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公开(公告)号:US09259710B2
公开(公告)日:2016-02-16
申请号:US14237182
申请日:2012-08-07
申请人: Martin Rempfer , Wolfgang Freudemann , Cornelia Winz , Ralf Flieg , Markus Storr , Manuela Klotz , Sandra Homeyer , Torsten Knoer
发明人: Martin Rempfer , Wolfgang Freudemann , Cornelia Winz , Ralf Flieg , Markus Storr , Manuela Klotz , Sandra Homeyer , Torsten Knoer
IPC分类号: B01J20/32 , B01J20/26 , B01J20/289
CPC分类号: B01J20/3278 , B01J20/26 , B01J20/289 , B01J20/321 , B01J20/3212 , B01J20/3219 , B01J20/3251 , B01J20/3255 , B01J20/3274 , B01J20/3291 , B01J2220/80
摘要: A separation material includes a saccharide bound via a linker to a matrix for enabling the separation from a liquid of substances that selectively bind to saccharide moieties. A method for preparing the material, a method for separating from a liquid substances that selective bind to saccharides, and a device including the separation material are also disclosed.
摘要翻译: 分离材料包括通过接头与基质结合的糖,以使得能够与选择性结合糖部分的物质的液体分离。 还公开了一种制备该材料的方法,一种与选择性结合糖类的液体物质分离的方法以及包括该分离材料的装置。
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公开(公告)号:US20150111194A1
公开(公告)日:2015-04-23
申请号:US14237182
申请日:2012-08-07
申请人: Martin Rempfer , Wolfgang Freudemann , Cornelia Winz , Ralf Flieg , Markus Storr , Manuela Klotz , Sandra Homeyer , Torsten Knoer
发明人: Martin Rempfer , Wolfgang Freudemann , Cornelia Winz , Ralf Flieg , Markus Storr , Manuela Klotz , Sandra Homeyer , Torsten Knoer
IPC分类号: B01J20/32 , B01J20/289
CPC分类号: B01J20/3278 , B01J20/26 , B01J20/289 , B01J20/321 , B01J20/3212 , B01J20/3219 , B01J20/3251 , B01J20/3255 , B01J20/3274 , B01J20/3291 , B01J2220/80
摘要: A separation material includes a saccharide bound via a linker to a matrix for enabling the separation from a liquid of substances that selectively bind to saccharide moieties. A method for preparing the material, a method for separating from a liquid substances that selective bind to saccharides, and a device including the separation material are also disclosed.
摘要翻译: 分离材料包括通过接头与基质结合的糖,以使得能够与选择性结合糖部分的物质的液体分离。 还公开了一种制备该材料的方法,一种与选择性结合糖类的液体物质分离的方法以及包括该分离材料的装置。
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公开(公告)号:US20140166580A1
公开(公告)日:2014-06-19
申请号:US14236921
申请日:2012-08-07
申请人: Martin Rempfer , Wolfgang Freudemann , Cornelia Winz , Ralf Flieg , Markus Storr , Sandra HOMEYER , Torsten KNOER
发明人: Martin Rempfer , Wolfgang Freudemann , Cornelia Winz , Ralf Flieg , Markus Storr , Sandra HOMEYER , Torsten KNOER
IPC分类号: A61M1/34
CPC分类号: A61M1/34 , A61M2205/3368 , B01J20/26 , B01J20/289 , B01J20/321 , B01J20/3212 , B01J20/3219 , B01J20/3255 , B01J20/327 , B01J20/3274 , B01J20/3278 , B01J20/328
摘要: A separation material includes a matrix that is bound to a saccharide, enabling the separation from a liquid of substances that selectively bind the saccharide. A method for preparing the separation material and a method for separating substances from a liquid that selectively bind a saccharide of the separation material are also described. A device employs the separation material for separating from a liquid substances that selectively bind to the saccharide of the separation material.
摘要翻译: 分离材料包括与糖结合的基质,使得能够与选择性结合糖的物质的液体分离。 还描述了制备分离材料的方法和从选择性结合分离材料的糖的液体中分离物质的方法。 一种装置使用分离材料与选择性地结合分离材料的糖的液体物质分离。
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公开(公告)号:US09844621B2
公开(公告)日:2017-12-19
申请号:US14236921
申请日:2012-08-07
申请人: Martin Rempfer , Wolfgang Freudemann , Cornelia Winz , Ralf Flieg , Markus Storr , Sandra Homeyer , Torsten Knoer
发明人: Martin Rempfer , Wolfgang Freudemann , Cornelia Winz , Ralf Flieg , Markus Storr , Sandra Homeyer , Torsten Knoer
IPC分类号: B01D24/00 , B01D39/00 , B01D39/14 , B01D63/00 , B01D67/00 , B29C44/04 , A61M1/34 , B01J20/26 , B01J20/289 , B01J20/32
CPC分类号: A61M1/34 , A61M2205/3368 , B01J20/26 , B01J20/289 , B01J20/321 , B01J20/3212 , B01J20/3219 , B01J20/3255 , B01J20/327 , B01J20/3274 , B01J20/3278 , B01J20/328
摘要: A separation material includes a matrix that is bound to a saccharide, enabling the separation from a liquid of substances that selectively bind the saccharide. A method for preparing the separation material and a method for separating substances from a liquid that selectively bind a saccharide of the separation material are also described. A device employs the separation material for separating from a liquid substances that selectively bind to the saccharide of the separation material.
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公开(公告)号:US20120160771A1
公开(公告)日:2012-06-28
申请号:US13397988
申请日:2012-02-16
申请人: Markus Storr , Egbert Müller , Wolfgang Freudemann
发明人: Markus Storr , Egbert Müller , Wolfgang Freudemann
IPC分类号: B01J20/26 , A61M1/36 , B01D69/08 , B01D71/78 , B01D15/08 , B01D63/04 , B01D67/00 , B01D69/02
CPC分类号: A61L2/0017 , B01D63/02 , B01D63/026 , B01D67/0006 , B01D67/0018 , B01D67/0093 , B01D69/08 , B01D69/125 , B01D71/40 , B01D71/78 , B01D2313/44 , B01D2323/38 , B01J20/26 , B01J20/28023 , B01J20/28033 , B01J20/3278 , B01J2220/62 , C08F257/02 , C08F265/04 , C08F265/10 , C08F267/10 , C08F271/00 , C08F271/02 , C08F285/00 , C08F289/00 , C08F291/00
摘要: A separating material formed by a solid substrate having a substrate surface, primary or secondary amines coupled to the substrate surface, and a graft polymer formed on the substrate by covalently coupling the primary or secondary amines with a thermally labile radical initiator and subsequently contacting the substrate surface with a solution of one or more polymerizable monomers. Methods for the extracorporeal treatment of blood, blood plasma or blood serum employing the separating material, for affinity adsorption, ion-exchange adsorption, hydrophobic adsorption, or hydrophilic adsorption employing the separating material, and a separating column employing the separating material are also disclosed.
摘要翻译: 由具有基底表面的固体基底形成的分离材料,与基底表面偶联的伯胺或仲胺,以及通过将伯胺或仲胺与热不稳定的自由基引发剂共价偶联而形成在基底上的接枝聚合物, 用一种或多种可聚合单体的溶液表面。 还公开了使用分离材料进行体外处理血液,血浆或血清,亲和吸附,离子交换吸附,疏水吸附或使用分离材料的亲水吸附的方法,以及使用分离材料的分离柱。
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公开(公告)号:US08303819B2
公开(公告)日:2012-11-06
申请号:US13397988
申请日:2012-02-16
申请人: Markus Storr , Egbert Muller , Wolfgang Freudemann
发明人: Markus Storr , Egbert Muller , Wolfgang Freudemann
CPC分类号: A61L2/0017 , B01D63/02 , B01D63/026 , B01D67/0006 , B01D67/0018 , B01D67/0093 , B01D69/08 , B01D69/125 , B01D71/40 , B01D71/78 , B01D2313/44 , B01D2323/38 , B01J20/26 , B01J20/28023 , B01J20/28033 , B01J20/3278 , B01J2220/62 , C08F257/02 , C08F265/04 , C08F265/10 , C08F267/10 , C08F271/00 , C08F271/02 , C08F285/00 , C08F289/00 , C08F291/00
摘要: A separating material formed by a solid substrate having a substrate surface, primary or secondary amines coupled to the substrate surface, and a graft polymer formed on the substrate by covalently coupling the primary or secondary amines with a thermally labile radical initiator and subsequently contacting the substrate surface with a solution of one or more polymerizable monomers. Methods for the extracorporeal treatment of blood, blood plasma or blood serum employing the separating material, for affinity adsorption, ion-exchange adsorption, hydrophobic adsorption, or hydrophilic adsorption employing the separating material, and a separating column employing the separating material are also disclosed.
摘要翻译: 由具有基底表面的固体基底形成的分离材料,与基底表面偶联的伯胺或仲胺,以及通过将伯胺或仲胺与热不稳定的自由基引发剂共价偶联而形成在基底上的接枝聚合物, 用一种或多种可聚合单体的溶液表面。 还公开了使用分离材料进行体外处理血液,血浆或血清,亲和吸附,离子交换吸附,疏水吸附或使用分离材料的亲水吸附的方法,以及使用分离材料的分离柱。
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公开(公告)号:US20120208256A1
公开(公告)日:2012-08-16
申请号:US13503204
申请日:2010-10-20
申请人: Ralf Flieg , Manuela Klotz , Markus Storr , Martin Rempfer , Wolfgang Freudemann , Cornelia Winz , Bernd Krause , Markus Hornung
发明人: Ralf Flieg , Manuela Klotz , Markus Storr , Martin Rempfer , Wolfgang Freudemann , Cornelia Winz , Bernd Krause , Markus Hornung
CPC分类号: C12N9/18 , C09D133/14 , C12N9/80 , C12N11/06 , C12N11/08
摘要: An immobilized enzyme comprises a solid support, an enzyme linked to the solid support and a spacer for coupling the enzyme to the solid support. A method for the production of immobilized enzymes comprises: providing a solid support having amino-functional groups coupled to the support surface; covalently coupling the amino-functional groups with a thermally labile radical initiator; and, contacting the support surface with a solution of polymerizable monomers. The polymerizable monomers comprise functional groups which do not take part in radical polymerization, under conditions where thermally initiated graft copolymerization of the monomers takes place, to form polymer chains on the surface of the support. If the polymer chains do not already comprise primary amino-functional groups, the method further comprises transforming the functional groups in the polymer chains into groups comprising primary amino-functional groups. The method further comprises coupling the enzyme to amino-functional groups of the polymer chains.
摘要翻译: 固定化酶包括固体支持物,与固体支持物连接的酶和用于将酶偶联到固体支持物的间隔物。 制备固定化酶的方法包括:提供具有与支持表面偶联的氨基官能团的固体支持物; 将氨基官能团与热不稳定的自由基引发剂共价偶联; 并且使支撑体表面与可聚合单体的溶液接触。 可聚合单体包括在发生单体的热引发接枝共聚的条件下不参与自由基聚合的官能团,以在载体的表面上形成聚合物链。 如果聚合物链不包括伯氨基官能团,则该方法还包括将聚合物链中的官能团转化为包含伯氨基官能团的基团。 该方法还包括将酶偶联到聚合物链的氨基官能团。
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公开(公告)号:US08142844B2
公开(公告)日:2012-03-27
申请号:US10572703
申请日:2004-08-30
申请人: Markus Storr , Egbert Müller , Wolfgang Freudemann
发明人: Markus Storr , Egbert Müller , Wolfgang Freudemann
CPC分类号: A61L2/0017 , B01D63/02 , B01D63/026 , B01D67/0006 , B01D67/0018 , B01D67/0093 , B01D69/08 , B01D69/125 , B01D71/40 , B01D71/78 , B01D2313/44 , B01D2323/38 , B01J20/26 , B01J20/28023 , B01J20/28033 , B01J20/3278 , B01J2220/62 , C08F257/02 , C08F265/04 , C08F265/10 , C08F267/10 , C08F271/00 , C08F271/02 , C08F285/00 , C08F289/00 , C08F291/00
摘要: The present invention provides a separating material producable by a) providing a solid substrate, having amino-functional groups coupled to the substrate surface, b) covalently coupling of the amino-functional groups with a thermally labile radical initiator, c) contacting the substrate surface with a solution of polymerizable monomers under conditions, where thermally initiated graft copolymerization of the monomers takes place, to form a structure of adjacent functional polymer chains on the surface of the substrate. The present invention further provides a method for the production of a separating material by a) providing a solid substrate, having aminofunctional groups coupled to the substrate surface, b) covalently coupling of the aminofunctional groups with a thermally labile radical initiator, c) contacting the substrate surface with a solution of polymerizable monomers under conditions, where thermally initiated graft copolymerization of the monomers takes place, to form a structure of adjacent functional polymer chains on the surface of the substrate.
摘要翻译: 本发明提供一种分离材料,其可通过以下步骤提供:a)提供具有与基底表面偶联的氨基官能团的固体基质,b)将氨基官能团与热不稳定的自由基引发剂共价偶联,c)使基材表面 在可发生单体的热引发的接枝共聚的条件下,使可聚合单体的溶液形成在基材表面上的相邻的官能聚合物链的结构。 本发明还提供了一种用于制备分离材料的方法,该方法是:a)提供具有偶联到基底表面的氨基官能团的固体基质,b)将氨基官能团与热不稳定的自由基引发剂共价偶联,c) 在单体发生热引发的接枝共聚的条件下,在基材表面上形成相邻的官能聚合物链的结构的条件下,可聚合单体的溶液的底物表面。
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公开(公告)号:US20060264355A1
公开(公告)日:2006-11-23
申请号:US10572703
申请日:2004-08-30
申请人: Markus Storr , Egbert Muller , Wolfgang Freudemann
发明人: Markus Storr , Egbert Muller , Wolfgang Freudemann
CPC分类号: A61L2/0017 , B01D63/02 , B01D63/026 , B01D67/0006 , B01D67/0018 , B01D67/0093 , B01D69/08 , B01D69/125 , B01D71/40 , B01D71/78 , B01D2313/44 , B01D2323/38 , B01J20/26 , B01J20/28023 , B01J20/28033 , B01J20/3278 , B01J2220/62 , C08F257/02 , C08F265/04 , C08F265/10 , C08F267/10 , C08F271/00 , C08F271/02 , C08F285/00 , C08F289/00 , C08F291/00
摘要: The present invention provides a separating material producable by a) providing a solid substrate, having amino-functional groups coupled to the substrate surface, b) covalently coupling of the amino-functional groups with a thermally labile radical initiator, c) contacting the substrate surface with a solution of polymerizable monomers under conditions, where thermally initiated graft copolymerization of the monomers takes place, to form a structure of adjacent functional polymer chains on the surface of the substrate. The present invention further provides a method for the production of a separating material by a) providing a solid substrate, having aminofunctional groups coupled to the substrate surface, b) covalently coupling of the aminofunctional groups with a thermally labile radical initiator, c) contacting the substrate surface with a solution of polymerizable monomers under conditions, where thermally initiated graft copolymerization of the monomers takes place, to form a structure of adjacent functional polymer chains on the surface of the substrate.
摘要翻译: 本发明提供一种分离材料,其可通过以下步骤提供:a)提供具有与基底表面偶联的氨基官能团的固体基质,b)将氨基官能团与热不稳定的自由基引发剂共价偶联,c)使基材表面 在可发生单体的热引发的接枝共聚的条件下,使可聚合单体的溶液形成在基材表面上的相邻的官能聚合物链的结构。 本发明还提供了一种用于制备分离材料的方法,该方法是:a)提供具有偶联到基底表面的氨基官能团的固体基质,b)将氨基官能团与热不稳定的自由基引发剂共价偶联,c) 在单体发生热引发的接枝共聚的条件下,在基材表面上形成相邻的官能聚合物链的结构的条件下,可聚合单体的溶液的底物表面。
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