公开(公告)号：US07756311B2

公开(公告)日：2010-07-13

申请号：US11545270

申请日：2006-10-10

申请人： Yoshiaki Yasuno ,  Toyohiko Yatagai ,  Yasufumi Fukuma ,  Hisashi Tsukada ,  Tsutomu Kikawa ,  Hiroyuki Aoki ,  Takashi Fujimura

发明人： Yoshiaki Yasuno ,  Toyohiko Yatagai ,  Yasufumi Fukuma ,  Hisashi Tsukada ,  Tsutomu Kikawa ,  Hiroyuki Aoki ,  Takashi Fujimura

IPC分类号： G06K9/00 ,  G01B9/02

CPC分类号： G01N21/4795 ,  A61B3/102 ,  A61B3/145 ,  G01N2021/1787

摘要： An optical image measuring device which can form a highly reliable image even if an object moves during scanning of a signal light is provided. An optical image forming device 1 comprises: an interferometer that splits a low coherence light L0 into a signal light LS and a reference light LR and generates an interference light LC by overlaying the signal light LS reflected by a fundus oculi with the reference light LR reflected by a reference mirror 14; a CCD 34 which receives the interference light LC and outputs a detection signal; Galvanometer mirrors 22 and 23 to scan the signal light LS in a main scanning direction and a sub-scanning direction; and a computer 40 forming tomographic images G1 to Gm along the main scanning direction at different positions of the sub-scanning direction. The Galvanometer mirrors 22 and 23 scan the signal light LS in a given direction crossing the main scanning direction, and the computer 40 forms a tomographic image for correction GR along the given direction to correct displacement of each topographic image Gi based on the tomographic image for correction GR.

摘要翻译： 提供了即使在信号光的扫描期间物体移动时也可以形成高可靠性图像的光学图像测量装置。 光学图像形成装置1包括：干涉仪，其将低相干光L0分解成信号光LS和参考光LR，并通过将由眼底反射的信号光LS与反射的参考光LR重叠而产生干涉光LC 通过参考反射镜14; CCD34，其接收干涉光LC并输出检测信号; 电流计镜22和23在主扫描方向和副扫描方向扫描信号光LS; 以及在副扫描方向的不同位置沿着主扫描方向形成断层图像G1〜Gm的计算机40。 电流计反射镜22和23沿与主扫描方向相交的给定方向扫描信号光LS，并且计算机40沿着给定方向形成用于校正GR的断层图像，以校正基于断层图像的每个地形图像Gi的位移 校正GR。

公开(公告)号：US08879070B2

公开(公告)日：2014-11-04

申请号：US13375427

申请日：2010-06-07

申请人： Yoshiaki Yasuno ,  Shuichi Makita ,  Masahide Ito

发明人： Yoshiaki Yasuno ,  Shuichi Makita ,  Masahide Ito

IPC分类号： G01B11/02 ,  G01N21/47 ,  A61B3/10 ,  A61B3/12 ,  A61B5/00

CPC分类号： G01N21/4795 ,  A61B3/102 ,  A61B3/1233 ,  A61B5/0066

摘要： The scanning speed of a sample in Doppler OCT, etc., is increased to enable quick measurement of blood flow rate, blood flow volume, etc. Wideband light from a light source 2 is linearly polarized by a polarization controller 3 and this linearly polarized beam is split into vertically polarized light and horizontally polarized light using a Wollaston prism 14 at a sample arm, which are then irradiated simultaneously onto two different locations of the sample in the scanning direction using a galvanometer mirror 18, and reference light from a reference arm 5 and object light from a sample arm 6 are merged and caused to interfere with each other, with the resulting interference signal light passed through a diffraction grating 26 for spectroscopy, while the horizontal component and vertical component are separated by a polarized beam splitter 28, to simultaneously measure the components with two polarization-sensitive optical detectors 29, 30 and thereby obtain two tomography images of the same location at different times by one mechanical scan, thus allowing the amount of temporal change in phase to be measured using the two tomography images.

摘要翻译： 增加多普勒OCT等中的样本的扫描速度，以便能够快速测量血流量，血流量等。来自光源2的宽带光线被偏振控制器3线性偏振，并且该线偏振光束 使用样品臂上的渥拉斯顿棱镜14将其分为垂直偏振光和水平偏振光，然后使用检流计镜18将样品在扫描方向上的两个不同位置同时照射到参考臂5的参考光 并且来自样品臂6的物体的光合并并引起相互干扰，所得到的干涉信号光通过用于光谱的衍射光栅26，而水平分量和垂直分量被偏振分束器28分离， 同时用两个偏振敏感光学检测器29,30测量各部件，从而获得t的两个断层图像 通过一次机械扫描在不同时间相同的位置，从而允许使用两个断层摄影图像测量相位的时间变化量。

公开(公告)号：US20100142780A1

公开(公告)日：2010-06-10

申请号：US11545270

申请日：2006-10-10

申请人： Yoshiaki Yasuno ,  Toyohiko Yatagai ,  Yasufumi Fukuma ,  Hisashi Tsukada ,  Tsutomu Kikawa ,  Hiroyuki Aoki ,  Takashi Fujimura

发明人： Yoshiaki Yasuno ,  Toyohiko Yatagai ,  Yasufumi Fukuma ,  Hisashi Tsukada ,  Tsutomu Kikawa ,  Hiroyuki Aoki ,  Takashi Fujimura

IPC分类号： G06K9/00

CPC分类号： G01N21/4795 ,  A61B3/102 ,  A61B3/145 ,  G01N2021/1787

摘要： An optical image measuring device which can form a highly reliable image even if an object moves during scanning of a signal light is provided. An optical image forming device 1 comprises: an interferometer that splits a low coherence light L0 into a signal light LS and a reference light LR and generates an interference light LC by overlaying the signal light LS reflected by a fundus oculi with the reference light LR reflected by a reference mirror 14; a CCD 34 which receives the interference light LC and outputs a detection signal; Galvanometer mirrors 22 and 23 to scan the signal light LS in a main scanning direction and a sub-scanning direction; and a computer 40 forming tomographic images G1 to Gm along the main scanning direction at different positions of the sub-scanning direction. The Galvanometer mirrors 22 and 23 scan the signal light LS in a given direction crossing the main scanning direction, and the computer 40 forms a tomographic image for correction GR along the given direction to correct displacement of each topographic image Gi based on the tomographic image for correction GR.

摘要翻译： 提供了即使在信号光的扫描期间物体移动时也可以形成高可靠性图像的光学图像测量装置。 光学图像形成装置1包括：干涉仪，其将低相干光L0分解成信号光LS和参考光LR，并通过将由眼底反射的信号光LS与反射的参考光LR重叠而产生干涉光LC 通过参考反射镜14; CCD34，其接收干涉光LC并输出检测信号; 电流计镜22和23在主扫描方向和副扫描方向扫描信号光LS; 以及在副扫描方向的不同位置沿着主扫描方向形成断层图像G1〜Gm的计算机40。 电流计反射镜22和23沿与主扫描方向相交的给定方向扫描信号光LS，并且计算机40沿着给定方向形成用于校正GR的断层图像，以校正基于断层图像的每个地形图像Gi的位移 校正GR。

公开(公告)号：US09471277B2

公开(公告)日：2016-10-18

申请号：US14122228

申请日：2012-04-25

申请人： Yoshiaki Yasuno ,  Lian Duan ,  Masahide Ito

发明人： Yoshiaki Yasuno ,  Lian Duan ,  Masahide Ito

IPC分类号： G01B9/02 ,  G06F7/483 ,  A61B5/00 ,  G01N21/27 ,  G01N21/47 ,  A61B3/10

CPC分类号： G06F7/483 ,  A61B3/102 ,  A61B5/0066 ,  A61B5/7203 ,  G01B9/02011 ,  G01B9/02027 ,  G01B9/02044 ,  G01B9/0207 ,  G01B9/02088 ,  G01B9/02091 ,  G01B2290/45 ,  G01B2290/70 ,  G01N21/274 ,  G01N21/4795

摘要： Data measured by PS-OCT is corrected in a non-linear manner to enhance the quantitative analysis capability of PS-OCT and permit accurate quantitative diagnosis, including diagnosis of disease stage of lesions, as a useful means for computer diagnosis. Even when retardation per PS-OCT 1 contains error and becomes noise and its distribution is not normal or symmetrical around the true value, measured data is converted using a distribution conversion function obtained by analyzing the characteristics of noise via Monte Carlo simulation to remove the systematic error and estimate the true value otherwise buried in noise and thereby correct the PS-OCT 1 image more clearly.

摘要翻译： 通过PS-OCT测量的数据以非线性方式进行校正，以增强PS-OCT的定量分析能力，并允许准确的定量诊断，包括诊断病变的疾病阶段，作为计算机诊断的有用手段。 即使每PS-OCT1的延迟包含误差并且成为噪声，并且其分布在真实值附近不是正态或对称的，所以使用通过蒙特卡罗模拟分析噪声特征而获得的分布转换函数来转换测量数据，以去除系统 误差并估计其它的噪声中的真值，从而更清楚地校正PS-OCT 1图像。

公开(公告)号：US07823782B2

公开(公告)日：2010-11-02

申请号：US12085423

申请日：2006-11-22

申请人： Toyohiko Yatagai ,  Yoshiaki Yasuno ,  Masami Tamura

发明人： Toyohiko Yatagai ,  Yoshiaki Yasuno ,  Masami Tamura

IPC分类号： G06K7/10

CPC分类号： G01N21/4795 ,  A61B5/0062 ,  A61B5/0066 ,  A61B5/0088 ,  A61B5/7257 ,  A61C13/0004 ,  G01B9/02004 ,  G01B9/02007 ,  G01B9/0205 ,  G01B9/02088 ,  G01B9/02091 ,  G01B11/2441 ,  G01B2290/70

摘要： A dental optical coherence tomography apparatus for measuring tissue in a stomatognathic region of a living body or an artificial composition in the stomatognathic region as a measured object includes: a variable wavelength light source (15); a light splitting portion (19) that splits light-source light emitted from the variable wavelength light source (15) into reference light (29) and measuring light (28); an interference portion (19) that causes the measuring light (28) and the reference light (29) to interfere with each other, thereby generating interference light; a photodetection portion (41) that measures the interference light; and an arithmetic portion (27b) that generates an image of a measured object (22) by Fourier transforming or inverse Fourier transforming the intensity of the interference light, whose wavelength changes with time, that has been detected by the photodetection portion for each of the wavelengths. Accordingly, an optical coherence tomography apparatus applicable to dental measurement can be provided.

摘要翻译： 一种用于测量作为测量对象的口腔身体区域中的生物体的口腔特征区域中的组织或人造组合物的牙科用光学相干断层摄影装置，包括：可变波长光源（15）; 将从所述可变波长光源（15）发射的光源光分解为参考光（29）和测量光（28）的光分离部（19）; 使测量光（28）和参考光（29）彼此干涉的干涉部分（19），从而产生干涉光; 测量干涉光的光电检测部分（41）; 以及算术部（27b），其通过傅里叶变换或傅立叶逆变换波长随时间变化的波长随时间变化的干涉光的强度来生成测量对象（22）的图像，所述干涉光的强度由光电检测部分检测到 波长。 因此，可以提供适用于牙齿测量的光学相干断层摄影装置。

公开(公告)号：US07710577B2

公开(公告)日：2010-05-04

申请号：US11572803

申请日：2005-03-17

申请人： Toyohiko Yatagai ,  Yoshiaki Yasuno

发明人： Toyohiko Yatagai ,  Yoshiaki Yasuno

IPC分类号： G01B9/02 ,  G01B11/02

CPC分类号： G01B9/02044 ,  G01B9/02028 ,  G01B9/02078 ,  G01B9/02091 ,  G01B2290/70 ,  G01N21/4795

摘要： The present invention achieves multiplexing spectrum interference optical coherence tomography capable of full-range OCT measurement that causes no delays in measurement time due to high-order scans and is also free from complex conjugated images. This multiplexing spectrum interference optical coherence tomography comprises: a first beam splitter 3 positioned in an optical path 2 from a light source 1 and used to separate an object light 4 and a reference light 5; a galvano mirror 6 positioned in the optical path of the object light 4 and used to scan the object light onto a measured object 8; a second beam splitter 10 positioned in the optical path of the reference light 5; a first reference mirror 12 positioned in the optical path of a first reference light 11 separated by the second beam splitter 10; a second reference mirror 15 positioned in the optical path of a second reference light 13 separated by the second beam splitter 10; and a chopper 16 that passes the first reference light 11 and second reference light 13 alternately.

摘要翻译： 本发明实现了能够进行全范围OCT测量的复用频谱干涉光学相干断层摄影，其不会由于高阶扫描而导致测量时间的延迟，并且也没有复杂的共轭图像。 该多路复用频谱干涉光学相干断层摄影包括：第一分束器3，其位于光源1的光路2中，用于分离物体光4和基准光5; 位于物体光4的光路中并用于将物体光扫描到测量对象8上的电流镜6; 位于参考光5的光路中的第二分束器10; 位于由第二分束器10分离的第一参考光11的光路中的第一参考反射镜12; 位于由第二分束器10分离的第二参考光13的光路中的第二参考镜15; 以及交替地使第一基准光11和第二参照光13通过的斩波器16。

公开(公告)号：US20090079993A1

公开(公告)日：2009-03-26

申请号：US12085423

申请日：2006-11-22

申请人： Toyohiko Yatagai ,  Yoshiaki Yasuno ,  Masami Tamura

发明人： Toyohiko Yatagai ,  Yoshiaki Yasuno ,  Masami Tamura

IPC分类号： G01B11/02

CPC分类号： G01N21/4795 ,  A61B5/0062 ,  A61B5/0066 ,  A61B5/0088 ,  A61B5/7257 ,  A61C13/0004 ,  G01B9/02004 ,  G01B9/02007 ,  G01B9/0205 ,  G01B9/02088 ,  G01B9/02091 ,  G01B11/2441 ,  G01B2290/70

摘要： A dental optical coherence tomography apparatus for measuring tissue in a stomatognathic region of a living body or an artificial composition in the stomatognathic region as a measured object includes: a variable wavelength light source (15); a light splitting portion (19) that splits light-source light emitted from the variable wavelength light source (15) into reference light (29) and measuring light (28); an interference portion (19) that causes the measuring light (28) and the reference light (29) to interfere with each other, thereby generating interference light; a photodetection portion (41) that measures the interference light; and an arithmetic portion (27b) that generates an image of a measured object (22) by Fourier transforming or inverse Fourier transforming the intensity of the interference light, whose wavelength changes with time, that has been detected by the photodetection portion for each of the wavelengths. Accordingly, an optical coherence tomography apparatus applicable to dental measurement can be provided.

摘要翻译： 一种用于测量作为测量对象的口腔身体区域中的生物体的口腔特征区域中的组织或人造组合物的牙科用光学相干断层摄影装置，包括：可变波长光源（15）; 将从所述可变波长光源（15）发射的光源光分解为参考光（29）和测量光（28）的光分离部（19）; 使测量光（28）和参考光（29）彼此干涉的干涉部分（19），从而产生干涉光; 测量干涉光的光电检测部分（41）; 以及算术部（27b），其通过傅里叶变换或傅立叶逆变换波长随时间变化的波长随时间变化的干涉光的强度来生成测量对象（22）的图像，所述干涉光的强度由光电检测部分检测到 波长。 因此，可以提供适用于牙齿测量的光学相干断层摄影装置。

公开(公告)号：US20080002183A1

公开(公告)日：2008-01-03

申请号：US11572803

申请日：2005-03-17

申请人： Toyohiko Yatagai ,  Yoshiaki Yasuno

发明人： Toyohiko Yatagai ,  Yoshiaki Yasuno

IPC分类号： G01N21/00 ,  G01B9/02 ,  G01J3/28

CPC分类号： G01B9/02044 ,  G01B9/02028 ,  G01B9/02078 ,  G01B9/02091 ,  G01B2290/70 ,  G01N21/4795

摘要： The present invention achieves multiplexing spectrum interference optical coherence tomography capable of full-range OCT measurement that causes no delays in measurement time due to high-order scans and is also free from complex conjugated images. This multiplexing spectrum interference optical coherence tomography comprises: a first beam splitter 3 positioned in an optical path 2 from a light source 1 and used to separate an object light 4 and a reference light 5; a galvano mirror 6 positioned in the optical path of the object light 4 and used to scan the object light onto a measured object 8; a second beam splitter 10 positioned in the optical path of the reference light 5; a first reference mirror 12 positioned in the optical path of a first reference light 11 separated by the second beam splitter 10; a second reference mirror 15 positioned in the optical path of a second reference light 13 separated by the second beam splitter 10; and a chopper 16 that passes the first reference light 11 and second reference light 13 alternately.

摘要翻译： 本发明实现了能够进行全范围OCT测量的复用频谱干涉光学相干断层摄影，其不会由于高阶扫描而导致测量时间的延迟，并且也没有复杂的共轭图像。 该多路复用频谱干涉光学相干断层摄影包括：第一分束器3，其位于光源1的光路2中，用于分离物体光4和基准光5; 位于物体光4的光路中并用于将物体光扫描到测量对象8上的电流镜6; 位于参考光5的光路中的第二分束器10; 位于由第二分束器10分离的第一参考光11的光路中的第一参考反射镜12; 位于由第二分束器10分离的第二参考光13的光路中的第二参考镜15; 以及交替地使第一基准光11和第二参照光13通过的斩波器16。

公开(公告)号：US20120120408A1

公开(公告)日：2012-05-17

申请号：US13375427

申请日：2010-06-07

申请人： Yoshiaki Yasuno ,  Shuichi Makita ,  Masahide Ito

发明人： Yoshiaki Yasuno ,  Shuichi Makita ,  Masahide Ito

IPC分类号： G01B9/02

CPC分类号： G01N21/4795 ,  A61B3/102 ,  A61B3/1233 ,  A61B5/0066

摘要： The scanning speed of a sample in Doppler OCT, etc., is increased to enable quick measurement of blood flow rate, blood flow volume, etc. Wideband light from a light source 2 is linearly polarized by a polarization controller 3 and this linearly polarized beam is split into vertically polarized light and horizontally polarized light using a Wollaston prism 14 at a sample arm, which are then irradiated simultaneously onto two different locations of the sample in the scanning direction using a galvanometer mirror 18, and reference light from a reference arm 5 and object light from a sample arm 6 are merged and caused to interfere with each other, with the resulting interference signal light passed through a diffraction grating 26 for spectroscopy, while the horizontal component and vertical component are separated by a polarized beam splitter 28, to simultaneously measure the components with two polarization-sensitive optical detectors 29, 30 and thereby obtain two tomography images of the same location at different times by one mechanical scan, thus allowing the amount of temporal change in phase to be measured using the two tomography images.

摘要翻译： 增加多普勒OCT等中的样本的扫描速度，以便能够快速测量血流量，血流量等。来自光源2的宽带光线被偏振控制器3线性偏振，并且该线偏振光束 使用样品臂上的渥拉斯顿棱镜14将其分为垂直偏振光和水平偏振光，然后使用检流计镜18将样品在扫描方向上的两个不同位置同时照射到参考臂5的参考光 并且来自样品臂6的物体的光合并并引起相互干扰，所得到的干涉信号光通过用于光谱的衍射光栅26，而水平分量和垂直分量被偏振分束器28分离， 同时用两个偏振敏感光学检测器29,30测量各部件，从而获得t的两个断层图像 通过一次机械扫描在不同时间相同的位置，从而允许使用两个断层摄影图像测量相位的时间变化量。