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公开(公告)号:US20110086834A1
公开(公告)日:2011-04-14
申请号:US12997868
申请日:2009-06-26
申请人: Guoqing Chen , Timothy D. Cushing , Paul Faulder , Benjamin Fisher , Xiao He , Kexue Li , Zhihong Li , Wen Liu , Lawrence R. Mcgee , Vatee Pattaropong , Jennifer L. Seganish , Youngshook Shin , Zhulun Wang
发明人: Guoqing Chen , Timothy D. Cushing , Paul Faulder , Benjamin Fisher , Xiao He , Kexue Li , Zhihong Li , Wen Liu , Lawrence R. Mcgee , Vatee Pattaropong , Jennifer L. Seganish , Youngshook Shin , Zhulun Wang
IPC分类号: A61K31/506 , C07D413/14 , C07D403/14 , C07D401/14 , C07D417/14 , C07D413/04 , C07D403/04 , C07D409/14 , C07D491/107 , C07D498/10 , C07D473/16 , C07D487/04 , C07D407/14 , C07D239/48 , C07D471/10 , C07D495/10 , C07D487/14 , A61K31/497 , A61K31/433 , A61K31/53 , A61K31/4439 , A61K31/427 , A61K31/52 , A61K31/5377 , A61K31/505 , A61K31/519 , A61K31/55 , A61P35/00 , A61P35/02 , A61P37/06 , A61P11/06 , A61P17/00 , A61P19/02 , A61P25/28 , A61P11/00 , A61P1/00 , A61P29/00
CPC分类号: C07D413/14 , C07D213/82 , C07D233/88 , C07D401/14 , C07D403/04 , C07D403/14 , C07D407/08 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04 , C07D471/10 , C07D487/04 , C07D487/06 , C07D487/10 , C07D487/16 , C07D491/10 , C07D495/10
摘要: Selected compounds are effective for prophylaxis and treatment of inflammation and inflammatory disorders, such as NIK-mediated disorders. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, inflammation and the like.
摘要翻译: 选择的化合物对于预防和治疗炎症和炎症性疾病如NIK介导的病症是有效的。 本发明包括新颖的化合物,类似物,前药和药学上可接受的盐,用于预防和治疗疾病和其它疾病或涉及炎症等的病症的药物组合物和方法。
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公开(公告)号:US08324160B2
公开(公告)日:2012-12-04
申请号:US12817084
申请日:2010-06-16
申请人: Yang Li , Xinle Wu , Zhulun Wang
发明人: Yang Li , Xinle Wu , Zhulun Wang
CPC分类号: C07K14/50 , C07K16/22 , C07K2319/00
摘要: The disclosure provides nucleic acid molecules encoding chimeric polypeptides, chimeric polypeptides, pharmaceutical compositions comprising chimeric polypeptides, and methods for treating metabolic disorders such as diabetes and obesity using such nucleic acids, polypeptides, or pharmaceutical compositions.
摘要翻译: 本公开内容提供了编码嵌合多肽的核酸分子,嵌合多肽,包含嵌合多肽的药物组合物,以及使用这种核酸,多肽或药物组合物治疗代谢性疾病如糖尿病和肥胖症的方法。
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公开(公告)号:US20070299080A1
公开(公告)日:2007-12-27
申请号:US11806461
申请日:2007-05-31
申请人: Jay Powers , Michael Degraffenreid , Lisa Julian , Jacob Kaizerman , Dustin McMinn , Yosup Rew , Daqing Sun , Xuelei Yan , Zhulun Wang
发明人: Jay Powers , Michael Degraffenreid , Lisa Julian , Jacob Kaizerman , Dustin McMinn , Yosup Rew , Daqing Sun , Xuelei Yan , Zhulun Wang
IPC分类号: A61K31/166 , A61K31/381 , A61K31/42 , A61K31/426 , A61K31/44 , A61K31/4965 , A61K31/50 , A61K31/505 , A61P3/04 , A61P3/10 , C07C235/42 , C07C271/12 , C07D213/56 , C07D237/08 , C07D239/26 , C07D241/12 , C07D261/08 , C07D277/30 , C07D333/24 , C07D333/38
CPC分类号: C07C235/42 , A61K31/166 , A61K31/381 , A61K31/42 , A61K31/426 , A61K31/44 , A61K31/4965 , A61K31/50 , A61K31/505 , C07C237/22 , C07C237/24 , C07C237/42 , C07C255/31 , C07C255/46 , C07C255/60 , C07C271/12 , C07C271/20 , C07C307/06 , C07C2601/02 , C07C2601/14 , C07C2603/94 , C07D213/30 , C07D213/53 , C07D237/08 , C07D239/26 , C07D241/12 , C07D261/08 , C07D277/22 , C07D277/24
摘要: Benzamide derivatives of formula I are described and have therapeutic utility, particularly in the treatment of diabetes, obesity and related conditions and disorders: wherein R1, R2, R3, R4, R5, R6, R7, R8, and n are as defined herein.
摘要翻译: 描述了式I的苯甲酰胺衍生物,并且具有治疗用途,特别是在治疗糖尿病,肥胖症和相关病症和病症中:其中R 1,R 2,R 2 R 3,R 4,R 5,R 6,R 7,R SUP, > 8,n如本文所定义。
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公开(公告)号:US07132438B2
公开(公告)日:2006-11-07
申请号:US10268412
申请日:2002-10-09
申请人: Alexander David Frenkel , Sarah Elizabeth Lively , Jay P. Powers , Andrew Smith , Daqing Sun , Craig Tomooka , Zhulun Wang
发明人: Alexander David Frenkel , Sarah Elizabeth Lively , Jay P. Powers , Andrew Smith , Daqing Sun , Craig Tomooka , Zhulun Wang
IPC分类号: A61K31/4184 , C07D235/30
CPC分类号: C07D249/08 , C07D231/12 , C07D233/56 , C07D235/30 , C07D401/06 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/12 , C07D409/12 , C07D471/04
摘要: Compounds, pharmaceutical compositions and methods are provided that are useful in the treatment of inflammatory and immune-related conditions or disorders. In particular, the invention provides compounds which modulate the expression and/or function of proteins involved in inflammation, immune response regulation and cell proliferation. The subject compounds are 2-amino-imidazole derivatives.
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公开(公告)号:US20100323954A1
公开(公告)日:2010-12-23
申请号:US12817084
申请日:2010-06-16
申请人: Yang LI , Xinle Wu , Zhulun Wang
发明人: Yang LI , Xinle Wu , Zhulun Wang
CPC分类号: C07K14/50 , C07K16/22 , C07K2319/00
摘要: The disclosure provides nucleic acid molecules encoding chimeric polypeptides, chimeric polypeptides, pharmaceutical compositions comprising chimeric polypeptides, and methods for treating metabolic disorders such as diabetes and obesity using such nucleic acids, polypeptides, or pharmaceutical compositions.
摘要翻译: 本公开内容提供了编码嵌合多肽的核酸分子,嵌合多肽,包含嵌合多肽的药物组合物,以及使用这种核酸,多肽或药物组合物治疗代谢性疾病如糖尿病和肥胖症的方法。
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公开(公告)号:US20100048565A1
公开(公告)日:2010-02-25
申请号:US12607931
申请日:2009-10-28
申请人: Alexander David Frenkel , Sarah Elizabeth Lively , Jay P. Powers , Andrew Smith , Daqing Sun , Craig Tomooka , Zhulun Wang
发明人: Alexander David Frenkel , Sarah Elizabeth Lively , Jay P. Powers , Andrew Smith , Daqing Sun , Craig Tomooka , Zhulun Wang
IPC分类号: A61K31/4184 , C07D235/30 , C07D413/04 , C07D401/10 , A61K31/5377 , A61K31/454 , A61P37/00
CPC分类号: C07D249/08 , C07D231/12 , C07D233/56 , C07D235/30 , C07D401/06 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/12 , C07D409/12 , C07D471/04
摘要: Compounds, pharmaceutical compositions and methods are provided that are useful in the treatment of inflammatory and immune-related conditions or disorders. In particular, the invention provides compounds which modulate the expression and/or function of proteins involved in inflammation, immune response regulation and cell proliferation. The subject compounds are 2-amino-imidazole derivatives.
摘要翻译: 提供了可用于治疗炎症和免疫相关病症或疾病的化合物,药物组合物和方法。 特别地,本发明提供调节参与炎症,免疫应答调节和细胞增殖的蛋白质的表达和/或功能的化合物。 主题化合物是2-氨基 - 咪唑衍生物。
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公开(公告)号:US08772296B2
公开(公告)日:2014-07-08
申请号:US11806461
申请日:2007-05-31
申请人: Jay P. Powers , Michael Degraffenreid , Lisa Julian , Jacob Kaizerman , Dustin McMinn , Yosup Rew , Daqing Sun , Xuelei Yan , Zhulun Wang , Felix Gonzalez Lopez De Turiso
发明人: Jay P. Powers , Michael Degraffenreid , Lisa Julian , Jacob Kaizerman , Dustin McMinn , Yosup Rew , Daqing Sun , Xuelei Yan , Zhulun Wang , Felix Gonzalez Lopez De Turiso
IPC分类号: A61K31/166 , A61K31/381 , A61K31/42 , A61K31/426 , A61K31/44 , A61K31/4965 , A61K31/50 , A61K31/505 , A61P3/04 , A61P3/10 , C07C235/42 , C07C271/12 , C07D213/56 , C07D237/08 , C07D239/26 , C07D241/12 , C07D261/08 , C07D277/30 , C07D333/24 , C07D333/38 , C07D277/22 , C07C237/24 , C07C237/42 , C07C237/22 , C07C255/31 , C07C255/46 , C07C271/20 , C07C307/06 , C07D213/30 , C07D213/53
CPC分类号: C07C235/42 , A61K31/166 , A61K31/381 , A61K31/42 , A61K31/426 , A61K31/44 , A61K31/4965 , A61K31/50 , A61K31/505 , C07C237/22 , C07C237/24 , C07C237/42 , C07C255/31 , C07C255/46 , C07C255/60 , C07C271/12 , C07C271/20 , C07C307/06 , C07C2601/02 , C07C2601/14 , C07C2603/94 , C07D213/30 , C07D213/53 , C07D237/08 , C07D239/26 , C07D241/12 , C07D261/08 , C07D277/22 , C07D277/24
摘要: Benzamide derivatives of formula I are described and have therapeutic utility, particularly in the treatment of diabetes, obesity and related conditions and disorders: wherein R1, R2, R3, R4, R5, R6, R7, R8, and n are as defined herein.
摘要翻译: 描述了式I的苯甲酰胺衍生物,并且具有治疗用途,特别是在治疗糖尿病,肥胖症和相关病症和病症中:其中R1,R2,R3,R4,R5,R6,R7,R8和n如本文所定义。
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公开(公告)号:US07635774B2
公开(公告)日:2009-12-22
申请号:US11513614
申请日:2006-08-30
申请人: Alexander David Frenkel , Sarah Elizabeth Lively , Jay P. Powers , Andrew Smith , Daqing Sun , Craig Tomooka , Zhulun Wang
发明人: Alexander David Frenkel , Sarah Elizabeth Lively , Jay P. Powers , Andrew Smith , Daqing Sun , Craig Tomooka , Zhulun Wang
IPC分类号: A61K31/5355 , C07D413/06
CPC分类号: C07D249/08 , C07D231/12 , C07D233/56 , C07D235/30 , C07D401/06 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/12 , C07D409/12 , C07D471/04
摘要: Compounds, pharmaceutical compositions and methods are provided that are useful in the treatment of inflammatory and immune-related conditions or disorders. In particular, the invention provides compounds which modulate the expression and/or function of proteins involved in inflammation, immune response regulation and cell proliferation. The subject compounds are 2-amino-imidazole derivatives.
摘要翻译: 提供了可用于治疗炎症和免疫相关病症或疾病的化合物,药物组合物和方法。 特别地,本发明提供调节涉及炎症,免疫应答调节和细胞增殖的蛋白质的表达和/或功能的化合物。 主题化合物是2-氨基 - 咪唑衍生物。
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公开(公告)号:US20070037803A1
公开(公告)日:2007-02-15
申请号:US11513614
申请日:2006-08-30
申请人: Alexander Frenkel , Sarah Lively , Jay Powers , Andrew Smith , Daqing Sun , Craig Tomooka , Zhulun Wang
发明人: Alexander Frenkel , Sarah Lively , Jay Powers , Andrew Smith , Daqing Sun , Craig Tomooka , Zhulun Wang
IPC分类号: A61K31/5377 , A61K31/454 , A61K31/4184 , C07D413/02 , C07D403/02
CPC分类号: C07D249/08 , C07D231/12 , C07D233/56 , C07D235/30 , C07D401/06 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/12 , C07D409/12 , C07D471/04
摘要: Compounds, pharmaceutical compositions and methods are provided that are useful in the treatment of inflammatory and immune-related conditions or disorders. In particular, the invention provides compounds which modulate the expression and/or function of proteins involved in inflammation, immune response regulation and cell proliferation. The subject compounds are 2-amino-imidazole derivatives.
摘要翻译: 提供了可用于治疗炎症和免疫相关病症或疾病的化合物,药物组合物和方法。 特别地,本发明提供调节参与炎症,免疫应答调节和细胞增殖的蛋白质的表达和/或功能的化合物。 主题化合物是2-氨基 - 咪唑衍生物。
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