6-alkylamino-2,2′-disubstituted-7,8-disubstituted-2H-1-benzopyran derivatives as 5-lipoxygenase inhibitor

    公开(公告)号:US07368575B2

    公开(公告)日:2008-05-06

    申请号:US10970046

    申请日:2004-10-20

    IPC分类号: C07D311/00 C07D405/00

    摘要: When a multi-step process reaction is carried out in a solution, it generally requires several treatments and purification procedures to go through with after the reaction, however, the inventive method for preparing 2,2′-disubstituted-3,4-dihydro-7,8-disubstituted-6-amino benzopyran derivative using a solid-phased synthetic method simplifies the treatment and purification procedures after the reaction, which makes possible to efficiently construct numerous drug-like libraries. In particular, since the inventive method of the present invention comprises the steps of introducing a carbonate linker of formula 2 into Wang resin used as a common solid support (Step 1); synthesizing various benzopyran in a carbamate form of formula 3 as a key intermediate by reacting various amino benzopyran derivatives with the carbamate resin of formula 2 (Step 2); synthesizing 2,2′-disubstituted-3,4-2H-6-substituted benzopyran resin of formula 4 (Step 3); and synthesizing 2,2′-disubstituted-3,4-2H-6-alkylamino benzopyran derivative of formula 1 using a dichloromethane solution containing TFA or an organic solvent containing an organic acid, the inventive method is capable of efficiently synthesizing various 2,2′-disubstituted-3,4-2H-6-alkylamino benzopyran derivatives.Consequently, the present invention has developed a new technique for constructing 2,2′-disubstituted-3,4-2H-6-alkylamino benzopyran library using a solid-phase parallel synthetic method and makes increased the applicability of combinatorial chemical synthetic method. Further, 2,2′-disubstituted-3,4-2H-6-alkylamino benzopyran derivative prepared by the inventive method has a high inhibitory effect to 5-lipoxygenase (5-LO) activity, and therefore, can be effectively used for developing a new propylactic or therapeutic drug for leukotriene activation-related diseases such as chronic inflammation, rheumatic arthritis, colitis, asthma and psoriasis.

    Hydraulic pump controller for construction machine
    6.
    发明授权
    Hydraulic pump controller for construction machine 有权
    施工机械液压泵控制器

    公开(公告)号:US08707690B2

    公开(公告)日:2014-04-29

    申请号:US13141583

    申请日:2009-12-23

    IPC分类号: F16D31/02

    摘要: A hydraulic pump controlling apparatus of a construction machine according to the present disclosure includes: a hydraulic pump in which a swash plate angle is controlled to control a discharge flow; an auxiliary pump; a control valve controlling a flowing direction of a fluid discharged from the hydraulic pump and selectively supplying the fluid to an actuator; an orifice and a relief valve connected between a center bypass line of the control valve and a tank T to be parallel to each other; signal pressure selecting units receiving a fluid passing through the center bypass line of the control valve and a fluid discharged from the auxiliary pump, and selecting the pressure of any one of the fluids as a signal pressure; and a regulator receiving the signal pressure selected from the signal pressure selecting units to control the swash plate angle of the hydraulic pump, and the signal pressure selecting unit selects the pressure of the fluid discharged from the auxiliary pump as the signal pressure and transfers the selected pressure to the regulator when the construction machine is in an idle state.

    摘要翻译: 根据本公开的施工机械的液压泵控制装置包括:液压泵,其中控制斜盘角度以控制排出流; 辅助泵 控制阀,控制从液压泵排出的流体的流动方向,并选择性地将流体供应到致动器; 连接在所述控制阀的中心旁路管路和箱体T之间以彼此平行的孔口和安全阀; 信号压力选择单元,其接收通过所述控制阀的中心旁路管路的流体和从所述辅助泵排出的流体,并且将所述流体中的任一个的压力选择为信号压力; 接收从信号压力选择单元选择的信号压力的调节器,控制液压泵的斜板角度,信号压力选择单元选择从辅助泵排出的流体的压力作为信号压力,并将所选择的 当施工机器处于空闲状态时对调压器施压。

    Method and apparatus for measuring the three-dimensional shape of an object using a moire equipment
    7.
    发明授权
    Method and apparatus for measuring the three-dimensional shape of an object using a moire equipment 有权
    使用莫尔设备测量物体的三维形状的方法和装置

    公开(公告)号:US06873421B2

    公开(公告)日:2005-03-29

    申请号:US10181679

    申请日:2001-10-31

    IPC分类号: H04N13/00 G01B11/25 G01B11/24

    CPC分类号: G01B11/2527

    摘要: An apparatus and method for measuring a three-dimensional shape of an object using a projection moiré device. The method comprises the steps of obtaining a grid pattern image projected on a reference plane of a moving table and applying a buckets algorithm thereto, thereby achieving a reference phase, obtaining a grid pattern image projected on the object set on the moving table and applying a buckets algorithm thereto, thereby achieving an object phase, calculating a difference phase between the object phase and the reference phase, thereby achieving a moiré phase, and unwrapping the moiré phase, thereby achieving a level information of the object. The apparatus and method measure the three-dimensional shape using a projection grid without a reference grid, thereby achieving compactness of equipment, simplicity in usage and manufacturing cost reduction.

    摘要翻译: 一种使用投影莫尔装置测量物体的三维形状的装置和方法。 该方法包括以下步骤:获得投影在移动台的参考平面上的网格图案图像并对其施加桶算法,从而实现参考相位,获得投影在移动台上的对象上的网格图案图像, 从而实现物体相位,计算物体相位与参考相位之间的差分相位,从而实现莫尔相位,并且展开莫尔相位,从而实现物体的等级信息。 该装置和方法使用没有参考网格的投影网格来测量三维形状,从而实现设备的紧凑性,使用简单性和制造成本降低。

    HYDRAULIC PUMP CONTROLLER FOR CONSTRUCTION MACHINE
    8.
    发明申请
    HYDRAULIC PUMP CONTROLLER FOR CONSTRUCTION MACHINE 有权
    液压泵控制器

    公开(公告)号:US20110262287A1

    公开(公告)日:2011-10-27

    申请号:US13141583

    申请日:2009-12-23

    IPC分类号: F04B49/00

    摘要: A hydraulic pump controlling apparatus of a construction machine according to the present disclosure includes: a hydraulic pump in which a swash plate angle is controlled to control a discharge flow; an auxiliary pump; a control valve controlling a flowing direction of a fluid discharged from the hydraulic pump and selectively supplying the fluid to an actuator; an orifice and a relief valve connected between a center bypass line of the control valve and a tank T to be parallel to each other; signal pressure selecting units receiving a fluid passing through the center bypass line of the control valve and a fluid discharged from the auxiliary pump, and selecting the pressure of any one of the fluids as a signal pressure; and a regulator receiving the signal pressure selected from the signal pressure selecting units to control the swash plate angle of the hydraulic pump, and the signal pressure selecting unit selects the pressure of the fluid discharged from the auxiliary pump as the signal pressure and transfers the selected pressure to the regulator when the construction machine is in an idle state.

    摘要翻译: 根据本公开的施工机械的液压泵控制装置包括:液压泵,其中控制斜盘角度以控制排出流量; 辅助泵 控制阀,控制从液压泵排出的流体的流动方向,并选择性地将流体供应到致动器; 连接在所述控制阀的中心旁路管路和箱体T之间以彼此平行的孔口和安全阀; 信号压力选择单元,其接收通过所述控制阀的中心旁路管路的流体和从所述辅助泵排出的流体,并且将所述流体中的任一个的压力选择为信号压力; 接收从信号压力选择单元选择的信号压力的调节器,控制液压泵的斜板角度,信号压力选择单元选择从辅助泵排出的流体的压力作为信号压力,并将所选择的 当施工机器处于空闲状态时对调压器施压。