摘要:
The present invention relates to animal models of metabolic disorders such as obesity, diabetes, metabolic syndrome, insulin resistance, hyperinsulinemia, glucose intolerance, hyperlipidemia, and the like. In particular, the invention relates to transgenic non-human animals having a reduction in functional Jhdm2a gene expression and use of such animals and cells having reduced Jhdm2a expression in drug discovery. The invention further relates to the identification of subjects having or at increased risk for developing a metabolic disorder based on a genetic marker in the Jhdm2a gene.
摘要:
The present invention provides polypeptides with histone H3 lysine 79 methyltransferase activity as well as nucleic acids encoding the same. Also provided are methods of using the polypeptides and nucleic acids of the invention in screening assays to identify compounds of interest. Further provided are diagnostic methods for leukemia and prognostic methods to predict the course of the disease in a subject.
摘要:
There is provided a display device capable of delivering adequate video display performance even when a lighting period of a backlight is varied in accordance with the content or the like of image data. The device has circuits (8050, 8060) for varying a lighting period of a backlight (8090) for illuminating a display panel (8010) in accordance with image data (8002), setting information (8003), and the like from an external device; and circuits (8070, 8080) for adjusting the timing of start (and turning off) of lighting of the backlight in accordance with the length of the lighting period.
摘要:
The present invention relates to methods of identifying candidate compounds for the treatment of leukemia and diagnostic methods based on histone methylation and HoxA5 promoter activity.
摘要:
An example system includes a game device including a game processing unit performing information processing concerning a game and a communication unit performing communication via a network, and a communication unit performing communication with the game device via the network. The game device includes a purchase request transmission unit transmitting a purchase request for the first item to be used in the game to the server by communication through the communication unit. The server includes a purchase request reception unit receiving the purchase request transmitted by the purchase request transmission unit, and a first item imparting unit imparting the first item in response to the purchase request received by the purchase request reception unit. An upper limit is set to the cumulative number of the purchased first items for the user who plays the game using the game device.
摘要:
A gate signal line driving circuit which suppresses noises in a gate signal and a display device which uses the gate signal line driving circuit are provided. A first basic circuit provided to a gate signal line driving circuit includes a HIGH voltage applying switching element which applies a HIGH voltage to gate signal lines in response to a signal HIGH period, and a LOW voltage applying switching circuit which applies a LOW voltage to the gate signal lines in response to a signal LOW period. In response to a signal HIGH period, a switch of the LOW voltage applying switching circuit of the first basic circuit is turned off based on a signal applied to a switch of the HIGH voltage applying switching element of a second basic circuit which assumes a signal HIGH period earlier than the first basic circuit.
摘要:
Each shift register includes a first element controlled by a first potential node to supply a first driving voltage to an output terminal, a second element controlled by a second potential node to supply a second driving voltage lower than the first driving voltage to the output terminal, and a third element for controlling the first potential node and the second potential node so as to have opposite potential levels. Voltages are applied to the third element so that a state of A>B and A>C and a state of A B and A C, or a state of A C and a state of A>B and A
摘要:
The invention provides DNA demethylases comprising Elp1, Elp2, Elp3, Elp4, Elp5 and/or Elp6. The invention also provides methods of modulating gene expression, for example, for the treatment of cancer or to modify the cellular transcription program (e.g., for regenerative medicine). Also provided are methods of identifying compounds that modulate the DNA demethylase activity of the DNA demethylases of the invention.
摘要:
A gate signal line drive circuit and a display device which realize the suppression of a threshold voltage of an element which is used for a long time are provided. With respect to elements to which a HIGH voltage is applied for a long time, a plurality of elements are connected parallel to each other and are controlled such that at least any one of the plurality of elements is driven by a switching element, and a period during which the element is not driven is set longer than a frame display period.
摘要:
A quantity totalizer for a three-dimensional arrangement and adjustment CAD includes integrating means for referring to parts information stored in the three-dimensional arrangement and adjustment CAD and associating line information, which is separated from the parts information for storage and which is unique to a line, with the parts information to generate integrated information in which the quantity of parts is totalized; numbering means for systematically numbering the integrated information and outputting a quantity totalization result; and comparing means for comparing the quantity totalization result output by the numbering means with a parts number column in a design drawing produced with the three-dimensional arrangement and adjustment CAD to check the parts having the same parts information and line information against each other and replacing parts numbers in the parts number column in the design drawing produced with the three-dimensional arrangement and adjustment CAD with parts numbers in the quantity totalization result output by the numbering means. With the above structure, it is possible to provide the quantity totalizer, a quantity totalizing program, and the quantity totalizing method for the three-dimensional arrangement and adjustment CAD, which are capable of improving the efficiency of the quantity totalization in the design with the three-dimensional arrangement and adjustment CAD and performing accurate parts management and design management while reducing the design cost.