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    Anti-tumor agent
    6.
    发明授权
    Anti-tumor agent 有权
    抗肿瘤药

    公开(公告)号：US07863243B2

    公开(公告)日：2011-01-04

    申请号：US11414100

    申请日：2006-04-28

    申请人： Yuji Matsuzawa ,  Tohru Funahashi ,  Shinji Tamura

    发明人： Yuji Matsuzawa ,  Tohru Funahashi ,  Shinji Tamura

    IPC分类号： A61K38/00

    CPC分类号： A61K38/2264

    摘要： The present invention provides a new anti-tumor agent containing adiponectin as an active ingredient, particularly, an anti-tumor agent capable of inhibiting carcinogenesis in the liver, use of adiponectin as an anti-tumor agent, and a prophylactic or therapeutic method against a tumor using adiponectin. The administration form may be either oral administration, e.g., by tablets or parenteral administration, e.g., by injection; in the case of intravenous injection for inhibiting carcinogenesis in the liver, the dosage is 1 to 100 mg/kg/day per adult patient.

    摘要翻译： 本发明提供了含有脂联素作为活性成分的新抗肿瘤剂，特别是能够抑制肝脏致癌作用的抗肿瘤剂，使用脂联素作为抗肿瘤剂，以及用于预防或治疗方法 使用脂联素的肿瘤。 给药形式可以是口服给药，例如通过片剂或肠胃外给药，例如通过注射; 在静脉注射用于抑制肝脏致癌作用的情况下，每位成年患者的剂量为1至100mg / kg /天。

    Liver regeneration promoting agent
    8.
    发明授权
    Liver regeneration promoting agent 有权
    肝再生促进剂

    公开(公告)号：US07375189B2

    公开(公告)日：2008-05-20

    申请号：US11371104

    申请日：2006-03-09

    申请人： Yuji Matsuzawa ,  Tohru Funahashi ,  Shinji Tamura

    发明人： Yuji Matsuzawa ,  Tohru Funahashi ,  Shinji Tamura

    IPC分类号： C07K14/00 ,  A61K38/00

    CPC分类号： A61K38/2264

    摘要： Although it is known that adiponectin, which is adipose-specific protein, has effects of suppressing the proliferation and migration of vascular smooth muscle, an effect against arteriosclerosis, an effect of inhibiting the activation of monocytes and macrophages and an anti-inflammatory effect, its action on hepatic stellate cells has never been known hitherto. The present invention has elucidated that adiponectin inhibits the actions of TGFB and PDGF on hepatic stellate cells and thereby exerts effects of suppressing hepatic fibrosis and promoting the proliferation of normal hepatocytes.

    摘要翻译： 虽然已知脂肪特异性蛋白质的脂联素具有抑制血管平滑肌的增殖和迁移，对动脉硬化的作用，抑制单核细胞和巨噬细胞活化的作用和抗炎作用的作用， 迄今为止从未知晓对肝星状细胞的作用。 本发明阐明脂联素抑制TGFB和PDGF对肝星状细胞的作用，从而发挥抑制肝纤维化和促进正常肝细胞增殖的作用。

    Anti-tumor agent
    9.
    发明申请
    Anti-tumor agent 有权
    抗肿瘤剂

    公开(公告)号：US20060247169A1

    公开(公告)日：2006-11-02

    申请号：US11414100

    申请日：2006-04-28

    申请人： Yuji Matsuzawa ,  Tohru Funahashi ,  Shinji Tamura

    发明人： Yuji Matsuzawa ,  Tohru Funahashi ,  Shinji Tamura

    IPC分类号： A61K38/17

    CPC分类号： A61K38/2264

    摘要： The present invention provides a new anti-tumor agent containing adiponectin as an active ingredient, particularly, an anti-tumor agent capable of inhibiting carcinogenesis in the liver, use of adiponectin as an anti-tumor agent, and a prophylactic or therapeutic method against a tumor using adiponectin. The administration form may be either oral administration, e.g., by tablets or parenteral administration, e.g., by injection; in the case of intravenous injection for inhibiting carcinogenesis in the liver, the dosage is 1 to 100 mg/kg/day per adult patient.

    摘要翻译： 本发明提供了含有脂联素作为活性成分的新抗肿瘤剂，特别是能够抑制肝脏致癌作用的抗肿瘤剂，使用脂联素作为抗肿瘤剂，以及用于预防或治疗方法 使用脂联素的肿瘤。 给药形式可以是口服给药，例如通过片剂或肠胃外给药，例如通过注射; 在静脉注射用于抑制肝脏致癌作用的情况下，每位成年患者的剂量为1至100mg / kg /天。

    Liver generation promoter
    10.
    发明授权
    Liver generation promoter 有权
    肝产生启动子

    公开(公告)号：US07074756B2

    公开(公告)日：2006-07-11

    申请号：US10479581

    申请日：2002-06-05

    申请人： Yuji Matsuzawa ,  Tohru Funahashi ,  Shinji Tamura

    发明人： Yuji Matsuzawa ,  Tohru Funahashi ,  Shinji Tamura

    IPC分类号： A61K38/00

    CPC分类号： A61K38/2264

    摘要： Although it is known that adiponectin, which is adipose-specific protein, has effects of suppressing the proliferation and migration of vascular smooth muscle, an effect against arteriosclerosis, an effect of inhibiting the activation of monocytes and macrophages and an anti-inflammatory effect, its action on hepatic stellate cells has never been known hitherto. The present invention has elucidated that adiponectin inhibits the actions of TGFB and PDGF on hepatic stellate cells and thereby exerts effects of suppressing hepatic fibrosis and promoting the proliferation of normal hepatocytes.

    摘要翻译： 虽然已知脂肪特异性蛋白质的脂联素具有抑制血管平滑肌的增殖和迁移，对动脉硬化的作用，抑制单核细胞和巨噬细胞活化的作用和抗炎作用的作用， 迄今为止从未知晓对肝星状细胞的作用。 本发明阐明脂联素抑制TGFB和PDGF对肝星状细胞的作用，从而发挥抑制肝纤维化和促进正常肝细胞增殖的作用。