摘要:
The invention provides vinblastine derivatives represented by the following formula 1 or their physiologically acceptable salts, their preparation, use and pharmaceutical compositions comprising the said derivatives. The said vinblastine derivatives show inhibiting activities against tumor cell lines and can be used as medicaments for treating malignant tumors.
摘要:
Disclosed is a suspensible external combined on-load tap changer, including: a switch box, a switch body and a motor mechanism, a top box wall of the switch box being opened with a top opening, a top box cover being mounted on the top opening, wherein the switch body is detachably mounted in the switch box and is entirely lifted in and lifted out by the top opening; and the motor mechanism is connected with the switch body in a driving manner. The switch body in the present invention uses a hoisting structure, and the top box wall of the switch box is opened with a top opening with a size large enough, so that the switch body is directly lifted in and lifted out of the switch box from the top opening, and installation and maintenance are easier.
摘要:
Disclosed is a change-over structure between a moving contact and a static contact of a tap selector, including an insulation changer base plate, and further including at least two static contacts, fixed on the insulation changer base plate in at least one column at intervals, where inner ends of at least two static contacts are electrically connected to two tap windings of a transformer respectively; at least one rotation shaft, where at least two moving contacts are evenly distributed on the one rotation shaft, and the at least two moving contacts are electrically connected to each other; and at least one arc-shaped conductor corresponding to the at least two static contacts in at least one column, where the arc-shaped conductor and outer ends of the at least two static contacts in at least one column are located at the same circumference with a center of the rotation shaft as a circle center, and when one of the moving contacts is changed over between the two static contacts, the other moving contact is certainly electrically connected to the arc-shaped conductor. Through the present invention, connection conductors in the changer are omitted, so that each component is fixed and reliable and is convenient to mount, and hidden fault troubles are reduced.
摘要:
The purpose of the present invention is to provide an animal toy and its manufacturing process. The animal is not easily destroyed when bitten by an animal, and its light weight reduces the risk of harm to an animal when the toy is thrown.
摘要:
The present invention discloses 3D-structure of SARS-CoV Viral 3CL Protease obtained through molecular simulation. The 3D-structure is used as a drug target for screening the existing medical database CMC (Comprehensive Medicinal Chemistry, MDL Information System, Inc.), and a group of compounds which have the activity of inhibiting SARS-CoV virus 3CL Protease are found. Cinanserin was tested at molecular and viral levels, and it was found to be able to inhibit the SARS-CoV viral 3CL protease and SARS-CoV viruses. Cinanserin analogs were synthesized and tested at molecular and viral levels, they were found to be able to inhibit the SARS-CoV virus 3CL Protease and SARS-CoV viruses, and may be used for treating and/or preventing SARS-CoV virus infection.
摘要翻译:本发明公开了通过分子模拟获得的SARS-CoV病毒3CL蛋白酶的三维结构。 使用3D结构作为筛选现有医学数据库CMC(Comprehensive Medicinal Chemistry,MDL Information System,Inc。)的药物靶点,并发现一组具有抑制SARS-CoV病毒3CL蛋白酶活性的化合物。 在分子和病毒水平测试了Cinanserin,发现能够抑制SARS-CoV病毒3CL蛋白酶和SARS-CoV病毒。 合成Cinanserin类似物并在分子和病毒水平进行测试,发现它们能够抑制SARS-CoV病毒3CL蛋白酶和SARS-CoV病毒,可用于治疗和/或预防SARS-CoV病毒感染。
摘要:
A change-over structure disposed between a moving contact and a static contact of a tap selector includes an insulation changer base plate, static contacts which are fixed on the insulation changer base plate in at least one column at intervals, the inner ends of the static contacts are electrically connected to respective tap windings of a transformer, rotation shafts, each comprising moving contacts that are evenly distributed on each of the rotation shafts and are electrically connected to each other, and arc-shaped conductors corresponding to the static contacts in at least one column. Each of the arc-shaped conductors and outer ends of the static contacts are disposed at the same circumference with a center of one of the rotation shafts as a circle center. When one of the moving contacts is changed over between the two static contacts, another moving contact is electrically connected to the arc-shaped conductor.
摘要:
The present invention provides an apparatus that assists a student with learning how to solve word problems, including cash flow type problems, by using the sense of touch to establish a greater pattern of formula recognition and usage. The word problems include a finite set of constant values for a predetermined number of variables. The apparatus includes a preliminary equation that is presolved for a particular set of values. A final equation is also presolved for the particular set of values. The preliminary equation and final equation are movably placed onto a work area which preferably includes a measurement line.
摘要:
A cloud server and a system for storing and searching image files configured to add search information for a search by a user to page images constituting an image file are disclosed. In the system for storing and searching the image files, an input display part of a user terminal displays a page image notification screen to make the user add the search information to the current displayed page image, a user-side communication part sends the search information and the current displayed page image to the cloud server, and an addition control part of the cloud server adds the search information to the corresponding page image.
摘要:
Disclosed is a suspensible external combined on-load tap changer, including: a switch box, a switch body and a motor mechanism, a top box wall of the switch box being opened with a top opening, a top box cover being mounted on the top opening, wherein the switch body is detachably mounted in the switch box and is entirely lifted in and lifted out by the top opening; and the motor mechanism is connected with the switch body in a driving manner. The switch body in the present invention uses a hoisting structure, and the top box wall of the switch box is opened with a top opening with a size large enough, so that the switch body is directly lifted in and lifted out of the switch box from the top opening, and installation and maintenance are easier.
摘要:
The invention relates to pharmaceutical compositions comprising benzopyranone derivatives for the treatment of Severe Acute Respiratory Syndrome (SARS).