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    Stabilized 3-Hydroxyflavan Compositions and Methods Therefor
    1.
    发明申请
    Stabilized 3-Hydroxyflavan Compositions and Methods Therefor 有权
    稳定的3-羟基黄烷组合物及其方法

    公开(公告)号：US20080300302A1

    公开(公告)日：2008-12-04

    申请号：US11996933

    申请日：2005-07-26

    申请人： Yukihiko Hara ,  Hiroshi Hojo ,  Slobodan Jovanovic

    发明人： Yukihiko Hara ,  Hiroshi Hojo ,  Slobodan Jovanovic

    IPC分类号： A61K31/352 ,  A61K31/353 ,  C07D311/04

    CPC分类号： C07D311/62

    摘要： Compositions and methods are directed to covalent adducts between reducing agents and optionally substituted 3-hydroxyflavans, wherein the reducing agent is covalently bound to the B-ring of the 3-hydroxyflavan. Such adducts exhibit markedly increased stability towards oxidation as compared to the unmodified 3-hydroxyflavan. Particularly preferred 3-hydroxyflavans include green tea catechins, and especially EGCG, while especially preferred reducing agents include NAC and glutathione.

    摘要翻译： 组合物和方法涉及还原剂和任选取代的3-羟基黄酮之间的共价加合物，其中还原剂与3-羟基黄烷的B-环共价结合。 与未改性的3-羟基黄烷相比，这种加合物显示出显着增加的氧化稳定性。 特别优选的3-羟基黄烷包括绿茶儿茶素，特别是EGCG，而特别优选的还原剂包括NAC和谷胱甘肽。

    Method for treating hyperplasia
    2.
    发明授权
    Method for treating hyperplasia 失效
    治疗增生的方法

    公开(公告)号：US5968973A

    公开(公告)日：1999-10-19

    申请号：US56378

    申请日：1998-04-07

    申请人： Shu Jun Cheng ,  De Chang Wang ,  Yukihiko Hara

    发明人： Shu Jun Cheng ,  De Chang Wang ,  Yukihiko Hara

    IPC分类号： A61K31/353 ,  A61K31/35

    CPC分类号： A61K31/353

    摘要： A method for a treatment of hyperplasia caused by papilloma virus, such as for treating Condyloma acuminata which comprises administering tea catechin. Tea catechins do not involve the risk of side-effects and may be easily applied to or inserted in the infected area by the patients themselves.

    摘要翻译： 一种治疗由乳头瘤病毒引起的增生的方法，例如用于治疗尖锐湿疣，其包括施用茶儿茶素。 茶儿茶素不涉及副作用的风险，并且可以容易地由患者本身应用于或插入感染区域。

    Antiviral filter air cleaner impregnated with tea extract
    3.
    发明授权
    Antiviral filter air cleaner impregnated with tea extract 失效
    浸有茶提取物的抗病毒过滤空气净化器

    公开(公告)号：US5747053A

    公开(公告)日：1998-05-05

    申请号：US647012

    申请日：1996-05-09

    申请人： Kazuo Nashimoto ,  Yoshikazu Tashiro ,  Yoshiomi Kosaka ,  Yukihiko Hara

    发明人： Kazuo Nashimoto ,  Yoshikazu Tashiro ,  Yoshiomi Kosaka ,  Yukihiko Hara

    IPC分类号： A61K9/00 ,  A61L2/00 ,  A61L2/02 ,  A61L9/16 ,  A47J31/00

    CPC分类号： A61L9/16 ,  A61K9/0095 ,  A61L2/0017 ,  A61L2/022 ,  F24F2003/1664 ,  F24F6/00

    摘要： The present invention provides a medicated gargling cup with which it is possible to form a liquid for gargling effective for preventing cold by merely pouring water into the cup; an antiviral mask having a nonwoven fabric impregnated with a tea extract, which mask can be easily produced commercially and is capable of maintaining a high virus trapping performance, inactivating the trapped viruses and preventing them from being rescattered; an antiviral filter and an antifungal, antibacterial and antiviral filter comprising in laminations a dust collecting filter and a filter impregnated with a tea extract; an air cleaner and an air cleaner-humidifier comprising the antiviral filter.

    摘要翻译： 本发明提供了一种药物漱口杯，可以通过仅将水倒入杯中形成用于漱口的液体，以有效地防止感冒; 具有浸渍有茶提取物的无纺织物的抗病毒面膜，该面膜可以容易地商业生产，并且能够保持高的病毒捕获性能，灭活被捕获的病毒并防止它们被再沉淀; 抗病毒过滤器和抗真菌，抗菌和抗病毒过滤器，其包括叠层的集尘过滤器和浸有茶提取物的过滤器; 包括抗病毒过滤器的空气净化器和空气净化器 - 加湿器。

    Stabilized 3-hydroxyflavan compositions and methods therefor
    4.
    发明授权
    Stabilized 3-hydroxyflavan compositions and methods therefor 有权
    稳定的3-羟基黄烷组合物及其方法

    公开(公告)号：US08138359B2

    公开(公告)日：2012-03-20

    申请号：US11996933

    申请日：2005-07-26

    申请人： Yukihiko Hara ,  Hiroshi Hojo ,  Slobodan Jovanovic

    发明人： Yukihiko Hara ,  Hiroshi Hojo ,  Slobodan Jovanovic

    IPC分类号： C07D311/62 ,  C07F9/50

    CPC分类号： C07D311/62

    摘要： Compositions and methods are directed to covalent adducts between reducing agents and optionally substituted 3-hydroxyflavans, wherein the reducing agent is covalently bound to the B-ring of the 3-hydroxyflavan. Such adducts exhibit markedly increased stability towards oxidation as compared to the unmodified 3-hydroxyflavan. Particularly preferred 3-hydroxyflavans include green tea catechins, and especially EGCG, while especially preferred reducing agents include NAC and glutathione.

    摘要翻译： 组合物和方法涉及还原剂和任选取代的3-羟基黄酮之间的共价加合物，其中还原剂共价结合到3-羟基黄烷的B-环上。 与未改性的3-羟基黄烷相比，这种加合物显示出显着增加的氧化稳定性。 特别优选的3-羟基黄烷包括绿茶儿茶素，特别是EGCG，而特别优选的还原剂包括NAC和谷胱甘肽。

    Tea polyphenol composition and method for producing the same
    5.
    发明授权
    Tea polyphenol composition and method for producing the same 有权
    茶多酚组合物及其制备方法

    公开(公告)号：US07763291B2

    公开(公告)日：2010-07-27

    申请号：US12631504

    申请日：2009-12-04

    申请人： Yukihiko Hara ,  Ryota Seto

    发明人： Yukihiko Hara ,  Ryota Seto

    IPC分类号： A61K36/82 ,  C07C39/12

    CPC分类号： A61K36/82 ,  A23L33/105 ,  A23V2002/00 ,  A61K8/97 ,  A61Q11/00 ,  A23V2250/214 ,  A23V2250/2132

    摘要： The objective of the present invention is to provide a tea polyphenol composition that has reduced bitterness and astringency while containing catechins with high purity. The present invention provides a tea polyphenol composition, (A) comprising 85% by weight to 95% by weight of catechins, (B) wherein the catechins contains epigallocatechin gallate and gallocatechin gallate at a ratio of 65% by weight to 80% by weight and (C) wherein the ratio given by (epigallocatechin gallate+gallocatechin gallate)/(epicatechin+catechin+epigallocatechin+gallocatechin+epicatechin gallate+catechin gallate) is from 2 to 4.

    摘要翻译： 本发明的目的是提供一种含有高纯度儿茶素的苦味和涩味降低的茶多酚组合物。 本发明提供一种茶多酚组合物，（A）包含85重量％至95重量％的儿茶素类，（B）其中儿茶素含有表没食子儿茶素没食子酸酯和没食子儿茶素没食子酸酯，比例为65重量％至80重量％ 和（C）其中由（表没食子儿茶素没食子酸没食子酸+没食子儿茶素没食子酸酯）/（表儿茶素+儿茶素+表没食子儿茶素+角叉菜胶+表儿茶素没食子酸酯没食子儿+没食子酸儿茶素没食子酸酯）给出的比例为2〜4。

    Process for the production of tea catechins
    10.
    发明授权
    Process for the production of tea catechins 失效
    生产茶儿茶素的方法

    公开(公告)号：US4613672A

    公开(公告)日：1986-09-23

    申请号：US624943

    申请日：1984-06-27

    申请人： Yukihiko Hara

    发明人： Yukihiko Hara

    IPC分类号： A23F3/18 ,  A61K36/18 ,  A61K36/82 ,  C07D311/32 ,  C07D311/62 ,  C07D311/04

    CPC分类号： C07D311/62 ,  A61K36/82

    摘要： Process for production of tea catechins selected from (-) epicatechin, (-) epigallocatechin, (-) epicatechin gallate and (-) epigallocatechin gallate comprising extracting tea leaves with hot water or an aqueous solution of methanol, ethanol or acetone, washing the extract containing solution with chloroform, transferring the washed solution into an organic solvent, removing the solution and passing the resulting solution through a reversed phase column in the presence of an eluting solution. Tea catechins and methods of using the same are also disclosed.

    摘要翻译： 选自（ - ）表儿茶素，（ - ）表儿茶素，（ - ）表儿茶素没食子酸酯和（ - ）表没食子儿茶素没食子酸酯的茶儿茶素的制造方法，包括用热水或甲醇，乙醇或丙酮的水溶液萃取茶叶，洗涤提取物 将洗涤的溶液转移到有机溶剂中，除去溶液，并在洗脱液存在下使所得溶液通过反相柱。 还公开了茶儿茶素及其使用方法。