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8 条记录 (耗时 0.016 秒)

    Anti-CD3 antibodies and methods of use thereof
    1.
    发明授权
    Anti-CD3 antibodies and methods of use thereof 有权
    抗CD3抗体及其使用方法

    公开(公告)号：US08551478B2

    公开(公告)日：2013-10-08

    申请号：US12750385

    申请日：2010-03-30

    申请人： Bernard Mach ,  Yann Dean ,  Marie Kosco-Vilbois ,  Greg Elson ,  Nicolas Fischer ,  Olivier Leger

    发明人： Bernard Mach ,  Yann Dean ,  Marie Kosco-Vilbois ,  Greg Elson ,  Nicolas Fischer ,  Olivier Leger

    IPC分类号： A61K39/395

    CPC分类号： C07K16/2809 ,  A61K39/3955 ,  A61K45/06 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/52 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/74

    摘要： The present invention is related to antibodies directed to the antigen CD3 and uses of such antibodies. In particular, the present invention provides fully human monoclonal antibodies directed to CD3. Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDR's), specifically from FR1 through FR4 or CDR1 through CDR3, are provided. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies are also provided.

    摘要翻译： 本发明涉及针对抗原CD3的抗体和这种抗体的用途。 特别地，本发明提供了完全针对CD3的人单克隆抗体。 编码的核苷酸序列和包含重链和轻链免疫球蛋白分子的氨基酸序列，特别是对应于跨越框架区和/或互补决定区（CDR）的连续重链和轻链序列的序列，特别是从FR1至FR4或CDR1至CDR3 ，提供。 还提供了表达这种免疫球蛋白分子和单克隆抗体的杂交瘤或其它细胞系。

    Combination Therapies and Methods Using Anti-CD3 Modulating Agents and Anti-IL-6 Antagonists
    3.
    发明申请
    Combination Therapies and Methods Using Anti-CD3 Modulating Agents and Anti-IL-6 Antagonists 审中-公开
    使用抗CD3调节剂和抗IL-6拮抗剂的组合疗法和方法

    公开(公告)号：US20120189621A1

    公开(公告)日：2012-07-26

    申请号：US13354813

    申请日：2012-01-20

    申请人： Yann Dean ,  Fabien Depis

    发明人： Yann Dean ,  Fabien Depis

    IPC分类号： A61K39/395 ,  A61P29/00 ,  A61P1/00 ,  A61P11/06 ,  A61P27/02 ,  A61P19/02 ,  A61P9/00 ,  A61P17/00 ,  A61P17/06 ,  A61P37/06 ,  A61P13/12

    CPC分类号： A61K39/39558 ,  A61K39/3955 ,  A61K2039/507 ,  C07K16/248 ,  C07K16/2809 ,  C07K2317/76

    摘要： This invention relates generally to compositions that contain multiple modulating agents, e.g., multiple modulating agents that target CD3 on T cells and neutralize one or more biological activities of interleukin-6 (IL-6), such as CD3 modulators including anti-CD3 antibodies and anti-IL-6 antagonists including anti-IL-6 antibodies, anti-IL-6R antagonists including anti-IL-6R antibodies, and/or anti-IL-6/IL-6R complex antagonists including anti-IL-6/IL-6R binding antibodies, and methods of using these compositions in the treatment, amelioration and/or prevention of relapse of an autoimmune disease.

    摘要翻译： 本发明一般涉及含有多种调节剂的组合物，例如靶向T细胞上CD3的多重调节剂并中和白细胞介素-6（IL-6）的一种或多种生物学活性，例如CD3调节剂，包括抗CD3抗体和 包括抗IL-6抗体的抗IL-6拮抗剂，包括抗IL-6R抗体的抗IL-6R拮抗剂和/或包含抗IL-6 / IL的抗IL-6 / IL-6R复合拮抗剂 -6R结合抗体，以及使用这些组合物治疗，改善和/或预防自身免疫疾病复发的方法。

    Anti-CD3 antibodies and methods of use thereof
    7.
    发明授权
    Anti-CD3 antibodies and methods of use thereof 有权
    抗CD3抗体及其使用方法

    公开(公告)号：US07728114B2

    公开(公告)日：2010-06-01

    申请号：US11145131

    申请日：2005-06-03

    申请人： Bernard Mach ,  Yann Dean ,  Marie Kosco-Vilbois ,  Greg Elson ,  Nicolas Fischer ,  Olivier Leger

    发明人： Bernard Mach ,  Yann Dean ,  Marie Kosco-Vilbois ,  Greg Elson ,  Nicolas Fischer ,  Olivier Leger

    IPC分类号： C12P21/08

    CPC分类号： C07K16/2809 ,  A61K39/3955 ,  A61K45/06 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/52 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/74

    摘要： The present invention is related to antibodies directed to the antigen CD3 and uses of such antibodies. In particular, the present invention provides fully human monoclonal antibodies directed to CD3. Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDR's), specifically from FR1 through FR4 or CDR1 through CDR3, are provided. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies are also provided.

    摘要翻译： 本发明涉及针对抗原CD3的抗体和这种抗体的用途。 特别地，本发明提供了完全针对CD3的人单克隆抗体。 编码的核苷酸序列和包含重链和轻链免疫球蛋白分子的氨基酸序列，特别是对应于跨越框架区和/或互补决定区（CDR）的连续重链和轻链序列的序列，特别是从FR1至FR4或CDR1至CDR3 ，提供。 还提供了表达这种免疫球蛋白分子和单克隆抗体的杂交瘤或其它细胞系。