公开(公告)号：US4933334A

公开(公告)日：1990-06-12

申请号：US274977

申请日：1988-11-22

申请人： Hisayoshi Shimizu ,  Yasushi Mikura ,  Yasuo Doi

发明人： Hisayoshi Shimizu ,  Yasushi Mikura ,  Yasuo Doi

IPC分类号： A61K9/00 ,  A61K31/545 ,  A61K47/02

CPC分类号： A61K31/545 ,  A61K47/02 ,  A61K9/0019

摘要： An antibiotic composition which comprises 7.beta.-[(Z)-(5-amino-1,2,4-thiadiazol-3-yl)-2(Z)-methoxyiminoacetamide]-3(1-imidazo[1,2-b]pyridazinium)-methyl-3-cephem-4-carboxylate hydrochloride and a pharmaceutically acceptable water-soluble basic substance, which is stable in storage and improved in solubility as well as free of local actions or hemolytic action.

公开(公告)号：US4167563A

公开(公告)日：1979-09-11

申请号：US835815

申请日：1977-09-22

申请人： Yasushi Mikura ,  Yoshiharu Matukura ,  Hiroshi Fujisawa

发明人： Yasushi Mikura ,  Yoshiharu Matukura ,  Hiroshi Fujisawa

IPC分类号： A61K9/08 ,  A61K9/00 ,  A61K38/04 ,  A61K38/06 ,  A61K47/10 ,  A61K47/26 ,  A61P25/28 ,  A61K37/02

CPC分类号： A61K47/26 ,  A61K38/066 ,  A61K9/0019

摘要： An injectable solution containing a trihydric to hexahydric sugar alcohol together with L-pyroglutamyl-L-histidyl-L-prolinamide or a physiologically acceptable salt thereof shows significantly reduced pain when administered to a host, especially subcutaneously or intramuscularly.

摘要翻译： 含有三价至六价糖醇与L-焦谷氨酰-L-组氨酰-L-脯氨酰胺或其生理上可接受的盐的注射溶液当给予宿主时尤其是皮下或肌内给药显着降低疼痛。

公开(公告)号：US5223515A

公开(公告)日：1993-06-29

申请号：US921996

申请日：1992-08-04

申请人： Yasushi Mikura ,  Akihiro Nagai ,  Hisayoshi Shimizu

发明人： Yasushi Mikura ,  Akihiro Nagai ,  Hisayoshi Shimizu

IPC分类号： A61K9/00 ,  A61K31/44 ,  A61K47/10

CPC分类号： A61K9/0019 ,  A61K31/44 ,  A61K47/10 ,  Y10S514/925

摘要： An injectable solution of a compound useful as an anti-ulcer agent of the formula; ##STR1## wherein R.sup.1 represents hydrogen, methoxy or trifluoromethyl group; R.sup.2 and R.sup.3, being the same as or different from each other, represent hydrogen or methyl group; and R.sup.4 represents a fluorinated C.sub.2 to C.sub.5 lower alkyl group, is provided by dissolving the compound in at least one of ethanol, propylene glycol and polyethylene glycol; or by dissolving the freeze-dried material of an alkaline aqueous solution of the compound in a mixture of an acidic substance and at least one of the above solvents.

摘要翻译： 用作下式的抗溃疡剂的化合物的可注射溶液; 其中R1代表氢，甲氧基或三氟甲基; R2和R3彼此相同或不同，表示氢或甲基; R4表示氟化C2〜C5低级烷基，是通过将化合物溶于乙醇，丙二醇和聚乙二醇中的至少一种来提供的; 或者将化合物的碱性水溶液的冷冻干燥物质溶解在酸性物质和上述溶剂中的至少一种的混合物中。