公开(公告)号：US4544659A

公开(公告)日：1985-10-01

申请号：US551816

申请日：1983-11-15

申请人： Urs Brombacher ,  Marc Montavon ,  Hermann Bretschneider ,  Joachim Schantl ,  Wolfgang Turk

发明人： Urs Brombacher ,  Marc Montavon ,  Hermann Bretschneider ,  Joachim Schantl ,  Wolfgang Turk

IPC分类号： A61K31/00 ,  A61K31/435 ,  A61P33/10 ,  C07D219/06 ,  C07D219/10 ,  C07D417/12 ,  A61K31/47 ,  C07D219/08

CPC分类号： C07D417/12 ,  C07D219/06 ,  C07D219/10

摘要： Acridanone derivatives of the formula ##STR1## wherein the dotted line is an optional bond, R.sup.1 is hydrogen, halogen or nitro, R.sup.2 is hydrogen or lower alkyl, one of the substituents R.sup.3 and R.sup.4 is hydrogen or lower alkyl and the other together with R is an additional bond and R.sup.5 is hydrogen, lower alkyl, lower alkenyl, lower alkynyl or lower alkyl substituted by halogen or lower alkoxy,and pharmaceutically acceptable acid addition salts thereof, processes for their preparation and pharmaceutical compositions based thereon, are described. The compounds of formula I are useful as schistosomicidal agents.

摘要翻译： 式Ⅰ的吖啶酮衍生物，其中虚线是任选键，R 1是氢，卤素或硝基，R 2是氢或低级烷基，取代基R 3和R 4之一是氢或低级烷基，另一个与 R是另外的键，R5是氢，低级烷基，低级烯基，低级炔基或被卤素或低级烷氧基取代的低级烷基，及其药学上可接受的酸加成盐，其制备方法和基于此的药物组合物。 式I的化合物可用作血吸虫病剂。