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公开(公告)号:US20100093055A1
公开(公告)日:2010-04-15
申请号:US12574947
申请日:2009-10-07
申请人: Naoyuki Fukuchi , Satoru Okamoto , Wataru Miyanaga , Sen Takeshita , Masaru Takayanagi , Yumiko Fukuda , Takao Ikenoue , Naoyuki Yamada , Naoko Arashida
发明人: Naoyuki Fukuchi , Satoru Okamoto , Wataru Miyanaga , Sen Takeshita , Masaru Takayanagi , Yumiko Fukuda , Takao Ikenoue , Naoyuki Yamada , Naoko Arashida
IPC分类号: C12N9/00 , G01N33/566 , C07D243/10 , C07D243/00
CPC分类号: C07D487/04 , A61K31/55 , A61K31/551 , C07D519/00 , C12Q1/485 , G01N33/5035 , G01N33/573 , G01N33/6845 , G01N33/6872 , G01N2333/4719 , G01N2333/91215 , G01N2500/04 , G01N2800/042
摘要: A method of screening a compound having a hypoglycemic effect (hereinafter referred to as “hypoglycemic compound”), a remedy for diabetes which contains a compound having a novel function mechanism, etc. More specifically speaking, a method of screening a hypoglycemic compound capable of binding to the β subunit of a trimeric GTP-binding protein, a remedy for diabetes comprising a hypoglycemic compound, which is characterized by being capable of binding to the β subunit of a trimeric GTP-binding protein, as the active ingredient, etc.
摘要翻译: 筛选具有降血糖作用的化合物的方法(以下称为“降血糖化合物”),含有具有新的功能机制的化合物的糖尿病治疗剂等。更具体地说,可以列举一种能够将降血糖化合物 绑定到&bgr 三聚GTP结合蛋白的亚单位,包含降血糖化合物的糖尿病治疗剂,其特征在于能够结合到该组合物上。 三聚GTP结合蛋白的亚基作为活性成分等
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公开(公告)号:US07396844B1
公开(公告)日:2008-07-08
申请号:US09356492
申请日:1999-07-19
申请人: Masaru Takayanagi , Kazuyuki Sagi , Tadakiyo Nakagawa , Masahiro Yamanashi , Takashi Kayahara , Shunji Takehana , Yumiko Fukuda , Mitsuo Takahashi , Masataka Shoji
发明人: Masaru Takayanagi , Kazuyuki Sagi , Tadakiyo Nakagawa , Masahiro Yamanashi , Takashi Kayahara , Shunji Takehana , Yumiko Fukuda , Mitsuo Takahashi , Masataka Shoji
IPC分类号: A61K31/155 , C07D207/14 , C07D221/02 , C07C249/02
CPC分类号: C07D207/327 , C07C257/18 , C07C279/18 , C07C311/13 , C07C311/19 , C07C327/48 , C07C2601/14 , C07D209/08 , C07D209/16 , C07D211/34 , C07D211/46 , C07D211/62 , C07D211/70 , C07D213/56 , C07D213/74 , C07D233/26 , C07D233/64 , C07D239/06 , C07D295/155 , C07D295/192 , C07D295/215 , C07D453/02 , C07F9/59
摘要: Benzamidine derivatives of the following formulae or analogs thereof, i.e., pharmaceutically acceptable salts thereof, are provided. These compounds or salts thereof have a blood-coagulation inhibiting effect based on an excellent effect of inhibiting the action of activated blood coagulation factor X, and they are useful as anticoagulants
摘要翻译: 提供了下式的苯甲脒衍生物或其类似物,即其药学上可接受的盐。 这些化合物或其盐基于抑制活化凝血因子X的作用的优异效果而具有凝血抑制作用,可用作抗凝剂
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公开(公告)号:US08357680B2
公开(公告)日:2013-01-22
申请号:US12574947
申请日:2009-10-07
申请人: Naoyuki Fukuchi , Satoru Okamoto , Wataru Miyanaga , Sen Takeshita , Masaru Takayanagi , Yumiko Fukuda , Takao Ikenoue , Naoyuki Yamada , Naoko Arashida
发明人: Naoyuki Fukuchi , Satoru Okamoto , Wataru Miyanaga , Sen Takeshita , Masaru Takayanagi , Yumiko Fukuda , Takao Ikenoue , Naoyuki Yamada , Naoko Arashida
CPC分类号: C07D487/04 , A61K31/55 , A61K31/551 , C07D519/00 , C12Q1/485 , G01N33/5035 , G01N33/573 , G01N33/6845 , G01N33/6872 , G01N2333/4719 , G01N2333/91215 , G01N2500/04 , G01N2800/042
摘要: A method of screening a compound having a hypoglycemic effect (hereinafter referred to as “hypoglycemic compound”), a remedy for diabetes which contains a compound having a novel function mechanism, etc. More specifically speaking, a method of screening a hypoglycemic compound capable of binding to the β subunit of a trimeric GTP-binding protein, a remedy for diabetes comprising a hypoglycemic compound, which is characterized by being capable of binding to the β subunit of a trimeric GTP-binding protein, as the active ingredient, etc.
摘要翻译: 筛选具有降血糖作用的化合物的方法(以下称为降血糖化合物),含有具有新的功能机制的化合物的糖尿病治疗剂等。更具体地说,可以列举能够结合至低血糖的化合物的方法 的&bgr 三聚GTP结合蛋白的亚单位,包含降血糖化合物的糖尿病治疗剂,其特征在于能够结合到该组合物上。 三聚GTP结合蛋白的亚基作为活性成分等
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公开(公告)号:US06812231B2
公开(公告)日:2004-11-02
申请号:US10073985
申请日:2002-02-14
申请人: Tadakiyo Nakagawa , Kazuyuki Sagi , Kaoru Yoshida , Yumiko Fukuda , Masataka Shoji , Shunji Takehana , Takashi Kayahara , Akira Takahara
发明人: Tadakiyo Nakagawa , Kazuyuki Sagi , Kaoru Yoshida , Yumiko Fukuda , Masataka Shoji , Shunji Takehana , Takashi Kayahara , Akira Takahara
IPC分类号: A61K31501
CPC分类号: C07D401/04 , C07C257/18 , C07D207/48 , C07D211/46 , C07D233/26 , C07D401/06 , C07D417/04 , C07F9/4015 , C07F9/4056 , C07F9/59 , C07F9/65583
摘要: Benzamidine derivatives of the following formula, analogs thereof and pharmaceutically acceptable salts thereof are provided. These compounds have an effect of inhibiting activated blood-coagulation factor X, and they are useful as agents for preventing or treating various diseases caused by thrombi or emboli.
摘要翻译: 提供下式的苄脒衍生物,其类似物和其药学上可接受的盐。 这些化合物具有抑制活化凝血因子X的作用,可用作预防或治疗由血栓或栓塞引起的各种疾病的药剂。
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公开(公告)号:US06410538B2
公开(公告)日:2002-06-25
申请号:US09731729
申请日:2000-12-08
申请人: Tadakiyo Nakagawa , Kazuyuki Sagi , Kaoru Yoshida , Yumiko Fukuda , Masataka Shoji , Shunji Takehana , Takashi Kayahara , Akira Takahara
发明人: Tadakiyo Nakagawa , Kazuyuki Sagi , Kaoru Yoshida , Yumiko Fukuda , Masataka Shoji , Shunji Takehana , Takashi Kayahara , Akira Takahara
IPC分类号: A61K3150
CPC分类号: C07D401/04 , C07C257/18 , C07D207/48 , C07D211/46 , C07D233/26 , C07D401/06 , C07D417/04 , C07F9/4015 , C07F9/4056 , C07F9/59 , C07F9/65583
摘要: Benzamidine derivatives of the following formula, analogs thereof and pharmaceutically acceptable salts thereof are provided. These compounds have an effect of inhibiting activated blood-coagulation factor X, and they are useful as agents for preventing or treating various diseases caused by thrombi or emboli.
摘要翻译: 提供下式的苄脒衍生物,其类似物和其药学上可接受的盐。 这些化合物具有抑制活化凝血因子X的作用,可用作预防或治疗由血栓或栓塞引起的各种疾病的药剂。
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