公开(公告)号：US10654892B2

公开(公告)日：2020-05-19

申请号：US13877768

申请日：2011-10-04

申请人： Haruo Sugiyama ,  Shinji Sogo ,  Masayoshi Sato ,  Ryuki Kitamoto ,  Yoshihiro Goto

发明人： Haruo Sugiyama ,  Shinji Sogo ,  Masayoshi Sato ,  Ryuki Kitamoto ,  Yoshihiro Goto

IPC分类号： A61K39/00 ,  C12N5/0783 ,  C07K7/08 ,  C07K14/82 ,  A61K35/17

摘要： The present invention relates to a method for activating helper T cells, which includes the step of activating helper T cells by adding a WT1 peptide to antigen presenting cells, wherein the WT1 peptide has the ability to bind to any MHC class II molecule of an HLA-DRB1*0101 molecule, an HLA-DRB1*0401 molecule, an HLA-DRB1*0403 molecule, an HLA-DRB1*0406 molecule, an HLA-DRB1*0803 molecule, an HLA-DRB1*0901 molecule, an HLA-DRB1*1101 molecule, an HLA-DRB3*0202 molecule, an HLA-DRB4*0101 molecule, an HLA-DPB1*0201 molecule or an HLA-DPB1*0301 molecule, and the like.

公开(公告)号：US08953865B2

公开(公告)日：2015-02-10

申请号：US13985758

申请日：2012-02-29

申请人： Yoshihiro Goto

发明人： Yoshihiro Goto

IPC分类号： G06K9/00 ,  G06T7/00 ,  G06T19/00 ,  G06T1/00 ,  A61B5/00 ,  A61B5/055 ,  A61B6/03 ,  A61B6/00

CPC分类号： G06T7/0012 ,  A61B5/004 ,  A61B5/055 ,  A61B5/4514 ,  A61B5/7425 ,  A61B5/7435 ,  A61B6/032 ,  A61B6/505 ,  G06T1/0007 ,  G06T19/00 ,  G06T2210/41 ,  G06T2219/008

摘要： Provided is, for example, a medical image display device which automatically create and display an image suitable for radiographic image interpretation of interosseous tissue or a 3-dimensional image of a vertebral body separated one by one with high precision. A medical image processing device (1) creates a first conversion image (in step (S1)), extracts a first intervertebral disc region from the first conversion image (in step (S2)), and specifies two coordinates (P1, P2) from among the pixels included in the first intervertebral disc region (in step (S3)). Next, the medical image processing device (1) creates a second conversion image (in step (S4)), extracts a second intervertebral disc region (in step (S5)), and specifies two coordinates (Q1, Q2) from the second intervertebral disc region (in step (S6)). Next, the medical image processing device (1) calculates a reference curved surface including at least four feature points of the coordinates (P1, P2, Q1, Q2) on a per intervertebral disc basis and, based on the reference curved surface, creates a display image (in step (S7)), and displays the display image (in step (S8)).

摘要翻译： 例如，提供了自动创建和显示适合于骨间组织的放射照相图像解释的图像或者以高精度逐个分离的椎体的3维图像的医学图像显示装置。 医疗图像处理装置（1）创建第一转换图像（步骤（S1）），从第一转换图像提取第一椎间盘区域（步骤（S2）），并且从两个坐标（P1，P2） 包括在第一椎间盘区域中的像素之中（步骤（S3））。 接下来，医疗用图像处理装置（1）创建第二转换图像（步骤（S4）），提取第二椎间盘区域（步骤（S5）），并从第二椎间盘指定两个坐标（Q1，Q2） 盘区域（步骤（S6））。 接下来，医疗用图像处理装置（1）在每个椎间盘基础上计算包括坐标（P1，P2，Q1，Q2）的至少四个特征点的基准曲面，并且基于参考曲面， 显示图像（步骤（S7）），并显示显示图像（步骤（S8））。

公开(公告)号：US08792698B2

公开(公告)日：2014-07-29

申请号：US12919129

申请日：2009-02-16

申请人： Yoshihiro Goto ,  Tetsuo Nakazawa ,  Kuniyoshi Nakashima

发明人： Yoshihiro Goto ,  Tetsuo Nakazawa ,  Kuniyoshi Nakashima

IPC分类号： G06T7/00 ,  G09G5/377

CPC分类号： G06T7/0012 ,  G06T2207/10072 ,  G06T2207/10132 ,  G06T2207/30004

摘要： Provided is a medical image processing device including: medical image information acquisition unit which acquires medical image information indicating a tomographic image of an object to be examined; evaluation region extraction unit which extracts an evaluation region for each of the tissues contained in the acquired medical image information according to a pixel value, a concentration value, or a luminance value for each of the tissues; and evaluation region display unit which displays the evaluation region on a display device.

摘要翻译： 本发明提供一种医疗用图像处理装置，包括：医用图像信息获取单元，其获取表示被检查物体的断层图像的医学图像信息; 评估区域提取单元，其根据每个组织的像素值，浓度值或亮度值提取所获取的医学图像信息中包含的每个组织的评估区域; 以及在显示装置上显示评价区域的评价区域显示单元。

公开(公告)号：US08697793B2

公开(公告)日：2014-04-15

申请号：US12727792

申请日：2010-03-19

申请人： Yoshihiro Goto

发明人： Yoshihiro Goto

IPC分类号： C08K5/01

CPC分类号： C08L9/06 ,  B60C1/0016 ,  C08K3/04 ,  C08K3/36 ,  C08L21/00 ,  C08L57/02 ,  C08L2666/04

摘要： A rubber composition for use in tires is described which provides increased fuel efficiency and improved wet grip performance. The rubber composition includes from 5 to 70 parts by mass of silica having a BET specific surface area from 50 to 200 m2/g per 100 parts by mass of a diene rubber. The rubber composition includes from 1 to 25 parts by mass of an aromatic modified terpene resin and at least one terpene per 100 parts by mass of a diene rubber. The rubber composition further includes from 1 to 70 parts by mass of a naphthenic oil per 100 parts by mass of a diene rubber, where a CN % proportion of a CA %·CP %·CN % ratio calculated according to ASTM D2140/ASTM D3238 is the greatest and the CA % proportion is less than 15%, and a dynamic viscosity at 40° C. is from 17 to 30 mm2/sec.

摘要翻译： 描述了一种用于轮胎的橡胶组合物，其提供了增加的燃料效率和改进的湿抓地性能。 橡胶组合物包含5〜70质量份的每100质量份二烯橡胶的BET比表面积为50〜200m 2 / g的二氧化硅。 橡胶组合物包含1至25质量份芳族改性萜烯树脂和至少一种萜烯/ 100质量份二烯橡胶。 橡胶组合物还包含每100质量份二烯橡胶1〜70质量份环烷油，其中CN％比例根据ASTM D2140 / ASTM D3238计算的CA％·CP％·CN％比 是最大的，CA％的比例小于15％，40℃下的动态粘度为17〜30mm 2 /秒。

公开(公告)号：US08385622B2

公开(公告)日：2013-02-26

申请号：US12670604

申请日：2008-07-23

申请人： Yoshihiro Goto ,  Tetsuo Nakazawa ,  Tetsushi Honda

发明人： Yoshihiro Goto ,  Tetsuo Nakazawa ,  Tetsushi Honda

IPC分类号： G06K9/00

CPC分类号： G06T7/0012 ,  G06T2207/10081 ,  G06T2207/30061

摘要： An image diagnostic support device is configured to acquire a tomographic image including a lung region of an object to be examined and is provided with image display to display the tomographic image. The device is also configured to set up a measurement range, extract the chest wall from the image in the set measurement range, extract a thickened portion incidental to the chest wall in the measurement range, and measure the thickness of a thickened portion at each position in the measurement range.

摘要翻译： 图像诊断支持装置被配置为获取包括待检查对象的肺区域的断层图像，并且设置有用于显示断层图像的图像显示。 该装置还被配置成设置测量范围，在设定的测量范围内从图像中提取胸壁，在测量范围内提取附在胸壁上的加厚部分，并测量每个位置处的加厚部分的厚度 在测量范围内。

公开(公告)号：US08326013B2

公开(公告)日：2012-12-04

申请号：US12993337

申请日：2009-05-18

申请人： Yoshihiro Goto

发明人： Yoshihiro Goto

IPC分类号： G06K9/40

CPC分类号： A61B6/032 ,  A61B6/463 ,  G06T5/002 ,  G06T5/20 ,  G06T2200/24 ,  G06T2207/10081 ,  G06T2207/10116 ,  G06T2207/20076 ,  G06T2207/30061

摘要： A technique is disclosed for reducing noise in a medical image, wherein plural anisotropic areas continuous with a pixel-of-interest contained in the medical image are set with the pixel-of-interest being centered a statistical amount of pixel values of pixels constituting each anisotropic area is calculated with respect to each of the plural anisotropic areas, and either an anisotropic area having the minimum statistical amount out of the plural anisotropic areas is determined and an anisotropic shape filter in the same direction as the anisotropic area concerned is constructed, or an anisotropic area having the maximum statistical amount out of the plural anisotropic areas is determined and an anisotropic shape filter is constructed by clockwise or counterclockwise rotating the anisotropic area concerned around the pixel-of-interest by 90° .

摘要翻译： 公开了一种用于降低医学图像中的噪声的技术，其中，将包含在医学图像中的与感兴趣像素连续的多个各向异性区域设置为感兴趣像素以构成每个像素的像素的像素值的统计量为中心 对于多个各向异性区域中的每一个区域计算各向异性面积，并且确定在多个各向异性区域中具有最小统计量的各向异性区域，并且构建与各向异性区域相同方向的各向异性形状滤波器，或 确定在多个各向异性区域中具有最大统计量的各向异性区域，并且通过将感兴趣像素周围的各向异性区域顺时针或逆时针旋转90°来构造各向异性形状滤波器。

公开(公告)号：US08027524B2

公开(公告)日：2011-09-27

申请号：US11795486

申请日：2006-01-18

申请人： Toshihiro Ogura ,  Yoshihiro Goto

发明人： Toshihiro Ogura ,  Yoshihiro Goto

IPC分类号： G06K9/00

CPC分类号： A61B6/032 ,  A61B5/4872 ,  G06F19/00 ,  Y10S128/922

摘要： An image diagnosis support apparatus according to the invention comprises an adipose distribution data computing device which figures out adipose distribution data measured of a desired site in a subject from at least one medical image; an abnormal shadow candidate detecting device which detects an abnormal shadow candidate based on the figured-out adipose distribution data; and a display device which displays the abnormal shadow candidate detected by the abnormal shadow candidate detecting device and the medical image in a manner of being related to each other.

摘要翻译： 根据本发明的图像诊断支持装置包括脂肪分布数据计算装置，其从至少一个医学图像中计算被检体中期望部位测量的脂肪分布数据; 异常阴影候选检测装置，其基于所计算出的脂肪分布数据检测异常阴影候选; 以及显示装置，其以彼此相关的方式显示由异常阴影候选检测装置和医学图像检测到的异常阴影候选。

公开(公告)号：US20110226395A1

公开(公告)日：2011-09-22

申请号：US12727792

申请日：2010-03-19

申请人： Yoshihiro Goto

发明人： Yoshihiro Goto

IPC分类号： B60C11/00 ,  C08K3/36

CPC分类号： C08L9/06 ,  B60C1/0016 ,  C08K3/04 ,  C08K3/36 ,  C08L21/00 ,  C08L57/02 ,  C08L2666/04

摘要： A rubber composition for use in tires is described which provides increased fuel efficiency and improved wet grip performance. The rubber composition includes from 5 to 70 parts by mass of silica having a BET specific surface area from 50 to 200 m2/g per 100 parts by mass of a diene rubber. The rubber composition includes from 1 to 25 parts by mass of an aromatic modified terpene resin and at least one terpene per 100 parts by mass of a diene rubber. The rubber composition further includes from 1 to 70 parts by mass of a naphthenic oil per 100 parts by mass of a diene rubber, where a CN % proportion of a CA %·CP %·CN % ratio calculated according to ASTM D2140/ASTM D3238 is the greatest and the CA % proportion is less than 15%, and a dynamic viscosity at 40° C. is from 17 to 30 mm2/sec.

摘要翻译： 描述了一种用于轮胎的橡胶组合物，其提供了增加的燃料效率和改进的湿抓地性能。 橡胶组合物包含5〜70质量份的每100质量份二烯橡胶的BET比表面积为50〜200m 2 / g的二氧化硅。 橡胶组合物包含1至25质量份芳族改性萜烯树脂和至少一种萜烯/ 100质量份二烯橡胶。 橡胶组合物还包含每100质量份二烯橡胶1〜70质量份环烷油，其中CN％比例根据ASTM D2140 / ASTM D3238计算的CA％·CP％·CN％比 是最大的，CA％的比例小于15％，40℃下的动态粘度为17〜30mm 2 /秒。

公开(公告)号：US07940975B2

公开(公告)日：2011-05-10

申请号：US11658617

申请日：2005-07-28

申请人： Kuniyoshi Nakashima ,  Yoshihiro Goto

发明人： Kuniyoshi Nakashima ,  Yoshihiro Goto

IPC分类号： G06K9/00

CPC分类号： G06T7/0014 ,  A61B5/055 ,  A61B6/032 ,  A61B6/463 ,  G06T7/11 ,  G06T2207/10072 ,  G06T2207/30061

摘要： A medical image diagnosing support method is provided that includes a site region extracting step for obtaining a tomographic image which is picked up by a medical diagnostic imaging apparatus and extracting a predetermined site region from the obtained tomographic image, a first region extracting step for extracting a first lesion candidate region from the site region based on pixel values of the site region extracted in the predetermined site region extracting step, a second region extracting step for extracting a second lesion candidate region from the site region based on a distribution of the pixel values of the site region extracted in the predetermined site region extracting step, and a region correcting step for correcting the first lesion candidate region extracted in the first region extracting step by using the second lesion candidate region extracted in the second region extracting step.

摘要翻译： 提供一种医疗图像诊断支援方法，其包括：站点区域提取步骤，用于获取由医疗诊断摄像装置拾取的断层图像，并从所获得的断层图像中提取预定的位置区域;第一区域提取步骤， 基于在所述预定位置区域提取步骤中提取的位点区域的像素值，从所述位置区域的第一病变候选区域，基于所述位置区域提取步骤的像素值的分布从所述位置区域提取第二病变候选区域的第二区域提取步骤; 在预定位置区域提取步骤中提取的位点区域，以及区域校正步骤，用于通过使用在第二区域提取步骤中提取的第二病变候选区域来校正在第一区域提取步骤中提取的第一病变候选区域。

公开(公告)号：US20110002522A1

公开(公告)日：2011-01-06

申请号：US12919129

申请日：2009-02-16

申请人： Yoshihiro Goto ,  Tetsuo Nakazawa ,  Kuniyoshi Nakashima

发明人： Yoshihiro Goto ,  Tetsuo Nakazawa ,  Kuniyoshi Nakashima

IPC分类号： G06T7/00 ,  G09G5/377

CPC分类号： G06T7/0012 ,  G06T2207/10072 ,  G06T2207/10132 ,  G06T2207/30004

摘要： Provided is a medical image processing device including: medical image information acquisition means which acquires medical image information indicating a tomographic image of an object to be examined; evaluation region extraction means which extracts an evaluation region for each of the tissues contained in the acquired medical image information according to a pixel value, a concentration value, or a luminance value for each of the tissues; and evaluation region display means which displays the evaluation region on a display device.

摘要翻译： 本发明提供一种医疗用图像处理装置，包括：医用图像信息取得单元，取得表示被检查物的断层图像的医用图像信息; 评估区域提取装置，其根据每个组织的像素值，浓度值或亮度值提取所获取的医学图像信息中包含的每个组织的评估区域; 以及在显示装置上显示评价区域的评价区域显示单元。