公开(公告)号：US07766919B2

公开(公告)日：2010-08-03

申请号：US11555942

申请日：2006-11-02

申请人： Yves Delmotte

发明人： Yves Delmotte

IPC分类号： A61B17/58

CPC分类号： A61B17/8816 ,  A61B17/8833 ,  A61B2017/00495 ,  A61B2017/8838 ,  A61F2/28 ,  A61F2/4601 ,  A61F2002/2817 ,  A61F2310/00293 ,  A61F2310/00377 ,  A61J1/2058 ,  A61J1/2075 ,  A61J1/2096 ,  A61M5/1782 ,  A61M5/19

摘要： This invention provides devices and methods for mixing and extruding compositions which are medically and non-medically useful. The devices are particularly useful for mixing substances which are relatively inert when alone but become reactive when mixed. A common feature of all of the devices is that they allow the user to mix and ultimately extrude a composition from a single device which includes a single container or multiple interconnected containers.

摘要翻译： 本发明提供用于混合和挤出组合物的装置和方法，所述组合物在医学和非医学上有用。 这些装置特别可用于混合当单独相对惰性但在混合时变得反应的物质。 所有设备的共同特征是它们允许用户混合并最终从包括单个容器或多个互连容器的单个设备中挤出组合物。

公开(公告)号：US20080109002A1

公开(公告)日：2008-05-08

申请号：US11555942

申请日：2006-11-02

申请人： Yves Delmotte

发明人： Yves Delmotte

IPC分类号： A61B17/58

CPC分类号： A61B17/8816 ,  A61B17/8833 ,  A61B2017/00495 ,  A61B2017/8838 ,  A61F2/28 ,  A61F2/4601 ,  A61F2002/2817 ,  A61F2310/00293 ,  A61F2310/00377 ,  A61J1/2058 ,  A61J1/2075 ,  A61J1/2096 ,  A61M5/1782 ,  A61M5/19

摘要： This invention provides devices and methods for mixing and extruding compositions which are medically and non-medically useful. The devices are particularly useful for mixing substances which are relatively inert when alone but become reactive when mixed. A common feature of all of the devices is that they allow the user to mix and ultimately extrude a composition from a single device which includes a single container or multiple interconnected containers.

摘要翻译： 本发明提供用于混合和挤出组合物的装置和方法，所述组合物在医学和非医学上有用。 这些装置特别可用于混合当单独相对惰性但在混合时变得反应的物质。 所有设备的共同特征是它们允许用户混合并最终从包括单个容器或多个互连容器的单个设备中挤出组合物。

公开(公告)号：US20070148161A1

公开(公告)日：2007-06-28

申请号：US11676904

申请日：2007-02-20

申请人： Yves Delmotte

发明人： Yves Delmotte

IPC分类号： A61K38/48

CPC分类号： A61L27/3886 ,  A61B17/00491 ,  A61B2017/00495 ,  A61L27/225 ,  A61L27/26 ,  A61L27/3804 ,  A61L27/3808 ,  A61L27/3813 ,  A61L27/44 ,  A61L27/56 ,  A61L27/60 ,  A61L31/046 ,  A61L31/146 ,  B05B11/0078 ,  B05B11/02 ,  C08L89/00

摘要： A biopolymermembrane in its substantially dry form having a thickness less than about 75 microns, a solvent content less than about 5% by weight of the membrane, a radius of curvature of less than about 5 centimeters, a density greater than about 1 g/cm3, and a maximum pore size of about 20 microns.

摘要翻译： 一种其基本干燥形式的生物膜，其厚度小于约75微米，溶剂含量小于膜重量的约5％，曲率半径小于约5厘米，密度大于约1g / cm 3，最大孔径约20微米。

公开(公告)号：US20060134094A2

公开(公告)日：2006-06-22

申请号：US11112156

申请日：2005-04-22

申请人： YVES DELMOTTE ,  James Diorio

发明人： YVES DELMOTTE ,  James Diorio

IPC分类号： A61K38/48

CPC分类号： A61K38/363 ,  A61K38/4833 ,  A61L31/046 ,  A61L31/145 ,  A61L31/146 ,  C07K14/75 ,  A61K2300/00

摘要： Abstract of the DisclosureThis invention describes a bioerodible fibrin material which is obtained by mixing fibrinogen and thrombin reconstituted or diluted with a particular high tonic strength medium, free of calcium. Such a fibrin-based biomaterial develops a tight structure with thin fibers and small pore size suitable for use as an anti-adhesion barrier. In this invention, thrombin is no longer the variable which governs the tightness and the porosity of the fibrin material obtained, but still controls the clotting time. The mechanical behavior, high-water capacity, and releasable retention properties for therapeutic agents of this fibrin structure causes the fibrin material to be ideally suited for use as a drug delivery device, capable of delivering proteins, hormones, enzymes, antibiotics, antineoplastic agents and even cells for local and systemic treatment of human and non-human patients.

摘要翻译： 本发明摘要本发明描述了一种生物浸渗性纤维蛋白材料，其通过将纤维蛋白原和凝血酶与特定的高强度强力培养基（不含钙）重构或稀释而获得。 这种基于纤维蛋白的生物材料用适合用作抗粘连屏障的细纤维和小孔径形成紧密结构。 在本发明中，凝血酶不再是控制所获得的纤维蛋白材料的紧密度和孔隙度的变量，而是控制凝血时间。 这种纤维蛋白结构的治疗剂的机械性能，高水容量和可释放的保留性质使得纤维蛋白材料理想地适合用作药物递送装置，能够递送蛋白质，激素，酶，抗生素，抗肿瘤剂和 甚至用于局部和全身治疗人和非人类患者的细胞。

公开(公告)号：US20130149740A1

公开(公告)日：2013-06-13

申请号：US13523328

申请日：2012-06-14

申请人： Yves Delmotte

发明人： Yves Delmotte

IPC分类号： C12P21/00 ,  C07K1/02

CPC分类号： C12P21/00 ,  B01F13/0071 ,  C07K1/02 ,  C07K14/75 ,  C07K14/765 ,  C07K14/78 ,  C08L5/04 ,  C08L5/08 ,  C08L89/00 ,  C08L89/06 ,  C12N9/54

摘要： The invention discloses a method for the production of a polymerized product comprising the following steps: providing a polymerization device to which a polymerization mixture and a separation medium can be applied and wherein flow of said mixture and medium can be conducted in appropriate ducts for said mixture and medium, transporting said polymerization mixture in a duct of said polymerization device thereby allowing the polymerization reaction, transporting said mixture in a duct of said polymerization device in a continuous flow, interrupting said continuous flow of said mixture with said separation medium so as to obtain consecutive volumes of said mixture and volumes of said separation medium, further transporting said consecutive volumes of said mixture and volumes of said separation medium in a duct of said polymerization device wherein said mixture further polymerizes to obtain a discontinuous polymerized product, and removing said discontinuous polymerized product from said polymerization device.

摘要翻译： 本发明公开了一种生产聚合产物的方法，包括以下步骤：提供聚合装置，聚合混合物和分离介质可以被施加到聚合装置上，并且所述混合物和介质的流动可以在用于所述混合物的适当管道中进行 在所述聚合装置的管道中输送所述聚合混合物，从而允许聚合反应，连续流动在所述聚合装置的管道中输送所述混合物，中断所述混合物与所述分离介质的所述连续流动，从而获得 连续体积的所述分离介质的所述混合物和体积，将所述分离介质的所述混合物和体积的所述连续体积进一步输送到所述聚合装置的管道中，其中所述混合物进一步聚合以获得不连续的聚合产物，并除去所述不连续聚合的 产品来自于 聚合装置。

公开(公告)号：US20100274279A1

公开(公告)日：2010-10-28

申请号：US11624113

申请日：2007-01-17

申请人： Yves Delmotte

发明人： Yves Delmotte

IPC分类号： A61B17/03 ,  B67D7/74 ,  G01F11/00

CPC分类号： A61B17/00491 ,  A61B2017/00495 ,  B01F5/0683 ,  B01F5/0685 ,  B01F5/0692 ,  B01F5/0693 ,  B01F13/002 ,  B01F13/0023 ,  B01F15/0203 ,  B01F15/0226 ,  B01F15/0237

摘要： The present invention includes various compositions, devices, systems and methods for mixing at least two separate streams of components. In one aspect of the invention, a device is provided for mixing at least two separate streams of components which, when mixed, form a combined fluid stream. The device comprises a first passageway adapted to communicate with one of the at least two separate streams, and a second passageway adapted to communicate with another of the at least two separate streams. The device further comprises a mixer communicating with each of the first and second passageways comprising a three-dimensional lattice defining a plurality of tortuous, interconnecting passages therethrough. The mixer has physical characteristics which include a selected one or more of mean flow pore size, thickness and porosity is positioned upstream of the dispensing end of the third passageway to mix the component streams of the combined fluid stream.

摘要翻译： 本发明包括用于混合至少两个单独的组分流的各种组合物，装置，系统和方法。 在本发明的一个方面，提供一种用于混合至少两个分开的组分流的装置，当混合时形成组合流体流。 所述装置包括适于与所述至少两个分离流中的一个连通的第一通道和适于与所述至少两个分离流中的另一个流通的第二通道。 该装置还包括与第一和第二通道中的每一个连通的混合器，其包括限定通过其的多个曲折的互连通道的三维网格。 混合器具有物理特征，其包括所选择的一个或多个平均流量孔径，厚度和孔隙率位于第三通道的分配端的上游，以混合组合流体流的组分流。

公开(公告)号：US5780043A

公开(公告)日：1998-07-14

申请号：US544915

申请日：1995-10-18

申请人： Greg Dane ,  Jean Kersten ,  Yves Delmotte

发明人： Greg Dane ,  Jean Kersten ,  Yves Delmotte

IPC分类号： A61L31/06 ,  C08K5/00 ,  A01N25/34

CPC分类号： A61L31/06 ,  C08K5/0008

摘要： The present invention relates to infection resistant polyurethane having the infection resistant agents incorporated into the matrix of the thermoplastic polyurethane resin. This agent acts as a pool of infection resistant material. This infection resistant material can be used to make gloves and condoms.

摘要翻译： 本发明涉及具有掺入热塑性聚氨酯树脂基质中的感染抗性剂的耐感染性聚氨酯。 该代理人作为感染抗性材料池。 这种耐感染材料可用于制作手套和避孕套。

公开(公告)号：US06599515B1

公开(公告)日：2003-07-29

申请号：US09566372

申请日：2000-05-08

申请人： Yves Delmotte

发明人： Yves Delmotte

IPC分类号： A61M3700

CPC分类号： A61L27/56 ,  A61B17/00491 ,  A61B2017/00495 ,  A61F2310/00377 ,  A61L15/32 ,  A61L27/225 ,  A61L27/44 ,  A61L31/046 ,  B05B11/0078 ,  B05B11/02 ,  C08L89/00

摘要： The present invention provides a porous structure of fibrin or fibrinogen material. The structure in its substantially dry form, having a compression strain of less than 8%, and a creep modulus higher than 1.5×106 Pa. The compression strain and creep modulus being measured for a sample having a diameter of 5 mm on which a compression of 2500 milli Newtons is exerted with a compression ramp of 500 milli Newtons per minute, after a compression release step following an initial compression of 2500 milli Newtons with a compression ramp of 500 milli Newtons per minute. After hydration, the structure has a porosity wherein at least 50% by volume of the total porosity is formed by channels with an open cross section of more than 500 &mgr;m2.

摘要翻译： 本发明提供纤维蛋白或纤维蛋白原材料的多孔结构。 其基本上干燥形式的结构，其压缩应变小于8％，蠕变模量高于1.5×10 6 Pa。对于直径为5mm的样品测量的压缩应变和蠕变模量，其上压缩 2500毫牛顿施加500牛顿每分钟的压缩斜坡，压缩释放步骤之后的初始压缩2500毫牛顿，压缩斜坡500牛顿每分钟。 在水合后，该结构具有孔隙率，其中总孔隙率的至少50体积％通过具有大于500mum2的开口横截面的通道形成。

公开(公告)号：US06461325B1

公开(公告)日：2002-10-08

申请号：US09386198

申请日：1999-08-31

申请人： Yves Delmotte ,  Arnold Bilstad ,  David Amrani ,  James DiOrio ,  Atif M. Yardimci ,  David W. Pennington ,  James S. Slepicka ,  Cristina Stadler

发明人： Yves Delmotte ,  Arnold Bilstad ,  David Amrani ,  James DiOrio ,  Atif M. Yardimci ,  David W. Pennington ,  James S. Slepicka ,  Cristina Stadler

IPC分类号： A61M3700

CPC分类号： A61B17/00491 ,  A61B2017/00495 ,  B05B11/0078 ,  B05B11/02

摘要： This invention provides a medical device for delivering volumetric quantities of a first and a second biochemically reactive fluid comprising a first container having an opening, the first container being adapted to contain the first biochemically reactive fluid; a second container having a second fluid opening adjacent the first fluid opening, the second container being adapted to contain the second biochemically reactive fluid; a spray unit for separately atomizing the first and second biochemically reactive fluids into an aerosol with at least one energy source of a liquid energy, a mechanical energy, a vibration energy, and an electric energy; a fluid pressurizer for pressurizing the first and the second biochemically reactive fluids for delivery under pressure through the spray unit onto a surface; and wherein the first and second biochemically reactive fluids first mix on the surface.

摘要翻译： 本发明提供了一种用于输送体积量的第一和第二生物化学反应性流体的医疗装置，其包括具有开口的第一容器，所述第一容器适于容纳所述第一生化反应性流体; 第二容器，具有与第一流体开口相邻的第二流体开口，第二容器适于容纳第二生化反应流体; 用于将第一和第二生化反应性流体分别雾化成具有液体能量，机械能，振动能量和电能的至少一个能量源的气溶胶的喷雾单元; 流体加压器，用于对第一和第二生化反应流体进行加压，以在压力下通过喷雾单元输送到表面上; 并且其中所述第一和第二生化反应性流体首先在所述表面上混合。

公开(公告)号：US07226657B1

公开(公告)日：2007-06-05

申请号：US09831121

申请日：1999-11-04

申请人： Yves Delmotte ,  Nathalie Belot ,  Pierre Vermeulen ,  Nicole Tasiaux

发明人： Yves Delmotte ,  Nathalie Belot ,  Pierre Vermeulen ,  Nicole Tasiaux

IPC分类号： B32B3/06

CPC分类号： B01D71/74 ,  A61L27/34 ,  A61L27/507 ,  A61L27/60 ,  B01D69/10 ,  Y10T428/249955 ,  Y10T428/249958 ,  Y10T428/249978 ,  Y10T428/249979 ,  Y10T428/24998 ,  Y10T428/249981 ,  A61L27/225 ,  C08L89/00

摘要： An element provided with a layer based on fibrin- or fibrinogen-containing material, said element comprising (a) a hydrophobic or substantially hydrophobic support, which has a porous part with a thickness of 0.1 to 5 mm, and whose pores, extending across its thickness have a node spacing of 5 to 100 μm, one face of said porous part being treated with a compound based on fibrin and/or a fibrinogen-containing material, and (b) a fibrin-based layer covering said treated surface of the support, characterized in that said fibrin-based layer is substantially uniform and homogeneous on said treated surface, and that the fibrin layer and at least the face of the support in contact with the fibrin layer are substantially free of fibrinogen.

摘要翻译： 提供有基于含纤维蛋白原或纤维蛋白原材料的层的元件，所述元件包括（a）疏水或基本疏水的载体，其具有厚度为0.1至5mm的多孔部分，并且其孔隙延伸穿过其 厚度具有5至100μm的节间距，所述多孔部分的一个面用基于纤维蛋白和/或含纤维蛋白原的材料的化合物进行处理，和（b）覆盖所述支持体的所述被处理表面的纤维蛋白基层 其特征在于，所述纤维蛋白基层在所述经处理的表面上基本均匀且均匀，并且纤维蛋白层和至少与纤维蛋白层接触的支持体的表面基本上不含纤维蛋白原。