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    Process for preparing optically pure (S)-3-hydroxy-&ggr;-butyrolactone
    1.
    发明授权
    Process for preparing optically pure (S)-3-hydroxy-&ggr;-butyrolactone 失效
    制备光学纯（S）-3-羟基-γ-丁内酯的方法

    公开(公告)号：US06713290B2

    公开(公告)日：2004-03-30

    申请号：US09946449

    申请日：2001-09-06

    申请人： Young Mi Park ,  Jongpil Chun ,  Yik-haeng Cho ,  Kyoung Rok Roh ,  Hosung Yu ,  Dae Hwang, II

    发明人： Young Mi Park ,  Jongpil Chun ,  Yik-haeng Cho ,  Kyoung Rok Roh ,  Hosung Yu ,  Dae Hwang, II

    IPC分类号： C12P1704

    CPC分类号： C07D307/33 ,  C07B2200/07 ,  C12P7/42 ,  C12P17/04 ,  C12P19/14 ,  C12P19/22

    摘要： The present invention relates to a process for preparing optically pure (S)-3-hydroxy-&ggr;-butyrolactone expressed by the following Formula 1 and more particularly, to a process that enables preparing optically pure (S)-3-hydroxy-&ggr;-butyrolactone economically in large quantities, by: (a) Preparing &agr;-(1,4) linked oligosaccharide with adequate sugar distribution by reacting starch which is easily available from natural product with enzyme under a specific condition; and (b) Performing oxidation and cyclization sequentially under a specific condition.

    摘要翻译： 本发明涉及一种制备由下式1表示的光学纯的（S）-3-羟基-γ-丁内酯的方法，更具体地说，涉及能够制备光学纯的（S）-3-羟基-γ-丁内酯的方法， 通过以下方式经济地经济地制备丁内酯：（a）通过在天然产物中容易获得的淀粉与酶在特定条件下反应制备具有足够糖分布的α-（1,4）连接的寡糖; 和（b）在特定条件下依次进行氧化和环化。

    Process for preparing optically pure(S)-3,4-dihydroxybutyric acid derivatives
    2.
    发明授权
    Process for preparing optically pure(S)-3,4-dihydroxybutyric acid derivatives 失效
    光学纯（S）-3,4-二羟基丁酸衍生物的制备方法

    公开(公告)号：US06221639B1

    公开(公告)日：2001-04-24

    申请号：US09359679

    申请日：1999-07-23

    申请人： Yik-haeng Cho ,  Jongpil Chun ,  Young Mi Park ,  Kyoung Rok Roh ,  Hosung Yu ,  Dae Il Hwang

    发明人： Yik-haeng Cho ,  Jongpil Chun ,  Young Mi Park ,  Kyoung Rok Roh ,  Hosung Yu ,  Dae Il Hwang

    IPC分类号： C12P762

    CPC分类号： C07D307/33 ,  C07B2200/07 ,  C12P7/42 ,  C12P17/04 ,  C12P19/14 ,  C12P19/22

    摘要： The present invention relates to a process for preparing optically pure (S)-3,4-dihydroxybutyric acid derivatives expressed by the following Formula 1 and more particularly, to a process that enables preparing optically pure (S)-3,4-dihydroxybutyric acid derivatives economically in large quantities, by: (a) Preparing &agr;-(1,4)-linked oligosaccharide with adequate sugar distribution by reacting amylopectin which is easily available from natural product with enzyme under a specific condition; and (b) Performing oxidation and esterification sequentially under a specific condition. wherein, R represents linear or branched alkyl group with 1˜5 carbon atoms.

    摘要翻译： 本发明涉及一种制备光学纯的（S）-3,4-二羟基丁酸衍生物的方法，该衍生物由下式1表示，更具体地说，涉及能够制备光学纯的（S）-3,4-二羟基丁酸 通过以下方式经济地制备衍生物：（a）通过在天然产物中容易获得的支链淀粉与酶在特定条件下反应制备具有足够糖分布的α-（1,4）连接的寡糖; 和（b）在特定条件下依次进行氧化和酯化。其中R表示具有1〜5个碳原子的直链或支链烷基。

    Continuous process for preparing optically pure (s)-3,4-dihydroxybutyric acid derivatives
    3.
    发明授权
    Continuous process for preparing optically pure (s)-3,4-dihydroxybutyric acid derivatives 失效
    用于制备光学纯的（S）-3,4-二羟基丁酸衍生物的连续方法

    公开(公告)号：US06288272B1

    公开(公告)日：2001-09-11

    申请号：US09359676

    申请日：1999-07-23

    申请人： Kyoung Rok Roh ,  Jongpil Chun ,  Yik-haeng Cho ,  Young Mi Park ,  Hosung Yu ,  Dae Il Hwang

    发明人： Kyoung Rok Roh ,  Jongpil Chun ,  Yik-haeng Cho ,  Young Mi Park ,  Hosung Yu ,  Dae Il Hwang

    IPC分类号： C07C6966

    CPC分类号： C07D307/33 ,  C07B2200/07 ,  C12P7/42 ,  C12P17/04 ,  C12P19/14 ,  C12P19/22

    摘要： The present invention relates to a continuous process for preparing optically pure (S)-3,4-dihydroxybutyric acid derivatives expressed by the following Formula 1 and more particularly, to the continuous process which enables preparing optically pure (S)-3,4-dihydroxybutyric acid derivatives economically in large quantities, by: (a) Preparing &agr;-(1,4) linked oligosaccharide having adequate sugar distribution by reacting amylopectin which is easily available from natural product with enzyme under a specific condition; and (b) Performing oxidatioin by running basic anion exchange resin with an oxidant to give (S)-3,4-dihydroxybutyric acid-anion exchange resin complex, dissociating the (S)-3,4-dihydroxybutyric acid from anion exchange resin complex and esterification sequentially under a specific condition.  wherein Represents linear or branched alkyl group with 1˜5 carbon atoms.

    摘要翻译： 本发明涉及用于制备由下式1表示的光学纯的（S）-3,4-二羟基丁酸衍生物的连续方法，更具体地说，涉及能够制备光学纯的（S）-3,4-二羟基丁酸衍生物的连续方法， 通过以下方式经济地制备二羟基丁酸衍生物：（a）通过使天然产物容易获得的支链淀粉与酶在特定条件下反应制备具有足够糖分布的α-（1,4）连接的寡糖; 和（b）通过用氧化剂运行碱性阴离子交换树脂来进行氧化，得到（S）-3,4-二羟基丁酸 - 阴离子交换树脂配合物，使（S）-3,4-二羟基丁酸与阴离子交换树脂复合物 并在特定条件下依次酯化。 其中表示具有1〜5个碳原子的直链或支链烷基。

    Continuous process for preparing optically pure (S)-3-hydroxy-&ggr;-butyrolactone
    4.
    发明授权
    Continuous process for preparing optically pure (S)-3-hydroxy-&ggr;-butyrolactone 失效
    制备光学纯（S）-3-羟基-γ-丁内酯的连续方法

    公开(公告)号：US06251642B1

    公开(公告)日：2001-06-26

    申请号：US09359712

    申请日：1999-07-23

    申请人： Jongpil Chun ,  Yik-haeng Cho ,  Kyoung Rok Roh ,  Young Mi Park ,  Hosung Yu ,  Dae Hwang, II

    发明人： Jongpil Chun ,  Yik-haeng Cho ,  Kyoung Rok Roh ,  Young Mi Park ,  Hosung Yu ,  Dae Hwang, II

    IPC分类号： C12P1704

    CPC分类号： C07D307/33 ,  C07B2200/07 ,  C12P7/42 ,  C12P17/04 ,  C12P19/14 ,  C12P19/22

    摘要： The present invention relates to a continuous process for preparing optically pure (S)-3-hydroxy-&ggr;-butyrolactone expressed by the following Formula 1 and more particularly, to a process which enables preparing optically pure (S)-3-hydroxy-&ggr;-butyrolactone economically in large quantities, by: (a) Preparing &agr;-(1,4) linked oligosaccharide with adequate sugar distribution by reacting amylopectin which is easily available from natural product with enzyme under a specific condition; and (b) Performing oxidation, esterification and cyclization sequentially under a specific condition.

    摘要翻译： 本发明涉及用于制备由下式1表示的光学纯的（S）-3-羟基-γ-丁内酯的连续方法，更具体地说，涉及能够制备光学纯的（S）-3-羟基-γ-丁内酯 通过以下方式经济地制备γ-丁内酯：（a）通过在天然产物中容易获得的支链淀粉与酶在特定条件下反应制备具有足够糖分布的α-（1,4）连接的寡糖; 和（b）在特定条件下依次进行氧化，酯化和环化。

    Process for manufacturing an optically active (S)-3,4-epoxybutyric acid salt
    5.
    发明授权
    Process for manufacturing an optically active (S)-3,4-epoxybutyric acid salt 失效
    制备光学活性（S）-3,4-环氧丁酸盐的方法

    公开(公告)号：US06284902B1

    公开(公告)日：2001-09-04

    申请号：US09744296

    申请日：2001-02-21

    申请人： Ho Sung Yu ,  Jae Young Bae ,  Yik Haeng Cho ,  Young Mi Park ,  Il Suk Byun

    发明人： Ho Sung Yu ,  Jae Young Bae ,  Yik Haeng Cho ,  Young Mi Park ,  Il Suk Byun

    IPC分类号： C07D30126

    CPC分类号： C07D303/38 ,  C07B2200/07

    摘要： This invention relates to a process for manufacturing an optically active (S)-3,4-epoxybutyric acid salt and more particularly, to a method for manufacturing (S)-3,4-epoxybutyric acid salt expressed by the following formula 1, wherein an optically active (S)-3-hydroxybutyrolactone is employed to undergo an economical ring-opening reaction and epoxvdation so that its chiral center is maintained in an original form, Wherein, R1 represents alkali metal atom, alkaline earth metal atom, alkylamine group or quarternary amine group.

    摘要翻译： 本发明涉及一种制备光学活性（S）-3,4-环氧丁酸盐的方法，更具体地说，涉及一种由下式1表示的（S）-3,4-环氧丁酸盐的制备方法，其中 使用光学活性（S）-3-羟基丁内酯进行经济的开环反应和环氧化，使得其手性中心保持原始形式，其中R1表示碱金属原子，碱土金属原子，烷基胺基或 季胺基。