network including patient data relating to disease progression, clinical trials and treatments rendered.
摘要翻译： 提供了系统和方法，包括用于管理患者数据的系统。 该系统包括包括处理单元和存储器的计算系统。 处理单元执行用于管理患者数据的一个或多个程序。 管理患者数据包括将患者登记在集中护理网络中，包括向每个患者呈现电子登记界面，为每个患者分配患者标识符，并且接收电子同意以收集数据。 管理患者数据还包括将患者数据提供给集中式护理网络，包括与疾病进展相关的患者数据，临床试验和所呈现的治疗。
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公开(公告)号：US07632814B2
公开(公告)日：2009-12-15
申请号：US11852177
申请日：2007-09-07
IPC分类号： A61K38/00
CPC分类号： G01N33/5011 , C07K7/06
摘要： The present invention concerns fragments and variants of the HYD1 peptide; polynucleotides encoding the peptides; host cells genetically modified with the polynucleotides; vectors comprising the polynucleotides; compositions containing these peptides, polynucleotides, vectors, or host cells; and methods of using the peptides, polynucleotides, vectors, and host cells as inhibitors of aberrant cell growth in vitro or in vivo, e.g., as anti-cancer agents for treatment of cancer, such as myeloma. The present invention further includes a method of increasing the efficacy of chemotherapy and radiation therapy, comprising administering an agent that binds β1 integrin to a patient in need thereof. In one embodiment, the β1 integrin binding agent is the HYD1 peptide, or a functional fragment or variant thereof. In another aspect, the invention pertains to a composition (an adhesion trap) comprising a substrate (also referred to as a surface or support) with a HYD1 peptide, or fragment or variant thereof, immobilized to the substrate, and a method of removing circulating tumor cells (CTC) from blood by contacting a subject's blood with the immobilized peptide. Another aspect of the invention concerns a method of identifying modulators of peptide binding. Another aspect of the invention concerns a method for detecting CTC.
摘要翻译： 本发明涉及HYD1肽的片段和变体; 编码肽的多核苷酸; 用多核苷酸遗传修饰的宿主细胞; 包含多核苷酸的载体; 含有这些肽，多核苷酸，载体或宿主细胞的组合物; 以及使用肽，多核苷酸，载体和宿主细胞作为体外或体内异常细胞生长的抑制剂的方法，例如用作治疗癌症如骨髓瘤的抗癌剂。 本发明进一步包括增加化学疗法和放射治疗功效的方法，其包括向有需要的患者施用结合β1整联蛋白的药剂。 在一个实施方案中，β1整联蛋白结合剂是HYD1肽或其功能片段或变体。 另一方面，本发明涉及一种组合物（粘附陷阱），其包含固定在基底上的HYD1肽或其片段或变体的底物（也称为表面或载体），以及除去循环的方法 通过使受试者的血液与固定的肽接触，从血液中获得肿瘤细胞（CTC）。 本发明的另一方面涉及鉴定肽结合调节剂的方法。 本发明的另一方面涉及一种检测CTC的方法。
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公开(公告)号：US07168708B2
公开(公告)日：2007-01-30
申请号：US11225625
申请日：2005-09-13
IPC分类号： F01D11/02
CPC分类号： F01D11/001 , F01D11/02 , F05D2240/56 , F16J15/164 , F16J15/3288 , F16J15/442
摘要： A seal segment for a turbine is provided having labyrinth teeth and a brush seal disposed along the labyrinth teeth. A plurality of the segments for a seal ring. The segments are separable from each other so that the seal can retract. Each segment has two ends, each of which abuts another segment, with those ends lying along a radius (when looking down the shaft of the turbine). The brush disposed in each segment has ends that do not lie along a radius, but fit together in a tongue and groove configuration when the seal segments come together to form a seal.
摘要翻译： 涡轮机的密封段设有迷宫齿和沿着迷宫齿布置的刷密封件。 用于密封环的多个段。 这些片段可彼此分离，以便密封件可以缩回。 每个段具有两个端部，每个端部邻接另一个段，其中端部沿着半径（当向下俯视涡轮机的轴时）。 设置在每个区段中的刷子具有不沿着半径放置的端部，但是当密封段一起形成密封件时，它们以榫舌和凹槽的形状配合在一起。
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公开(公告)号：US5487549A
公开(公告)日：1996-01-30
申请号：US328016
申请日：1994-10-24
IPC分类号： F16J15/44 , F16J15/447
CPC分类号： F16J15/442
摘要： In an elastic fluid turbine employing a segmented packing ring mounted in a ring-like stationary holder or diaphragm having upper and lower half-parts which meet at a horizontal joint and circumscribe a rotor to minimize leakage between the components, interfitting butt ends on certain of the packing ring segments at the diaphragm horizontal joint, and cam pins on the diaphragm at the horizontal joint and engageable with slots in said certain of the packing ring segments for accurately positioning the packing ring segments relative to the horizontal joint.
摘要翻译： 在采用安装在环状静止支架或隔膜中的分段填料环的弹性流体涡轮机中，其具有在水平接头处相交的上半部分和下半部分，并围绕转子以最小化部件之间的泄漏， 隔膜水平接头处的填料环段和在水平接头处的隔膜上的凸轮销，并与所述某些填料环段中的槽接合，用于相对于水平接头精确地定位填料环段。
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公开(公告)号：US5433453A
公开(公告)日：1995-07-18
申请号：US204959
申请日：1994-03-02
申请人： William S. Dalton
发明人： William S. Dalton
CPC分类号： F16J15/164 , F01D11/005
摘要： In a turbine inclusive of: a turbine shaft having a longitudinal axis, a steam pipe, a casing circumadjacent the pipe, the pipe and casing being shiftable in vertical and transverse and axial directions relative to the longitudinal axis of the shaft, and a seal assembly disposed between the pipe and casing and comprising a stack of interdigitated relatively large and small piston rings, each large ring loosely fitting inside the shell during nonoperative conditions and having teeth firmly and sealingly engaging the casing during operative conditions; and having a coefficient of thermal expansion greater than that of the casing for expanding at a rate faster than the expansion rate of the casing under a condition of increased temperature, each small ring loosely fitting around the pipe during nonoperative conditions and having teeth firmly and sealingly engaging the pipe during operative conditions; and having a coefficient of thermal expansion less than that of the pipe for expanding at a rate slower than the expansion rate of the pipe under a condition of increased temperature, with the large and small rings tightening upon the respective casing and pipe respectively under an increasing temperature condition and shrinking from the respective shell and pipe respectively under a decreasing temperature condition, and the teeth of the rings deforming to create a complete seal.
摘要翻译： 在涡轮机中，包括：具有纵向轴线的涡轮轴，蒸汽管，围绕管的套管，所述管和壳体可相对于所述轴的纵向轴线在垂直和横向和轴向方向上移动;以及密封组件 设置在管和壳体之间并且包括交叉相对较大和小的活塞环的堆叠，每个大环在非操作条件下松散地配合在壳体内部，并且在操作条件下具有牢固且密封地接合壳体的齿; 并且在温度升高的条件下，其热膨胀系数大于壳体的膨胀系数，其速度比壳体的膨胀率快，在非操作状态下松动地配合在管周围并且牢固且密封地具有齿 在操作条件下接合管道; 并且在温度升高的条件下，其热膨胀系数小于管道膨胀系数，其速度比管道的膨胀速率慢，在大的和小的环分别在相应的套管和管道上分别紧固在各自的套管和管道上 分别在降温条件下从相应的壳体和管道收缩，并且环的齿变形以形成完整的密封。
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公开(公告)号：US5353516A
公开(公告)日：1994-10-11
申请号：US14140
申请日：1993-02-05
申请人： William S. Dalton
发明人： William S. Dalton
CPC分类号： G01B5/14
摘要： The invention comprises a measuring device for turbine packing rings which may be used for measuring the critical distance from the free ends of the packing ring teeth to the packing ring hook fit slot.
摘要翻译： 本发明包括用于涡轮机密封环的测量装置，其可以用于测量从填料环齿的自由端到填料环钩配合槽的临界距离。
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公开(公告)号：US20130065837A1
公开(公告)日：2013-03-14
申请号：US13636010
申请日：2011-03-21
摘要： Integrin interaction inhibitors using a beta-turn promoter are described herein. These peptides are useful in treating cancer, such as multiple myeloma, by administering a therapeutically effective amount of the integrin interaction inhibitor. Data show that integrin interaction inhibitors act synergistically or additively interact with anti-proliferative agents such as doxorubicin, SAHA, arsenic trioxide, and etoposide.
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10.发明授权公开(公告)号：US08175896B2
公开(公告)日：2012-05-08
申请号：US13205536
申请日：2011-08-08
申请人： William S. Dalton , Timothy Yeatman
发明人： William S. Dalton , Timothy Yeatman
摘要： Computers, computer program products, and methods for identifying a plurality of subjects for a clinical trial are provided. A candidate set of molecular profiles in a stored plurality of molecular profiles are identified. Each such profile has measurements for a discriminating set of cellular constituents that match the measurements of corresponding cellular constituents in a responder set of biological samples, thereby identifying the plurality of subjects for the trial from those subjects from which the candidate set of molecular profiles were derived. Each respective molecular profile in the stored plurality of profiles has measurements of a plurality of cellular constituents from a respective biological sample in a plurality of samples obtained from a first plurality of subjects. The discriminating set of cellular constituents is identified from those cellular constituents in the plurality of cellular constituents whose measurement values discriminates between the responder and nonresponder sets of biological samples.
摘要翻译： 提供了计算机，计算机程序产品和用于识别用于临床试验的多个对象的方法。 鉴定存储的多个分子谱中的候选分子谱集。 每个这样的简档具有与生物样本的响应者组中的相应细胞成分的测量相匹配的细胞成分鉴别组的测量结果，从而从衍生出候选分子谱的集合的那些受试者中鉴定出试验的多个受试者 。 存储的多个轮廓中的每个相应分子轮廓具有来自从第一组多个受试者获得的多个样本中的相应生物样品的多个细胞成分的测量。 从多个细胞组分中的细胞成分鉴别细胞组分的鉴别集，其测量值区分应答者和生物样品的无应答组。
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