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1.发明授权Pharmaceutical composition with antibody that binds to heat shock protein 27(HSP270) and method for promoting wound healing 有权具有与热休克蛋白27（HSP270）结合的抗体的药物组合物和促进伤口愈合的方法公开(公告)号：US08815243B2
公开(公告)日：2014-08-26
申请号：US13817760
申请日：2011-08-18
Applicant: Yoon Jin Lee , Yun-Sil Lee , Hae-June Lee , Seo-Hyun Choi , Kyeng-Jung Kim
Inventor： Yoon Jin Lee , Yun-Sil Lee , Hae-June Lee , Seo-Hyun Choi , Kyeng-Jung Kim
IPC: C07K16/18 , C07K14/435 , C07K16/44 , A61K39/395
CPC classification number: A61K39/3955 , A61K39/395 , A61K2039/505 , C07K16/18 , C07K2317/76
Abstract: The present invention relates to a pharmaceutical composition for promoting angiogenesis, containing an antibody that specifically binds to heat shock protein (HSP) 27. In addition, the present invention relates to a pharmaceutical composition containing an antibody that specifically binds to HSP 27, for treating an angiogenesis-dependent ailment selected from a group consisting of a wound, chronic ulcer, ischemic stroke, myocardial infarction, angina pectoris, and cerebrovascular dementia. In addition, the present invention relates to a method for promoting the in vitro growth of endothelial cells using an antibody that specifically binds to HSP27. In addition, the present invention relates to a method for screening for active substances for promoting angiogenesis or for active substances for treating an angiogenesis-dependent ailment, the method comprising the following steps: treating vascular endothelial cell lines with each specimen; measuring the content of HSP27 in the respective vascular endothelial cell lines; and selecting a specimen in which the HSP27 content in the vascular endothelial cell lines are decreased as compared to a control group.
Abstract translation: 本发明涉及用于促进血管生成的药物组合物，其含有与热休克蛋白（HSP）27特异性结合的抗体。此外，本发明涉及含有与HSP27特异性结合的抗体的药物组合物，用于治疗 选自伤口，慢性溃疡，缺血性中风，心肌梗死，心绞痛和脑血管性痴呆的血管发生依赖性疾病。 此外，本发明涉及使用特异性结合HSP27的抗体促进内皮细胞体外生长的方法。 此外，本发明涉及一种筛选用于促进血管发生的活性物质的方法或用于治疗血管生成依赖性疾病的活性物质的方法，所述方法包括以下步骤：用每个样品处理血管内皮细胞系; 测量各血管内皮细胞系中HSP27的含量; 并且与对照组相比，选择其中血管内皮细胞系中HSP27含量降低的标本。
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公开(公告)号：US20090176888A1
公开(公告)日：2009-07-09
申请号：US12399384
申请日：2009-03-06
Applicant: Su Jae LEE , Yun Sil LEE , Soo Kwan KIM , Kyung Joong KIM , Chul Koo CHO , Chang Mo KANG , Tae Hwan KIM , Sangwoo BAE , Moon Taek PARK , Jung A. CHOI , Min Jeong KIM , Hee Yong CHUNG , Sujong KIM , Seongnam KANG , Weon Ik CHOI , Jung A. KANG
Inventor： Su Jae LEE , Yun Sil LEE , Soo Kwan KIM , Kyung Joong KIM , Chul Koo CHO , Chang Mo KANG , Tae Hwan KIM , Sangwoo BAE , Moon Taek PARK , Jung A. CHOI , Min Jeong KIM , Hee Yong CHUNG , Sujong KIM , Seongnam KANG , Weon Ik CHOI , Jung A. KANG
IPC: A61K31/13
CPC classification number: A61K31/164 , A61K31/133
Abstract: Provided is a composition for cancer treatment including phytosphingosine or a derivative thereof, or a pharmaceutically acceptable salt thereof as an active ingredient.
Abstract translation: 本发明提供包含植物鞘氨醇或其衍生物或其药学上可接受的盐作为活性成分的癌症治疗用组合物。
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3.发明申请PHARMACEUTICAL COMPOSITION FOR SUPPRESSING ANGIOGENESIS, AND METHOD FOR SCREENING ACTIVE MATERIAL FOR SUPPRESSING ANGIOGENESIS 有权用于抑制血管生成的药物组合物和用于筛选活性物质以抑制血管生成的方法
公开(公告)号：US20130184336A1
公开(公告)日：2013-07-18
申请号：US13817738
申请日：2011-08-18
Applicant: Yoon Jin Lee , Yun-Sil Lee , Hae-June Lee , Seo-Hyun Choi , Kyeng-Jung Kim
Inventor： Yoon Jin Lee , Yun-Sil Lee , Hae-June Lee , Seo-Hyun Choi , Kyeng-Jung Kim
IPC: A61K38/17
CPC classification number: A61K38/1709 , A61K48/00 , C07K16/18 , C07K2317/76 , G01N33/57407 , G01N33/57484
Abstract: The present invention provides a pharmaceutical composition for suppressing angiogenesis, containing heat shock protein 27 (HSP27) or a nucleic acid encoding HSP27. In addition, the present invention provides a pharmaceutical composition for treating cancer, containing HSP27 or a nucleic acid encoding HSP27. Additionally, the present invention provides a method of suppressing the in vitro growth of endothelial cells using HSP27. Further, the present invention provides a method of screening an active material for suppressing angiogenesis or an active material for treating cancer, comprising the following steps: processing endothelial cell lines into samples, respectively; measuring the content of HSP27 in an endothelial cell line; and selecting the sample in which the content of HSP27 in an endothelial cell line is increased compared with a control group.
Abstract translation: 本发明提供了含有热休克蛋白27（HSP27）或编码HSP27的核酸的血管生成抑制药物组合物。 此外，本发明提供了含有HSP27或编码HSP27的核酸的治疗癌症的药物组合物。 此外，本发明提供了使用HSP27抑制内皮细胞的体外生长的方法。 此外，本发明提供了筛选用于抑制血管生成的活性物质或用于治疗癌症的活性物质的方法，包括以下步骤：分别将内皮细胞系分别加工成样品; 测量内皮细胞系中HSP27的含量; 并且与对照组相比，选择其中内皮细胞系中HSP27的含量增加的样品。
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4.发明授权Pharmaceutical composition for suppressing angiogenesis, and method for screening active material for suppressing angiogenesis 有权用于抑制血管发生的药物组合物，以及筛选用于抑制血管发生的活性物质的方法
公开(公告)号：US09149505B2
公开(公告)日：2015-10-06
申请号：US13817738
申请日：2011-08-18
Applicant: Yoon Jin Lee , Yun-Sil Lee , Hae-June Lee , Seo-Hyun Choi , Kyeng-Jung Kim
Inventor： Yoon Jin Lee , Yun-Sil Lee , Hae-June Lee , Seo-Hyun Choi , Kyeng-Jung Kim
IPC: A61K38/17 , G01N33/574 , C07K16/18 , A61K48/00
CPC classification number: A61K38/1709 , A61K48/00 , C07K16/18 , C07K2317/76 , G01N33/57407 , G01N33/57484
Abstract: The present invention provides a pharmaceutical composition for suppressing angiogenesis, containing heat shock protein 27 (HSP27) or a nucleic acid encoding HSP27. In addition, the present invention provides a pharmaceutical composition for treating cancer, containing HSP27 or a nucleic acid encoding HSP27. Additionally, the present invention provides a method of suppressing the in vitro growth of endothelial cells using HSP27. Further, the present invention provides a method of screening an active material for suppressing angiogenesis or an active material for treating cancer, comprising the following steps: processing endothelial cell lines into samples, respectively; measuring the content of HSP27 in an endothelial cell line; and selecting the sample in which the content of HSP27 in an endothelial cell line is increased compared with a control group.
Abstract translation: 本发明提供了含有热休克蛋白27（HSP27）或编码HSP27的核酸的血管生成抑制药物组合物。 此外，本发明提供了含有HSP27或编码HSP27的核酸的治疗癌症的药物组合物。 此外，本发明提供了使用HSP27抑制内皮细胞的体外生长的方法。 此外，本发明提供了筛选用于抑制血管生成的活性物质或用于治疗癌症的活性物质的方法，包括以下步骤：分别将内皮细胞系分别加工成样品; 测量内皮细胞系中HSP27的含量; 并且与对照组相比，选择其中内皮细胞系中HSP27的含量增加的样品。
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5.发明申请PHARMACEUTICAL COMPOSITION FOR PROMOTING ANGIOGENESIS, AND METHOD FOR SCREENING FOR ACTIVE SUBSTANCES FOR PROMOTING ANGIOGENESIS 有权用于促进血管生成的药物组合物和用于促进促血管发生的活性物质筛选方法
公开(公告)号：US20130156787A1
公开(公告)日：2013-06-20
申请号：US13817760
申请日：2011-08-18
Applicant: Yoon Jin Lee , Yun-Sil Lee , Hae-June Lee , Seo-Hyun Choi , Kyeng-Jung Kim
Inventor： Yoon Jin Lee , Yun-Sil Lee , Hae-June Lee , Seo-Hyun Choi , Kyeng-Jung Kim
IPC: A61K39/395
CPC classification number: A61K39/3955 , A61K39/395 , A61K2039/505 , C07K16/18 , C07K2317/76
Abstract: The present invention relates to a pharmaceutical composition for promoting angiogenesis, containing an antibody that specifically binds to heat shock protein (HSP) 27. In addition, the present invention relates to a pharmaceutical composition containing an antibody that specifically binds to HSP 27, for treating an angiogenesis-dependent ailment selected from a group consisting of a wound, chronic ulcer, ischemic stroke, myocardial infarction, angina pectoris, and cerebrovascular dementia. In addition, the present invention relates to a method for promoting the in vitro growth of endothelial cells using an antibody that specifically binds to HSP27. In addition, the present invention relates to a method for screening for active substances for promoting angiogenesis or for active substances for treating an angiogenesis-dependent ailment, the method comprising the following steps: treating vascular endothelial cell lines with each specimen; measuring the content of HSP27 in the respective vascular endothelial cell lines; and selecting a specimen in which the HSP27 content in the vascular endothelial cell lines are decreased as compared to a control group.
Abstract translation: 本发明涉及用于促进血管生成的药物组合物，其含有与热休克蛋白（HSP）27特异性结合的抗体。此外，本发明涉及含有与HSP27特异性结合的抗体的药物组合物，用于治疗 选自伤口，慢性溃疡，缺血性中风，心肌梗死，心绞痛和脑血管性痴呆的血管发生依赖性疾病。 此外，本发明涉及使用特异性结合HSP27的抗体促进内皮细胞体外生长的方法。 此外，本发明涉及一种筛选用于促进血管发生的活性物质的方法或用于治疗血管生成依赖性疾病的活性物质的方法，所述方法包括以下步骤：用每个样品处理血管内皮细胞系; 测量各血管内皮细胞系中HSP27的含量; 并且与对照组相比，选择其中血管内皮细胞系中HSP27含量降低的标本。
