-
1.发明申请Von Willebrand Factor- and Factor VIII-Polymer Conjugates Having a Releasable Linkage 有权Von Willebrand因子和因子VIII-聚合物缀合物具有可释放的连接公开(公告)号：US20120142594A1
公开(公告)日：2012-06-07
申请号：US13371275
申请日：2012-02-10
Applicant: Mary J. Bossard , Gayle Stephenson , Zhihao Fang , Harold Zappe , Stacy Mitchell , Ping Zhang , Friedrich Scheiflinger , Peter Turecek , Juergen Siekmann , Katalin Varadi , Herbert Gritsch
Inventor： Mary J. Bossard , Gayle Stephenson , Zhihao Fang , Harold Zappe , Stacy Mitchell , Ping Zhang , Friedrich Scheiflinger , Peter Turecek , Juergen Siekmann , Katalin Varadi , Herbert Gritsch
IPC: C07K14/755 , C07K14/745 , C07K17/08
CPC classification number: C07K14/755 , A61K47/60
Abstract: The present invention provides von Willebrand Factor-polymer conjugates and Factor VIII-polymer conjugates, each having a releasable linkage. Methods of making conjugates, methods for administering conjugates, are also provided.
Abstract translation: 本发明提供了von Willebrand因子 - 聚合物共轭物和因子VIII-聚合物缀合物，其各自具有可释放的连接。 还提供了制备缀合物的方法，用于施用缀合物的方法。
-
2.发明申请Multifunctional Forms of Polyoxazoline Copolymers and Drug Compositions Comprising the Same 有权多官能团形式的聚恶唑啉共聚物和药物组合物组成公开(公告)号：US20120123055A1
公开(公告)日：2012-05-17
申请号：US13356552
申请日：2012-01-23
Applicant: Kunsang Yoon , Michael David Bentley , J. Milton Harris , Zhihao Fang , Tacey Viegas
Inventor： Kunsang Yoon , Michael David Bentley , J. Milton Harris , Zhihao Fang , Tacey Viegas
IPC: C08G73/02
CPC classification number: A61K47/48207 , A61K38/09 , A61K47/59 , C08G73/0233
Abstract: The present disclosure provides copolymers of 2-substituted-2-oxazolines possessing two or three reactive functional groups which are also chemically orthogonal. The copolymers described may be random copolymers, block copolymers or a mixture of random and block copolymer configurations. Furthermore, the present disclosure provides novel methods for synthesizing the above polymers and for conjugating to molecules such as targeting, diagnostic and therapeutic agents.
Abstract translation: 本公开提供了具有两个或三个也是化学正交的反应性官能团的2-取代-2-恶唑啉的共聚物。 所述共聚物可以是无规共聚物，嵌段共聚物或无规嵌段共聚物构型的混合物。 此外，本公开提供了用于合成上述聚合物并用于与靶标，诊断和治疗剂等分子缀合的新方法。
-
3.发明授权Methods for the formation of hydrogels using thiosulfonate compositions and uses thereof 有权使用硫代磺酸盐组合物形成水凝胶的方法及其用途公开(公告)号：US07312301B2
公开(公告)日：2007-12-25
申请号：US10751010
申请日：2003-12-31
Applicant: Zhihao Fang , Michael D. Bentley
Inventor： Zhihao Fang , Michael D. Bentley
IPC: C09K5/06
CPC classification number: C08G65/3342 , A61K47/60 , A61L24/0031 , A61L24/046 , C08G65/329 , C08J3/24 , C08J2300/14 , C08J2381/00 , C08L2203/02 , C08L81/08
Abstract: The present invention provides both crosslinked polymer compositions capable of forming hydrogel upon exposure to an aqueous environment and thiosulfonate hydrogel-forming components. The thiosulfonate hydrogel-forming components of the invention are preferably multi-arm thiosulfonate polymer derivatives that form a crosslinked polymer composition when exposed to a base without requiring the presence of a second cross-linking reagent, redox catalyst, or radiation. Methods for forming hydrogel compositions, as well as methods for using the hydrogel, are also provided.
Abstract translation: 本发明提供了两种能够在暴露于水性环境中形成水凝胶的交联聚合物组合物和形成硫代磺酸盐的水凝胶组分。 本发明的硫代磺酸盐水凝胶形成成分优选为在不需要存在第二交联剂，氧化还原催化剂或辐射的情况下暴露于碱而形成交联聚合物组合物的多臂硫代磺酸盐聚合物衍生物。 还提供了形成水凝胶组合物的方法以及使用该水凝胶的方法。
-
公开(公告)号：US20060183855A1
公开(公告)日：2006-08-17
申请号：US11402350
申请日：2006-04-11
Applicant: Antoni Kozlowski , Xiaoming Shen , Michael Bentley , Zhihao Fang , Tony Sander
Inventor： Antoni Kozlowski , Xiaoming Shen , Michael Bentley , Zhihao Fang , Tony Sander
IPC: A61K47/48
CPC classification number: C08G65/329 , A61K47/56 , A61K47/60 , Y10S530/815
Abstract: Segmented water soluble polymers, containing a higher molecular weight segment linked to a lower molecular weight segment, are described. In one embodiment, the polymer segments are poly(ethylene glycol) segments. The segmented polymers are functionalized and are useful for conjugation to various moieties such as pharmacologically active substances. Also described are conjugates of such polymers and methods of their preparation.
-
5.发明申请Methods for the formation of hydrogels using thiosulfonate compositions and uses thereof 有权使用硫代磺酸盐组合物形成水凝胶的方法及其用途公开(公告)号：US20050143484A1
公开(公告)日：2005-06-30
申请号：US10751010
申请日：2003-12-31
Applicant: Zhihao Fang , Michael Bentley
Inventor： Zhihao Fang , Michael Bentley
IPC: A61K47/48 , A61L24/00 , A61L24/04 , C08G65/329 , C08G65/334 , C08J3/24 , C08K3/00
CPC classification number: C08G65/3342 , A61K47/60 , A61L24/0031 , A61L24/046 , C08G65/329 , C08J3/24 , C08J2300/14 , C08J2381/00 , C08L2203/02 , C08L81/08
Abstract: The present invention provides both crosslinked polymer compositions capable of forming hydrogels upon exposure to an aqueous environment and thiosulfonate hydrogel-forming components. The thiosulfonate hydrogel-forming components of the invention are preferably multi-arm thiosulfonate polymer derivatives that form a crosslinked polymer composition when exposed to a base without requiring the presence of a second cross-linking reagent, redox catalyst, or radiation. Methods for forming hydrogel compositions, as well as methods for using the hydrogels, are also provided.
Abstract translation: 本发明提供了能够在暴露于水性环境中形成水凝胶的交联聚合物组合物和形成硫代磺酸盐的水凝胶组分的交联聚合物组合物。 本发明的硫代磺酸盐水凝胶形成成分优选为在不需要存在第二交联剂，氧化还原催化剂或辐射的情况下暴露于碱而形成交联聚合物组合物的多臂硫代磺酸盐聚合物衍生物。 还提供了形成水凝胶组合物的方法以及使用水凝胶的方法。
-
Patent Agency Ranking
6.发明授权Von willebrand factor- and factor VIII-polymer conjugates having a releasable linkage 有权具有释放键的冯维勒布兰因子和因子VIII-聚合物共轭物公开(公告)号：US09493544B2
公开(公告)日：2016-11-15
申请号：US13620285
申请日：2012-09-14
Applicant: Mary J. Bossard , Gayle Stephenson , Zhihao Fang , Harold Zappe , Stacy Mitchell , Ping Zhang , Friedrich Scheiflinger , Peter Turecek , Juergen Siekmann , Katalin Varadi , Herbert Gritsch
Inventor： Mary J. Bossard , Gayle Stephenson , Zhihao Fang , Harold Zappe , Stacy Mitchell , Ping Zhang , Friedrich Scheiflinger , Peter Turecek , Juergen Siekmann , Katalin Varadi , Herbert Gritsch
IPC: C07K14/755 , C07K14/745 , C07K17/08 , A61K47/48
CPC classification number: C07K14/755 , A61K47/60
Abstract: The present invention provides von Willebrand Factor-polymer conjugates and Factor VIII-polymer conjugates, each having a releasable linkage. Methods of making conjugates, methods for administering conjugates, are also provided.
Abstract translation: 本发明提供了von Willebrand因子 - 聚合物共轭物和因子VIII-聚合物缀合物，其各自具有可释放的连接。 还提供了制备缀合物的方法，用于施用缀合物的方法。
-
公开(公告)号：US08450390B2
公开(公告)日：2013-05-28
申请号：US13554292
申请日：2012-07-20
Applicant: Zhihao Fang , Michael D. Bentley
Inventor： Zhihao Fang , Michael D. Bentley
IPC: C09K5/06 , C07C381/04
CPC classification number: C08G65/3342 , A61K47/60 , A61L24/0031 , A61L24/046 , C08G65/329 , C08J3/24 , C08J2300/14 , C08J2381/00 , C08L2203/02 , C08L81/08
Abstract: The present invention provides both crosslinked polymer compositions capable of forming hydrogels upon exposure to an aqueous environment and thiosulfonate hydrogel-forming components. The thiosulfonate hydrogel-forming components of the invention are preferably multi-arm thiosulfonate polymer derivatives that form a crosslinked polymer composition when exposed to a base without requiring the presence of a second cross-linking reagent, redox catalyst, or radiation. Methods for forming hydrogel compositions, as well as methods for using the hydrogels, are also provided.
-
8.发明授权Thioester-terminated water soluble polymers and method of modifying the N-terminus of a polypeptide therewith 有权硫酯封端的水溶性聚合物和用其修饰多肽的N末端的方法公开(公告)号：US08329876B2
公开(公告)日：2012-12-11
申请号：US13282129
申请日：2011-10-26
Applicant: Michael J. Roberts , Zhihao Fang
Inventor： Michael J. Roberts , Zhihao Fang
Abstract: The invention provides reagents and methods for conjugating a polymer specifically to the α-amine of a polypeptide. The invention provides monofunctional, bifunctional, and multifunctional PEGs and related polymers having a terminal thioester moiety capable of specifically conjugating to the α-amine of a polypeptide having a cysteine or histidine residue at the N-terminus. The invention provides reactive thioester-terminated PEG polymers that have suitable reactivity with an N-terminal cysteine or histidine residue of a polypeptide to produce an amide bond between the PEG molecule and the polypeptide.
Abstract translation: 本发明提供了将聚合物与多肽的α-胺特异性缀合的试剂和方法。 本发明提供了具有能够在N末端具有半胱氨酸或组氨酸残基的多肽的α-胺特异性缀合的末端硫酯部分的单功能，双官能和多官能PEG和相关聚合物。 本发明提供了具有与多肽的N-末端半胱氨酸或组氨酸残基的合适反应性的反应性硫酯封端的PEG聚合物，以在PEG分子和多肽之间产生酰胺键。
-
9.发明授权公开(公告)号：US08101706B2
公开(公告)日：2012-01-24
申请号：US12787241
申请日：2010-05-25
Applicant: Kunsang Yoon , Michael David Bentley , J. Milton Harris , Zhihao Fang , Tacey Viegas
Inventor： Kunsang Yoon , Michael David Bentley , J. Milton Harris , Zhihao Fang , Tacey Viegas
CPC classification number: A61K47/48207 , A61K38/09 , A61K47/59 , C08G73/0233
Abstract: The present disclosure provides copolymers of 2-substituted-2-oxazolines possessing two or three reactive functional groups which are also chemically orthogonal. The copolymers described may be random copolymers, block copolymers or a mixture of random and block copolymer configurations. Furthermore, the present disclosure provides novel methods for synthesizing the above polymers and for conjugating to molecules such as targeting, diagnostic and therapeutic agents.
-
10.发明申请Multifunctional Forms of Polyoxazoline Copolymers and Drug Compositions Comprising the Same 有权多官能团形式的聚恶唑啉共聚物和药物组合物组成公开(公告)号：US20100330023A1
公开(公告)日：2010-12-30
申请号：US12787241
申请日：2010-05-25
Applicant: Kunsang Yoon , Michael David Bentley , J. Milton Harris , Zhihao Fang , Tacey Viegas
Inventor： Kunsang Yoon , Michael David Bentley , J. Milton Harris , Zhihao Fang , Tacey Viegas
IPC: A61K31/785 , A61P35/00
CPC classification number: A61K47/48207 , A61K38/09 , A61K47/59 , C08G73/0233
Abstract: The present disclosure provides copolymers of 2-substituted-2-oxazolines possessing two or three reactive functional groups which are also chemically orthogonal. The copolymers described may be random copolymers, block copolymers or a mixture of random and block copolymer configurations. Furthermore, the present disclosure provides novel methods for synthesizing the above polymers and for conjugating to molecules such as targeting, diagnostic and therapeutic agents.
Abstract translation: 本公开提供了具有两个或三个也是化学正交的反应性官能团的2-取代-2-恶唑啉的共聚物。 所述共聚物可以是无规共聚物，嵌段共聚物或无规嵌段共聚物构型的混合物。 此外，本公开提供了用于合成上述聚合物并用于与靶标，诊断和治疗剂等分子缀合的新方法。
-
-
-
-
-
-
-
-
-
Search Results
49
records
(took 0.022 seconds)
