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公开(公告)号:US11834406B2
公开(公告)日:2023-12-05
申请号:US16539342
申请日:2019-08-13
发明人: R. Yongxin Zhao , Yue Zhang , Yourang Ma
IPC分类号: C07D207/40 , A61K45/06 , A61K47/64 , A61K47/68
CPC分类号: C07D207/40 , A61K45/06 , A61K47/64 , A61K47/6803 , A61K47/6811 , A61K47/6849 , A61K47/6851 , A61K47/6855 , A61K47/6863 , A61K47/6867 , Y02A50/30
摘要: A conjugate of a potent cytotoxic agent with a cell-surface receptor binding molecule having a Formula (I), wherein T, L, m, n, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R1, R12, and R13 are defined herein, can be used for targeted treatment of cancer, autoimmune disease, and infectious disease.
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公开(公告)号:US20230020152A1
公开(公告)日:2023-01-19
申请号:US17948116
申请日:2022-09-19
申请人: Yue Zhang
发明人: Yue Zhang
IPC分类号: F28D15/04
摘要: A plate vapor chamber array assembly with a plurality of plate vapor chambers joined in an array and each chamber having an evaporation area and an evacuated sealed chamber. The plate vapor chambers may be in direct contact with adjacent plate vapor chambers. A vapor chamber clamp surrounding the array has an inner surface engaging an outer edge of at least two of the plate vapor chambers of the array to press a surface of the plate vapor chamber array directly against the heat source.
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公开(公告)号:US20200172480A1
公开(公告)日:2020-06-04
申请号:US16782456
申请日:2020-02-05
发明人: R. Yongxin ZHAO , Yue ZHANG , Yourang MA
IPC分类号: C07D207/40 , A61K47/68 , A61K45/06 , A61K47/64
摘要: A conjugate of a potent cytotoxic agent with a cell-binding molecule having a structure represented by Formula (I), wherein T, L, m, n, , R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, and R13 are as defined herein, can be used for targeted treatment of cancer, autoimmune disease, and infectious disease.
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公开(公告)号:US20180021448A9
公开(公告)日:2018-01-25
申请号:US14253881
申请日:2014-04-16
发明人: R. Yongxin Zhao , Yue Zhang , Yourang Ma
IPC分类号: A61K45/06
CPC分类号: C07D207/40 , A61K45/06 , A61K47/64 , A61K47/6803 , A61K47/6811 , A61K47/6849 , A61K47/6851 , A61K47/6855 , A61K47/6863 , A61K47/6867 , Y02A50/412 , Y02A50/416
摘要: A conjugate of a potent cytotoxic agent with a cell-surface receptor binding molecule having a Formula (I), wherein T, L, m, n, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, and R13 are defined herein, can be used for targeted treatment of cancer, autoimmune disease, and infectious disease.
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公开(公告)号:US09618418B2
公开(公告)日:2017-04-11
申请号:US14541353
申请日:2014-11-14
申请人: Yue Zhang , Hao Ming Chang
发明人: Yue Zhang , Hao Ming Chang
CPC分类号: G01M3/2807 , F17D5/02 , G01F1/00 , G01F25/0007
摘要: Disclosed is a leakage detection system (200) and a leakage detection method for detecting leakage in a gas supply system (10′) comprising a gas source (11; 12) connected to a gas delivery module (14) by a pipeline. The leakage detection system (200) comprises a flow meter (113) connectable along the pipeline remotely from an inlet of the gas delivery module (14); and a detection module (110) configured to receive signals representing a measured flow rate from the flow meter (113), and to compare the measured flow rate (115) to a stored leakage-free reference value (116) to detect an increase in flow rate in the presence of a leak. A flow resistance between the detection module (110) and an outlet of the gas delivery module (14) amplifies the increase in flow rate in the presence of a leak. The system (200) may comprise a flow rate elevation system (121) connectable between the gas source (11; 12) and the flow meter (113) for temporarily increasing the flow rate in the pipeline.
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6.
公开(公告)号:US09539246B2
公开(公告)日:2017-01-10
申请号:US14241720
申请日:2012-08-29
IPC分类号: A61K33/00 , A61K31/4365 , A61K31/519 , A61K45/06 , A61K31/64 , A61K31/7076
CPC分类号: A61K31/4365 , A61K31/519 , A61K31/64 , A61K31/7076 , A61K33/00 , A61K45/06 , A61K2300/00
摘要: Disclosed is a treatment of diabetes insipidus. Methods of treating diabetes insipidus disorders associated with P2Y receptors using the compounds and compositions are also disclosed.
摘要翻译: 披露了治疗尿崩症。 还公开了使用该化合物和组合物治疗与P2Y受体相关的尿崩症的方法。
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公开(公告)号:US09345764B2
公开(公告)日:2016-05-24
申请号:US13878232
申请日:2011-10-08
申请人: Yue Zhang , Jun Bao , Hua Mao , Zhinan Shou , Weina Situ
发明人: Yue Zhang , Jun Bao , Hua Mao , Zhinan Shou , Weina Situ
IPC分类号: C07K7/08 , A61K38/08 , A61K38/20 , A61K45/06 , A61K38/19 , A61K38/10 , C07K7/06 , A61K39/395 , C07K16/18 , C07K16/28
CPC分类号: A61K39/3955 , A61K38/08 , A61K38/10 , A61K38/191 , A61K38/2006 , A61K38/204 , A61K38/2086 , A61K45/06 , C07K7/06 , C07K7/08 , C07K16/18 , C07K16/28 , C07K2317/73 , C07K2317/76 , A61K2300/00
摘要: The present application provides compositions and methods useful for treating and diagnosing diseases and disorders associated with moesin activation.
摘要翻译: 本申请提供了用于治疗和诊断与moesin活化相关的疾病和病症的组合物和方法。
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8.
公开(公告)号:US20160132466A1
公开(公告)日:2016-05-12
申请号:US14539919
申请日:2014-11-12
申请人: Kit Yue Zhang , David Hsia , Dominic Philip Haine
发明人: Kit Yue Zhang , David Hsia , Dominic Philip Haine
CPC分类号: G06Q10/063
摘要: Techniques are described for exporting organizational charts being presented inside a browser window. The system can present an export canvas that identifies the portion of the organizational chart that is to be exported. In some embodiments, the export canvas can be automatically adjusted to prevent collisions with tiles within the organizational chart. In some examples, the export canvas can be presented on a different layer than the organizational chart, thus allowing the export canvas to move around freely without disrupting the underlying organizational chart.
摘要翻译: 描述了用于导出在浏览器窗口中呈现的组织图的技术。 系统可以呈现一个导出画布,用于标识要导出的组织结构图的部分。 在一些实施例中,可以自动调整导出画布以防止与组织图内的拼贴相冲突。 在一些示例中,导出画布可以显示在与组织结构图不同的图层上,从而允许导出画布自由移动,而不会中断基础组织图。
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公开(公告)号:US08797769B2
公开(公告)日:2014-08-05
申请号:US13248786
申请日:2011-09-29
申请人: Yury Gaknoki , David Kung , Michael Yue Zhang
发明人: Yury Gaknoki , David Kung , Michael Yue Zhang
IPC分类号: H02M3/335
CPC分类号: H02M3/33515 , H02M1/08 , H02M3/33523 , H02M2001/0025
摘要: An example controller for a power converter includes a feedback sampling circuit, drive logic and a false sampling prevention circuit. The feedback sampling circuit is coupled to sample a feedback signal received from a terminal of the controller and to generate a sample signal representative of a value of the feedback signal. The drive logic is coupled to the feedback sampling circuit and coupled to control the power switch to regulate an output of the power converter in response to the sample signal. The false sampling prevention circuit is coupled to receive a sampling complete signal that indicates when the sampling of the feedback signal is complete. The false sampling prevention circuit is further coupled to the drive logic to extend the off time of the power switch until the sampling complete signal indicates that the sampling of the feedback signal by the feedback sampling circuit is complete.
摘要翻译: 用于功率转换器的示例性控制器包括反馈采样电路,驱动逻辑和假采样防止电路。 反馈采样电路被耦合以对从控制器的端子接收的反馈信号进行采样,并产生表示反馈信号的值的采样信号。 驱动逻辑耦合到反馈采样电路并被耦合以响应于采样信号来控制功率开关来调节功率转换器的输出。 虚假采样防止电路被耦合以接收指示反馈信号的采样何时完成的采样完成信号。 假采样防止电路还耦合到驱动逻辑以延长电源开关的关断时间,直到采样完成信号指示反馈采样电路的反馈信号的采样完成为止。
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公开(公告)号:US08770064B2
公开(公告)日:2014-07-08
申请号:US13616318
申请日:2012-09-14
申请人: Xin Yue Zhang , Toshimi Yamagishi , Keiji Ueura
发明人: Xin Yue Zhang , Toshimi Yamagishi , Keiji Ueura
IPC分类号: F16H33/00
CPC分类号: F16H1/321 , F16C19/06 , F16C27/04 , F16C33/585 , F16C2240/40 , F16C2361/61 , F16H49/001 , Y10T74/19
摘要: The flexible bearing of the wave generator for a wave gear device is a deep-groove ball bearing in which an outer race and an inner race form an annular flexible bearing ring capable of bending in a radial direction. A ball diameter Da is set to be 5 to 15% greater than that of each model of the currently available product. Dimensions of orbital plane radii ro, ri of the inner and outer races are set so that the ratio ro/Da of the orbital plane radius ro of the inner race and the ball diameter Da, as well as the ratio ri/Da of the orbital plane radius ri of the outer race and the ball diameter Da, are both in the range of 0.51 to 0.52. With this configuration, the service life of the flexible bearing can be extended.
摘要翻译: 用于波齿轮装置的波发生器的柔性轴承是深沟球轴承,其中外座圈和内座圈形成能够沿径向弯曲的环形柔性轴承环。 球直径Da设定为比当前可用产品的每个型号的球直径大5至15%。 设定内圈和外圈的轨道平面半径r i,ri的尺寸,使得内圈的轨道平面半径ro与球直径Da的比率ro / Da以及轨道的比率ri / Da 外圈的平面半径ri和球直径Da均在0.51〜0.52的范围内。 通过这种配置,可以延长柔性轴承的使用寿命。
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