公开(公告)号：US20050288525A1

公开(公告)日：2005-12-29

申请号：US10504831

申请日：2003-03-03

申请人： James Leighton ,  Xiaolun Wang ,  James Kinnaird

发明人： James Leighton ,  Xiaolun Wang ,  James Kinnaird

IPC分类号： C07C29/38 ,  C07C33/14 ,  C07C33/20 ,  C07C41/30 ,  C07C41/56 ,  C07C43/178 ,  C07C43/23 ,  C07C241/02 ,  C07C241/04 ,  C07C243/28 ,  C07C243/32 ,  C07F7/02 ,  C07F7/04 ,  C07F7/08 ,  C07F7/10 ,  C07F7/12 ,  C07F7/18

CPC分类号： C07C403/08 ,  C07B2200/07 ,  C07C29/38 ,  C07C41/30 ,  C07C43/1787 ,  C07C43/23 ,  C07C241/04 ,  C07C2601/14 ,  C07F7/045 ,  C07F7/12 ,  C07F7/122 ,  C07F7/1804 ,  C07F7/1876 ,  C07F7/188 ,  C07C243/28 ,  C07C33/48 ,  C07C33/03 ,  C07C33/14 ,  C07C33/26 ,  C07C33/30

摘要： A new class of reagents and method of use of the reagents in the reaction of the reagents with electrophilic compounds. The invention in one embodiment is directed to a method for the formation of an alcohol of the formula (I). The method includes reacting reagent of the formula (II) with an aldehyde of the formula R10CHO to form the alcohol. X3 is one of O and C(R4)(R5). Each of X1 and X2 is independently O or N—R. Each of Ca and Cb is independently an achiral center, an (S) chiral center or an (R) chiral center. Ra and Rb are (i) each independently C1-10 alkyl, C6-10 aryl or C3-9 heteroaryl, or (ii) taken together to form a C3-C4 alkylene chain which together with Ca and Cb forms a 5-membered or 6-membered aliphatic ring. Rc and Rd are each independently hydrogen, C1-10 alkyl, C6-10 aryl or C3-9 heteroaryl. R is C1-10 alkyl, C6-10 aryl or C3-9 heteroaryl. Each of R1, R2, R3, R4, R5 is independently hydrogen, C1-C10 alkyl, C6-10 aryl, C3-9 heteroaryl, C1-10 alkoxy, C6-10 aryloxy, C1-10 dialkylamino, C1-10 alkyl-C6-10 arylamino, C1-10 diarylamino, or halogen. R6 is halogen, hydrogen, C1-10 alkyl, C6-10 aryl, C3-9 heteroaryl, C1-10 alkoxy, C6-10 aryloxy, C1-10 alkyl-C6-10 arylamino, C1-10 diarylamino, OSO2CF3 or SR. R10 may be C1-10 alkyl, C6-10 aryl, or C3-9 heteroaryl.

公开(公告)号：US20100029657A1

公开(公告)日：2010-02-04

申请号：US12393565

申请日：2009-02-26

申请人： Jeremy Ian Levin ,  Darrin William Hopper ,  Nancy Torres ,  Minu Dhanjisha Dutia ,  Dan Maarten Berger ,  Xiaolun Wang ,  Martin Joseph Di Grandi ,  Chunchun Zhang ,  Alejandro Lee Dunnick

发明人： Jeremy Ian Levin ,  Darrin William Hopper ,  Nancy Torres ,  Minu Dhanjisha Dutia ,  Dan Maarten Berger ,  Xiaolun Wang ,  Martin Joseph Di Grandi ,  Chunchun Zhang ,  Alejandro Lee Dunnick

IPC分类号： A61K31/4985 ,  C07D487/04 ,  A61K31/519 ,  A61P35/00 ,  A61P29/00

CPC分类号： C07D519/00

摘要： Compounds of formula A: and pharmaceutically acceptable salts thereof are described, which selectively inhibit Raf kinase activity and are useful for treating disorders mediated by Raf kinases.

摘要翻译： 描述了式A的化合物及其药学上可接受的盐，其选择性地抑制Raf激酶活性，并且可用于治疗由Raf激酶介导的病症。

公开(公告)号：US20150224113A1

公开(公告)日：2015-08-13

申请号：US14693110

申请日：2015-04-22

申请人： Jason W. Brown ,  Melinda Davis ,  Anthony Ivetac ,  Benjamin Jones ,  Andre A. Kiryanov ,  Jon Kuehler ,  Marion Lanier ,  Joanne Miura ,  Sean Murphy ,  Xiaolun Wang

发明人： Jason W. Brown ,  Melinda Davis ,  Anthony Ivetac ,  Benjamin Jones ,  Andre A. Kiryanov ,  Jon Kuehler ,  Marion Lanier ,  Joanne Miura ,  Sean Murphy ,  Xiaolun Wang

IPC分类号： A61K31/5513 ,  A61K31/4985 ,  A61K31/5377 ,  A61K31/496 ,  A61K31/444 ,  A61K31/4545

CPC分类号： C07D401/14 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/4985 ,  A61K31/5377 ,  A61K31/551 ,  A61K31/5513 ,  C07D401/04 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/08 ,  C07D487/04 ,  C07D487/06 ,  C07D487/10 ,  C07D491/10 ,  C07D491/107

摘要： The present invention provides a method of treating acute heart failure by administering a compound of the formula: or a pharmaceutically acceptable salt thereof.

摘要翻译： 本发明提供了通过给予下式化合物或其药学上可接受的盐治疗急性心力衰竭的方法。

公开(公告)号：US08013676B2

公开(公告)日：2011-09-06

申请号：US12816726

申请日：2010-06-16

申请人： Yongge Su ,  Siqing Ye ,  Dandong He ,  Weimin Yin ,  Xikun Zhang ,  Xiaolun Wang ,  Qianhua Wei

发明人： Yongge Su ,  Siqing Ye ,  Dandong He ,  Weimin Yin ,  Xikun Zhang ,  Xiaolun Wang ,  Qianhua Wei

IPC分类号： H03F1/26

CPC分类号： H03F1/3247 ,  H03F1/02 ,  H03F1/3241 ,  H03F2200/405 ,  H03F2200/408

摘要： A high-efficiency power amplifier is provided, including a drive amplifier and a final power amplifier, and further including a first digital pre-distortion (DPD) correction module and a second DPD correction module. The first DPD correction module is configured to pre-distort nonlinear characteristics of drive signals output by the drive amplifier, and the second DPD correction module is connected to the first DPD correction module in series, and is configured to pre-distort nonlinear characteristics of amplified signals output by the final power amplifier. Another high-efficiency power amplifier is also provided, including a drive amplifier and a final power amplifier, and further including a second multi-path control module, a fourth DPD correction module, and a second gating module. The overall efficiency of the high-efficiency power amplifier is increased by improving the working efficiency of the drive amplifier. Further, higher overall efficiency is also achieved for a power amplifier with a higher gain.

摘要翻译： 提供了一种高效率功率放大器，包括驱动放大器和最终功率放大器，还包括第一数字预失真（DPD）校正模块和第二DPD校正模块。 第一DPD校正模块被配置为对由驱动放大器输出的驱动信号的非线性特性进行预失真，并且第二DPD校正模块串联连接到第一DPD校正模块，并且被配置为预失真放大的非线性特性 信号由最终功率放大器输出。 还提供了另一种高效率功率放大器，包括驱动放大器和最终功率放大器，并且还包括第二多路径控制模块，第四DPD校正模块和第二门控模块。 通过提高驱动放大器的工作效率，提高了高效率功率放大器的整体效率。 此外，对于具有较高增益的功率放大器，也实现更高的总体效率。

公开(公告)号：US20100253426A1

公开(公告)日：2010-10-07

申请号：US12816726

申请日：2010-06-16

申请人： Yongge Su ,  Siqing Ye ,  Dandong He ,  Weimin Yin ,  Xikun Zhang ,  Xiaolun Wang ,  Qianhua Wei

发明人： Yongge Su ,  Siqing Ye ,  Dandong He ,  Weimin Yin ,  Xikun Zhang ,  Xiaolun Wang ,  Qianhua Wei

IPC分类号： H03F1/26

CPC分类号： H03F1/3247 ,  H03F1/02 ,  H03F1/3241 ,  H03F2200/405 ,  H03F2200/408

摘要： A high-efficiency power amplifier is provided, including a drive amplifier and a final power amplifier, and further including a first digital pre-distortion (DPD) correction module and a second DPD correction module. The first DPD correction module is configured to pre-distort nonlinear characteristics of drive signals output by the drive amplifier, and the second DPD correction module is connected to the first DPD correction module in series, and is configured to pre-distort nonlinear characteristics of amplified signals output by the final power amplifier. Another high-efficiency power amplifier is also provided, including a drive amplifier and a final power amplifier, and further including a second multi-path control module, a fourth DPD correction module, and a second gating module. The overall efficiency of the high-efficiency power amplifier is increased by improving the working efficiency of the drive amplifier. Further, higher overall efficiency is also achieved for a power amplifier with a higher gain.

摘要翻译： 提供了一种高效率功率放大器，包括驱动放大器和最终功率放大器，还包括第一数字预失真（DPD）校正模块和第二DPD校正模块。 第一DPD校正模块被配置为对由驱动放大器输出的驱动信号的非线性特性进行预失真，并且第二DPD校正模块串联连接到第一DPD校正模块，并且被配置为预失真放大的非线性特性 信号由最终功率放大器输出。 还提供了另一种高效率功率放大器，包括驱动放大器和最终功率放大器，并且还包括第二多路径控制模块，第四DPD校正模块和第二门控模块。 通过提高驱动放大器的工作效率，提高了高效率功率放大器的整体效率。 此外，对于具有较高增益的功率放大器，也实现更高的总体效率。

公开(公告)号：US07534905B2

公开(公告)日：2009-05-19

申请号：US10504831

申请日：2003-03-03

申请人： James L. Leighton ,  Xiaolun Wang ,  James Kinnaird

发明人： James L. Leighton ,  Xiaolun Wang ,  James Kinnaird

IPC分类号： C07F7/10 ,  C07F7/08 ,  C07F7/18

CPC分类号： C07C403/08 ,  C07B2200/07 ,  C07C29/38 ,  C07C41/30 ,  C07C43/1787 ,  C07C43/23 ,  C07C241/04 ,  C07C2601/14 ,  C07F7/045 ,  C07F7/12 ,  C07F7/122 ,  C07F7/1804 ,  C07F7/1876 ,  C07F7/188 ,  C07C243/28 ,  C07C33/48 ,  C07C33/03 ,  C07C33/14 ,  C07C33/26 ,  C07C33/30

摘要： A new class of reagents and method of use of the reagents in the reaction of the reagents with electrophilic compounds. The invention in one embodiment is directed to a method for the formation of an alcohol of the formula (I). The method includes reacting a reagent of the formula (II) with an aldehyde of the formula R10CHO to form the alcohol. X3 is one of O and C(R4)(R5). Each of X1 and X2 is independently O or N—R. Each of Ca and Cb is independently an achiral center, an (S) chiral center or an (R) chiral center. Ra and Rb are (i) each independently C1-10 alkyl, C6-10 aryl or C3-9 heteroaryl, or (ii) taken together to form a C3—C4 alkylene chain which together with Ca and Cb forms a 5-membered or 6-membered aliphatic ring. Rc and Rd are each independently hydrogen, C1-10 alkyl, C6-10 aryl or C3-9 heteroaryl. R is C1-10 alkyl, C6-10 aryl or C3-9 heteroaryl. Each of R1, R2, R3, R4, R5 is independently hydrogen, C1—C10 alkyl, C6-10 aryl, C3-9 heteroaryl, C1-10 alkoxy, C6-10 aryloxy, C1-10 dialkylamino, C1-10 alkyl-C6-10 arylamino, C1-10 diarylamino, or halogen. R6 is halogen, hydrogen, C1-10 alkyl, C6-10 aryl, C3-9 heteroaryl, C1-10 alkoxy, C6-10 aryloxy, C1-10 alkyl-C6-10 arylamino, C1-10 diarylamino, OSO2CF3 or SR. R10 may be C1-10 alkyl, C6-10 aryl, or C3-9 heteroaryl.

摘要翻译： 在试剂与亲电子化合物的反应中使用新一类试剂和试剂的使用方法。 在一个实施方案中，本发明涉及形成式（I）的醇的方法。 该方法包括使式（II）的试剂与式R 10 CHO的醛反应以形成醇。 X3是O和C（R4）（R5）之一。 X1和X2各自独立地为O或N-R。 Ca和Cb各自独立地是非手性中心，（S）手性中心或（R）手性中心。 R a和R b分别为（i）各自独立地为C 1-10烷基，C 6-10芳基或C 3-9杂芳基，或（ii）一起形成C 3 -C 4亚烷基链，其与Ca和Cb一起形成5元或 6元脂肪环。 R c和R d各自独立地为氢，C 1-10烷基，C 6-10芳基或C 3-9杂芳基。 R是C 1-10烷基，C 6-10芳基或C 3-9杂芳基。 R 1，R 2，R 3，R 4，R 5各自独立地为氢，C 1 -C 10烷基，C 6-10芳基，C 3-9杂芳基，C 1-10烷氧基，C 6-10芳氧基，C 1-10二烷基氨基，C 1-10烷基 - C6-10芳基氨基，C1-10二芳基氨基或卤素。 R6是卤素，氢，C1-10烷基，C6-10芳基，C3-9杂芳基，C1-10烷氧基，C6-10芳氧基，C1-10烷基-C6-10芳基氨基，C1-10二芳基氨基，OSO2CF3或SR。 R 10可以是C 1-10烷基，C 6-10芳基或C 3-9杂芳基。