摘要:
The invention relates to 4-[(3-ethynylphenyl)amino]-6,7-benzo-12-crown-quinazoline hydrochloride, its new crystalline forms, its therapeutic usage for treatment of diseases mediated by EGFR kinase and its combinatory therapeutic usage together with other therapeutic agents. The invention also provides synthetic methods for preparation of 4-[(3-ethynylphenyl)amino]-6,7-benzo-12-crown-quinazoline hydrochloride, its new crystalline forms, and the relevant synthetic intermediates for synthesis of 4-[(3-ethynylphenyl)amino]-6,7-benzo-12-crown-quinazoline hydrochloride.
摘要:
Provided is a glucagon-like peptide-1 (GLP-1) analogue shown as the following formula, wherein X is selected from glycine and glycinamide. The GLP-1 analogue has a non-proteogenic amino acid residue in position 8 relative to the sequence GLP-1, and is acylated with a moiety comprising two acidic groups to the lysine residue in position 26. The GLP-1 analogue is resistant to dipeptidyl peptidase IV so as to have an extended half-life in vivo. Also provided is a use of the GLP-1 analogue in conquering blood sugar.
摘要:
The invention relates to 4-[(3-ethynylphenyl)amino]-6,7-benzo-12-crown-quinazoline hydrochloride, its new crystalline forms, its therapeutic usage for treatment of diseases mediated by EGFR kinase and its combinatory therapeutic usage together with other therapeutic agents. The invention also provides synthetic methods for preparation of 4-[(3-ethynylphenyl)amino]-6,7-benzo-12-crown-quinazoline hydrochloride, its new crystalline forms, and the relevant synthetic intermediates for synthesis of 4-[(3-ethynylphenyl)amino]-6,7-benzo-12-crown-quinazoline hydrochloride.
摘要:
A high-temperature shutdown protecting relay comprises a base; a L copper pin and a N copper pin are provided on the base with resting contacts provided at their bottoms respectively; stretchy copper blades are provided on the base, which are fit to the L copper pin and the N copper pin respectively, with movable contacts provided thereon, which are fit to said resting contacts; a stand is provided on the base and above the stretchy copper blades; grooves are provided on the lower side of the stand with ceramic rods for insulating the stand from the stretchy copper blades embedded therein. The high-temperature shutdown protecting relay provided by the present utility model can keep normal operating property under high temperature. When the movable contacts and the resting contacts are engaged with each other, a larger locking force can be kept therebetween; when the movable contacts and the resting contacts are disengaged, there is a larger disengaging force to ensure these two kinds of contacts disengaged, and to ensure a certain disengaging interval therebetween and very quick disengaging time.
摘要:
The compound of Formula (I), pharmaceutically acceptable salts thereof, solvates thereof, chelates thereof, non-covalent complexes thereof or produgs of compounds mentioned above or the mixture of any form above mentioned are provided. The use of the compounds in manufacturing a medicament for the treatment and/or prevention of diabetes, obesity and related disorders.
摘要:
This invention relates to certain novel fused quinazoline derivatives (Formula I) as c-Met inhibitors which is shown as formula I, their synthesis and their use for treating a c-Met mediated disorder. More particularly, this invention is directed to fused heterocyclic derivatives useful inhibitors of c-Met, methods for producing such compounds and methods for treating as c-Met mediated disorder
摘要:
Provided is a glucagon-like peptide-1 (GLP-1) analog shown as the following formula, wherein X is selected from glycine and glycinamide. The GLP-1 analog has a non-proteogenic amino acid residue in position 8 relative to the sequence GLP-1, and is acylated with a moiety comprising two acidic groups to the lysine residue in position 26. The GLP-1 analog is resistant to dipeptidyl peptidase IV so as to have an extended half-life in vivo. Also provided is a use of the GLP-1 analog in conquering blood sugar.
摘要:
The polymorphic forms of the compound of Formula I, the preparation thereof including the preparation of the intermediates, the pharmaceutical compositions thereof and the uses of a polymorph above in the manufacture of medicaments for treating a disease, a disorder or a condition are disclosed.
摘要:
A high-temperature shutdown protecting relay comprises a base; a L copper pin and a N copper pin are provided on the base with resting contacts provided at their bottoms respectively; stretchy copper blades are provided on the base, which are fit to the L copper pin and the N copper pin respectively, with movable contacts provided thereon, which are fit to said resting contacts; a stand is provided on the base and above the stretchy copper blades; grooves are provided on the lower side of the stand with ceramic rods for insulating the stand from the stretchy copper blades embedded therein. The high-temperature shutdown protecting relay provided by the present utility model can keep normal operating property under high temperature. When the movable contacts and the resting contacts are engaged with each other, a larger locking force can be kept therebetween; when the movable contacts and the resting contacts are disengaged, there is a larger disengaging force to ensure these two kinds of contacts disengaged, and to ensure a certain disengaging interval therebetween and very quick disengaging time.
摘要:
The present invention relates to novel analogs of glucagon like peptide and compositions that are useful for up-regulating insulin expression in mammals and for treating diabetes. In particular, these peptide derivatives have a peptide mimic linker and provides long duration of action for the treatment of diabetes and other insulinotropic peptide related diseases, gastrointestinal function and activities associated with glucagon levels.